BIOCHEMISTRY OF PROTEINS. The course outline is available at:h6p://home.cc.umanitoba.ca/ ~joneil/chem4630.course.outline.htm

Transcription

1 CHEM 4630 BIOCHEMISTRY OF PROTEINS The course outline is available at:h6p://home.cc.umanitoba.ca/ ~joneil/chem4630.course.outline.htm Some themes in the Biochemistry of Proteins: 1. Proteins are BIG organic molecules. The physical-chemical properkes of the amino acids and the pep,de bond explain the physical-chemical properkes of proteins which explain the BIOLOGICAL properkes and funckons of proteins. 2. A theme of structural biology is: Structure Determines FuncKon The annual number of molecular structures deposited in the Brookhaven Protein Data Bank are graphed to the right. h6p:// stakskcs/contentgrowthchart.do? content=total&seqid=100 1

2 3. A major area of research is how protein structure expresses funckon through protein dynamics. e.g. The enzyme F o F 1 ATP synthase uses energy stored in a proton gradient to synthesize ATP from ADP and P i. The conformakonal change that releases ATP is the spinning of a central rotor relakve to the rest of the protein. In the absence of a proton gradient the protein dynamics is stochas,c (unpredictable) but in the presence of a proton gradient direc@onal rotakon occurs owing to protonakon of a charged glutamic acid side-chain. The mokon was observed directly by a6aching a fluorescent ackn filament to the protein: h6ps:// v=qehcafkawm8 The following movies of the protein mokon are based on interpolakon of X-ray diffrackon structures using flip-book or animakon techniques: h6ps:// 4. The outstanding queskons in protein chemistry can be gleaned from the Ktles of talks given at internakonal conferences. 2

3 1/4/16 APS 2015 American Peptide Symposium /4/16, 12:44 PM AMERICAN PEPTIDE SYMPOSIUM JUNE ORLANDO, FLORIDA JOIN US FOR THE 24TH APS SYMPOSIUM Our Sponsors Welcome to the American Peptide Society's 24th International Symposium W e extend to you a warm Orlando welcome to the 24th American Peptide Symposium. A couple of years ago, we were asked to organize the 24th Meeting of the American Peptide Society. Initially, this seemed like a daunting task but we were keen to take on the challenge! This unique opportunity to host the peptide community for 6 days of stimulating science was too hard to resist, despite the amount of work we needed to invest in this project. In our quest to understand the best possible mix of topics to appeal to the widest audience from Academia to Industry, we found the answer: we wanted the enabling aspects of peptide science to come through in the strongest possible way. The meeting theme Enabling Peptide Research from Basic ( Science to Drug Discovery embraces the spirit of the scientific and social programs we have assembled for you.! Ved Srivastava, Ph.D. (mailto:2015aps@gmail.comsubject=message%20from%20aps%20website) GlaxoSmithKline, Symposium CoChair Recently, the use of peptides as drugs has been increasing exponentially, especially in metabolic diseases and in exploring intracellular targets. A presymposium, with a theme of peptides in metabolic diseases, is planned with an emphasis on basic pharmacology and peptide targets. This is followed by Disney Discounts a number of regular scientific sessions, which focus on topics as diverse as macrocycles, synthetic peptides, medicinal chemistry and peptide therapeutics, all representing emerging peptide technologies. The scientific program for 2015 opens with distinguished lecture by Dr. Richard A. Lerner ( of The Scripps Research Institute followed by a social gathering at the Upper Pool Deck of the resort. The symposium will be concluded with a lecture by Dr. Jeffrey Friedman ( of the Rockefeller Institute, which will be followed by the closing banquet.! Andrei Yudin, Ph.D. (mailto:ayudin@chem.utoronto.ca? Subject=Message%20from%20APS%20Website), University of Toronto, Symposium Unlike previous events, two workshops will be conducted at this meeting: (1) Co-Chair workshop on peptide Chemistry Manufacturing and Controls (CMC) and regulatory challenges; and (2) workshop on career development, job search strategy and interview preparation. The lectures from awards winners, Save time and money by purchasing Disney tickets at a discount through our special Disney Microsite! Disney including the Merrifield, Vincent du Vigneaud, Makineni, and Goodman Awards are spread out over the six days of the symposium. Symposium Venue Orlando, Florida is offering exclusive afternoon After 2PM and After 4 PM tickets, as well as a 10% savings on all multi-day, 2+ day, tickets for attendees and guests. All Multi-day tickets include an additional complimentary "Bonus read more + Visit" admission. VISIT DISNEY! read more + read more + ( ( (travel/our_hotel.html) and-events.html) ( Page 1 of 2 APS 2015 Our Sponsors 1/4/16, 12:46 PM Scientific Topics. ( Poster and Oral Presentations will Cover the Following Topics: Symposium Sessions topics Peptides in Metabolic Disease Synthetic methods Macrocycles Peptide biomaterials Bioactive peptides Peptide structure and function Proteomics and Epigenetic Peptide catalysis Cell Penetrating Peptides Peptide medicinal chemistry Metabolism - ADME Peptide therapeutics Peptides in the clinic Peptide formulation and delivery Emerging Peptide Technologies Immunotherapy Stay Connected Contact Us juewarne@indiana.edu (mailto:juewarne@indiana.edu) 2014 American Peptide Society (../index.html) Page 1 of 1 3

4 Peptalk - The Protein Science Week 1/4/16, 12:34 PM Agenda Sponsor/Exhibitor Downloads Travel CD/DVD Posters Press Register #PTK16 <><>. PepTalk 2016 Recombinant Protein Therapeutics Enhancing Antibody Binding and Specificity Membrane Proteins Emerging Technologies for Antibody Discovery and Engineering Next-Generation Cancer Immunotherapies Antibody-Drug Conjugates Bispecific Antibody Therapeutics Optimizing Biologics Formulation Development Lyophilization and Emerging Drying Technologies Protein Aggregation and Emerging Analytical Tools Engineering Genes, Vectors, Constructs and Clones Recombinant Protein Expression Membrane Proteins PepTalk: The Protein Science Week is one of the largest gatherings of protein science researchers in the world. It offers an array of education, innovation and networking programs, and provides many opportunities to scientists. PepTalk is an annual gathering where industry experts from around the world convene to share case studies, unpublished data, breakthroughs and solutions that support and enhance research, and to gain new perspectives on the evolution of biologics. Event Features Include: Network with over 1200 attendees from over 30 countries Hear unpublished data and case studies from industry leaders Create your own agenda Premium Package allows access to all conferences for one price! Showcase your research by presenting a scientific poster Participate in the popular BuzZ Session Roundtable Discussions View over 150 scientific posters Build your own schedule using the event mobile app Visit over 100 companies in the exhibit hall Take advantage of student fellowships available for grad students and Ph.D. candidates Download 2016 Brochure Download Conference At A Glance Premier Sponsors: CHO Cell Culture Applying Expression Platforms View All Sponsors Characterization of Biotherapeutics View Media Partners Detection and Characterization of Particulates and Impurities View 2016 Participant list Extractables and Leachables Single-Use Technologies and Continuous Processing Protein Purification and Recovery Membrane Proteins Higher-Throughput Protein Purification Page 1 of 2 BIT's 9th Annual World Protein & Peptide Conference 1/4/16, 12:32 PM. Annual World Protein and Peptide Conference 2016 Home About Conference Program Participant Registration Sponsorship & Exhibition Media Optional Tour Scientific Program BIT s 9 th Annnual World Protein & Peptide Conference Theme: Translation, Health and Happiness Time: April 25-28, 2016 Venue: International Conference Center, Dalian, China Scientific Program Keynote Forum Symposium 1 Symposium 2 Symposium 3 Symposium 4 Symposium 5 Symposium 6 Y Keynote Forum of PepCon-2016 Day 1: Afternoon, Tuesday, April 26, :30-16:35 Moderator: Dr. Matthew He, Assistant Dean, Full Professor, Nova Southeastern University, USA Time FaceOn Speeches and Speakers Org. Logo Page 1 of 4 4

5 IUBMB 2015 SBBq - Confirmed Speakers 1/4/16, 12:37 PM The Event Search International Union for Biochemistry and Molecular Biology 2015 Home Scientific Program» Young Scientist» Registration» Congress Information» Participant Guidelines» Exhibition and Sponsorship Sponsors Satellite Meeting Special Activities Abstract Book Feedback SBBq Award Confirmed Speakers Keynote Lecturers (confirmed): Bruce Alberts, University of California, San Francisco, USA Günther Meister, University of Regensburg, Germany Johann Deisenhofer, University of Texas Southwestern Medical Center, USA Jose Onuchic, Rice University, USA Kurt Wüthrich, The Scripps Research Institute, USA Martin Chalfie, Columbia University, USA Tom Steitz, Howard Hughes Medical Institue, USA Salvador Moncada, The University of Manchester, UK Symposia Speakers (confirmed): Abel Santamaria, Universidad Autonoma Del Mexico, MX Adi Kimchi, Weizmann Institute of Science, Israel Akihiko Nakano, University of Tokyo, Japan Alejandro Buschiazzo, Institut Pasteur de Montevideo, Uruguay Alexandra Newton, University of California, San Diego, USA Amira Klip, University of Toronto, Ontario, Canada Anamaria Camargo Aranha, Instituto Ludwig, Brazil Andrea Thompson Da Poian, Universidade Federal do Rio de Janeiro, Brazil Andrea Cristina Paula Lima, Universidad de Chile, Chile Andy Weyrich, University of Utah, USA Anthony J. Kettle, University of Otago, New Zealand Beatriz Alvarez, Universidad de La Republica, Uruguay Bonnie Wallace, Instiute of Structural and Molecular Biology, Birkbeck College, University of London, UK Bianca Zingales, Universidade de São Paulo, Brazil Byron Caughney, NIH-NIAID, USA Bruce Alberts, University of California, San Francisco, USA Carol Prives, Columbia University, USA Celso Caruzo Neves, Universidade do Rio de Janeiro, Brazil Chunlin Long, College of Life and Environmental Sciences, Minzu University of China, China Claudio J. Soto, University of Texas, USA Dario S. Zamboni, Faculdade de Medicina, USP-RP, Brazil David Carling, Imperial College of London, UK Debora Foguel, Universidade do Rio de Janeiro, Brazil Deborah Kurrasch, University of Alberta, Canada Deborah Schechtman, Universidade de São Paulo, Brazil Diogo Onofre de Souza, Universidade Federal do Rio Grande do Sul, Brazil Dmitry Korzhnev, University of Connecticut Health Center, USA Ehud Gazit, Tel Aviv University, Israel Eduardo Galembeck, Universidade Estadual de Campinas, Brazil Efstathios S. Gonos, National Hellenic Research Foundation, Greece Elena N. Elpidina, M.V. Lomonosov Moscow State University, Moscow Eric Lam, Rutgers, the State University of New Jersey, USA Enrico Gratton, University of California Irvine, USA Etelvino J.H. Bechara, Universidade de São Paulo, Brazil Fabio C.L. Almeida, Universidade Federal do Rio de Janeiro, Brazil Fernanda de Felice, Universidade Federal do Rio de Janeiro, Brazil Fernando Goldbaum, Fundación Instituto Leloir, Argentina Francisco Ambrósio, Universidade de Coimbra, Portugal Francisco José BARRANTES, University of Argentina-CONICET Francisco Laurindo, Universidade de São Paulo, Brazil Fred Robert Tabita, The Ohio State University, USA Page 1 of 4 CSHL Meetings 1/4/16, 2:48 PM Cold Spring Harbor Symposium 2016 Home Meetings Courses Cancer 'Omics Neuro All Cell/Mol Bio Genetics Immun/Infect Meetings & Conferences Meeting Name Meeting Dates Abstracts Due Systems Biology: Global Regulation of Gene Expression Tue Mar 15 - Sat Mar Fri Jan Evolutionary Biology of Caenorhabditis & Other Nematodes Wed Mar 30 - Sat Apr Fri Jan Neuronal Circuits Wed Apr 6 - Sat Apr Fri Jan The PARP Family & ADP-ribosylation Wed Apr 13 - Sat Apr Fri Jan Protein Homeostasis in Health & Disease Mon Apr 18 - Fri Apr Fri Jan Gene Expression & Signaling in the Immune System Tue Apr 26 - Sat Apr Fri Feb Nuclear Organization & Function Tue May 3 - Sat May Fri Feb The Biology of Genomes Tue May 10 - Sat May Fri Feb The Cell Cycle Tue May 17 - Sat May Fri Feb Retroviruses Mon May 23 - Sat May Fri Mar st Cold Spring Harbor Symposium: Targeting Cancer Wed Jun 1 - Mon Jun Fri Mar Glia in Health & Disease Thu Jul 21 - Mon Jul Fri May Genome Engineering: The CRISPR/Cas Revolution Wed Aug 17 - Sat Aug Fri May Regulatory & Non-Coding RNAs Tue Aug 23 - Sat Aug Fri Jun The PI3K-mTOR-PTEN Network in Health & Disease Tue Aug 30 - Sat Sep Fri Jun Translational Control Tue Sep 6 - Sat Sep Fri Jun Epigenetics & Chromatin Tue Sep 13 - Sat Sep Fri Jun Page 1 of 2 5

6 CSHL Meetings 1/4/16, 2:48 PM Epigenetics & Chromatin Tue Sep 13 - Sat Sep Fri Jun Axon Guidance, Synapse Formation & Regeneration Tue Sep 20 - Sat Sep Fri Jul Mechanisms of Aging Mon Sep 26 - Fri Sep Mon Jul Germ Cells Tue Oct 4 - Sat Oct Fri Jul Thirty Years of HIV/AIDS Research: The Science & Beyond Wed Oct 12 - Sat Oct Thu Sep Biological Data Science Tue Oct 25 - Sat Oct Fri Aug Neurodegenerative Diseases: Biology & Therapeutics Wed Nov 30 - Sat Dec Fri Sep Blood Brain Barrier Wed Dec 7 - Sat Dec Fri Sep Cold Spring Harbor Laboratory Meetings & Courses Program PO Box 100, 1 Bungtown Road Cold Spring Harbor, NY Phone (516) Fax: (516) meetings@cshl.edu Page 2 of 2 The Protein Society: The home for the international protein science community 1/4/16, 12:25 PM JOIN LIST MEMBERS ACCESS PROTEIN SCIENCE HERE: A GLOBAL COMMUNITY OF RESEARCHERS DEDICATED TO THE UNDERSTANDING OF PROTEINS ABOUT MEETINGS MEMBERSHIP AWARDS THE JOURNAL RESOURCES GET INVOLVED 30 th Anniversary Symposium of The Protein Society SYMPOSIUM THE 30TH ANNIVERSARY SYMPOSIUM OF THE PROTEIN SOCIETY Topics Baltimore, Maryland USA July 16-19, 2016 Hyatt Regency Baltimore Birth, Life, & Death of Proteins Protein Evolution & Design Protein Folding & Misfolding Emerging Methods for Protein Research Membrane Protein Folding & Function Proteins on the Move AWARDS CRITERIA Applied Protein Research Dynamic Modulation of Protein Function Interface Between Proteins & Nucleic Acids Interdisciplinary Approaches to Protein Science 2016 Program Planning Committee Brenda Schulman, St. Jude Children s Research Hospital Andreas Plückthun, University of Zurich Ralf Langen, University of Southern California Nieng Yan, Tsinghua University 2016 Confirmed Speakers Anna Marie Pyle, Yale University Andrzej Joachimiak, University of Chicago Beili Wu, The Scripps Research Institute Bil Clemons, California Institute of Technology Cliff Brangwynne, Princeton University Dan Tawfik, Weizmann Institute of Science David Eisenberg, University of California, Los Angeles Emmanuelle Charpentier, Molecular Infection Medicine Sweden Page 1 of 3 6

7 Gordon Research Conferences - Meeting List: /4/16, 12:27 PM Alert for GRC Attendees: GRC has received reports of a phone scam which is targeting conference attendees. Click here for more information. X Gordon Research Conferences Meeting List: 2016 Gordon Research Conferences 2016 The following meetings are currently scheduled for The meeting list can be sorted by conference name, type (GRC or GRS), date, or location, by clicking on the corresponding column heading. The list can also be narrowed down in different ways by selecting one of the tabs below. Click on a meeting name to view more details, including the current program (if available). All Meetings By Category By Site By Date By Keyword By Discipline Display only New Meetings Hide meetings that have taken place Display only Gordon Research Seminars Displaying: 325 of 325 Total Meetings Type Conference Name Dates Conference Site Advanced Health Informatics The Use of Big Data in Health Related Research Jul The Chinese University of Hong Kong Advanced Materials for Sustainable Infrastructure Development The Science and Technology of Sustainable Concrete Jul 31 - Aug 5 The Hong Kong University of Science and Technology Alcohol & the Nervous System Breakthroughs in Alcohol Neuroscience Research at the Level of Molecules, Cells, Synapses, and Behavior Feb 7-12 Hotel Galvez Angiotensin Angiotensin: From Cell Biology and Signaling Networks to Novel Physiological Paradigms and Therapeutics Feb Renaissance Tuscany Il Ciocco Angiotensin (GRS) The Renin Angiotensin System in Health and Disease: Latest Advances and New Technologies Feb Renaissance Tuscany Il Ciocco Antibody Biology & Engineering Mar Hotel Galvez Page 1 of 29 Diffrac@on Methods in Structural Biology (GRS) Protein FuncKon in Time and Space: Insights from DiffracKon Experiments Intrinsically Disordered Proteins Disordered Proteins: From Mechanisms to TherapeuKc OpportuniKes Lipoprotein Metabolism Lipid and Lipoprotein Metabolism in Chronic Disease Pathogenesis and Treatment Membrane Transport Proteins Membrane Transporters: TranslaKng Molecules to Medicine Phosphoryla@on & G-Protein Mediated Signaling Networks New Druggable Targets Underlying Structural and SpaKal Aspects of Signaling in Metabolic, Inflammatory, and Other Stress-Related Disease Pathways 7

8 Protein Folding Dynamics Folding: The Landscapes of Natural and SyntheKc Life Protein Processing, Trafficking & Secretory and EndocyKc Pathways in Health and Disease Protein Transport Across Cell Membranes Protein Transport Across Cell Membranes: Mechanism, Structure, and RegulaKon Enzymes, Coenzymes & Metabolic Pathways Advances in Enzymology from Determining Enzyme FuncKon to the Interplay of Large Enzyme Systems Intermediate Filaments (GRS) Breaking Barriers in Intermediate Filament Biology: From Structure to Mechanisms and Targets in Human Diseases Ion Channels Molecular Basis for Electrical Signaling in the Nervous System and Beyond Ligand & Molecular Molecular Basis of Ligand RecogniKon and GaKng in Transmembrane Signaling and Transport Muscle & Molecular Motors Motor Mechanisms from Single Molecules to Cellular FuncKon Notch Signaling in Development, & Disease Notch Signaling: Phenotypes to Molecular Mechanisms NOX Family NADPH Oxidases NOX Molecular Insights Leading to TranslaKon Chemistry & Biology of Crossing Barriers by PepKde Science for Health and Wellness 8

9 Thiol-Based Redox & Signaling (GRS) Redox Biology in Diseases of Aging: Fundamental Mechanisms and TherapeuKc PotenKal Three Dimensional Electron Microscopy Advancing and Reshaping Structural Biology with Electron Cryo- Microscopy Gordon Research Conferences Meeting - Protein Folding Dynamics 1/4/16, 12:28 PM Alert for GRC Attendees: GRC has received reports of a phone scam which is targeting conference attendees. Click here for more information. X Gordon Research Conferences Meeting Details Protein Folding Dynamics Gordon Research Conference Folding: The Landscapes of Natural and Synthetic Life Dates January 10-15, 2016 Location Hotel Galvez Galveston, TX Organizers Chair: Peter G. Wolynes Vice Chair: Benjamin Schuler Application Deadline The application deadline for this meeting was December 13, You may still submit an application, which may be considered by the conference chair if there is still room available. Meeting Description The protein folding problem has long been regarded as a fundamental mystery blocking our understanding of how the genetic information locked in DNA is transformed into a dynamic living organism. In the last decades, however, a basic understanding of the folding process has been achieved. The keys to this progress include borrowing theoretical ideas about energy landscapes from condensed matter physics and physical chemistry, employing powerful computer simulation techniques and bringing to bear new experimental tools such as single molecule methods and ultrafast spectroscopy, as well as elaborating the classical kinetic techniques of biophysical chemistry while exploiting the capabilities of protein engineering. Thus many communities from physics, chemistry and biology have merged to form the discipline of protein folding dynamics. Many of the fundamental issues about how proteins fold remain under intense investigation. New frontiers include understanding the diversity and basic time scales of folding larger proteins building on what has been learned in small model systems. Also we can now enquire how folding behavior has evolved in natural history, using huge quantities of genomic data. Folding is now known to be an emergent property. Recognizing this, to test our understanding, the community is now also exploring whether folding can be instantiated in completely novel designed systems, so-called "foldamers". Folding is not just a preliminary step to biological function but is intimately involved in functional processes such as allosteric change and molecular recognition. Furthermore the evolution of these capabilities has shown its mark on protein folding dynamics, an area of great ferment bringing together a new group of biologists. The misfolding of some proteins seems central to the progress of many diseases such as Alzheimer's and here the new tools of the folding community are bringing new insights. Finally we now can ask whether the hard won paradigms of protein folding dynamics gleaned from studying small globular proteins can be applied to membrane protein folding in which other biological actors are implicated as chaperones. Also can folding concepts be applied Page 1 of 5 9

10 Gordon Research Conferences Meeting - Protein Folding Dynamics 1/4/16, 12:28 PM to studying how the very largest structures in the cell are organized, such as chromosomes? Sessions covering both new developments in the basic areas as well as applications of folding dynamics to more complex biology are planned. Contributors Meeting Program Sunday 4:00 pm - 8:00 pm Arrival and Check-in 6:00 pm Dinner 7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff 7:40 pm - 9:30 pm Keynote Session: The Atomistic Basis of Folding Energy Landscapes Discussion Leader: Angel Garcia (Los Alamos National Laboratory, USA) 7:40 pm - 8:25 pm Robert Best (National Institutes of Health, USA) "Molecular Origins of Internal Friction in Protein Folding Dynamics" 8:25 pm - 8:35 pm Discussion 8:35 pm - 9:20 pm Klaus Schulten (University of Illinois, USA) "What Can Be Learnt from the Molecular Dynamics View of Protein Translocation, Folding and Aggregation?" 9:20 pm - 9:30 pm Discussion Monday 7:30 am - 8:30 am Breakfast 8:30 am Group Photo 9:00 am - 12:30 pm The Rights and Wrongs of Folding Discussion Leader: Jose Onuchic (Rice University, USA) 9:00 am - 9:45 am Sheena Radford (University of Leeds, United Kingdom) "Stopping the Amyloid Cascade: New Molecular Insights and Some New Opportunities" 9:45 am - 10:00 am Discussion 10:00 am - 10:30 am Coffee Break 10:30 am - 11:15 am Paul Whitford (Northeastern University, USA) "The Role of Disorder in Biomolecular Assemblies" 11:15 am - 11:30 am Discussion Page 2 of 5 Gordon Research Conferences Meeting - Protein Folding Dynamics 1/4/16, 12:28 PM 11:30 am - 12:15 pm Susan Marqusee (University of California, Berkeley, USA) "Touring the Landscape: The View Depends on How You Look" 12:15 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm Fast Folding Discussion Leader: Martin Gruebele (University of Illinois at Urbana-Champaign, USA) 7:30 pm - 8:15 pm Gerhard Hummer (Max Planck Institute of Biophysics, Germany) "Fast Folding: Mechanisms from Simulations" 8:15 pm - 8:30 pm Discussion 8:30 pm - 9:15 pm Victor Munoz (University of California, Merced, USA) "Gradual Disorder of Fast Folding Proteins Monitored at Atomic Resolution" 9:15 pm - 9:30 pm Discussion Tuesday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Folding the Chromosome Discussion Leader: Bin Zhang (Rice University, USA) 9:00 am - 9:45 am Andrew Belmont (University of Illinois, USA) "Boundary Conditions for Chromosome Folding Models from Direct Visualization of Native and Reconstituted Chromosomes" 9:45 am - 10:00 am Discussion 10:00 am - 10:30 am Coffee Break 10:30 am - 11:15 am Erez Lieberman Aiden (Baylor College of Medicine, USA) "How the Genome Folds: Now Inside the Loop" 11:15 am - 11:30 am Discussion 11:30 am - 12:15 pm Masaki Sasai (Nagoya University, Japan) "Fluctuating Three-Dimensional Genome Architecture and Gene Regulation" 12:15 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm Towards Synthetic Life: The World of Foldamers Page 3 of 5 10

11 Gordon Research Conferences Meeting - Protein Folding Dynamics 1/4/16, 12:28 PM Discussion Leader: Jeffrey Hartgerink (Rice University, USA) 7:30 pm - 8:15 pm Samuel Gellman (University of Wisconsin-Madison, USA) "Higher Order Structure in Peptidic Foldamers" 8:15 pm - 8:30 pm Discussion 8:30 pm - 9:15 pm Ivan Huc (Université de Bordeaux / CNRS, France) "Designing Foldamers with Predictable Structures" 9:15 pm - 9:30 pm Discussion Wednesday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Folding One Molecule at a Time Discussion Leader: William Eaton (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) 9:00 am - 9:45 am Jane Clarke (University of Cambridge, United Kingdom) "Folding Proteins On and Off the Ribosome" 9:45 am - 10:00 am Discussion 10:00 am - 10:30 am Coffee Break 10:30 am - 11:15 am Ashok Deniz (The Scripps Research Institute, USA) "Single-Molecule Folding Biophysics of Disordered Proteins" 11:15 am - 11:30 am Discussion 11:30 am - 12:15 pm Michael Woodside (University of Alberta, Canada) "Observing Transition Paths in the Folding of Proteins and Nucleic Acids with Single-Molecule Force Spectroscopy" 12:15 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:00 pm - 7:30 pm Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 7:30 pm - 9:30 pm Folding Membrane Proteins Discussion Leader: Daniel Otzen (Aarhus University, Denmark) 7:30 pm - 8:15 pm Paula Booth (King's College London, United Kingdom) "Helical Membrane Proteins and Lipid Bilayer Mechanics" 8:15 pm - 8:30 pm Discussion 8:30 pm - 9:15 pm James Bowie (University of California, Los Angeles, USA) Page 4 of 5 Gordon Research Conferences Meeting - Protein Folding Dynamics 1/4/16, 12:28 PM "Folding Membrane Proteins One at a Time" 9:15 pm - 9:30 pm Discussion Thursday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Misfolding Landscapes Discussion Leader: Yaakov Levy (Weizmann Institute of Science, Israel) 9:00 am - 9:45 am Tuomas Knowles (University of Cambridge, United Kingdom) "Kinetics of Protein Aggregations" 9:45 am - 10:00 am Discussion 10:00 am - 10:30 am Coffee Break 10:30 am - 11:15 am Pernilla Wittung-Stafshede (Chalmers University of Technology, Sweden) "In Vitro Protein Cross-Reactivity: Links Between Parkinson's, Bacteria and Diabetes?" 11:15 am - 11:30 am Discussion 11:30 am - 12:15 pm Martin Zanni (University of Wisconsin-Madison, USA) "Humans but Not Rats? Cats but Not Dogs? A Study into the Molecular Mechanism of Type 2 Diabetes Using 2D IR Spectroscopy" 12:15 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm Frustration and the Evolution of the Folding Landscape Discussion Leader: Elizabeth Komives (University of California, San Diego, USA) 7:30 pm - 8:15 pm Faruck Morcos (University of Texas at Dallas, USA) "Investigating Co-Evolutionary Landscapes of Interaction Specificity in Signaling Proteins" 8:15 pm - 8:30 pm Discussion 8:30 pm - 9:15 pm Diego Ferreiro (University of Buenos Aires, Argentina) "Frustration and the Energy Landscapes of Repeat- Proteins" 9:15 pm - 9:30 pm Discussion Friday 7:30 am - 8:30 am Breakfast 9:00 am Departure Page 5 of 5 11

12 Home - Miami Winter Symposium /4/16, 12:40 PM Elsevier Conferences Nature: Miami Winter Symposium 2016 HOME CONFERENCE PROGRAM LOCATION EXHIBITION & SPONSORSHIP DEADLINES CONTACT US SIGN UP FOR UPDATES Miami 2016 Winter Symposium Inflammation Global Events List Help & FAQs January 24 27, 2016 Hyatt Regency Miami, USA Latest News: There is still time to register for the Miami 2016 Winter Symposium - hurry register here! WARNING - SCAM ALERT: Exhibitor Housing Services (EHS) Read more here! Sessions Acute Inflammation Cardiovascular and Metabolic Inflammation Neuroinflammation Cancer and Inflammation Resolution of Inflammation Inflammation has remained during evolution for a good reason: it helps combating pathogens, opposing tissue injury, and healing wounds. However, in some scenarios, inflammation cannot resolve and exerts detrimental effects on human health. The list of tissues and systems adversely affected by inflammation Page 1 of 6 Home - Miami Winter Symposium /4/16, 12:40 PM continues to lengthen and includes the nervous system, the vasculature, metabolism, and tumors. This Symposium leads off with a session on acute inflammation and its resolution or development into chronic inflammation. Subsequent sessions focus on the impact of inflammation on cardiovascular metabolism, nervous system, and cancer. A final session is centered on the pharmacological control of inflammation resolution. Other conferences are focused on a single inflammatory condition (one tissue, one organ): at variance with this, this Symposium program brings together experts that will discuss side by side different types of inflammation with different technical approaches and competences. This Symposium will be therefore of interest to a wide range of scientists: immunologists, neuroscientists, those working on diseases including diabetes, cancer, autoimmunity, neurological disorders, stroke and atherosclerosis. Many biotechnology and pharmaceutical companies are developing therapies to interfere with proinflammatory cytokines and their receptors and/or with cytokine signaling pathways. Some speakers from these companies will be present to describe how basic science can develop into translational results. Miami 2017 Winter Symposium Sunday 22nd Wednesday 25th January 2017 Diabetes: Today s Research Tomorrow s Therapies Register Now Submit Abstract View Program Conference Speakers David Artis, USA Glen Barber, USA Ajay Chawla, USA Vishwa Dixit, USA Christopher Glass, USA Page 2 of 6 12

13 5. Proteomics: The study of global protein expression pa6erns that define cells in specific biological states. -ome is a noun suffix from the LaKn oma meaning mass. It may involve the study of all the proteins in an organelle, cell, Kssue, or organism. It may include other aspects of protein analysis including structure, dynamics, locakon, ackvity, funckon, drug binding, interackons, regulakon etc. 6. Genome Sequencing has discovered the molecular basis of the more than 1000 human genekc diseases. e.g. CysKc Fibrosis, Muscular Dystrophy, Parkinson s Disease, Toure6e s Syndrome.. What about the proteins which are the products of those genes? To understand the diseases and cure them requires a detailed understanding of the proteins and their structures. The most spectacular advance to date has been the development of Asp protease inhibitors useful in suppressing HIV-1. The drugs were designed using the 3D structure of Asp protease. 7. How do proteins fold into their biologically-ackve 3D structures? Here are some examples of protein folding diseases: 13

14 h6p:// pharmtech/formulakon/ arkcle/detail/