Microsol4. General Purpose Decontaminant Effective Against DNA/RNA Contamination

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Baldwin Hancock
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1 Microsol4 All-in-One Cleaning and Disinfection Concentrate for Dilution Ready-to-Use Spray Ready-to-Use Wipes General Purpose Decontaminant Effective Against DNA/RNA Contamination

2 Microsol 4 Microsol 4 Decontamination Solution with HLD4 Formulation In the late 1990 s Anachem identified a need for a new and effective decontamination and cleaning product for use in its service area. This was in main due to the large number of pipettes returned for service from a variety of customers including research, clinical and blood labs. Anachem needed to find a simple solution to decontaminating these products with no risk to its staff or customers. In 1997 a solution was formulated called Virosolve which in 1999 was rebranded as MicroSol. MicroSol has undergone a variety of changes over the years to ensure that it continues to achieve all of the objectives set out above. Our current formulation is MicroSol4 and the active ingredient is the HLD4 formulation We needed to find a solution that satisfied the following criteria: Effective against key risks (Viral, DNA/RNA and Bacterial) Safe to handle and use (little risk from contact or inhalation) Cleans and Disinfects in One Step Environmentally safe No risk of residues Easy to use Long shelf life = low wastage PLEASE CONTACT US FOR PRICING OR ANY OTHER INFORMATION T F E orders@anachem.co.uk

Enhanced Broad Spectrum Efficacy MicroSol 4 offers an enhanced broad spectrum efficacy, improved environmental safety and is recommended for treatment of all laboratory equipment including surface

This combination enhances the efficacy compared to single chain Q.A.Cs and amphoterics either as single biocides and even combined.

European Efficacy Standards Where possible, data has been collected using the new European efficacy standards (EN Methods).

3 Enhanced Broad Spectrum Efficacy MicroSol 4 offers an enhanced broad spectrum efficacy, improved environmental safety and is recommended for treatment of all laboratory equipment including surface decontamination. MicroSol 4 is reformulated to include a unique and synergistic blend of twin chain quaternary ammonium compounds (Q.A.C.s) and amphoteric biocides. This combination enhances the efficacy compared to single chain Q.A.Cs and amphoterics either as single biocides and even combined. MicroSol 4 efficacy is therefore enhanced in the face of organic challenge due to the new Q.A.C. and has been tested at reputable independent test labs in the UK. European Efficacy Standards Where possible, data has been collected using the new European efficacy standards (EN Methods). These methods will be the standards required for the recently adopted European Biocides Product Directive under which all biocides in the EU will be regulated. As additional methods transition from provisional to approved, further studies will be added. HLD4 Formulation The HLD4 Formulation is being supported through BPD and REACH and contains no substances classified as dangerous to health. HLD4 combines a formidable array of microbiological credentials with the enhanced facilities of faster and more effective anti-pathogenic activity. Safety, Security and Simplicity have been enhanced too, allowing Microsol4 to offer economic dilutions for virtually all environmental challenges. Microsol4 is manufactured in accordance with Quality Management System ISO 900 I and is biodegradable under OECD conditions. Concentrate for Dilution Ready-to-Use Spray Ready-to-Use Wipes Safe-to-Use Disposable Non-Fragranced Convenient Disposable Non-Fragranced Convenient Disposable Ready-to-Use

4 BACTERICIDAL ACTIVITY Microsol 4 EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in food, industrial, domestic and institutional areas Test method and requirements (phase 2, step 1) Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae Clean conditions (0.3g/l bovine albumin) - Dirty conditions (3.0g/l bovine albumin) Industry specific (must also pass under standard dirty conditions) Obligatory - Log reduction 5 in 5 minutes at 20 C Acinetobacter calcoaceticus 1:30 EN1276 Dirty > LOG 5 Enterococcus hirae 1:100 EN1276 Dirty > LOG 5 Enterococcus hirae 1:100 EN1276 Dirty > LOG 5 Escherichia coli 1:100 EN1276 Dirty > LOG 5 Escherichia coli 1:100 EN1276 Dirty > LOG 5 Listeria monocytogenes 1:100 EN1276 Dirty > LOG 5 Methicillin -resistant Staphylococcus aureus 1:100 EN1276 Dirty > LOG 5 Methicillin-resistant Staphylococcus pseudintermedius 1:100 EN1276 Dirty > LOG 5 Pseudomonas aeruginosa 1:100 EN1276 Dirty > LOG 5 Pseudomonas aeruginosa 1:100 EN1276 Dirty > LOG 5 Salmonella tryphimurium 1:100 EN1276 Dirty > LOG 5 Staphylococcus aureus 1:100 EN1276 Dirty > LOG 5 Staphylococcus aureus 1:100 EN1276 Dirty > LOG 5 Streptococcus equi 1:100 EN1276 Dirty > LOG 5 EN Chemical disinfectants and antiseptics Quantitative non-porous surface test for the evaluation of bactericidal and/or fungicidal activity of chemical disinfectants used in food, industrial, domestic and institutional areas Test method and requirements without mechanical action (phase 2, step 2) BACTERIA - Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae FUNGI - Aspergillus niger, Candida albicans Clean conditions (0.3g/l bovine albumin)- Dirty conditions (3.0g/l bovine albumin) Industry specific (must also pass under standard dirty conditions) Obligatory - Bacteria - Log reduction 4 in 5 minutes at 20 C, FUNGI Log reduction 3 in 15 minutes at 20 C Enterococcus hirae 1:100 EN13697 Dirty > LOG 5 Escherichia coli 1:100 EN13697 Dirty > LOG 5 Pseudomonas aeruginosa 1:100 EN13697 Dirty > LOG 5 Staphylococcus aureus 1:100 EN13697 Dirty > LOG 5 EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in the veterinary area Test method and requirements (phase 2, step 1) Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, Enterococcus hirae Low-level soiling (3g/l bovine albumin) - High-level soiling (10g/l bovine albumin + 10g/l yeast extract) Obligatory - Log reduction 5 in 30 minutes at 10 C Bordetella bronchiseptica 1:100 EN1656 Dirty > LOG 5 Campylobacter jejuni 1:100 EN1656 Dirty > LOG 5 Methicillin-resistant Staphylococcus pseudintermedius 1:100 EN1656 Dirty > LOG 5 Rhodococcus equi 1:100 EN1656 Dirty > LOG 5 Streptococcus equi 1:100 EN1656 Dirty > LOG 5 EN 13623, Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity against Legionella pneumophila of chemical disinfectants for aqueous systems Test method and requirements (phase 2, step 1) Obligatory- Log reduction 5 in 60 minutes at 30 C Legionella pneumophila 1:100 EN13623 > LOG 5

5 HLD4 formulation has also been tested under EN1275 and EN1040 EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of basic bactericidal activity of chemical disinfectants and antiseptics Test method and requirements (phase 1) Pseudomonas aeruginosa, Staphylococcus aureus Obligatory - Lg reduction 5 in 5 minutes at 20 C EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of basic fungicidal or basic yeasticidal activity of chemical disinfectants and antiseptics Test method and requirements (phase 1) Aspergillus niger, Candida albicans Obligatory - Lg reduction 4 in 15 minutes at 20 C VIRUCIDAL ACTIVITY BS EN 14476: Chemical disinfectants and antiseptics. Virucidal quantitative suspension test for chemical disinfectants and antiseptics used in human medicine. Test method and requirements (phase 2, step 1) Adenovirus and Poliovirus Obligatory Lg reduction 4 (Requirements may vary by claim) Adenovirus 1:100 EN14476 DIRTY LOG 3.67 Canine Parvovirus (CPV2) 1:100 EN14476 CLEAN > LOG 4 Canine Parvovirus (CPV2) 1:50 EN14476 DIRTY > LOG 4 Feline Infectious Peritonitis 1:50 EPA DIRTY > LOG 4 Hepatitis B 1:50 EN14476 CLEAN LOG 4.67 Herpes Simplex 1:50 EN14476 DIRTY LOG 4.16 Human Immunodeficiency Virus 1:50 EN14476 DIRTY LOG 4.50 Norovirus (Feline Calicivirus) 1:50 EN14476 DIRTY LOG 4.00 SPORICIDAL ACTIVITY EN Chemical disinfectants and antiseptics Basic sporicidal activity Test method and requirements (phase 1) Bacillus subtilis, Bacillus cereus Obligatory - Lg reduction 3 in 60 minutes at 20 C Bacillus cereus 1:50 (10 deg C) EN14347 LOG 3.18 Bacillus subtilis 1:50 (10 deg C) EN14347 LOG 3.17 EN Chemical disinfectants Quantitative suspension test for the evaluation of sporicidal activity of chemical disinfectants used in human medicine, veterinary field, and food, industrial, domestic and institutional areas Test method and requirements (phase 2, step 1) Bacillus subtilis, Bacillus cereus Clean conditions (0.3g/l bovine albumin)- Dirty conditions (3.0g/l bovine albumin + 3.0ml/l sheep erythrocytes) Obligatory - Lg reduction 3 in 60 minutes at 20 C Clostridium difficile 1:10 (10 deg C) EN13704 DIRTY > LOG 3

6 MYCOBACTERICIDAL ACTIVITY EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants and antiseptics used in the veterinary area Test method and requirements (phase 2, step 1) Microsol 4 Mycobacterium avium Low-level soiling (3g/l bovine albumin)- High-level soiling (10g/l bovine albumin + 10g/l yeast extract) Obligatory - Lg reduction 4 in 60 minutes at 10 C Mycobacterium avium 1:50 EN14204 DIRTY > LOG 4 Mycobacterium bovis 1:50 EN14204 DIRTY > LOG 4 Mycobacterium terrae 1:50 EN14204 DIRTY > LOG 4 EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants in the medical area including instrument disinfectants Test method and requirements (phase 2, step 1) Mycobacterium avium, Mycobacterium terrae Clean conditions (0.3g/l bovine albumin)- Dirty conditions (3.0g/l bovine albumin + 3.0ml/l sheep erythrocytes) Obligatory - Lg reduction 4 in 60 minutes at 20 C Mycobacterium avium 1:20 EN14348 CLEAN > LOG 4 Mycobacterium avium 1:20 EN14348 DIRTY > LOG 4 Mycobacterium terrae 1:20 EN14348 CLEAN > LOG 4 Mycobacterium terrae 1:20 EN14348 DIRTY > LOG 4 FUNGICIDAL ACTIVITY EN Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of fungicidal or yeasticidal activity of chemical disinfectants and antiseptics used in food, industrial, domestic and institutional areas Test method and requirements (phase 2, step 1) Aspergillus niger, Candida albicans Clean conditions (0.3g/l bovine albumin)- Dirty conditions (3.0g/l bovine albumin) Industry specific (must also pass under standard dirty conditions) Obligatory - Lg reduction 4 in 15 minutes at 20 C Aspergillus niger 1:100 (10 deg C) EN1650 DIRTY > LOG 4 Candida albicans 1:100 (10 deg C) EN1650 DIRTY > LOG 4 Microsporum canis 1:100 EN1650 DIRTY > LOG 4 Trichophyton rubrum 1:100 EN1650 DIRTY > LOG 4 EN Chemical disinfectants and antiseptics Quantitative non-porous surface test for the evaluation of bactericidal and/or fungicidal activity of chemical disinfectants used in food, industrial, domestic and institutional areas Test method and requirements without mechanical action (phase 2, step 2) Aspergillus niger, Candida albicans Clean conditions (0.3g/l bovine albumin) - Dirty conditions (3.0g/l bovine albumin) Industry specific (must also pass under standard dirty conditions) Fungicidal/Yeasticidal Obligatory Lg - reduction 3 in 15 minutes at 20 C Candida albicans 1:50 EN13697 DIRTY > LOG 4 Candida albicans 1:100 EN13697 DIRTY > LOG 4

7 DNA / RNA HLD4 formulation is proven to denature / precipitate DNA / RNA immediately at dilutions of 1:20 or 1:50 according to Cambridge University Technical Services CUTS can report that at dilutions of HLD4 less than 1:100 (v/v) 1:20 or 1:50 for example nucleic acids are precipitated immediately. For such dilutions (less than or equal to 1:100), the contact time for immersed solutions should be a few minutes at maximum. The product was not tested in aerosol form. However, it is likely that if the concentrations of HLD4 in an aerosol formulation is similar and the active ingredients are stable that it would behave similarly.

ALL-IN-ONE CLEANING & DISINFECTION Part No Description Qty 30312915 5L Concentrate 1

uk visit for more information Anachem 1 & 2 Titan Court, Laporte Way Luton,

8 ALL-IN-ONE CLEANING & DISINFECTION Part No Description Qty L Concentrate ml Spray (1:20 dilution) Ready-to-Use wipes visit for more information Anachem 1 & 2 Titan Court, Laporte Way Luton, Bedfordshire, LU4 8EF T F E orders@anachem.co.uk Mettler-Toledo Limited Registered Office: 64 Boston Road, Beaumont Leys, Leicester, LE4 1AW, UK Registration No: (England) Anachem is a trading name of Mettler-Toledo Limited

STERI-7 XTRA Concentrate Technical Information

STERI-7 XTRA Concentrate Technical Information Product Description STERI-7 XTRA Concentrate is formulated to be diluted and dispensed for high volume cleaning solutions. STERI-7 XTRA Concentrate is lowfoaming