Pharmacology, Toxicology, and Experimental Therapeutics Track. Lee Ann MacMillan-Crow; Director

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1 Pharmacology, Toxicology, and Experimental Therapeutics Track Lee Ann MacMillan-Crow; Director

2 What is Pharmacology? Pharmacology is the study of the substances that interact with living systems through biological and chemical processes. The ultimate goal of a pharmacologist is to improve the health and well-being of people by applying medical and basic science knowledge to the physiology, biochemistry and pathology of living systems. Most of the advances in modern medicine have resulted from the development of new medicines and the understanding of their mechanisms of action.

3 What is Toxicology? Toxicology is the study of the adverse effects of external factors (free radicals, chemicals, poisons, or drugs) on living systems. Toxicologists are also interested in the inherent mechanisms that mediate the toxic insults to biological or environmental systems. They are at the often at the center of the development of new therapeutic agents, the testing of their safety and the regulation of their use.

4 Our Training An emphasis on therapeutic development, identification of drug targets and mechanisms of organ injury prepare our trainees for a career in drug discovery and medical toxicology. Basic research training is the key to providing excellence in graduate education and opens a portal for new drug discoveries. We are proud of our more than 165 alumni, who have graduated from our training programs. Many hold academic, industrial and teaching positions at institutions across the country and worldwide.

5 Primary Courses Year 1 Spring Principles and Methods of Pharmacology and Toxicology General Physiology Year 2 Fall Graduate Pharmacology and Therapeutics Elective (choose to take in Fall or Spring of 2 nd year) Year 2 Spring Systems Therapeutics required for SPaT students Qualifier Exam then focus on RESEARCH!!

6 NIH T32 Training Program Systems Pharmacology and Toxicology (SPaT): funded by the National Institute of General Medical Sciences (NIGMS) Housed in Pharmacology/Toxicology Department PI: Dr. Philip Mayeux The SPaT program trains students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling.

7 SPaT Students are selected at the end of their first year; mentor must be a SPaT faculty member. Project must incorporate an in vivo model. Provides specialized training and stipend support.

8 Partnership with NCTR National Center of Toxicological Research-Jefferson, AR (45 min away). Only FDA (Food and Drug Administration) center outside of Washington DC. NCTR is a global resource for collaboration providing consultation, training, and innovative scientific solutions in support of FDA's mission to improve public health. PTET students must select co-mentors (one from UAMS and one from NCTR) to complete their PhD. First two years of research training will take place at UAMS

9 PTET Mentors Michael Borelli Radiology NCTR Gunnar Boysen Environmental and OccuSPaT NCTR Bill Fantegrossi Pharmacology SPaT NCTR Robert Griffin Radiology SPaT NCTR Fuson Kilic Biochemistry SPaT MacMillan-Crow Pharmacology SPaT NCTR Philip Mayeux Pharmacology SPaT NCTR Grover Miller Biochemistry SPaT NCTR Paul Prather Pharmacology SPaT NCTR Robert Reis Aging Nancy Rusch Pharmacology SPaT

10 NCTR mentors teams still forming Syed Ali *Sherry Ferguson Amy Goodwin Paul Howard *Annie Lumen- Igor Korturbash *Bill Mattes- Lee Ann MacMillan-Crow *Merle Paule Sumit Sarkar-Paul Gottschall Bill Slikker John Talpos * SPaT faculty

11 Interested and want to know more? or come talk with me: Talk with our current students GPIBS seminar August 30th

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