Can-Fite Presentation January 2015

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1 Can-Fite Presentation January

2 Forward Looking Statement This presentation contains forward-looking statements, about Can-Fite s expectations, beliefs or intentions regarding, among other things, its product development efforts, business, financial condition, results of operations, strategies or prospects. In addition, from time to time, Can-Fite or its representatives have made or may make forward-looking statements, orally or in writing. Forward-looking statements can be identified by the use of forward-looking words such as believe, expect, intend, plan, may, should or anticipate or their negatives or other variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical or current matters. These forward-looking statements may be included in, but are not limited to, various filings made by Can-Fite with the U.S. Securities and Exchange Commission (the SEC ), press releases or oral statements made by or with the approval of one of Can-Fite s authorized executive officers. Forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause Can-Fite s actual results to differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause Can-Fite s actual activities or results to differ materially from the activities and results anticipated in such forward-looking statements, including, but not limited to, the factors summarized in Can-Fite s filings with the SEC and in its periodic filings with the Tel-Aviv Stock Exchange. 2

3 Company Profile Advanced clinical stage drug development company Phase II and Phase II/III clinical studies Small molecule drugs Autoimmune Inflammatory diseases Cancer Sexual Dysfunction Company Operations Headquarters and Discovery Labs Petach-Tikva, Israel Drug Development & Clinical Operations Boston, USA Two regional out-licensing deals Japan: for inflammation Korea: for rheumatoid arthritis 3 3

4 Equity Profile Ticker on NYSE: CANF Ticker on Israeli TASE: CFBI 1 ADR = 2 Ordinary Shares 52 Week Range: $ $6.75 Shares Out: 21.3M Ordinary Shares Market Capitalization: ~$40M Avg. Trading Volume (30 day): 516,473 ADRs 4

5 From Concept to Technology 5 5

6 Platform Technology Therapeutic Target A3 adenosine receptor (A3AR) Highly expressed in inflammatory and cancer cells Drug product Small molecules Orally bioavailable drugs Therapeutic Effect Anti-inflammatory and anti-cancer effects in Phase II studies; Excellent safety profile A3AR is utilized as Predictive Biomarker Used to predict patient s response to the drug Inflammatory / Tumor Cells Normal Cells A3 Adenosine Receptor (A3AR) Targeted therapy, specifically aimed at diseased cells 6 6

7 Drug Development Pipeline 7 7

8 Market Opportunity* *Global Data, GIA, Visiongain 8 8

9 Corporate Partnership Regional out-licensing deals [Traded on the Tokyo Stock Exchange (Ticker:4548)] Exclusive license to develop and commercialize CF101 in Japan Up to $20 M in upfront, milestone and annual payments ($7.5M received to date) Up to 12% royalties [Traded on South Korean Stock Exchange (Ticker: A009290)] Exclusive regional license to develop and commercialize CF101 for the treatment of rheumatoid arthritis in Korea $1.5 M in upfront and milestone payments ($0.5M received to date) 7% royalties. Such payments are subject to development and marketing milestones Scientific Collaborations Collaborations with two leading medicinal chemistry laboratories in the field of A3AR for supply of new molecules U.S. National Institutes of Health (NIH) Leiden University, the Netherlands 9 9

10 CF101 Anti-Inflammatory Properties Highly Selective A3AR Agonist Nucleoside derivative Molecular weight Water insoluble Orally bioavailable Half life time in blood 8-9 hours Is not metabolized in the body (secreted unchanged) Anti-Inflammatory Effect Proof of concept in pre-clinical pharmacology studies: Rheumatoid Arthritis Osteoarthritis Inflammatory Bowel Disease Uveitis Mechanism of Action CF101 Fishman et al. Drug Discovery Today 17: A3 Adenosine Receptor (A3AR) 10 10

11 Rheumatoid Arthritis - Positive Data from Phase II Study Phase IIb study, Placebo controlled, 79 patients, enrolled based on the biomarker 11 11

12 Psoriasis Positive Data from IA Phase II/III Study Interim analysis after 100 patients Excellent safety profile in all tested dosages Linear improvement along the 24 week study period (PGA-53%; PASI 75-41%) The linear response predicts better PASI &PGA under longer treatment The 2 mg treated group yielded the best response Additional 200 patients were enrolled, 100 placebo and mg, total 300 patients Data are expected in Q Interim Data - PGA Phase II data Before After 12

13 CF102 Anti-Cancer Properties Highly Selective A3AR Agonist Nucleoside derivative Molecular weight Water insoluble Orally bioavailable Half life time in blood 12 hours Anti-Cancer Effect Proof of concept in pre-clinical pharmacology studies: Hepatocellular Carcinoma Colon Carcinoma Prostate Cancer Melanoma Mechanism of Action CF102 A3 Adenosine Receptor (A3AR) 13

14 Liver Cancer Phase II Global Study Ongoing Phase II - Ongoing Patient enrolment for a global Phase II study has been initiated and designed as follows: Second-Line Treatment Advanced Hepatocellular Carcinoma; Child-Pugh B 78 patients; US, Europe and Israel Phase I/II Positive Results Very favorable safety profile and lack of hepatotoxicity Prolongation of survival time Regression of skin tumor metastases Stable disease (22%) Proof of concept for A3AR utilization as a biomarker U.S. FDA Orphan Drug Approval (Feb 2012) Stemmer et al. The Oncologist,

15 CF602 Sexual Dysfunction Properties A3AR allosteric modulator Molecular weight Water insoluble Orally bioavailable Belong to the family of imidazoquinoline derivatives Improving sexual dysfunction Diabetic rat model - Improvement of erectile dysfunction Mechanism of action Untreated Treated with CF602 Current status Pre-Clinical studies - ongoing Cohen et al. Mediators of Inflammation Histological evaluation using a Masson Trichrome stain for smooth muscle detection in Corpus Cavernous blood vessels in an erectile dysfunction model in diabetic rats 15

16 Intellectual Property Portfolio 150 patents issued and pending internationally for inventions including both in-licensed and Can-Fite invented and owned Exclusive licensee of the U.S. National Institutes of Health (NIH) and Leiden University in the Netherlands for patents covering A 3 AR Agonists 15 patent families IP covers composition of matter, synthesis of matter, and clinical applications 16

17 Capitalization / Ownership Table OWNERSHIP TABLE (1) Number of Fully Diluted Shares % of Fully Diluted Shares Holder Name Officers & Directors Pnina Fishman, Ph. D. CEO 569, % Other Officer & Directors 353, % Total Officers & Directors 923, % Israeli Funds / Greater than 5% Ownership Emprey Asset Management L.P. 2,696, % Cranshire Capital Advisors LLC. 2,696, % Total Israeli Funds / Greater than 5% ownership 5,393, % OphthaliX Inc 446, % Public Float 24,165, % TOTAL Fully Diluted Shares 30,929, % CAPITALIZATION TABLE (1) Security type Number Exercise Price (NIS) Index linked Expiration date Common Shares Outstanding (5) 21,763,404 N/A N/A N/A Warrants (3) 1,124,785 (2) No Warrants to PIPE investors 1,080,578 (4) No March 9, 2018 Warrants to December 2014 investors 1,977,528 (4) 8.85 No December Options no. 9 (3) 486, No May 1, 2015 Options no. 10 (3) 1,561, No Oct. 31, 2015 Options no. 11 (3) 1,494, No April 30, 2016 Options no. 12 1,470, No October 22, 2016 Total Fully Diluted 30,929,546 (1) Source: Company Internal Data and Tel-Aviv Stock Exchange Filings (2) Weighted average (3) Adjusted for a 1:25 reverse share split such that split so 1 warrant represented in the table above is currently equal to 25 warrants which are exercisable for 1 ordinary share (4) Exercise price of $2.23 (5) 21,316,577 not including treasury shares 17 17

18 Financials Balance Sheet / Income Statement INCOME STATEMENT (U.S. $ 1 = NIS as of Sep.30, 2014) in thousands $USD LTM of Sep. 30, 2014 Total Revenue - Operating Income ($11,546) The Company raised $8 M in December 2014 The Company has sufficient resources to support its activities for at least the next 12 months EBITDA ($11,533) Net Income / (Loss) ($8,300) BALANCE SHEET (ILS=$USD as of Sep.30, 2014) ASSETS in thousands $USD of Sep. 30, 2014 LIABILITIES & EQUITY in thousands $USD of Sep.30, 2014 Current Assets Current Liabilities Cash & Equivalents $4,118 Trade Payables $682 Accounts Receivable 688 Other accounts payable 779 Non Current Assets 47 Total Current Liabilities 1,461 Total Assets $4,853 Other liabilities 410 Total Liabilities 1,871 Total Equity 2,982 Total Liabilities & Equity $4,853 MONTHLY CASH BURN RATE in thousands $USD Research $30 Development $190 Patent & Royalties $20 G&A $200 Total $

19 Spotlight on 2015 Milestones Indication Milestone Status Biomarker Development of a commercial kit Q CF102 PRIMARY LIVER CANCER PHASE I/II Psoriasis Data from II/III 300 patients study Q Rheumatoid Arthritis Phase III : Regulatory Approvals Q Glaucoma Data from Phase II 88 patients study H CF602 Pre-Clinical studies Q Liver Cancer Finalizing Patient Enrolment for Phase II Trial 78 patients study Q

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