AOAC Metals Subgroup. Co-chairs: Cory Murphy Canadian Food Inspection Agency Jenny Nelson Agilent Technologies Ltd.

Transcription

1 AOAC Metals Subgroup Co-chairs: Cory Murphy Canadian Food Inspection Agency Jenny Nelson Agilent Technologies Ltd.

2 Metals SubGroup Co-Chairs Cory Murphy Canadian Food Inspection Agency Jenny Nelson Agilent Technologies 2

3 AGENDA AOAC Metals Subgroup Tuesday, Sept 20, 2016, pm Welcome/Introductions AOAC SPSFAM activities Heavy Metals ERP Arsenic Speciation ERP Metals & Metals Speciation Activities Around the Globe European Union Canada USA NanoDefine Update Other Method needs for community? Other activities of interest? 3

4 The AOAC process how do methods get approved? Stakeholder panels are created comprising of scientists from academia, government, and private industry Stakeholder Panel on Strategic Food Analytical Methods (SPSFAM) Voting members of the panel vote on method needs Working group created SMPR created Call for methods from AOAC Methods should meet SMPR and should have completed a single lab validation Expert Review Panel (chosen by OMB) is created Review submitted methods and compare to SMPR Vote on whether method is rejected, moved to first action status, or needs revision Reproducibility data to demonstrate method performance Final action status 4

5 SPSFAM Update Heavy Metals in Foods ERP 5

6 6

7 SPSFAM Update Heavy Metals in Foods ERP Reproducibility data will be required by AOAC to move method to final action The ERP decided to determine if there was interest in a multi-lab study using the method Several labs interested Rick Reba (Nestle) is the Study Director Materials to be sourced soon 7

8 SPSFAM Update Speciated Arsenic in Food ERP 8

9 SPSFAM Update Speciated Arsenic in Food ERP Call for methods ended Dec. 31st, methods submitted The ERP met March 14 th, 2016 at the AOAC midyear meeting to review the submitted methods 1 method moved to first action status (fruit juice) 2 other methods were sent back to authors and asked them address some actions and then resubmit the methods for evaluation as first action status (beverages and rice) Unsure when ERP will re-convene 9

10 10

11 Metals/Speciated Metals Activities Around the Globe European Union Barbro Kollander, National Food Agency, Sweden Canada Canadian Food Inspection Agency, Canada USA Bill Mindak, US Food and Drug Administration 11

12 CFIA Dartmouth Lab Chemistry specialization has led to national centers of expertise for all chemistry laboratories Dartmouth is the national center of expertise for: Veterinary drug residues in fish Toxic elements in food/fish Shellfish Toxins 12

13 CFIA Toxic Elements Testing Program Dartmouth Lab Maple and other tree syrup/products (Pb) Raw milk (metals) Fish and Shellfish (metals and mercury) Honey (metals) Fresh Fruit and Veggies (metals) Nuts and seeds (metals) Wine at retail (speciated arsenic) Frozen and processed fish (methyl Hg) Spices (metals) 13

14 CFIA Toxic Elements Testing Program Private Laboratories Cheese (metals) Eggs (metals) Meat and poultry (metals) Processed fruits and veggies (metals) Grain based products (metals) Frozen ready-to-eat meals (metals) 14

15 Toxic Elements Unit Research Themes Speciation Methods Various food matrices Arsenic Mercury Antimony Analysis by LC-ICP-MS Efficiency gains for total metals analysis Expand the scope of existing total metals ICP-MS method to include Hg and validate using the AOAC food triangle 15

16 Toxic Elements Unit Future Research Effect of organic amendments on the uptake of heavy metals in food Develop additional speciation techniques for elements of concern in target foods Inorganic Nanoparticles Food Application Silver (antibacterial properties) Titanium dioxide (white pigment in candies/gum) New testing platforms Single Particle ICP-MS Field Flow Fractionation QqQ ICP-MS 16

17 FDA News Release FDA proposes limit for inorganic arsenic in infant rice cereal Agency releases new data and scientific assessment on arsenic in rice, provides advice for pregnant women and infants 17

18 NanoDefine Update Katrin Löschner -DTU DTU knows of several national research projects regarding nanoparticles in food in Europe (e.g. Belgium, Netherlands, Germany, Austria, Denmark). DTU Food are currently focusing on developing methods for analysis of nanoparticles in food in the context of a larger project funded by the Danish Veterinary and Food Administration focusing on DEVELOPMENT OF METHODOLOGY FOR CHEMICAL SCREENING AND ANALYSES IN FOOD SURVEILLANCE. 18

19 NanoDefine Update Katrin Löschner -DTU The objective is to develop a procedure to determine the types and content of different size fractions of particles in food and develop a strategy to estimate particle exposure. DTU considers nanoparticles of several sources: fraction of food additives, natural source, intentionally added but not declared, environmental contamination, migration from food contact materials. The main methods are single particle icpms, FFF-icp-ms and electron microscopy. 19

20 NanoDefine Update Katrin Löschner -DTU Many nanotechnology-based products are currently under research and development. They may enter the market in the near future. Mandatory labelling for nanomaterials (in the ingredient list) is already part of EU legislation on food and cosmetics. Control laboratories need to be prepared in order to assure that food and cosmetics are properly labelled and nanotechnology-based food additives, feed additives, novel foods, food supplements, food contact materials not introduced without pre-market approval. 20

21 NanoDefine Update Katrin Löschner -DTU FP7 EU project NanoDefine, the method development stage is a about to be finalized and the focus is on in-house validation / interlab studies. Single particle ICP-MS is among the selected methods. Within the project, DTU Food is developing a quantitative method for detection and characterization of aluminum oxide particles in toothpaste based on field flow fractionation (FFF) coupled to ICP-MS. An SOP is currently under development at DTU 21

22 Jens Sloth-DTU From trace element/speciation in food in the CEN system, the CEN method on inorganic arsenic in food by LC-ICPMS now has become an official European standard (EN16802:2016) and also the method on MeHg (by GC-ICPMS) has been issued (EN16801:2016). Both standards are from the CEN-food group (ias project was lead by DTU and the GC-ICPMS by NIFES in Norway). 22

23 Jens Sloth-DTU In the CEN-feed group, are 3 methods currently under development (for trace elements). 1. Iodine by ICPMS (lead by DTU) 2. Multielement method (lead by German lab) 3. Inorganic arsenic by LC-ICPMS (lead by DTU) For 1 and 2 the collaborative trials have been conducted (and technically approved) and for 3 the collaborative trial is planned for

24 Other Business Method Needs? Other items of interest for members? Webinars? Survey? 24

25 25