Institute of Polymers

Transcription

1 Bulgarian Academy of Sciences Institute of Polymers Acad. G. Bonchev St., bl. 103A 1113 Sofia, Bulgaria (34 68)

2 Main research topics Novel biocompatible and (bio)degradable materials from natural and synthetic polymers, stimuliresponsive materials (ph-sensitive, magnetosensitive), metal-ion-chelating polymers Electrospun biocompatible porous materials for cell and tissue engineering scaffolds, wound dressings, local cancer treatment, remediation of water Non-woven textile based on functional polymers from renewable sources for agriculture, packaging and food preservation New water-soluble bioadhesive macromolecular carriers of bioactive substances, enzymes, microorganisms

3 Lab-scale technology for electrospinning/electrospraying high voltage power supply pump to control flow rate rotating drum collectors Home-made equipment Know-how

4 Lab-scale devices for self-organization and coaxial electrospinning Multi-needle electrode Home-made devices Know-how

5 Bulgaria is represented by the works of LBAP-IP (data from Science Citation Index SCI, ) Bulgarian Academy of Sciences Institute of Polymers Ranking of the countries in Europe on the number of scientific publications in the field of nanofibrous materials prepared by electrospinning Austria (2%) Spain (2.5%) Poland France (2.5%) (2%) Russia (3%) Switzerland (3.4%) Sweden (3.9%) Bulgaria (4.9%) Italy (11.3%) Croatia, Czech Republic, Greece, Portugal (1%) Hungary, Romania (0.5%) Germany (27%) England (14.3%) Belgium (4.9%) Netherlands (7.9%) Finland (5.4%) 6 th in Europe 15 th in the world

6 Self-organization of polycation/polyanion polyelectrolyte pairs bundles Non-woven textile from oriented nanofibers Fluffy textile

7 Haemostatic and antibacterial activity contact with blood PLLA scpla contact with S. aureus PLLA scpla

8 Direct electrospinning onto injured area of patient s hand

9 Antitumor activity of quaternized chitosan/copla/dox Apoptosis in HeLa human cervical cancer cells QCh/coPLA/DOX Antitumor activity of electrospun implants against Graffi myeloid tumor copla

10 Lab-scale technology for embedding of biopesticides Stimulate the plant protection Impede the development of plant pathogens Ensure favorable conditions for the plant growth Environmentally friendly plant protection systems based on chitosan

11 Medicinal plants New pharmaceutical and cosmetic formulations (nanomedicine) Pharmacognosy is the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.

12 Current Projects Cooperations Belgium Italy France Ukraine Lithuania Novel hybrid nanostructured materials for local cancer treatment (Grant DO /08) Self-assembly of conducting nanofibers into yarns during electrospinning of polyelectrolyte solutions (Grant DO /08) New antibacterial and hemostatic nanofibrous wound dressings (Grant /08) New nanostructured materials with antioxidant activity for wound healing applications (Grant /08) Study of the interaction chitosan (solutions, microgels or nanostructured spheres) beneficial/pathogenic microorganisms agricultural crops (Grant TK-Ch- 1719/07) Financial support from National Science Fund

13 Bulgarian Academy of Sciences Institute of Polymers Head of the Laboratory Prof. N. Manolova, D.Sc. Assoc. Prof. M. Ignatova, Ph.D. Assoc. Prof. O. Stoilova, Ph.D. Assoc. Prof. D. Paneva, Ph.D. Res. Assoc. M. Spasova, Ph.D. A. Toncheva, Ph.D. student E. Korina, Ph.D. student N. Stoyanova, Ph.D. student Ts. Petrova, Researcher Prof. I. Rashkov, D.Sc. acad. G. Bonchev st., bl. 103A 1113 Sofia, Bulgaria tel.: (34 68)