THE CELL BIOLOGY BEHIND THE ONCOGENIC PIP3 LIPIDS

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1 WORKSHOPS CURRENT TRENDS IN BIOMEDICINE 2018 SEDE ANTONIO MACHADO BAEZA, SPAIN THE CELL BIOLOGY BEHIND THE ONCOGENIC PIP3 LIPIDS Baeza, Spain 15 th -17 th October 2018

2 Organized by: Richard A. Anderson Ana C. Carrera Bart Vanhaesebroeck Madison, WI, USA. Madrid, Spain. London, UK. Sponsor: SCOPE The high incidence of mutations in the Phosphoinositide 3-kinase pathway in cancer (in 50% of the human tumors) has posed hope on the use of pharmacological inhibitors to PI3K as a treatment for cancer. Clinical testing of Phosphoinositide 3-kinase-directed compounds has proven that simple blockade of the Phosphoinositide 3-kinase family members by the use of pan-inhibitors is not an optimal therapeutic approach. We have learned that total inhibition of this route promotes undesired secondary effects. Second, in many tumour types, cells develop alternative strategies. Finally, in many cases, the cells develop rapidly resistance. In some tumour types, however, the use of compounds for this pathway has extended life expectation. These facts show the urgent need of a deeper knowledge on the cell biology behind the oncogenic PIP3 lipids (the products of PI3K). This is the topic of our conference, a good starting point for the discussion between experts of a more subtle and rational design of novel therapeutic strategies to interfere the with the high PIP3 levels of cancer cells.

3 FORMAT OF THE WORKSHOP The workshop will bring together a maximum of 15 speakers and 35 participants, to form a group of around 50 people. The scientific programme will start in the morning of Monday, October 15 th, and will end around noon on Wednesday, October 17 th. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. VENUE OF THE WORKSHOP The workshop will be held in Baeza, at the Sede Antonio Machado, a XVII century building turned into a Conference Centre of the Universidad Internacional de Andalucía (UNIA). This Seat includes a residence, where participants will be accommodated. Baeza is a World Historic Heritage town, renowned for its Renaissance and Gothic buildings. SPEAKERS Richard A. Anderson University of Wisconsin-Madison, School of Medicine and Public Health. Madison, WI, USA. Jonathan M. Backer Department of Molecular Pharmacology / Department of Biochemistry; Albert Einstein College of Medicine. Bronx, NY, USA. María A. Blasco Lewis C. Cantley Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO). Madrid, Spain. Meyer Cancer Center / Department of Medicine; Weill Cornell Medicine. New York, NY USA.

4 Ana C. Carrera Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid. Madrid, Spain. Mariona Graupera Vascular Signalling Laboratory, Institut d Investigació Biomèdica de Bellvitge (IDIBELL). Barcelona, Spain. Volker Haucke Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) / Freie Universität Berlin, Faculty of Biology, Chemistry, Pharmacy. Berlin, Germany. Emilio Hirsch Klaus Okkenhaug Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino. Torino, Italy. Department of Pathology, University of Cambridge. Cambridge, UK. Thomas M. Roberts Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. Len R. Stephens Lloyd C. Trotman Signalling Programme, Babraham Institute. Cambridge, UK. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA. Bart Vanhaesebroeck UCL Cancer Institute, University College London. London, UK. Roger L. Williams Medical Research Council (MRC) Laboratory of Molecular Biology. Cambridge, UK.

5 Pascale Zimmermann Department of Human Genetics, KU Leuven. Leuven, Belgium // Centre de Recherche en Cancérologie de Marseille (CRCM), Aix- Marseille Université / Inserm, U1068, Institut Paoli-Calmettes / CNRS, UMR7258. Marseille, France. DEADLINE: 20 th JULY 2018 MORE INFORMATION AND APPLICATION: workshops.biomed@unia.es Universidad Internacional de Andalucía Sede Antonio Machado Palacio de Jabalquinto Plaza de Santa Cruz, s/n Baeza (Jaén), Spain Tel: Fax: baeza@unia.es