PASSION? What is your. Tell us your story. Visit NEBPassionInScience.com

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1 What is your PASSION? New England Biolabs is pleased to announce our 2016 Passion In Science Awards, recognizing those within the scientific community working to make a diference in the world through their scientific mentorship, humanitarian eforts, environmental stewardship, or arts and creativity. Through July 31st, 2016, we invite you to nominate yourself or a colleague for one of these awards. Award winners will be our guests at a celebration at the NEB campus in Ipswich MA, USA and will also receive a donation to help further their cause. Remember, no act is too big or too small. Help us celebrate those individuals who demonstrate true passion in science. Tell us your story. Visit NEBPassionInScience.com Content is covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc. For more information, please contact NEB s Global Business Development team at gbd@neb.com. Terms and conditions apply. Science and art come together in the artwork displayed outside the NEB laboratory facility in Ipswich, MA, USA. Building artwork created by Nicole Gordon. Sculpture by Dale Rogers.

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3 life science EXPERT and e-commerce leader The life science leaders of EMD Millipore + Sigma-Aldrich have joined together and, with our agile e-commerce and global distribution, we can help to simplify your world. So you can focus with confidence on tackling life scienceís biggest challenges. MilliporeSigma now offers: ï An extended global network across more than 66 countries ï A world-class e-commerce platform to simplify transactions ï A vast portfolio that has grown to over 300,000 products Our combined strengths will deliver the knowledge, know-how, and best-in-class resources. Learn more at milliporesigma.com The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada. EMD Millipore, MilliporeSigma and the vibrant M are trademarks of Merck KGaA, Darmstadt, Germany and its affiliates. Sigma-Aldrich is a trademark of Sigma-Aldrich Co. LLC and its affiliates. Copyright 2016 EMD Millipore Corporation. All Rights Reserved.

4 life science EXPERT and e-commerce leader The life science leaders of Merck Millipore + Sigma-Aldrich have joined together and, with our agile e-commerce and global distribution, we can help to simplify your world. So you can focus with confidence on tackling life scienceís biggest challenges. The life science business of Merck now offers: ï An extended global network across more than 66 countries ï A world-class e-commerce platform to simplify transactions ï A vast portfolio that has grown to over 300,000 products Our combined strengths will deliver the knowledge, know-how, and best-in-class resources. Learn more at merckgroup.com/life-science The life science business of Merck operates as MilliporeSigma in the U.S. and Canada. Merck, Merck Millipore and the vibrant M are trademarks of Merck KGaA and its affiliates. Sigma-Aldrich is a trademark of Sigma-Aldrich Co. LLC and its affiliates. Copyright 2016 Merck KGaA. All Rights Reserved.

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6 Image: jim /AdobeStock Be Among the First to Publish in Science Robotics NOW ACCEPTING MANUSCRIPTS ScienceRobotics.org Science Robotics is a unique journal created to help advance the research and development of robotics for all environments. Science Robotics will provide a much-needed central forum to share the latest technological discoveries and to discuss the feld s critical issues. Join in the excitement for the Fall 2016 debut!

7 LIFE SCIENCE TECHNOLOGIES NEW PRODUCTS Produced by the Science/AAAS Custom Publishing Office Scavenger Screening Kit The new Metal Scavenger Screening Kit contains a selection of Biotage industrial metal scavengers in an easy-to-use format, with detailed instructions that enable researchers to screen active pharmaceutical ingredient product mixtures and identify an optimum scavenger for their downstream metal-removal process. of ISOLUTE Si-TMT, ISOLUTE SCX-2, ISOLUTE Si-Trisamine, ISOLUTE Si-Thiol, and Biotage MP-TMT metal scavengers. Biotage metal scavengers are industry proven, supported by a comprehensive pliant manufacturing facility. Each scavenger is batch controlled and has served the chemical industries for many years. Biotage For info: Chiral Columns The 3-µm particle size is the latest addition - Lux polysaccharide columns are ideal for ultra-high-performance liquid chromatog- ing and analysis. Now with two sizesóthe new 3-µm and existing 5-µm particlesó method scalability from analytical work to able enantioselectivity and is a guaranteed alternative to other phases with the same chiral selector. The 3-µm particle media is available in analytical columns, while the 5-µm particle media is available in both analytical columns and Phenomenex-patented Axia preparative column hardware, both of which are stable in normal phase, reversed phase, polar organic, and SFC conditions. The Phenomenex Lux amylose and cellulose chiral column line of six chiral selectors com- stability up to 300 bar in a wide range of conditions. Phenomenex Sample Tracking Rack/Reader Designed to improve sample tracking and protection, a new barcoded latch rack and wireless barcode reader broad portfolio of automated and semiautomated laboratory instruments and related consumables for secure sample collection and storage. Barcoded tubes and racksówith both 2D and linear barcodesócan now be read with the VisionMate wireless reader. Unlike currently available wireless barcode readers, the unit is designed to on the benchtop and scan tubes or racks without holding it. For samples that should not be exposed to ambient conditions, the reader can easily be used as a handheld instrument, reading samples while they remain safely in storage. The VisionMate wireless reader can read tubes in a cold environment, capturing and sending data via Bluetooth to a paired computer. For info: for use in biotechnological applications, especially for membrane screening and small-volume process development. Sarto- 2 and a wide variety of self-contained unit eliminates the need for a compression holder and is available in membrane is a stable polymer suitable for - It is extremely hydrophilic, making it nonprotein-binding and virtually nonfouling, polyethersulfone membrane, which is well established in the biotechnological and pharmaceutical industries, is a stable temperature range. Sartorius Stedim Biotech One-Step Conjugation Kits New red, black, and blue 400-nm LATEX conjugation kits are one-step kits for the covalent conjugation of antibodies and proteins to specially treated latex beads. The new conjugation kits are easy to use antibodies, proteins, and peptides to latex beads, potentially simplifying and improving assay development while reducing development timelines. Additionally, the range of available colors enables multi- in assay design. The kits are suitable for development of diagnostics, in lateral compatible with human serum. Conjugation to latex particles using conventional methodology is complex, time consuming, and typically requires extensive optimization and relatively large quantities of antibodies, with aggregation often a major problem associated for passive conjugation techniques. Innova Biosciences Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier JUNE 2016 VOL 352 ISSUE 6293 sciencemag.org/custom-publishing SCIENCE

8 Don tmissthedebutof Science Immunology. Image: Eraxion / istockphoto NOW ACCEPTING PAPERS Science is expanding its reach into immunology now ofering the newest online-only, weekly journal in the Science family of publications. Science Immunology will provide original, peer-reviewed research articles that report critical advances in all areas of immunological research, including studies that provide insight into the human immune response in health and disease. Be a part of the Science Immunology debut issue publishing Summer 2016! Submit your manuscript today at ScienceImmunology.org.

9 CELL SIGNALING TECHNOLOGY Deciphering Cancer Antibodies to evaluate key signaling networks in growth and diferentiation. Download pathways at For Research Use Only. Not For Use In Diagnostic Procedures Cell Signaling Technology, Inc. Cell Signaling Technology and CST are trademarks of Cell Signaling Technology, Inc. 16PADDBIO0072ENG