Y1 Biology 131 Syllabus - Academic Year
|
|
- Franklin Gerard Cannon
- 6 years ago
- Views:
Transcription
1 Y1 Biology 131 Syllabus - Academic Year Monday 28/11/2016 DNA Packaging Week 11 Tuesday 29/11/2016 Regulation of gene expression Wednesday 22/9/2014 Cell cycle Sunday 4/12/2016 Tutorial Monday 5/12/2016 Regulation of cell cycle Week 12 Tuesday 6/12/2016 Protein trafficking Wednesday 7/12/2016 Introduction to intracellular signaling المولد النبوي - Birthday Sunday 11/12/2016 Prophet s Week 13 Monday 12/12/2016 Cell death /apoptosis Tuesday 13/12/2016 Review session
2 DNA packaging Dr. Sarray sameh, Ph.D
3 Why DNA packaging is required and how DNA is packaged into chromosomes? - If stretched end to end, a DNA is about 3 meters long and it has to be packed in a nucleus which is only a few micrometers in diameter: the DNA must be tightly compacted to fit. This occurs through an elaborate, multilevel system of DNA packing. There are various orders of packaging: First order of packaging: nucleosomes Second order of packaging: solenoid fiber Looped domain Chromosome
4 DNA compaction -The compaction of linear DNA in eukaryotic chromosomes involves interactions between DNA and proteins: Histones proteines -The combination of DNA and histones proteins : Chromatin During interphase of the cell cycle, chromatin fibers are usually highly extended within the nucleus. During mitosis, the chromatin condenses to form chromosomes. 2 types: heterochromatin & euchromatin
5 Basic protein;their positively charged amino acids ( lysine and arginine) bind tightly to negatively charged DNA (phosphate group). Responsible for the first level of DNA packing 5 types of histones: Histones proteins NUCLEOSOME * H2A, H2B, H3 and H4: are the core histones; and two of each make up the octamer The DNA is wrapped around histones * H1 is the linker histone: binds to DNA Nucleosome
6 In electron micrographs, nucleosomes has the appearance of beads on a string. Each bead is a nucleosome, Nucleosomes as beads on a string. Regularly spaced nucleosomes consist of core histone proteins bound to DNA.
7 - The beaded string seems to remain essentially intact throughout the cell cycle. - Histones leave the DNA only transiently during DNA replication. - They stay with the DNA during transcription: By changing shape and position, nucleosomes allow RNA-synthesizing polymerases to move along the DNA.
8 Levels of DNA packing - 1 st level: nucleosome - 2 nd level: solenoid fiber - 3 rd level: looped domain - 4 th level: chromosome
9 1 st level: Nucleosome Solenoid fiber Looped domain chromatid chromosome
10 First level of packing: nucleosome -Nucleosome: fundamental repeating subunits: DNA wrapped twice around an octamer of core histones (2 of each)+h1 -The DNA that is between each histone octamer is called the linker DNA -Nucleosome diameter: 11nm This structure shortens the DNA length about seven fold!!!!
11 2nd level: Solenoid Fiber
12 Second level of packing: Solenoid fiber - 6 nucleosome aggregate together forms solenoid - H1 stabilizes the structure -Solenoid fiber is organized in a stacked spiral of nucleosome -The solenoid fiber shortens the total length of DNA about, seven fold more
13 3 rd level of packing: formation of loop domains making up a 300-nm fiber - Involves interaction between 30nm fiber and the nuclear matrix -The loops are attached to the nuclear matrix to organize the chromosomes within the nucleus. loops Matrix protein /scaffold associated chromatin loop domains
14 Fourth level of packing: Chromosome (super solenoid structure) - Final level of packaging - Occurs during mitosis: The looped domains themselves coil and fold forming the characteristic metaphase chromosome -2 multiprotein complexes help to form and organize metaphase chromosomes: * condensin (role in condensation) and * cohesin (role in sister chromatid alignement) 700 nm 1,400 nm (d) Metaphase chromosome
15
16 Heterochromatin vs Euchromatin The compaction level of interphase chromosomes is not completely uniform: Euchromatin: it is lightly packed form of DNA 92% of human genome is euchromatic Transcriptionnaly active: its unfolded structure allows the gene regulatory proteins and RNA polymerase to bind with DNA sequence and initiate transcription Heterochromatin Tightly compacted regions of chromosomes e.g; Centromere and telomere both are heterochromatin Transcriptionally inactive less accessible to transcription factors
17
18 Modifications in Histones Histones can be changed to alter DNA packing (increase & decrease). There are 3 main types of modifications: /decrease These modifications can lead to regulation of Gene expression: Acetylation and phosphorylation make the histone more negative which weakens the packing ability of histones due to the repelling of negative-negative charges:easy access for gene transcription. Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones are methylated, and how many methyl groups are attached: Methylation events that weaken chemical attractions increase transcription; However, if histones becomes more hydrophobic so it will enable the histone to more tightly pack (turn off the gene transcription)
19 Exemples of methylation: Methylation of histone H4 on Arginine amino acid at the 4th position, opens the chromatin structure leading to transcriptional activation Methylation of H3 on lysines residues at the 4 th and 79 th position, opens the chromatin structure leading to transcriptional activation * Methylation of histone H3 on lysines residues at the 9 th and 27 th position condenses the chromatin structure leading to transcriptional inactivation
20 THE END!
21 Non- Histones proteins They are all the proteins associated with the DNA apart from the histones. They are Acidic in nature (negative charge) and likely to bind the positively charged histones Mostly act as enzyme Functions: Structural: role in the shape of chromosome Regulatory: by promoting gene expression Enzymatic: many enzymatic activities associated with chromatin (nucleases, polymerases..are all nonhistone proteine)
22 Chromosome structure - Each chromosome contains many origins of replication that are interspersed about base pairs. -Each chromosome contain a centromere that forms a recognition site for the kinetochore protein. It is the region where sister chromatids are connected and split chromosome into 2 arms: p arm (petit), q arm (long arm). -Telomeres contain specialized sequences (TTAGGG) located at both ends of the chromosome. - Genes are interspersed throughout the chromosome - Repetitive sequences are commonly found near centromeric and telomeric region but they may be interspersed throughout the chromosome.
NUCLEUS. Fig. 2. Various stages in the condensation of chromatin
NUCLEUS Animal cells contain DNA in nucleus (contains ~ 98% of cell DNA) and mitochondrion. Both compartments are surrounded by an envelope (double membrane). Nuclear DNA represents some linear molecules
More informationDNA: The Genetic Material. Chapter 10
DNA: The Genetic Material Chapter 10 DNA as the Genetic Material DNA was first extracted from nuclei in 1870 named nuclein after their source. Chemical analysis determined that DNA was a weak acid rich
More informationGenes - DNA - Chromosome. Chutima Talabnin Ph.D. School of Biochemistry,Institute of Science, Suranaree University of Technology
Genes - DNA - Chromosome Chutima Talabnin Ph.D. School of Biochemistry,Institute of Science, Suranaree University of Technology DNA Cellular DNA contains genes and intragenic regions both of which may
More informationChapter 13. The Nucleus. The nucleus is the hallmark of eukaryotic cells; the very term eukaryotic means having a "true nucleus".
Chapter 13 The Nucleus The nucleus is the hallmark of eukaryotic cells; the very term eukaryotic means having a "true nucleus". Fig.13.1. The EM of the Nucleus of a Eukaryotic Cell 13.1. The Nuclear Envelope
More informationChapter 5 DNA and Chromosomes
Chapter 5 DNA and Chromosomes DNA as the genetic material Heat-killed bacteria can transform living cells S Smooth R Rough Fred Griffith, 1920 DNA is the genetic material Oswald Avery Colin MacLeod Maclyn
More informationLecture 21: Epigenetics Nurture or Nature? Chromatin DNA methylation Histone Code Twin study X-chromosome inactivation Environemnt and epigenetics
Lecture 21: Epigenetics Nurture or Nature? Chromatin DNA methylation Histone Code Twin study X-chromosome inactivation Environemnt and epigenetics Epigenetics represents the science for the studying heritable
More informationChromatin. Structure and modification of chromatin. Chromatin domains
Chromatin Structure and modification of chromatin Chromatin domains 2 DNA consensus 5 3 3 DNA DNA 4 RNA 5 ss RNA forms secondary structures with ds hairpins ds forms 6 of nucleic acids Form coiling bp/turn
More informationCHAPTERS , 17: Eukaryotic Genetics
CHAPTERS 14.1 14.6, 17: Eukaryotic Genetics 1. Review the levels of DNA packing within the eukaryote nucleus. Label each level. (A similar diagram is on pg 188 of your textbook.) 2. How do the coding regions
More informationDivision Ave. High School AP Biology
Control of Eukaryotic Genes 2007-2008 The BIG Questions n How are genes turned on & off in eukaryotes? n How do cells with the same genes differentiate to perform completely different, specialized functions?
More informationChromatin Structure and its Effects on Transcription
Chromatin Structure and its Effects on Transcription Epigenetics 2014 by Nigel Atkinson The University of Texas at Austin From Weaver 4th edition and Armstrong 1st edition What is the point? DNA is not
More informationGENE REGULATION slide shows by Kim Foglia modified Slides with blue edges are Kim s
GENE REGULATION slide shows by Kim Foglia modified Slides with blue edges are Kim s 2007-2008 Bacterial metabolism Bacteria need to respond quickly to changes in their environment STOP GO if they have
More informationThe DNA Molecule: The Molecular Basis of Inheritance
Slide hapter 6 he DN Molecule: he Molecular Basis of Inheritance PowerPoint Lecture Presentations for Biology Eighth Edition Neil ampbell and Jane Reece Lectures by hris Romero, updated by Erin Barley
More informationFig. 16-7a. 5 end Hydrogen bond 3 end. 1 nm. 3.4 nm nm
Fig. 16-7a end Hydrogen bond end 1 nm 3.4 nm 0.34 nm (a) Key features of DNA structure end (b) Partial chemical structure end Fig. 16-8 Adenine (A) Thymine (T) Guanine (G) Cytosine (C) Concept 16.2: Many
More informationChapter 18: Regulation of Gene Expression. 1. Gene Regulation in Bacteria 2. Gene Regulation in Eukaryotes 3. Gene Regulation & Cancer
Chapter 18: Regulation of Gene Expression 1. Gene Regulation in Bacteria 2. Gene Regulation in Eukaryotes 3. Gene Regulation & Cancer Gene Regulation Gene regulation refers to all aspects of controlling
More informationTypes of nucleic acid
RNA STRUCTURE 1 Types of nucleic acid DNA Deoxyribonucleic acid RNA ribonucleic acid HOCH 2 O OH HOCH 2 O OH OH OH OH (no O) ribose deoxyribose 2 Nucleic acids consist of repeating nucleotide that have
More informationOverview: Life s Operating Instructions Concept 16.1: DNA is the genetic material The Search for the Genetic Material: Scientific Inquiry
Overview: Life s Operating Instructions In 1953, James Watson and Francis Crick introduced an elegant double-helical model for the structure of deoxyribonucleic acid, or DNA DNA, the substance of inheritance,
More informationDifferential Gene Expression
Biology 4361 Developmental Biology Differential Gene Expression September 28, 2006 Chromatin Structure ~140 bp ~60 bp Transcriptional Regulation: 1. Packing prevents access CH 3 2. Acetylation ( C O )
More informationEpigenetics. Medical studies in English, Lecture # 12,
Epigenetics Medical studies in English, 2018. Lecture # 12, Epigenetics Regulation of gene activity in eukaryotes Correlation of chromatin structure with transcription stably heritable phenotype resulting
More information6.2 Chromatin is divided into euchromatin and heterochromatin
6.2 Chromatin is divided into euchromatin and heterochromatin Individual chromosomes can be seen only during mitosis. During interphase, the general mass of chromatin is in the form of euchromatin. Euchromatin
More informationChapter 3. DNA Replication & The Cell Cycle
Chapter 3 DNA Replication & The Cell Cycle DNA Replication and the Cell Cycle Before cells divide, they must duplicate their DNA // the genetic material DNA is organized into strands called chromosomes
More informationProblem Set Unit The base ratios in the DNA and RNA for an onion (Allium cepa) are given below.
Problem Set Unit 3 Name 1. Which molecule is found in both DNA and RNA? A. Ribose B. Uracil C. Phosphate D. Amino acid 2. Which molecules form the nucleotide marked in the diagram? A. phosphate, deoxyribose
More informationDNA Replication. The Organization of DNA. Recall:
Recall: The Organization of DNA DNA Replication Chromosomal form appears only during mitosis, and is used in karyotypes. folded back upon itself (chromosomes) coiled around itself (chromatin) wrapped around
More informationSection 10. Junaid Malek, M.D.
Section 10 Junaid Malek, M.D. Cell Division Make sure you understand: How do cells know when to divide? (What drives the cell cycle? Why is it important to regulate this?) How is DNA replication regulated?
More informationNUCLEIC ACIDS Genetic material of all known organisms DNA: deoxyribonucleic acid RNA: ribonucleic acid (e.g., some viruses)
NUCLEIC ACIDS Genetic material of all known organisms DNA: deoxyribonucleic acid RNA: ribonucleic acid (e.g., some viruses) Consist of chemically linked sequences of nucleotides Nitrogenous base Pentose-
More informationCell Division. Use Target Reading Skills. This section explains how cells grow and divide.
Name Date Class Cell Processes Guided Reading and Study Cell Division This section explains how cells grow and divide. Use Target Reading Skills As you read, make a cycle diagram that shows the events
More informationDifferential Gene Expression
Biology 4361 Developmental Biology Differential Gene Expression June 19, 2008 Differential Gene Expression Overview Chromatin structure Gene anatomy RNA processing and protein production Initiating transcription:
More informationDNA RNA PROTEIN SYNTHESIS -NOTES-
DNA RNA PROTEIN SYNTHESIS -NOTES- THE COMPONENTS AND STRUCTURE OF DNA DNA is made up of units called nucleotides. Nucleotides are made up of three basic components:, called deoxyribose in DNA In DNA, there
More informationThe Molecular Basis of Inheritance
The Molecular Basis of Inheritance Chapter 16 Objectives Describe the contributions of the following people: Griffith; Avery, McCary, and MacLeod; Hershey and Chase; Chargaff; Watson and Crick; Franklin;
More informationChromatin and Transcription
Chromatin and Transcription Chromatin Structure Chromatin Represses Transcription Nucleosome Positioning Histone Acetylation Chromatin Remodeling Histone Methylation CHIP Analysis Chromatin and Elongation
More informationChapter 10: Gene Expression and Regulation
Chapter 10: Gene Expression and Regulation Fact 1: DNA contains information but is unable to carry out actions Fact 2: Proteins are the workhorses but contain no information THUS Information in DNA must
More informationCELLULAR PROCESSES; REPRODUCTION. Unit 5
CELLULAR PROCESSES; REPRODUCTION Unit 5 Cell Cycle Chromosomes and their make up Crossover Cytokines Diploid (haploid diploid and karyotypes) Mitosis Meiosis What is Cancer? Somatic Cells THE CELL CYCLE
More informationChromosomes. Ms. Gunjan M. Chaudhari
Chromosomes Ms. Gunjan M. Chaudhari Chromsomes Chromosome structure Chromatin structure Chromosome variations The new cytogenetics Prokaryotic chromosomes Circular double helix Complexed with protein in
More informationChapter 14. How many genes? Control of Eukaryotic Genome. Repetitive DNA. What about the rest of the DNA? Fragile X Syndrome
Chapter 14 Control of Eukaryotic Genome How many genes? Genes only ~3% of human genome protein-coding sequences 1% of human genome non-protein coding genes 2% of human genome trna ribosomal RNAs sirnas
More informationGenomics and Gene Recognition Genes and Blue Genes
Genomics and Gene Recognition Genes and Blue Genes November 3, 2004 Eukaryotic Gene Structure eukaryotic genomes are considerably more complex than those of prokaryotes eukaryotic cells have organelles
More information14 DNA STRUCTURE, REPLICATION, AND ORGANIZATION
14 DNA STRUCTURE, REPLICATION, AND ORGANIZATION Chapter Outline 14.1 ESTABLISHING DNA AS THE HEREDITARY MOLECULE Experiments began when Griffith found a substance that could genetically transform pneumonia
More informationGenome Architecture Structural Subdivisons
Lecture 4 Hierarchical Organization of the Genome by John R. Finnerty Genome Architecture Structural Subdivisons 1. Nucleotide : monomer building block of DNA 2. DNA : polymer string of nucleotides 3.
More informationEUKARYOTIC REGULATION C H A P T E R 1 3
EUKARYOTIC REGULATION C H A P T E R 1 3 EUKARYOTIC REGULATION Every cell in an organism contains a complete set of DNA. But it doesn t use all of the DNA it receives Each cell chooses different DNA sequences
More informationControlling DNA. Ethical guidelines for the use of DNA technology. Module Type: Discussion, literature review, and debate
Ethical guidelines for the use of DNA technology Author: Tara Cornelisse, Ph.D. Candidate, Environmental Studies, University of California Santa Cruz. Field-tested with: 11 th -12 th grade students in
More informationEpigenetics in. Saccharomyces cerevisiae. Chapter 4 2/4/14
Epigenetics in Saccharomyces cerevisiae Chapter 4 2/4/14 The budding yeast - Saccharomyces cerevisiae The fission yeast - Schizosaccharomyces pombe The budding yeast, Saccharomyces cerevisiae and the fission
More informationBiology Lecture 2 Genes
Genes Definitions o Gene: DNA that codes for a single polypeptide/mrna/rrna/trna o Euchromatin: region of DNA containing genes being actively transcribed o Heterochromatin: region of DNA containing genes
More informationDNA Structure & the Genome. Bio160 General Biology
DNA Structure & the Genome Bio160 General Biology Lecture Outline I. DNA A nucleic acid II. Chromosome Structure III. Chromosomes and Genes IV. DNA vs. RNA I. DNA A Nucleic Acid Structure of DNA: Remember:
More informationLesson Overview DNA Replication
12.3 THINK ABOUT IT Before a cell divides, its DNA must first be copied. How might the double-helix structure of DNA make that possible? Review Question! At what stage of the cell cycle do cells duplicate
More information10-2 Cell Division (Pages )
10-2 Cell Division (Pages 244-245) What do you think would happen if a cell were simply to split into two, without any advance preparation? Would each daughter cell have everything it needed to survive?
More informationNucleic Acid Structure. Nucleic Acid Sequence Abbreviations. Sequence Abbreviations, con t.
BC 4054 Spring 2001 Chapter 11 & 12 Review Lecture otes Slide 1 ucleic Acid Structure Linear polymer of nucleotides Phosphodiester linkage between 3 and 5 positions See Figure 11.17 Slide 2 ucleic Acid
More informationDNA replication: Enzymes link the aligned nucleotides by phosphodiester bonds to form a continuous strand.
DNA replication: Copying genetic information for transmission to the next generation Occurs in S phase of cell cycle Process of DNA duplicating itself Begins with the unwinding of the double helix to expose
More informationDNA and RNA. Chapter 12
DNA and RNA Chapter 12 Warm Up Exercise Test Corrections Make sure to indicate your new answer and provide an explanation for why this is the correct answer. Do this with a red pen in the margins of your
More informationNeurospora mutants. Beadle & Tatum: Neurospora molds. Mutant A: Mutant B: HOW? Neurospora mutants
Chapter 10: Central Dogma Gene Expression and Regulation Mutant A: Neurospora mutants Mutant B: Not made Not made Fact 1: DNA contains information but is unable to carry out actions Fact 2: Proteins are
More informationREGULATION OF PROTEIN SYNTHESIS. II. Eukaryotes
REGULATION OF PROTEIN SYNTHESIS II. Eukaryotes Complexities of eukaryotic gene expression! Several steps needed for synthesis of mrna! Separation in space of transcription and translation! Compartmentation
More informationBCMB Nucleic Acids - Chapter 33. DNA is the genetic component of life
BCMB 3100 - Nucleic Acids - Chapter 33 Discovery of DNA Nucleotides, nucleosides & bases Polynucleotides DNA as genetic material Structure of double-stranded DNA Chromatin RNA Nucleases 1 DNA is the genetic
More informationDNA and RNA. Chapter 12
DNA and RNA Chapter 12 History of DNA Late 1800 s scientists discovered that DNA is in the nucleus of the cell 1902 Walter Sutton proposed that hereditary material resided in the chromosomes in the nucleus
More information3. How Genomes Function
3. How Genomes Function In order for the cell to utilize the biological information contained within its genome, groups of genes, each gene representing a single unit of information, have to be expressed
More informationZool 3200: Cell Biology Exam 2 2/20/15
Name: TRASK Zool 3200: Cell Biology Exam 2 2/20/15 Answer each of the following short and longer answer questions in the space provided; circle the BEST answer or answers for each multiple choice question
More informationPost-translational modifications of histones: encoding or patterning? Histones are subject to an enormous number of posttranslational
R546 Primer Histones and histone modifications Craig L. Peterson and Marc-André Laniel Imagine trying to stuff about 10,000 miles of spaghetti inside a basketball. Then, if that was not difficult enough,
More informationChapter 13 Active Reading Guide The Molecular Basis of Inheritance
Name: AP Biology Mr. Croft Chapter 13 Active Reading Guide The Molecular Basis of Inheritance Section 1 1. What are the two chemical components of chromosomes? 2. Why did researchers originally think that
More informationVocabulary. Nucleic Acid Nucleotide Base pairing Complementary Template Strand Semiconservative Replication Polymerase
DNA and Replication TEKS (6) Science concepts. The student knows the mechanisms of genetics, including the role of nucleic acids and the principles of Mendelian Genetics. The student is expected to: (A)
More information1. Mitosis = growth, repair, asexual reproduc4on
Places Muta4ons get passed on: Cell Reproduc4on: 2 types of cell reproduc4on: 1. Mitosis = growth, repair, asexual reproduc4on Photocopy machine Growth/Repair Passed on in the same body 2. Meiosis = sexual
More informationGene Expression: Transcription
Gene Expression: Transcription The majority of genes are expressed as the proteins they encode. The process occurs in two steps: Transcription = DNA RNA Translation = RNA protein Taken together, they make
More informationCHAPTER 11 LECTURE SLIDES
CHAPTER 11 LECTURE SLIDES Prepared by Brenda Leady University of Toledo To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn audio/text on or off.
More informationBiology Review 1/28/2011. Cell Structure. Biological Molecules (DNA & Proteins) Central Dogma. Prokaryotic cell DNA (no nucleus) Membrane
Biology Review Cell Structure Biological Molecules (DNA & Proteins) Central Dogma Structure and Function of DNA Replication, Transcription, Translation Regulation of Gene Expression Eukaryotic cell Membrane
More informationNucleosomes: Structure and Function
Nucleosomes: Structure and Function Karolin Luger, Colorado State University, Fort Collins, Colorado, USA The structure of the nucleosome core particle, the basic repeating unit in eukaryotic chromatin,
More informationChapter 13 Section 2: DNA Replication
Chapter 13 Section 2: DNA Replication Opening Activity DNA is considered to be a relatively stable molecule. What gives it this stability, even though the hydrogen bonds between the nitrogen bases are
More informationCell cycle. Chen Li. Department of cellular and genetic medicine
Cell cycle Chen Li Department of cellular and genetic medicine 13 223 chenli2008@fudan.edu.cn Outline A. Historical background B. Phases of cell cycle C. DNA replication D. Telomere & telomerase E. DNA
More informationProblem Set 2B Name and Lab Section:
Problem Set 2B 9-26-06 Name and Lab Section: 1. Define each of the following rearrangements (mutations) (use one phrase or sentence for each). Then describe what kind of chromosomal structure you might
More informationDNA Structure and Analysis. Chapter 4: Background
DNA Structure and Analysis Chapter 4: Background Molecular Biology Three main disciplines of biotechnology Biochemistry Genetics Molecular Biology # Biotechnology: A Laboratory Skills Course explorer.bio-rad.com
More informationRegulation of Gene Expression
Slide 1 Chapter 18 Regulation of Gene Expression PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
More information2. Outline the levels of DNA packing in the eukaryotic nucleus below next to the diagram provided.
AP Biology Reading Packet 6- Molecular Genetics Part 2 Name Chapter 19: Eukaryotic Genomes 1. Define the following terms: a. Euchromatin b. Heterochromatin c. Nucleosome 2. Outline the levels of DNA packing
More informationName: Class: Date: ID: A
Class: _ Date: _ CH 12 Review Multiple Choice Identify the choice that best completes the statement or answers the question. 1. How many codons are needed to specify three amino acids? a. 6 c. 3 b. 12
More informationTHE CELLULAR AND MOLECULAR BASIS OF INHERITANCE
Umm AL Qura University THE CELLULAR AND MOLECULAR BASIS OF INHERITANCE Dr. Neda Bogari www.bogari.net EMERY'S ELEMENTS OF MEDICAL GENETICS Peter Turnpenny and Sian Ellard 13 th edition 2008 COURSE SYLLABUS
More informationNucleic acids deoxyribonucleic acid (DNA) ribonucleic acid (RNA) nucleotide
Nucleic Acids Nucleic acids are molecules that store information for cellular growth and reproduction There are two types of nucleic acids: - deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) These
More informationWhat we ll do today. Types of stem cells. Do engineered ips and ES cells have. What genes are special in stem cells?
Do engineered ips and ES cells have similar molecular signatures? What we ll do today Research questions in stem cell biology Comparing expression and epigenetics in stem cells asuring gene expression
More informationBIOLOGY. Chapter 16 GenesExpression
BIOLOGY Chapter 16 GenesExpression CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson 18 Gene Expression 2014 Pearson Education, Inc. Figure 16.1 Differential Gene Expression results
More informationBIOMEDICAL IMPORTANCE CHROMATIN IS THE CHROMOSOMAL MATERIAL IN THE NUCLEI OF CELLS OF EUKARYOTIC ORGANISMS. 1 de 32 01/02/ :57 p.m. Figure 35 1.
1 de 32 01/02/2011 05:57 p.m. Print Close Window Note: Large images and tables on this page may necessitate printing in landscape mode. Copyright The McGraw-Hill Companies. All rights reserved. Harper's
More informationDo engineered ips and ES cells have similar molecular signatures?
Do engineered ips and ES cells have similar molecular signatures? Comparing expression and epigenetics in stem cells George Bell, Ph.D. Bioinformatics and Research Computing 2012 Spring Lecture Series
More information2012 GENERAL [5 points]
GENERAL [5 points] 2012 Mark all processes that are part of the 'standard dogma of molecular' [ ] DNA replication [ ] transcription [ ] translation [ ] reverse transposition [ ] DNA restriction [ ] DNA
More informationChapter 8 Lecture Outline. Transcription, Translation, and Bioinformatics
Chapter 8 Lecture Outline Transcription, Translation, and Bioinformatics Replication, Transcription, Translation n Repetitive processes Build polymers of nucleotides or amino acids n All have 3 major steps
More informationThe replication of DNA Kornberg 1957 Meselson and Stahl 1958 Cairns 1963 Okazaki 1968 DNA Replication The driving force for DNA synthesis. The addition of a nucleotide to a growing polynucleotide
More informationStructure/function relationship in DNA-binding proteins
PHRM 836 September 22, 2015 Structure/function relationship in DNA-binding proteins Devlin Chapter 8.8-9 u General description of transcription factors (TFs) u Sequence-specific interactions between DNA
More informationReplication Review. 1. What is DNA Replication? 2. Where does DNA Replication take place in eukaryotic cells?
Replication Review 1. What is DNA Replication? 2. Where does DNA Replication take place in eukaryotic cells? 3. Where does DNA Replication take place in the cell cycle? 4. 4. What guides DNA Replication?
More informationWhat is DNA??? DNA = Deoxyribonucleic acid IT is a molecule that contains the code for an organism s growth and function
Review DNA and RNA 1) DNA and RNA are important organic compounds found in cells, called nucleic acids 2) Both DNA and RNA molecules contain the following chemical elements: carbon, hydrogen, oxygen, nitrogen
More informationDNA Transcription. Dr Aliwaini
DNA Transcription 1 DNA Transcription-Introduction The synthesis of an RNA molecule from DNA is called Transcription. All eukaryotic cells have five major classes of RNA: ribosomal RNA (rrna), messenger
More informationGene Expression and Heritable Phenotype. CBS520 Eric Nabity
Gene Expression and Heritable Phenotype CBS520 Eric Nabity DNA is Just the Beginning DNA was determined to be the genetic material, and the structure was identified as a (double stranded) double helix.
More informationReview of Protein (one or more polypeptide) A polypeptide is a long chain of..
Gene expression Review of Protein (one or more polypeptide) A polypeptide is a long chain of.. In a protein, the sequence of amino acid determines its which determines the protein s A protein with an enzymatic
More informationProtein Synthesis. DNA to RNA to Protein
Protein Synthesis DNA to RNA to Protein From Genes to Proteins Processing the information contained in DNA into proteins involves a sequence of events known as gene expression and results in protein synthesis.
More informationDNA STRUCTURE AND REPLICATION
AP BIOLOGY EVOLUTION/HEREDITY UNIT Unit 1 Part 2 Chapter 16 Activity #2 BUILDING BLOCKS OF DNA: Nucleotides: NAME DATE PERIOD DNA STRUCTURE AND REPLICATION 1. 5 carbon sugar (deoxyribose) 2. Nitrogenous
More informationDNA is the genetic material [2].
GUIDED READING - Ch. 16 MOLECULAR BASIS OF INHERITANCE NAME: Please print out these pages and HANDWRITE the answers directly on the printouts. Typed work or answers on separate sheets of paper will not
More informationThe information provided below may be useful in answering some questions.
Molecular Exam 1 More Tutorial at www.dumblittledoctor.com The information provided below may be useful in answering some questions. INFORMATION ON COMPONENTS OF RIBOSOMES I. Prokaryotes (e.g. E. coli)
More informationTranscription in Eukaryotes
Transcription in Eukaryotes Biology I Hayder A Giha Transcription Transcription is a DNA-directed synthesis of RNA, which is the first step in gene expression. Gene expression, is transformation of the
More informationNuclear Organization and Gene Expression Dr. David L. Spector
NUCLEAR ORGANIZATION AND GENE EXPRESSION David L. Spector, Ph.D. Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, New York 11724 Visit our website at www.cshl.edu/spectorlab 1 Orphanides
More informationAnswers to the multiple choice questions are at the bottom of the last page of this document.
Review for Unit Test #2: Cell Parts, Functions and Protein Synthesis, Answers Answers to the multiple choice questions are at the bottom of the last page of this document. 1. Know all of the material on
More informationChapter 11: Regulation of Gene Expression
Chapter Review 1. It has long been known that there is probably a genetic link for alcoholism. Researchers studying rats have begun to elucidate this link. Briefly describe the genetic mechanism found
More informationEstablishing epigenetic domains via chromatin-bound histone modifiers
Ann. N.Y. Acad. Sci. ISSN 0077-8923 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Issue: Evolutionary Dynamics and Information Hierarchies in Biological Systems Establishing epigenetic domains via chromatin-bound
More informationDNA makes RNA makes Proteins. The Central Dogma
DNA makes RNA makes Proteins The Central Dogma TRANSCRIPTION DNA RNA transcript RNA polymerase RNA PROCESSING Exon RNA transcript (pre-mrna) Intron Aminoacyl-tRNA synthetase NUCLEUS CYTOPLASM FORMATION
More informationDNA Replication in Eukaryotes
OpenStax-CNX module: m44517 1 DNA Replication in Eukaryotes OpenStax College This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section,
More informationDNA RNA PROTEIN. Professor Andrea Garrison Biology 11 Illustrations 2010 Pearson Education, Inc. unless otherwise noted
DNA RNA PROTEIN Professor Andrea Garrison Biology 11 Illustrations 2010 Pearson Education, Inc. unless otherwise noted DNA Molecule of heredity Contains all the genetic info our cells inherit Determines
More informationDNA replication. Begins at specific sites on a double helix. Proceeds in both directions. Is initiated at many points in eukaryotic chromosomes.
DNA replication Begins at specific sites on a double helix. Proceeds in both directions. Is initiated at many points in eukaryotic chromosomes. Figure 10.8 http://www.hhmi.org/biointeractive/media/ DNAi_replication_schematic-lg.mov
More informationDifferential Gene Expression
Biology 4361 - Developmental Biology Differential Gene Expression June 18, 2009 Differential Gene Expression Overview Chromatin structure Gene anatomy RNA processing and protein production Initiating transcription:
More informationBio11 Announcements. Ch 21: DNA Biology and Technology. DNA Functions. DNA and RNA Structure. How do DNA and RNA differ? What are genes?
Bio11 Announcements TODAY Genetics (review) and quiz (CP #4) Structure and function of DNA Extra credit due today Next week in lab: Case study presentations Following week: Lab Quiz 2 Ch 21: DNA Biology
More informationMolecular Biology of the Gene
Molecular Biology of the Gene : where the genetic information is stored, blueprint for making proteins. RNA: Always involved in protein synthesis Macromolecules (polymers!) Monomers (units): nucleotides
More informationFig Ch 17: From Gene to Protein
Fig. 17-1 Ch 17: From Gene to Protein Basic Principles of Transcription and Translation RNA is the intermediate between genes and the proteins for which they code Transcription is the synthesis of RNA
More information