Supporting Information
|
|
- Charles Carpenter
- 6 years ago
- Views:
Transcription
1 Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Supporting Information Ball-in-ball ZrO 2 Nanostructure for Simultaneous CT Imaging and Highly Efficient Synergic Microwave Ablation and Tri-stimuli Responsive Chemotherapy of Tumor Dan Long, Meng Niu, Longfei Tan, Changhui Fu, Xiangling Ren, Ke Xu, Hongshan Zhong, Jingzhuo Wang, LaifengLi, Xianwei Meng Figure S1. (a) TEM image and (b) diameters histograms distribution of tree-layer ZrO 2 NPs. Three-layer ZrO 2 NPs have been synthesized through the improved template method and the particles size was 325±3 nm as shown in Figure S1 (a-b). The unique physical and chemical properties multi-layer nanomaterials need to be further explored and found. They are expected to be used for further biological applications.
2 Figure S2. (a-b) FT-IR spectrums of IL, DOX, tetradecanol, BB-ZrO 2, keratin and 2. (c) TGA curves of BB-ZrO 2, 2 and ZrO 2. (d) Standard curve of DOX at 483 nm under different concentrations (0, 1, 5, 10, 20 and 30 μg ml -1 ). To further verify the existence of IL, DOX and tetradecanol, FT-IR was used to determine functional groups in the as-prepared system (Figure S2a). The characteristic peaks of IL appeared at 840 cm -1 (the absorption peak of P-F), 1573 and 1469 cm -1 (the imidazole skeleton vibration) and 1167 cm -1 (imidazole ring stretching vibration). The characteristic peaks of 1621, 1580, 1438 and 1498 cm -1 were the characteristic peaks of the aromatic ring in DOX. The peaks of tetradecanol appeared at 3631, 3296 cm -1 (respectively from the free stretching vibration and intermolecular
3 hydrogen bond of O-H), 1065 cm -1 (C-O) and 683 cm -1 (plane bending peak of O-H), respectively. The characteristic peaks of keratin appeared at 539 cm -1 (-S-S-), 760 cm - 1 (the C=O stretching vibration in the COOH) and 3550 cm -1 (the O-H stretching vibration of -COOH). All of the characteristic peaks of IL, DOX, keratin and tetradecanol could be found in the X@BB-ZrO 2 system as shown in Figure S2a-b. TGA was used to investigate the thermal effects of BB-ZrO 2, IL@BB-ZrO 2 and tetradecanol@bb-zro 2 in a range of temperature. Compared with the TGA curve of BB-ZrO 2, the loading capacity of IL and tetradecanol was 5.1% and 10.0%, respectively (Figure S2c). The loading and encapsulation efficiency of DOX were calculated by the standard curve established at 483 nm. The linear equation as shown in Figure S2d was Y= X , and R 2 =0.99, where Y represents the absorbance, and X represents the concentration of DOX. Figure S3. In vitro cytotoxicity test of IL/tetradecanol/keratin@BB-ZrO 2 and X@BB-ZrO 2. (a) Hemolysis test of the IL/tetradecanol/keratin@BB-ZrO 2 NPs under different concentrations (1000, 500, 250, 125 and 62.5 ug ml -1 ). HepG-2 cells viability by MTT assay of (b) IL/tetradecanol/keratin@BB-ZrO 2 (200, 100, 50, 25, 12.5 and 0 μg ml -1 ) and (c) X@BB-ZrO 2 (50, 25, 12.5, 6.25, 3.13, 1.56 and 0 μg ml - 1 ).
4 The as-made 2 NPs were proved to have a good microwave heating effect and could significantly increase the ablation area via experiments in vitro, which was expected to be used in further experiments in vivo. Therefore, the biocompatibility should be taken into consideration. The hemolysis test result (Figure S3a) of the as-prepared IL/tetradecanol/keratin@BB-ZrO 2 NPs under different concentrations shows no obvious hemolysis, the hemolysis rates were lower than 5% even at the highest concentration of 1000 μg ml -1. The cytotoxicity of the as-made and X@BB-ZrO 2 system was investigated in HepG-2 cells by MTT assay. As shown in Figure S3b, the cytotoxicity of IL/tetradecanol/keratin@BB-ZrO 2 was more than 80 % even at a high concentration of 200 μg ml -1, indicating the low cytotoxicity of the IL/tetradecanol/keratin@BB-ZrO 2. However, the viability of the cells decreased rapidly after DOX was loaded (Figure S3c), the viability was lower than 80% when the concentration was higher than 12.5 μg ml -1, indicating that the as-made X@BB- ZrO 2 have favorable lethality to tumor cells. To further validate the toxicity of the as-prepared materials, the systematic toxicity in vivo experiment was utilized. Healthy ICR mice were randomly assigned into 10 groups (n=5): IL@BB-ZrO 2 at different injection dose (400, , 40, 20 mg kg -1 ), and different treatment methods at the same injected dose of 40 mg kg -1, including IL@BB-ZrO 2 +MW, BB-ZrO 2, BB-ZrO 2 +MW, MW and control group. 10 h post-injection, the mice of microwave irradiation groups were irradiated by microwave for 5 min. After 14 days, the mice were terminated and main organs (liver,
5 Figure S4. H&E stained images of main organs (liver, heart, spleen, lung and kidney) collected from each group (all of the scale bars were 100 μm).
6 heart, spleen, lung and kidney) were collected with 4% formalin solution for histochemistry analysis. Compared with control group, the H&E stained images (Figure S4) of main organs (liver, heart, spleen, lung and kidney) collected from mice in each group indicated no obvious abnormalities. The results demonstrated the good biocompatibility of 2 +MW, BB-ZrO 2, BB-ZrO 2 +MW, MW, even at a high injection dose of 400 mg kg -1, the BB-ZrO 2 didn t show significant adverse effects on the health of mice. To evaluate the microwave thermotherapy effect of the as-prepared X@BB-ZrO 2 NPs on the subcutaneous tumors, ICR mice bearing H-22 tumors were divided into control, MW, X@BB-ZrO 2, IL@BB-ZrO 2 +MW, X@BB-ZrO 2 +MW and DOX groups. ICR mice bearing H-22 tumors (tumor size in any direction not exceeding 10 mm) were divided into 6 groups (n=5 per group). The mice were tail-intravenously injected with PBS, X@BB-ZrO 2, IL@BB-ZrO 2 and DOX. In addition to DOX group (16 mg kg -1 ), the injected dose was 40 mg kg h post-injection, half of the mice of X@BB-ZrO 2 and PBS; whole of the IL@BB-ZrO 2 groups were irradiated by a microwave ablation antenna at a power of 2 W for 5 min. When the tumor size of mice was more than 20 mm in any direction, the mice were sacrificed and the main organs and tumors were collected for further histochemistry analysis. Compared with control group the H&E stained images of major organs (liver, heart, spleen, lung and kidney) collected from mice in each group showed no significantly pathologies (Figure S5a). The results demonstrated the good biocompatibility of the different treatments. As shown in Figure S5b, the tumors of
7 MW groups 2 +MW, MW and 2 +MW) represented strong signs of necrosis areas contrast with other groups.
8 Figure S5. H&E stained images of (a) main organs (liver, heart, spleen, lung and kidney) and (b) tumors collected from mice in control, 2 +MW, ZrO 2 +MW, MW, DOX and X@BB-ZrO 2 groups (all of the scale bars were 100 μm). Figure S6. The tumor photos taken at 6 th day postoperative, the white tissue in red circle is tumor and the surrounding of the red circle is normal liver tissue (all of the scale bar were 10 mm). To further investigate the therapeutic effect in the deep tumor of the as-made X@BB-ZrO 2 NPs. Liver VX2 tumor bearing rabbits were utilized as animal model. The VX2 tumor bearing rabbits were randomly separated into MW, X@BB- ZrO 2 +MW and control group. The as-made X@BB-ZrO 2 NPs were injected into the rabbits of X@BB-ZrO 2 +MW group via auricular vein at the dose of 3.2 mg kg -1, and the MW and control group were injected with saline. After 8 h, the tumor site of each group rabbits was irradiated by 10 W MW for 2 min. Then the therapeutic effect was monitored by CT in real time. 6 days after treatments, the rabbits were sacrifice and
9 the tumors were collected. As shown in Figure S6, the representative photos of tumor in each group were corresponding with the CT imaging results.
Supporting information
Supporting information Large Hollow Cavity Luminous Nanoparticles with Near-Infrared Persistent Luminescence and Tunable Sizes for Tumor Afterglow Imaging and Chemo/Photodynamic Therapies Jun Wang, Jinlei
More informationSize-Modulable Nanoprobe for High-Performance. Ultrasound Imaging and Drug Delivery against
Size-Modulable Nanoprobe for High-Performance Ultrasound Imaging and Drug Delivery against Cancer Lu Zhang,,,#, Tinghui Yin,#, Bo Li, Rongqin Zheng*,, Chen Qiu, Kit S. Lam*,, Qi Zhang, Xintao Shuai*,,
More informationReal-Time Monitoring of Arsenic Trioxide Release and Delivery
Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T 1 Imaging Zhenghuan Zhao, Xiaomin Wang, Zongjun Zhang, Hui Zhang, Hanyu Liu, Xianglong Zhu, Hui Li, Xiaoqin Chi, Zhenyu Yin,
More informationSupplementary Information
Supplementary Information Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors Wang et al. Supplementary Figure 1. The effect of Pt/Co ratio
More informationElectronic Supplementary Information. MMP2-targeting and redox-responsive PEGylated chlorin e6
Electronic Supplementary Information MMP2-targeting and redox-responsive PEGylated chlorin e6 nanoparticles for cancer near-infrared imaging and photodynamic therapy Wenxiu Hou 1,2, Fangfang Xia 1, Carla
More informationSupplementary Information. Trojan Horse Nanotheranostics with Dual Transformability and Multifunctionality. for Highly Effective Cancer Treatment
Supplementary Information Trojan Horse Nanotheranostics with Dual Transformability and Multifunctionality for Highly Effective Cancer Treatment Xue et. al. Supplementary Figure 1. Synthetic route of PhD
More informationShanghai JiaoTong University School of Medicine, Shanghai , People s Republic of China.
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Phase and Morphological Control of MoO 3-x Nanostructures for Efficient Cancer Theragnosis Therapy
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information RGD-QD-MoS 2 nanosheets for targeted fluorescent imaging
More informationSupporting Information. For
Supporting Information For A Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumor by Attenuating Radio-Resistance and Enhancing Radiation Response Yuan Yong 1,, Chunfang Zhang 1,
More informationElectronic Supplementary Information. Fibrillation Kinetics of Aβ(1-40) Peptide Depend on Surface Curvature at Nano-Bio Interfaces
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information Submitted to Nanoscale Fibrillation Kinetics of Aβ(1-40)
More informationSupplementary Figure 1. Determination of the purity of CP. a, SDS-PAGE of CP and CP- PTX conjugate, and b, HPLC trace of purified CP.
Supplementary Figure 1. Determination of the purity of CP. a, SDS-PAGE of CP and CP- PTX conjugate, and b, HPLC trace of purified CP. Supplementary Figure 2. Synthesis of CP-PTX conjugate. Supplementary
More informationExperimental supporting information
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Experimental supporting information Preparation of peptide derivatives: The peptide derivative
More informationSupporting Information. Osteoblast-Targeting Peptide-Modified Nanoparticle for sirna/microrna Delivery
Supporting Information Osteoblast-Targeting Peptide-Modified Nanoparticle for sirna/microrna Delivery Yao Sun 2,4,5*, Xiongzhen Ye 1*, Mingxiang Cai 2*, Xiangning Liu 3*, Jia Xiao 1, Chenyang Zhang 2,Yayu
More informationSUPPLEMENTARY MATERIALS
Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3 -diindolylmethane nanoparticles through blood brain barrier prevents glioma progression SUPPLEMENTARY MATERIALS Supplementary
More informationOxygen Vacancies-Enhanced CeO 2 :Gd. Nanoparticles for Sensing Tumor Vascular. Microenvironment by Magnetic Resonance
Supporting Information Oxygen Vacancies-Enhanced CeO 2 :Gd Nanoparticles for Sensing Tumor Vascular Microenvironment by Magnetic Resonance Imaging Chulun Shao,,, Aijun Shen,, Meng Zhang,, Xianfu Meng,
More informationSupplementary Electronic Information for:
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 25 Supplementary Electronic Information for: Nanotoxicity of polyelectrolyte-functionalized titania
More informationSUPPLEMENTARY INFORMATION
VOLUME: 1 ARTICLE NUMBER: 0011 In the format provided by the authors and unedited. In situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy Chao Wang 1, 2, Wujin
More informationA Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic. Structure for Acidity/Reducibility-Specific Photothermal Conversion
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion Chen Zhang, Wenbo Bu,*,, Dalong Ni, Changjing Zuo, Chao Cheng, Qing
More information1 Electronic Supplementary information. 2 Co-assembling FRET nanomedicine with self-indicating drug
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2018 1 Electronic Supplementary information 2 Co-assembling FRET nanomedicine with self-indicating drug
More informationSupporting Information
Supporting Information Se/Ru-decorated Porous Metal-Organic Framework Nanoparticles for The Delivery of Pooled sirnas to Reversing Multidrug Resistance in Taxol-resistant Breast Cancer Cells Qingchang
More informationSupplementary Figure 1: Sequence alignment of partial stem region of flaviviruses
Supplementary Figure 1: Sequence alignment of partial stem region of flaviviruses E prtoeins. Polyprotein sequences of viruses were downloaded from GenBank and aligned by CLC Sequence Viewer software.
More informationSupporting Information
Supporting Information Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles Na Li, Qiaoqiao Sun, Zhengze Yu, Xiaonan Gao, Wei Pan,
More informationImmune Checkpoint Blockade for Anti-Metastatic Cancer Immunotherapy Rui Ge, Cangwei Liu, Xue Zhang, Wenjing Wang, Binxi Li, Jie Liu, Yi Liu, Hongchen
Supporting Information Photothermal-Activatable Fe 3 O 4 Superparticles Nano-Drug Carriers with PD-L1 Immune Checkpoint Blockade for Anti-Metastatic Cancer Immunotherapy Rui Ge, Cangwei Liu, Xue Zhang,
More informationSupporting Information
1 Recognition, neutralization and clearance of target peptides in the blood stream of living mice by molecular imprinted polymer nanoparticles: a plastic antibody Yu Hoshino, *, Hiroyuki Koide, Takeo Urakami,
More informationQuantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin
Supporting Information for Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin Hye-Yeong Kim 1,2+, Ran Li 1+, Thomas S.C. Ng 1, Gabriel Courties
More informationIn Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood-Brain Barrier
Supporting Information In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood-Brain Barrier Yang Song, Dan Du, Lei Li, Jun Xu, Prashanta Dutta *,, and Yuehe Lin *, School of Mechanical
More informationTHE DELIVERY EXPERTS. in vivo-jetpei DNA & sirna Delivery Protocol PROTOCOL
THE DELIVERY EXPERTS in vivo-jetpei DNA & sirna Delivery Protocol PROTOCOL DESCRIPTION in vivo-jetpei is a linear polyethylenimine, which mediates efficient nucleic acid (DNA, shrna, sirna, oligonucelotides,
More informationOne-step route to Ag nanowires with diameter below 40 nm and. aspect ratio above 1000
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supplementary Materials One-step route to Ag nanowires with diameter below 40 nm and aspect ratio
More informationFacile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy
Supplementary Data For Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy Chen Shao, Kun Shang, Huaibao Xu, Yu Zhang, Zhichao Pei* and Yuxin Pei* E-mail: peiyx@nwafu.edu.cn;
More informationCompact Plasmonic Blackbody for Cancer Theranosis in Near-Infrared II Window
Supporting Information for Compact Plasmonic Blackbody for Cancer Theranosis in Near-Infrared II Window Jiajing Zhou,, Yuyan Jiang,, Shuai Hou, Paul Kumar Upputuri, Di Wu,, Jingchao Li, Peng Wang, Xu Zhen,
More informationSupporting Information For
Supporting Information For Stimuli-Responsive Functionalized Mesoporous Silica Nanoparticles for Drug Release in Response to Various Biological Stimuli Xin Chen a,b, Xiaoyu Cheng a,b, Alexander H. Soeriyadi
More informationFigure S Relative MUC4 transcript level* CD18/HPAF CD18/HPAF-Scr CD18/HPAF-siMUC4
Figure S1 Relative MUC4 transcript level* 1.4 1.2 1 0.8 0.6 0.4 0.2 0 CD18/HPAF CD18/HPAF-Scr CD18/HPAF-siMUC4 Figure S2 * * CD18/HPAF-Scr CD18/HPAF-siMUC4 CD18/HPAF-Scr CD18/HPAF-siMUC4 Figure S3 CD18/HPAF-Scr
More informationSilica/Porphyrin Hybrid Nanotubes for In Vivo Cell Tracking
Electronic Supplementary Information Silica/Porphyrin Hybrid Nanotubes for In Vivo Cell Tracking by Near-Infrared Fluorescence Imaging Koichiro Hayashi,* Michihiro Nakamura and Kazunori Ishimura Department
More informationin vivo-jetpei Nucleic Acid Delivery Protocol
in vivo-jetpei Nucleic Acid Delivery Protocol DESCRIPTION in vivo-jetpei is a linear polyethylenimine, which mediates efficient nucleic acid (DNA, shrna, sirna, oligonucleotides, ) delivery to a wide range
More informationSupporting Information. methacrylate) modified hyperbranched polyethylene for flexible conductive film
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Supporting Information Noncovalent dispersion of multi-walled carbon nanotubes with poly(tert-butyl
More informationFolic Acid-Conjugated Chitosan Functionalized Gold Nanoparticles for Targeted Delivery of 5-Fluorouracil in Breast Cancer
Proceedings of the 3 rd World Congress on Recent Advances in Nanotechnology (RAN'18) Budapest, Hungary April 10-12, 2018 Paper No. NDDTE 103 DOI: 10.11159/nddte18.103 Folic Acid-Conjugated Chitosan Functionalized
More informationin vivo-jetpei DNA & sirna delivery reagent
in vivo-jetpei DNA & sirna Delivery Protocol Company Information... 2 Product Information... 3 In vivo Delivery Protocol... 5 1. Reagents required... 5 2. Recommended amount of nucleic acid and injection
More informationA histone H1-binding-aptide based apoptosis-imaging probe for monitoring
Electronic Supplementary Material (ESI) for MedChemComm. This journal is The Royal Society of Chemistry 2017 Supporting Information A histone H1-binding-aptide based apoptosis-imaging probe for monitoring
More informationSupporting Information. Rationally Designed Self-Healing Hydrogel Electrolyte towards a Smart and. Sustainable Supercapacitor
Supporting Information Rationally Designed Self-Healing Hydrogel Electrolyte towards a Smart and Sustainable Supercapacitor Jingchen Wang, Fatang Liu, Feng Tao, Qinmin Pan* (State Key Laboratory of Robotics
More informationSupplementary Information
1 2 Supplementary Information 3 4 5 6 7 8 Supplementary Figure 1. Loading of R837 into PLGA nanoparticles. The loading efficiency (a) and loading capacity (b) of R837 by PLGA nanoparticles obtained at
More information64 CuCl 2 in 50 µl 0.1N NaOAc buffer, and 20 µg of each DOTA-antibody conjugate in 40 µl
Number of DOTA per antibody The average number of DOTA chelators per antibody was measured using a reported procedure with modifications (1,2). Briefly, nonradioactive CuCl 2 (80-fold excess of DOTA antibodies)
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information Coffee-ring Effect-based Simultaneous SERS Substrate Fabrication
More informationReverse Microemulsion-Mediated Synthesis of Bi 2 S 3 2 -PEG for Dual Modal CT/ Fluorescence Imaging in vitro and in vivo
Supporting Information Reverse Microemulsion-Mediated Synthesis of Bi 2 S 3 -QD@SiO 2 -PEG for Dual Modal CT/ Fluorescence Imaging in vitro and in vivo Jun Chen +, Xiao-Quan Yang +, Yuan-Zheng Meng, Meng-Yao
More informationAbstract P : Single dose acute toxicity and long-term biodistribution of perfluoropentane loaded iron doped silica nanoshells
Poster Session Abstracts Abstract P5-01-08: Single dose acute toxicity and long-term biodistribution of perfluoropentane loaded iron doped silica nanoshells Sarah L Blair, Alexander Liberman, Robert Viveros,
More informationSelective In Vivo Metabolic Cell Labeling Mediated Cancer Targeting
SUPPLEMENTARY INFORMATION Selective In Vivo Metabolic Cell Labeling Mediated Cancer Targeting Hua Wang b,*, Ruibo Wang b,*, Kaimin Cai b,*, Hua He a, Yang Liu b, Jonathan Yen c, Zhiyu Wang b, Ming Xu b,
More informationSupporting Information
Supporting Information of Laser Immunotherapy in Combination with Perdurable PD-1 Blocking for Treatment of Metastatic Tumor Lihua Luo, Chunqi Zhu, Hang Yin, Mengshi Jiang, Junlei Zhang, Bing Qin, Zhenyu
More informationSupplementary Figure 1. In vitro activity screen of PLK1 sirna sequences. Activity of native PLK1 sirna sequences targeting human PLK1 mrna were
Supplementary Figure legends Supplementary Figure 1. In vitro activity screen of PLK1 sirna sequences. Activity of native PLK1 sirna sequences targeting human PLK1 mrna were assessed in the HT29 cell viability
More informationSUPPLEMENTARY INFORMATION
SUPPLEMENTARY INFORMATION DOI: 10.1038/NNANO.2013.54 A biomimetic nanosponge that absorbs pore-forming toxins Che-Ming J. Hu, Ronnie H. Fang, Jonathan Copp, Brian T. Luk, Liangfang Zhang* Supplementary
More informationSupplementary Information. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
Supplementary Information Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing Adam J. Shuhendler 1*, Kanyi Pu 1*, Lina Cui 1, Jack P. Uetrecht &
More informationSupplementary Figure 1. CryoTEM images of the barcoded nanoparticles (a) and
a b Supplementary Figure 1. CryoTEM images of the barcoded nanoparticles (a) and size measurements of the particles (b). Liposomes were loaded with DNA barcodes and were imaged using cryo-tem and measured
More informationSuppressing Nanoparticle-Mononuclear Phagocyte. System Interactions of Two-Dimensional Gold. Nanorings for Improved Tumor Accumulation and
Supporting information Suppressing Nanoparticle-Mononuclear Phagocyte System Interactions of Two-Dimensional Gold Nanorings for Improved Tumor Accumulation and Photothermal Ablation of Tumors Yijing Liu,
More informationGene therapy has gained significant attention over the past two decades as a potential method for treating genetic disorders such as severe combined
Abstract Gene therapy has gained significant attention over the past two decades as a potential method for treating genetic disorders such as severe combined immunodeficiency, cystic fibrosis, and Parkinson
More informationSupporting information
Supporting information Bioengineered Boronic Esters Modified Dextran Polymer Nanoparticles as Reactive Oxygen Species Responsive Nanocarrier for Ischemic Stroke Treatment Wei Lv 1, 3#, Jianpei Xu 1#, Xiaoqi
More informationSupporting Information. Self-supplied tumor oxygenation through separated liposomal delivery of H 2 O 2
Supporting Information Self-supplied tumor oxygenation through separated liposomal delivery of H 2 O 2 and catalase for enhanced radio-immunotherapy of cancer Xuejiao Song 1,2, Jun Xu 2, Chao Liang 2,
More informationKazuki N. Sugahara, Tambet Teesalu, Priya Prakash Karmali, Venkata Ramana Kotamraju, Lilach
Cancer Cell, Volume 16 Supplemental Data Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors Kazuki N. Sugahara, Tambet Teesalu, Priya Prakash Karmali, Venkata Ramana Kotamraju, Lilach
More informationY 2 O 3 Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells
Supporting Information Y 2 O 3 Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells Chunyue Gao, Yi Jin*,, Guang Jia, Xiaomin Suo, Huifang
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information Nitrogen-doped graphene quantum dots coupled
More informationOn-chip Selective Capture of Cancer Cells and. Ultrasensitive Fluorescence Detection of. Survivin mrna in Single Living Cell
Supporting Information On-chip Selective Capture of Cancer Cells and Ultrasensitive Fluorescence Detection of Survivin mrna in Single Living Cell Xiang-Ling Li, Shu Shan, Meng Xiong, Xing-Hua Xia, Jing-Juan
More informationSupporting Information for
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2015 Supporting Information for Large-Scale Freestanding Nanometer-thick Graphite Pellicle for Mass
More informationIn vivo Aggregation-Induced Transition between T 1 and T 2. Relaxations of Magnetic Ultra-Small Iron Oxide
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 017 Supporting information In vivo Aggregation-Induced Transition between T 1 and T Relaxations of
More informationNuclear-Targeting Gold Nanorods for Extremely Low NIR Activated Photothermal Therapy
Supporting Information Nuclear-Targeting Gold Nanorods for Extremely Low NIR Activated Photothermal Therapy Limin Pan, Jianan Liu, and Jianlin Shi* State Key Laboratory of High Performance Ceramics and
More informationElectronic Supplementary Material
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2018 Electronic Supplementary Material 2D holey cobalt sulfide nanosheets derived
More informationElectronic Supplementary Material (ESI) for Journal of Materials Chemistry This journal is The Royal Society of Chemistry 2011.
Experimental: MTT assay: To determine cell viability the colorimetric MTT metabolic activity assay was used. Hela cells (1 10 4 cells/well) were cultured in a 96-well plate at 37 C, and exposed to varying
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers Chang, Y.; Li, X.; Zhang, L.; Xia, L.; Liu,
More informationSupporting Information
Supporting Information Experimental Section Chemicals Luminol was obtained from Sigma Aldrich Chemical Co. Naringin, hesperidin and naringin dihydrochalcone were obtained from zeliang Co. (Nanjing, China).
More informationSupplementary Figures
Supplementary Figures Supplementary Figur e 1. DLS analyses of DSPE PEG 2000 Amine DC(8,9)PC LM (a) immediately after its preparation and (b) after 3 days. Supplementary Figure 2. Particle size distribution
More informationSuppression of Hepatic Inflammation via Systemic sirna Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles
Suppression of Hepatic Inflammation via Systemic sirna Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine
More informationMorphogenesis of Cement Hydrate
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2016 Morphogenesis of Cement Hydrate S. E. Moghaddam, 1,2,3 V. Hejazi, 1,4 S.
More informationNature Medicine: doi: /nm.4356
SUPPLEMENTARY FIGURES Supplementary Figure 1: Characterization of IVT mrna encoding highly active bsab. (a) IVT mrna quality and purity analysis on an Agilent 2100 Bioanalyzer. Full-length mrna peaks are
More informationA comparative study of cellular uptake and cytotoxicity of multi-walled carbon
A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotube, graphene oxide, and nanodiamond Xiaoyong Zhang,* a,b Wenbing Hu, a Jing Li, a Lei tao, b and Yen wei b Preparation
More informationLarge-scale fabrication of free-standing and sub-μm PDMS through-holes membranes
Electronic Supplementary Material (ESI) for. This journal is The Royal Society of Chemistry 2018 Large-scale fabrication of free-standing and sub-μm PDMS through-holes membranes Hai Le-The,* a Martijn
More informationA novel fluorescent probe for Hg 2+ detection in a wide ph range and its application in living cell imaging
Electronic Supplementary Material (ESI) for Analytical Methods. This journal is The Royal Society of Chemistry 2018 Electronic Supplementary Information A novel fluorescent probe for Hg 2+ detection in
More informationph-responsive gold nanoparticles-in-liposome hybrid nanostructures for
Electronic Supplementary Information ph-responsive gold nanoparticles-in-liposome hybrid nanostructures for enhanced systemic tumor delivery Jutaek Nam, a Yeong Su Ha, b Sekyu Hwang, a Woonghee Lee, b
More informationNature Biotechnology: doi: /nbt.4086
Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3 p815 p815-hcd2 Ag (-) anti-cd3
More informationIn-situ synthesis of one-dimensional MWCNT/SiC porous. nanocomposites with excellent microwave absorption properties
Supplementary Information: In-situ synthesis of one-dimensional MWCNT/SiC porous nanocomposites with excellent microwave absorption properties Hui-Ling Zhu, Yu-Jun Bai *, Rui Liu, Ning Lun, Yong-Xin Qi,
More informationSupplementary Information
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2014 Shear Disassembly of Hierarchical
More informationSupplementary Information
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2018 Supplementary Information An All-in-One Antitumor and Anti- Recurrence/Metastasis Nanomedicine
More informationSupporting Information
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 215 Supporting Information Quantitative Description of Thermodynamic and Kinetic Properties of the
More informationEffect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser
Supporting information Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser Wen-Tsan Chang,,Δ Shean-Jen Chen,,,,Δ Chia-Yuan Chang,,,Δ Yi-Hsien Liu, Chang-Hsin
More informationSupporting Information for. Bongseo Choi, 1, Hyojin Moon, 1, Sung Joon Hong, 1 Changsik Shin, 1 Yoonkyung Do, 1 Seongho Ryu, 2,* Sebyung Kang 1,*
Supporting Information for Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cytotoxic T Cell Activation and Tumor Rejection Bongseo Choi, 1, Hyojin
More informationThe One Year Fate of Iron Oxide Coated Gold. Nanoparticles in Mice
Supporting Information The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice Jelena Kolosnjaj-Tabi, 1,2+ Yasir Javed, 3+ Lénaic Lartigue, 1,3 Jeanne Volatron, 1 Dan Elgrabli, 1 Iris Marangon,
More informationSupplementary Figures
Supplementary Figures Supplementary Figure S1. In vitro determination of the detection limit of vanco-800cw (a) Specificity of vanco-800cw for different clinical bacterial isolates. The in vitro imaging
More informationEfficient dual sirna and drug delivery using engineered lipoproteoplexes
Supporting Information Efficient dual sirna and drug delivery using engineered lipoproteoplexes Che Fu Liu, Raymond Chen, Joseph A. Frezzo, Priya Katyal, Lindsay K. Hill, Liming Yin, Nikita Srivastava,
More informationLeaf-inspired Artificial Microvascular Networks (LIAMN) for Threedimensional
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Supporting Information Leaf-inspired Artificial Microvascular Networks (LIAMN) for Threedimensional
More informationAbstract: Keywords: Gold nanoparticle, Folic acid, Folate, Hela cell, Mcf7 cell, Targeting, 4-aminothiophenol, 6- mercapto-1-hexanol
Abstract: Cancer Nanotechnology Treatment through Folate Conjugated Gold Nanoparticles ( * ) Ali Shakeri-Zadeh and G.Ali Mansoori ( ** ) University of Illinois at Chicago (*) Invited paper. (**) Corresponding
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Supporting Information A Green Route to Fabricate MoS 2 Nanosheets in Water/ethanol/CO 2 Yuhang
More informationNanoscintillator-mediated X-ray inducible photodynamic. therapy for in vivo cancer treatment
Supporting Information for Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment Hongmin Chen, 1,2,3,4 Geoffrey D. Wang, 1 Yen-Jun Chuang, 5 Zipeng Zhen, 1,2 Xiaoyuan
More informationPSi (u-psi) e, a strong and δo-hh. assigned to of substrate. I at 1654 cmc cm
Supplementary Figure 1. Characterizationn of PSi microparticl es. (a) High-resolution scanning electron micrograph of PSi microparticles, (b) Particle size distribution, and (c) ATR-FTIR spectra of PSi,
More informationSupporting Information
Supporting Information Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in vivo Imaging of Amyloid- Plaques with a Negligible Background Signal Dokyoung Kim,, Hyunsoo
More informationIn situ semi-quantitative assessment of single cell viability by resonance
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2018 Electronic Supplementary Information (ESI) In situ semi-quantitative assessment
More informationSynthesis of copper sulfide nanoparticles and evaluation of in vitro antibacterial activity and in vivo
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2017 Synthesis of copper sulfide nanoparticles and evaluation of in vitro antibacterial activity
More informationSupporting Information. Engineering PD-1-Presenting Platelets for Cancer Immunotherapy
Supporting Information Engineering PD-1-Presenting Platelets for Cancer Immunotherapy Xudong Zhang,,, #, Jinqiang Wang,, #, Zhaowei Chen, Quanyin Hu, Chao Wang, Junjie Yan, Gianpietro Dotti, Peng Huang,
More informationSupporting Information. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis,
Supporting Information Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts Ken-Hsuan Liao,, Yu-Shen Lin,, Christopher W. Macosko,, * and Christy L. Haynes,, * Department
More informationThreshold Rigidity Values for the Asbestos-like Pathogenicity. of High-Aspect-Ratio Carbon Nanotubes in a Mouse Pleural. Inflammation Model
Supporting information for Threshold Rigidity Values for the Asbestos-like Pathogenicity of High-Aspect-Ratio Carbon Nanotubes in a Mouse Pleural Inflammation Model Dong-Keun Lee, Soyeon Jeon, Youngju
More informationSUPPLEMENTARY FIG. S2. Expression of single HLA loci in shns- and shb 2 m-transduced MKs. Expression of HLA class I antigens (HLA-ABC) as well as
Supplementary Data Supplementary Methods Flow cytometric analysis of HLA class I single locus expression Expression of single HLA loci (HLA-A and HLA-B) by shns- and shb 2 m-transduced megakaryocytes (MKs)
More informationSupporting Information. Redirecting immunity via covalently incorporated immunogenic sialic. acid on tumor cell surface
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2016 Supporting Information Redirecting immunity via covalently incorporated immunogenic sialic
More informationDramatic enhancements in toughness of polyimide nanocomposite via. long-cnt-induced long-range creep
Electronic supplementary information for Dramatic enhancements in toughness of polyimide nanocomposite via long-cnt-induced long-range creep Xilai Jia, a Qiang Zhang, a,* Meng-Qiang Zhao, a Guang-Hui Xu,
More informationUrchin-like V 2 O 3 /C Hollow Nanospheres Hybrid for High-Capacity and Long-Cycle-Life Lithium Storage
Supporting Information Urchin-like V 2 O 3 /C Hollow Nanospheres Hybrid for High-Capacity and Long-Cycle-Life Lithium Storage Peng Yu, Xu Liu, Lei Wang,* Chungui Tian, Haitao Yu, and Honggang Fu* Key Laboratory
More informationDesign of Thiol ene Photoclick Hydrogels Using Facile Techniques for Cell Culture Applications
Electronic Supplementary Material (ESI) for Biomaterials Science. This journal is The Royal Society of Chemistry 2014 Design of Thiol ene Photoclick Hydrogels Using Facile Techniques for Cell Culture Applications
More informationSupporting information. Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and MRI contrast agent
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2015 Supporting information Magnetic nanoscale metal organic frameworks for potential targeted
More information