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1 exchange rates as of 11/ THE BIOSENSORS BELOW HAVE VARIOUS APPLICATIONS Q indicates the biosensor can be used for quantita purposes. K indicates the biosensor can be used for kinetic experiments with off rates greater than 15 minutes. DIP and READ BIOSENSORS Biosensor / Anti-Human IgG Fc Q Anti-human IgG Fc Biosensors, Fc Specific - One tray of 96 biosensors coated with anti-human IgG. 290 Biosensor / Anti-Human IgG Fc 5 Q Pack Anti-human IgG Fc Biosensors, Fc Specific - Five trays of 96 biosensors coated with anti-human IgG. 10% 1,300 Biosensor / Anti-Human IgG Fc 20 Q Case Anti-human IgG Fc Biosensors, Fc Specific - Twenty trays of 96 biosensors coated with anti-human IgG. 20% 4,617 Biosensor / Protein A Q Protein A Biosensors - One tray of 96 biosensors coated with Protein A. 342 Biosensor / Protein A 5 Q Pack Biosensor / Protein A 20 Q Case Protein A Biosensors - Five trays of 96 biosensors coated with Protein A. 10% Protein A Biosensors - Twenty trays of 96 biosensors coated with Protein A. 20% 1,537 5,462 Biosensor / Protein G Q Protein G Biosensors - One tray of 96 biosensors coated with Protein G. 342 Biosensor / Protein G 5 Q Pack Biosensor / Protein G 20 Q Case Protein G Biosensors - Five trays of 96 biosensors coated with Protein G. 10% Protein G Biosensors - Twenty trays of 96 biosensors coated with Protein G. 20% 1,537 5,462 Biosensor / Protein L Q Protein L Biosensors - One tray of 96 biosensors coated with Protein L. 342 Biosensor / Protein L 5 Q Pack Biosensor / Protein L 20 Q Case Protein L Biosensors - Five trays of 96 biosensors coated with Protein L. 10% Protein L Biosensors - Twenty trays of 96 biosensors coated with Protein L. 20% 1,537 5,462 Biosensor / Anti-FLAG (FLG) QK Biosensor / Anti-FLAG (FLG) 5 QK Pack Anti-FLAG (FLG) Biosensors - One tray of 96 biosensors coated with anti-flag antibody for both quantita and kinetic applicas of FLAG-tagged recombinant proteins. Anti-FLAG (FLG) Biosensors - Five trays of 96 biosensors coated with anti- FLAG antibody for both quantita and kinetic applicas of FLAG-tagged recombinant proteins. 10% 558 2,507 Biosensor / Anti-FLAG (FLG) 20 QK Case Anti-FLAG (FLG) Biosensors - Twenty trays of 96 biosensors coated with anti- FLAG antibody for both quantita and kinetic applicas of FLAG-tagged recombinant proteins 20% 8,907 Biosensor / Anti-Human Fab-CH1 (FAB) QK Anti-Human Fab-CH1 (FAB) Biosensors One tray of 96 biosensors coated with anti-human Fab-CH1 affinity ligand for quantita and kinetic measurements of human IgG, Fab, and F(ab )2 molecules. 485 Biosensor / Anti-Human Fab-CH1 (FAB) 5 QK Pack Anti-Human Fab-CH1 (FAB) Biosensors Five trays of 96 biosensors coated with anti-human Fab-CH1 affinity ligand for quantita and kinetic measurements of human IgG, Fab, and F(ab )2 molecules. 10% Discount on 2,177 Biosensor / Anti-Human Fab-CH1 (FAB) 20 QK Case Anti-Human Fab-CH1 (FAB) Biosensors Twenty trays of 96 biosensors coated with anti-human Fab-CH1 affinity ligand for quantita and kinetic measurements of human IgG, Fab, and F(ab )2 molecules. 20% Discount on 7,737 Biosensor / Anti-Murine IgG Fv Q Anti-Murine IgG Fv Biosensors - One tray of 96 biosensors coated with goat-antimouse IgG. 290 Biosensor / Anti-Murine IgG Fv 5 Q Pack Anti-Murine IgG Fv Biosensors - Five trays of 96 biosensors coated with goat anti-mouse IgG. 10% 1,300 Biosensor / Anti-Murine IgG Fv 20 Q Case Anti-Murine IgG Fv Biosensors - Twenty trays of 96 biosensors coated with goat anti-mouse IgG. 20% 4,617 Effective Date: August 18, 2014 Page 1
2 DIP and READ BIOSENSORS continued Biosensor / Ni-NTA (NTA) QK Biosensor / Ni-NTA (NTA) 5 QK Pack Biosensor / Ni-NTA (NTA) 20 QK Case Ni-NTA (NTA) Biosensors - One tray of 96 biosensors coated with nickelcharged tris-nta for both quantita and kinetic applicas of HIS-tagged molecules. Ni-NTA (NTA) Biosensors - Five trays of 96 biosensors coated with nickelcharged tris-nta for both quantita and kinetic applicas of HIS-tagged molecules. 10% Ni-NTA (NTA) Biosensors - Twenty trays of 96 biosensors coated with nickelcharged tris-nta for both quantita and kinetic applicas of HIS-tagged molecules. 20% 419 1,885 6,697 Biosensor / Anti-Penta-HIS (HIS) Q Anti-Penta-HIS (HIS) Biosensors - One tray of 96 biosensors coated with the Qiagen Penta-HIS antibody for quantita applicas. 647 Biosensor / Anti-Penta-HIS (HIS) 5 tray Q Pack Anti-Penta-HIS (HIS) Biosensors - Five trays of 96 biosensors coated with the Qiagen Penta-HIS antibody for quantita applicas. 10% Discount on tray pricing included. 2,909 Biosensor / Anti-Penta-HIS (HIS) 20 Q Case Anti-Penta-HIS (HIS) Biosensors - Twenty trays of 96 biosensors coated with the Qiagen Penta-HIS antibody for quantita applicas. 20% Discount on tray pricing included. 10,338 Biosensor / Anti-HIS (HIS2) Q Anti-HIS (HIS2) Biosensors - One tray of 96 biosensors coated with the MBS high-affinity, high specificity anti-his antibody for quantitative applicas of all HIS-tagged proteins. 647 Biosensor / Anti-HIS (HIS2) 5 Q Pack Anti-HIS (HIS2) Biosensors - Five trays of 96 biosensors coated with the MBS high-affinity, high specificity anti-his antibody for quantitative applicas of all HIS-tagged proteins. 10% 2,909 Biosensor / Anti-HIS (HIS2) 20 Q Case Anti-HIS (HIS2) Biosensors - Twenty trays of 96 biosensors coated with the MBS high-affinity, high specificity anti-his antibody for quantitative applicas of all HIS-tagged proteins. 20% 10,338 Biosensor / Anti-GST (GST) QK Biosensor / Anti-GST (GST) 5 QK Pack Biosensor / Anti-GST (GST) 20 QK Case Anti-GST (GST) Biosensors - One tray of 96 biosensors coated with an anti-gst antibody for both quantita and kinetic applicas. Anti-GST (GST) Biosensors - Five trays of 96 biosensors coated with an anti- GST antibody for both quantita and kinetic applicas. 10% Discount on Anti-GST (GST) Biosensors - Twenty trays of 96 biosensors coated with an anti- GST antibody for both quantita and kinetic applicas. 20% Discount on 395 1,775 6,307 Biosensor / Streptavidin (SA) K Biosensor / Streptavidin (SA) 5 K Pack Streptavidin (SA) Biosensors - One tray of 96 biosensors coated with streptavidin for quantita, screening, or kinetic applicas. Streptavidin (SA) Biosensors - Five trays of 96 biosensors coated with streptavidin for quantita, screening, or kinetic applicas. 10% Discount on 419 1,885 Biosensor / Streptavidin (SA) 20 K Case Streptavidin (SA) Biosensors - Twenty trays of 96 biosensors coated with streptavidin for quantita, screening, or kinetic applicas. 20% Discount on 6,697 Effective Date: August 18, 2014 Page 2
3 DIP and READ BIOSENSORS continued Biosensor / High Precision Streptavidin (SAX) QK High Precision Streptavidin (SAX) Biosensors - One tray of 96 precisioncontrolled (CV<4%) streptavidin biosensors for high precision quantita, screening, or kinetic applicas. 504 Biosensor / High Precision Streptavidin (SAX) 5 QK Pack High Precision Streptavidin (SAX) Biosensors - One tray of 96 precisioncontrolled (CV<4%) streptavidin biosensors for high precision quantita, screening, or kinetic applicas. 10% 2,264 Biosensor / High Precision Streptavidin (SAX) 20 QK Case High Precision Streptavidin (SAX) Biosensors - One tray of 96 precisioncontrolled (CV<4%) streptavidin biosensors for high precision quantita, screening, or kinetic applicas. 20% 8,046 Biosensor / Amine Reactive Second Genera (AR2G) K Amine Reactive Second Genera (AR2G) Biosensors - One tray of 96 biosensors compatible with amine reactive coupling chemistry for kinetic analysis. Requires amine coupling second genera kit ( ). 419 Biosensor / Amine Reactive Second Genera (AR2G) 5 K Pack Amine Reactive Second Genera (AR2G) Biosensors - Five trays of 96 biosensors compatible with amine reactive coupling chemistry for kinetic analysis. Requires amine coupling second genera kit ( ). 10% 1,885 Biosensor / Amine Reactive Second Genera (AR2G) 20 K Case Amine Reactive Second Genera (AR2G) Biosensors - Twenty trays of 96 biosensors compatible with amine reactive coupling chemistry for kinetic analysis. Requires amine coupling second genera kit ( ). 20% 6,697 Biosensor / Anti-mIgG Fc Capture (AMC) K Anti-mouse IgG Fc Capture Biosensors - One tray of 96 biosensors for the immobiliza of mouse IgG or other proteins containing the mouse Fc region for kinetic analysis. 371 Biosensor / Anti-mIgG Fc Capture (AMC) 5 K Pack Anti-mouse IgG Fc Capture Biosensors - Five trays of 96 biosensors for the immobiliza of mouse IgG or other proteins containing the mouse Fc region for kinetic analysis. 10% 1,665 Biosensor / Anti-mIgG Fc Capture (AMC) 20 K Case Anti-mouse IgG Fc Capture Biosensors - Twenty trays of 96 biosensors for the immobiliza of mouse IgG or other proteins containing the mouse Fc region for kinetic analysis. 20% 5,917 Biosensor / Anti-hIgG Fc Capture (AHC) K Anti-human IgG Fc Capture Biosensors - One tray of 96 biosensors for the immobiliza of human IgG or other proteins containing the human Fc region for kinetic analysis. 371 Biosensor / Anti-hIgG Fc Capture (AHC) 5 K Pack Anti-human Fc Capture Biosensors - Five trays of 96 biosensors for the immobiliza of human IgG or other proteins containing the human Fc region for kinetic analysis. 10% 1,665 Biosensor / Anti-hIgG Fc Capture (AHC) 20 K Case Anti-human IgG Fc Capture Biosensors - Twenty trays of 96 biosensors for the immobiliza of human IgG or other proteins containing the human Fc region for kinetic analysis. 20% 5,917 Biosensor / Super Streptavidin (SSA) K Super Streptavidin (SSA) Biosensors - One tray of 96 biosensors coated with streptavidin for small molecule kinetic analysis. 1,033 Biosensor / Super Streptavidin (SSA) 5 K Pack Super Streptavidin (SSA) Biosensors - Five trays of 96 biosensors coated with streptavidin for small molecule kinetic analysis. 10% Discount on tray pricing included. 4,645 Biosensor / Super Streptavidin (SSA) 20 K Case Super Streptavidin (SSA) Biosensors - Twenty trays of 96 biosensors coated with streptavidin for small molecule kinetic analysis. 20% Discount on tray pricing included. 16,514 Biosensor / Aminopropylsilane (APS) Biosensor / Aminopropylsilane (APS) 5 Biosensor / Aminopropylsilane (APS) 20 K K Pack K Case Aminopropylsilane (APS) Biosensors - One tray of 96 biosensors coated with aminopropylsilane for standard kinetic analysis. Aminopropylsilane (APS) Biosensors - Five trays of 96 biosensors coated with aminopropylsilane for standard kinetic analysis. 10% Discount on tray pricing included. Aminopropylsilane (APS) Biosensors - Twenty trays of 96 biosensors coated with aminopropylsilane for kinetic analysis. 20% Discount on tray pricing included ,098 3,901 Effective Date: August 18, 2014 Page 3
4 DIP and READ ASSAY KITS Assay Kit / Host Cell Protein (HCP) Q Host Cell Protein Detec Kit for the quantita of residual CHO host cell proteins in bioprocess samples. Includes 1 assay kit, containing 1 tray of 96 biosensors coated with Cygnus 3G anti-cho HCP antibody, and all calibrators, reagents, and buffers necessary to analyze 96 HCP samples on all current Octet systems. 585 Assay Kit / Host Cell Protein (HCP) 5 Q Pack Host Cell Protein Detec Kit for the quantita of residual CHO host cell proteins in bioprocess samples. Includes 5 assay kits, each containing 1 tray of 96 biosensors coated with Cygnus 3G anti-cho HCP antibody, and all calibrators, reagents, and buffers necessary to analyze 96 HCP samples on all current Octet systems. 10% 2,634 Assay Kit / Immunogenicity QK (sensor) Immunogenicity Assay Kit for detec of Anti-Drug Antibodies- Includes one tray of Biosensors, 1 bottle of Immunogenicity Reagent and 1 bottle of Sample Diluent with ProClin Assay Kit / Residual Protein A Q (sensor) Residual Protein A Kit for detec of native or recombinant Protein A or MabSelect SuRe in bioprocess samples. Includes one tray of Residual Protein A Biosensors, recombinant Protein A calibrator, reagents, and buffers. 468 REAGENTS and ACCESSORY ITEMS Reagent / Sample Diluent Q Bottle Sample Buffer for use with quantita biosensors and contains PBS. 40 Reagent / IgG Calibrators Standard Range Reagent / IgG Calibrators Extended Range Q Set Q Set Reagent / Kinetics Buffer 10X K Bottle Reagent/Amine Coupling Second Genera Reagent Kit K Kit Immunogenicity Reagent bottle Sample Diluent with ProClin bottle Set of 8 IgG Calibrators filled at 10 ml/vial. Includes negative control. Concentra range is ug/ml. Recommended for use with Anti-Human IgG Fc or Protein A Biosensors for valida purposes only. Not for use with crude samples. Set of 8 IgG Calibrators filled at 10 ml/vial. Includes negative control. Concentra range is ug/ml. Recommended for use with Protein A Biosensors for valida purposes only. Not for use with crude samples. One bottle kinetics grade buffer for sample dilu for screening and kinetics grade biosensors, 50 ml, packaged as 10X. Amine Coupling Second Genera Reagent Kit is sufficient for 960 immobilizas onto Amine Reactive Second Genera (AR2G) Biosensors. For screening and kinetics biosensors only. Sample Treatment for use with immunogenicity assays. Contains 1 bottle with PBS and acetic acid. Used as step 1 of Immunogenicity Kit. Sample diluent for use with immunogenicity assays. Contains 1 bottle with PBS and ProClin 300 as a preservative. Used to dilute assay reagents and controls Accessory / Biosensor Dispenser QK Each Octet biosensor transfer tool Well Tilted-bottom Plate (Pack) K Pack 384 well polypropylene microplate with black tilted bottom,10 per pack Well Tilted-bottom Plate (Case) K Case 384 well polypropylene microplate with black tilted bottom,100 per case. SOFTWARE PACKAGES Software Upgrade / Octet Software NA Each Upgrade of Octet instrument software to the latest version of software. Includes 4 seat licenses. If Octet Q or QK with serial number <FB00165, then part number is also required. CFR Part 11 Software for Octet Systems NA Each Current version of CFR Part 11 Software Module for Octet systems. Provides tools to support FDA 21 CFR Part 11 compliance and valida. Includes 4 seat licenses. CFR Software Upgrade / Octet Software NA Each Upgrade of CFR Octet instrument software (4.X or 6.X) to the latest version of software. Includes 4 seat licenses. If Octet QK with serial number <FB00165, then part number is also required. 4,060 Software Installa and PC Integra NA Each On-site software installa and computer integra service. 3,043 BLItz Pro CFR Software Each Current version of BLItz Pro CFR software for BLItz systems. Provides tools to support FDA 21 CFR Part 11 compliance. Includes 4 seat licenses. 1,825 Effective Date: August 18, 2014 Page 4
5 ADDITIONAL SOFTWARE LICENSES Analysis Software Version 8.x Each Addial single user license for version 8.x for offline data analysis. Requires previous purchase of version 8.x. 779 Site License Octet Data Analysis Software Version 8.x Each Unlimited installa and use of the Octet standard software version 8.x at a physical site (single city or ZIP code) as defined in the purchase order. Requires previous purchase of version 8.x. 7,033 Site License Upgrade to the Latest Version of Octet Data Analysis Software Each Upgrade of site license to the latest Octet standard software version at a physical site (single city or ZIP code) as defined in the purchase order. Requires previous purchase of Site License Octet Data Analysis Software. 3,517 Analysis Software Version 7.x Each Addial single user license for version 7.x for offline data analysis. Requires previous purchase of version 7.x. Site License Octet Data Analysis Software Version 7.x Each Unlimited installa and use of the Octet standard software version 7.x at a physical site (single city or ZIP code) as defined in the purchase order. Requires previous purchase of version 7.x. Analysis Software CFR Part 11 Version 7.x Each Addial single user license for version 7.x for offline CFR Part 11 data analysis. Requires previous purchase of part number Site License CFR Part 11 Data Analysis Software Version 7.x Each Unlimited installa and use of the Octet 21 CFR Part 11 software version 7.x at a physical site (single city or ZIP code) as defined in the purchase order. Requires previous purchase of part number Analysis Software CFR Part 11 Version 6.x Each Addial single user license for version 6.x for offline CFR Part 11 data analysis. Requires previous purchase of version 6.x. Site License CFR Part 11 Data Analysis Software Version 6.x Each Unlimited installa and use of the Octet 21 CFR Part 11 software version 6.x at a physical site (single city or ZIP code) as defined in the purchase order. Requires previous purchase of version 6.x. Stand Alone Octet Data Acquisi and Analysis Software Licences Each Stand Alone Octet Data Acquisi and Analysis Software Licence. Required for customers who acquired a second-hand Octet system without a valid software license. 6,717 Single Seat License BLItz CFR Software Each Addial single user license for BLItz Pro CFR software. Requires previous purchase of BLItz Pro CFR software (Part ). 380 VALIDATION AND COMPLIANCE OPTIONS Kit for Octet QK and Octet QKe systems Each Installa and opera (IQ/OQ) documenta and testing kit for the Octet QK and Octet QKe systems. 1,586 Kit for Octet QK384 system Each Installa and opera (IQ/OQ) documenta and testing kit for the Octet QK384 system. 1,586 Kit for Octet RED96 and Octet RED systems Each Installa and opera (IQ/OQ) documenta and testing kit for the Octet RED96 and Octet RED systems. 1,748 Kit for Octet RED384 system Each Installa and opera (IQ/OQ) documenta and testing kit for the Octet RED384 system. 1,748 IQOQ Valida Service for Octet - Non-HTX NA Each Valida services to execute the Octet IQ/OQ documenta and testing at customer facility. Requires purchase of or or or ,438 Octet Performance Certifica - Non-HTX NA Each Instrument calibra service visit and performance certifica at customer facility. Lamp replacement included. Repairs will be included if customer is under warranty. Parts and labor estimate for repairs will be given to customers not covered by warranty or service contract. Certificate is provided. 3,189 Kit for BLItz System NA Each Installa and opera (IQ/OQ) documenta and testing kit for the BLItz system. 618 Effective Date: August 18, 2014 Page 5
6 BLItz ACCESSORIES Blitz Drop Holder, 6-pack Pack Drop Holder for use in BLItz system. Pack of six (6). 82 BLItz Lamp Change Kit Kit Customer-performed lamp change kit for BLItz system. 407 BLItz Starter Kit Kit On-Site Work-BLItz N/A Each BLItz Starter kit contains one tray of 32 Protein A biosensors, stock human IgG, stock mouse IgG, 0.5 N Hydrochloric acid, 20 conical tubes (0.5 ml), two 96- well, black, flat-bottom polypropylene microplates, drop holder, pack of swabs and 50 ml of Sample Diluent. Half day of on-site consultative work by field applica scientist for quantifica assays on the BLItz system TRAINING AND SERVICE OPTIONS ForteBio Advanced Training NA Each One day on-site consultative training. 2,392 ForteBio Basic Training NA Each Fortebio on-site basic training for new users. 1,372 Octet HTX System Installa NA Each Octet QK384 or RED384 Installa NA Each Octet QKe or RED96 Installa NA Each Service Contract for Octet HTX NA Each Service Contract Octet Q NA Each Service Contract Octet QK NA Each Service Contract Octet QKe NA Each Service Contract Octet RED NA Each Service Contract Octet RED96 NA Each Service Contract Octet QK384 NA Each On-site installa and performance valida of Octet HTX system. Includes labor and travel. On-site installa and performance valida of Octet RED384 or Octet QK384 system. Includes labor and travel. On-site installa and performance valida for Octet QK, QKe, RED, or RED96 Systems. Includes labor and travel. On-Site Service Contract for Octet HTX System. One year extended warranty with one Preventive Maintenance Service (Part no ) On-Site Service Contract for Octet Q System. One year of extended coverage. One year extended warranty with one Preventive Maintenance Service. (Part no ) On-Site Service Contract for Octet QK System. One year extended warranty with one Preventive Maintenance Service. (Part no ) On-Site Service Contract for Octet QKe System. One year extended warranty On-Site Service Contract for Octet RED System. One year extended warranty On-Site Service Contract for Octet RED96 System. One year extended warranty On-Site Service Contract for Octet QK384 System. One year extended warranty 3,517 2,345 1,196 28,521 8,557 8,557 10,322 15,742 15,742 14,228 Effective Date: August 18, 2014 Page 6
7 TRAINING AND SERVICE OPTIONS Continued Service Contract Octet RED384 NA Each On-Site Service Contract for Octet RED384 System. One year extended warranty 18,843 Depot Service Contract Sidekick NA Each Depot Service Contract BLItz N/A Each Depot Service Contract for Sidekick. One year of extended coverage. Customer must ship Sidekick to ForteBio. Shipping costs included. Depot Service Contract for BLItz system. One year of extended coverage. Customer must request shipping case from ForteBio to ship BLItz system. Shipping costs included. 1,954 1,915 Instrument Inspec Service NA Each Pre-contract instrument inspec service for instruments out of warranty or contract. Field service visit required. Any parts, labor and travel required to repair instrument will be quoted. 2,392 Octet Sample Work Up and Evalua NA Each Octet Sample Work Up and Evalua. Does not include biosensors. 3,986 Octet HTX Preventive Maintenance Service NA Each Preventive Maintenance service for Octet HTX systems. Includes funcal testing and calibra at the customer site. Lamp replacement, labor, materials, and travel included. Addial parts, labor, and travel to repair non-funcal instruments must be purchased if not covered by warranty or extended warranty service contract. 4,689 Octet Preventive Maintenance - Non- HTX NA Each Preventive Maintenance Service includes funcal testing of the instrument, lamp replacement and calibra at customer site. Addial parts and labor for repairs must be purchased if not covered by warranty or service contract. 2,392 ORDERING To order biosensor consumables, a purchase order referencing the correct part number and list price or quote number should be provided using one of the methods below. WEB: US customers (not available to customers outside the US) can order online 24/7 at Orders received before 12 PM PT are shipped out the same day. fortebio_sales@pall.com. European, Korean, Japanese, Singapore and Indian customers, please send in your orders to the respective Pall Life Sciences office locally. FAX Pall Corpora standard terms and condis apply to all orders. Terms can be found at Pricing is contingent on acceptance of these terms. Please supply the following informa on your purchase order : Full delivery address Invoice Address Purchase order number ForteBio quote # ( if applicable) Contact name and telephone number Fax number or address for receiving confirma LIMITATIONS ON USE The Octet Systems, BLItz and its biosensor consumables are sold for Research Use Only. Any quess - Please contact your local Pall ForteBio representative or contact us at fortebio_sales@pall.com Effective Date: August 18, 2014 Page 7
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