New Programs in Quantitative Biology: Hunter College.
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1 New Programs in Quantitative Biology: Hunter College
2 What is QuBi? Quantitative Biology An initiative to join computational and quantitative disciplines to the analysis of biological data. Bioinformatics, computational biology Exciting, multidisciplinary field with many career options
3 Traditional Biological Research Benchwork Data Analysis & Interpretation Quantitative Biological Research HighThroughput Benchwork DATA DATA DATA DATA DATA DATA DATA DATA DATA DATA Analysis & Interpretation
4 Hunter College Hunter has excellence in Quantitative Biology given existing departmental, faculty, and infrastructural strengths. We have revised our curriculum to have Quantitative Biology concentrations in 5 majors (Biology, Chemistry, Computer Science, Mathematics, Statistics) The National Institutes of Health (NIH) and Hunter College have recognized this excellence with grants and student scholarship support Excellent Student Opportunities at Hunter!
5 Student Support QuBi Scholarships MARC Harcourt Fellows
6 Research & Career Options Work with Hunter Faculty on Exciting Research Projects Prepare for Graduate Work or a Career in Fields including: Computational Biology Biostatistics Protein Chemistry/Pharma Biological Software Engineering
7 QuBi Faculty Research
8 CS Research in QuBi Mneimneh: Computational approaches to study RNARNA Structure prediction RNA folding and interaction (each one is optimal) RNA folding and interaction (each one is nonoptimal) 6 4 optimal folding of RNA 1 optimal folding of RNA 2 nonoptimal folding of RNA 1 nonoptimal folding of RNA 2 RNA folding and interaction (but better together) 7 Optimal structure for RNA 1 and RNA 2
9 Chem Research in QuBi Kawamura: Genomic Screening using Microarray Data Genes up or down Identify surrogate markers of therapeutic effects Herbal medicine Cell treatment GeneChip profiling 2. Find the compounds that regulate the surrogate biomarkers Identification of active compounds Herbal medicine Fractionation Treatment w/ fractions Real time PCR Kawamura, A. et al. Bioorg. Med. Chem. Lett., 2006, 16, Kawamura, A. et al. Bioorg. Med. Chem. Lett., 2007, 17, 6879.
10 Bio Research in QuBi Qiu: Comparative Genomics of Lyme Disease Identification of Virulence Genes and Vaccine Targets Development of WebTools for Visualizing Genome Differences borreliagenome.org
11 The QuBi Curricula Concentrations within the Biology, Chemistry, Computer Science, Mathematics, Statistics Majors Within each Major, these QuBi Concentrations are multidisciplinary, drawing on new and existing courses
12 Example QuBi Course STAT319: Bayesian Inference in the Sciences Modeling Biological Variables: Markov Chains: sequence of nucleotide base pairs in DNA Hidden Markov chain Models: coding vs. noncoding regions in DNA Small class (1215 students) allows for individualized attention and mentoring
13 Example QuBi Course CHEM388: Chemical Genomics Chemical and computational tools for genomics and proteomics research with two main themes: Molecular visualization of three dimensional structures of macromolecules (proteins, DNA, etc.) as well as small molecules (drugs, etc.) Chemical and computational tools for genomics and proteomics analysis.
14 Example QuBi Course BIOL425: Computational Molecular Biology QuBi Capstone Course Hands On Learning Bioinformatics Theory & Applications to: Gene Prediction Protein Structure Prediction Molecular Phylogenetics Gene Expression Analysis
15 Some QuBi Facilities UNIX Lab BioSAM Lab BIOL100 Lab
16 QuBi Advisors Kawamura Chem Mneimneh CS Steiper Anthro Teller CS Draghicescu Math Qiu Bio Talih Stats Alaie Bio
17 Please go to the website to contact any of the faculty advisors or send to Veronica Lichman, QuBi Grant Administrator at
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