GE Healthcare Life Sciences. Biacore systems. Confidence that comes with the right interactions

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1 GE Healthcare Life Sciences Biacore systems Confidence that comes with the right interactions

2 Confidence that comes with the right interactions Biacore systems from GE Healthcare Life Sciences Label-free analysis using Biacore systems provides comprehensive characterization of biomolecular interactions. The information-rich data enables deeper insights into the biological processes and molecular binding mechanisms crucial to your research. Equipped with the right information, you can make speedy, smart decisions with confidence. The wealth of information provided by Biacore systems binding kinetics, affinity, specificity, thermodynamics, and concentration measurement is invaluable across many applications such as unraveling molecular mechanisms, vaccine research, fragment screening, antibody characterization, the detection of early immune response, process development, and quality control. A full range of consumables along with our novel system solutions, designed specifically for GLP/GMP-regulated working processes, provide a secure foundation that supports your research and development. Processes are simplified, enabling faster and more accurate critical decision making. The value of more than 20-years experience, knowledge, expertise, and support from GE Healthcare gives you the confidence to meet the high standards of quality, performance, and compliance that your work demands. For more information about Biacore systems and applications visit

3 Label-free interaction analysis from research, through drug discovery and development to QC Biacore 4000 Throughput without compromise Biacore 4000 a powerful solution for large-scale, label-free molecular analysis, delivering high throughput without compromising on data quality. Screen and select fragments and lead compounds in drug discovery based on kinetics and affinity Select MAb and proteins early based on kinetic screening of supernatants and serum Define specificity through epitope mapping and inhibition studies Benefit from innovative software tools specifically designed for large-scale interaction analysis Biacore T200 When quality comes first Biacore X100 Successful assays from day one Biacore T200 a versatile system with exceptional sensitivity, that enables detailed interaction analysis with greater precision and confidence. Select and characterize drug targets, biotherapeutic candidates, and diagnostic markers based on kinetics Analyze interactions involving the smallest low molecular weight (LMW) compounds in drug discovery Detect and characterize low- and high affinity anti-drug antibodies (ADA) in immunogenicity studies Determine the active concentration in vaccine development Gain increased understanding of structure-function relationships Biacore X100 outstanding support from assay development to data interpretation enabling excellent interaction data. Characterize molecular mechanisms and interaction pathways based on kinetics and affinity Gain increased understanding of structure-function relationships Characterize potential therapeutic candidates based on kinetics Determine the active concentration without the need for standard curves Define potential drug targets and diagnostic markers Biacore 3000 Interaction analysis with SPR-MS interface Biacore 3000 dedicated to characterize and identify binding partners with wizard driven and automated recovery functions for mass spectrometry (MS). Recover and characterize interaction partners using MALDI-MS interface Elucidate disease mechanisms by characterizing native or recombinant protein interactions Define potential drug targets and diagnostic markers Biacore C Rapid and reliable protein quantitation Biacore C dedicated for rapid and reproducible concentration analysis in GxP environment, from preclinical development to quality control (QC). Determine the active concentration of MAbs, protein therapeutics, and vaccines Quantitate process-specific impurities during process development and manufacturing Monitor quality and stability in formulations development and protein manufacturing Perform biopharmaceutical release testing and monitor product comparability

4 Which system is right for you? Choosing the optimal system is not just a matter of comparing specifications. Biacore systems have been designed to suit the many different ways in which label-free interaction analysis contributes to research, drug discovery and development, manufacturing and QC. The table on the right can be used as a preliminary guide to choosing the right system. Your local representative will be happy to discuss your needs in more detail. Application/performance Biacore 4000 Throughput without compromise Applications Kinetics/Affinity characterization Kinetics/Affinity screening Single cycle kinetics LMW interaction analysis Fragment screening Epitope mapping Immunogenicity Concentration analysis Calibration-free concentration analysis Transition-state thermodynamics Sample recovery MS Performance Measuring spots 20 Unattended run capacity Throughput Automated data evaluation Sensitivity Kinetic range User guidance Analysis temperature 4 C to 40 C (in-line degasser) Cooled sample storage GxP Compliance support Yes Optimal Excellent Good Feature not included

5 Biacore T200 Biacore X100 Biacore 3000 Biacore C When quality comes first Successful assays from day one Interaction analysis with SPR-MS interface Rapid and reliable protein quantitation Included in Plus Package Yes Yes Included in Plus Package Included in Plus Package C to 45 C (in-line degasser) 25 C Plus Package (including in-line degasser and opportunity to run analysis at 4 C to 40 C) 4 C to 40 C 25 C GxP package GxP package Yes

6 Share our depth of knowledge Biacore systems are derived from a multitude of patented research developments and innovative solutions; they are precision instruments that combine optical pathways, microfluidics, robotics, pneumatics, electronics, consumables, and data management. Our GE Healthcare service engineers and application specialists are trained to maintain and support your Biacore system and analysis, so you can rely on your results and concentrate on your research. Preventive maintenance Preventive maintenance (PM) keeps your Biacore system operating in peak condition, ensures quality of your results, and extends the system lifetime. Service agreements Benefit from the full potential of our service organization through a Service agreement that best suits your needs: Confidence in your results through regular PM visits Predictable ownership costs rates are guaranteed for the duration of the contract Minimal disruption with priority response from our trained service engineers Validation support Validation and qualification services are available for our 21 CFR Part 11 compliant systems. These include necessary GxP documentation as well as GxP Services with IQ/OQ/IPQ performed on-site by qualified service engineers.

7 Training and application support System and application knowledge support you in generating high quality data that you can trust and to make research conclusion with confidence. A range of training tools are available to familiarize you with the use of Biacore systems. E-learning courses on our Web site provide learning opportunities on-demand System-specific, train-yourself tools Classroom training to facilitate one-on-one support from our experienced lecturers In addition our experienced application specialists offer customized application support and on-site training. These application specialists answer your specific questions concerning assay set up and development but also for data interpretation to get the most out of your protein interaction analysis. You will also find analysis support tools and technical tips on the Web site with a section for download of the latest software, handbooks, and other product-specific materials. For more information and downloads visit

8 GE Healthcare Life Sciences For local office contact information, visit GE Healthcare Bio-Sciences AB Björkgatan Uppsala Sweden imagination at work GE, imagination at work, and GE monogram are trademarks of General Electric Company. Biacore is a trademark of GE Healthcare companies General Electric Company All rights reserved. First published Oct All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare which supplies them. A copy of these terms and conditions is available on request. Contact your local GE Healthcare representative for the most current information. GE Healthcare UK Limited Amersham Place Little Chalfont Buckinghamshire, HP7 9NA UK GE Healthcare Europe, GmbH Munzinger Strasse 5 D Freiburg Germany GE Healthcare Bio-Sciences Corp. 800 Centennial Avenue, P.O. Box 1327 Piscataway, NJ USA GE Healthcare Japan Corporation Sanken Bldg., , Hyakunincho Shinjuku-ku, Tokyo Japan AA 10/2011