UNC s Biomedical Imaging Research Center (BRIC) Roger Sit, Ph.D., CHP NCHPS Spring 2013 Meeting February 28, 2013

Transcription

1 UNC s Biomedical Imaging Research Center (BRIC) Roger Sit, Ph.D., CHP NCHPS Spring 2013 Meeting February 28, 2013

2 Outline Introduction History Describe capabilities of the Center developed over last few years Describe the evolution taking place presently Describe the capabilities that are planned Tie in to Health Physics or Radiation safety Describe some of the challenges Future new imaging modalities

3 The BRIC Biomedical Research Imaging Center Established in 2005 to serve the imaging needs of UNC-Chapel Hill biomedical researchers and to advance the rapidly developing science of biomedical imaging. The Center enables a better understanding of disease, including cancer and neurologic diseases and studies the effects of genetic changes on disease development and progression.

4 Example: Therapeutic agent for Ovarian Cancer Ho-165 (n,g) Ho-166 Used mesopourous silica nanoparticles as carrier Study done in ovarian tumor-bearing mice Ho-166 emits low energy gamma for imaging as well as high energy betas for therapy SPECT/CT used for tissue biodistribution studies PET/CT used for disease progression Conclusion: The retention of holmium in nanoparticles during irradiation and in vivo after intraperitoneal administration as well as their efficacy in extending survival in tumor-bearing mice underscores their potential as a radiotherapeutic agent for ovarian cancer metastasis.

5 Truly Interdisciplinary Psychiatry Neurology Psychology Pathology Oncology Physics Biology Rheumatology Cardiology Gastroenterolo gy Public health Genetics Dentistry Pharmacology Biomedical engineering Chemistry Bioinformatics Pharmacy Pharmacology Nursing Radiology And others. hopefully Radiation Safety

6 Humble beginnings

7 Early Years Half focused on fmri imaging of humans 3-T Siemens Trio (whole body) 3-T Siemens Allegra dedicated to neurological exams of the brain Half focused on research imaging of animals SPECT/CT PET/CT CT Ultrasound MRI Optical

8 Siemens Trio Siemens Allegra

9 Animal Imaging: MRI Bruker 9.4 T MRI Scanner

10 Animal Imaging: CT SCANCO mct 40 GE explore CT120

11 Animal Imaging : CT Carbon Nanotube (CNT) based microct Imaging System

12 Animal Imaging: SPECT/CT GE explore speczt System

13 Animal Imaging: PET/CT GE explore Vista

14 Animal Imaging: Ultrasound Visualsonics Vevo2100

15 Animal Imaging: Optical IVIS Kinetic Optical System

16 Animal Imaging: Optical VisEn FMT-2500 In-vivo Optical Imaging System

17 NC Cancer Research Fund In 2007, the North Carolina Legislature established the NCCRF and began a long term financial commitment to research and treatment of cancer to improve the health and well being of the citizens of North Carolina. The fund enabled: highly successful recruitment of new investigators major expansion of research capabilities new buildings

18 BRIC Growth Addition of a 500 sq. feet enclosure

19 New Imaging Research Building

20 2012 A Banner year Installed the fourth PET/MR fusion imaging device in the US. This is the Siemens Biograph mmr combining the functional imaging of PET with the superior soft tissue contrast of MRI imaging. Big advantage in having simultaneous imaging. PET/CT had been the best imaging technique but requires imaging with a PET scanner, then CT, then overlaying images. PET/MR provides better image, lower patient dose, and quicker scans

21 Siemens Biograph mmr

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23 2012 continued Installed the second dose-on-demand minicyclotron in the US. This is the ABT Biomarker Generator

24 ABT Biomarker Generator - Cyclotron

25 BRIC Building AND

26 New Capabilities for New Building GE PETtrace 17-MeV cyclotron Irradiator Siemens 7T Full Body Scanner 850 MHz NMR PET/CT Full body scanner

27 Vault for Two Cyclotrons

28 Vault Door: Plug on Rails

29 GE PETtrace Cyclotron

30 Irradiator

31 Siemens 7T Full Body Scanner

32 Bruker Ascend 850 MHz NMR

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34 New Building Sub-basement Cyclotron, radiochemistry, QC NMR Suite 7 T MRI Animal facilities: 9.4 T, optical, ultrasound, PET/CT, SPECT/CT, microct Basement Shell space for commercial partner Irradiator 1 st Floor 3T MRI PET/MR PET/CT

35 IRB Sub-basement

36 IRB Basement

37 IRB First floor

38 HP Challenges Plethora of machines and materials concerns Work with multiple shielding contractors Work with multiple equipment contractors Work with both branches of NC-RPS Bridging the knowledge gap for funding organization, architects, and /or construction management Integrate safety issues that may not have always been a consideration (magnetic fields, cryogenics, high rf, etc) Trying to convince line management that additional resources are necessary Working out case-by-case procedures for external

39 Future X-ray Luminescence CT X-ray Fluorescence CT Cerenkov imaging

40 The End Thank you