MARINE BIOTECHNOLOGY IN SCHLESWIG-HOLSTEIN

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1 MARINE BIOTECHNOLOGY IN SCHLESWIG-HOLSTEIN Dr. Marina Gebert

2 Marine Biotechnology Workflow (Source: European Science Foundation) (Aqua-) Marine Biotechnology is part of global biotechnology and its specificity lies in the uniqueness of marine living resources and their derived products and services through the use of a set of tools ranging from biodiversity assessment to systems biology, from cultures to engineering.

3 Marine Biotechnology research priorities Target research area Examples Food: Development of food products and ingredients of marine origin (algae, invertebrates, fish) with optimal nutritional properties for human health Energy: Development and demonstration of viable renewable energy products and processes, notably through the use of marine algae Health: Development of novel drugs, treatments and health and personal care products Industrial Products and Processes: Development of marine-derived molecules exploitable by industry including enzymes, biopolymers and biomaterials Environment: Development of biotechnological approaches, mechanisms and applications to address key environmental issues dietary supplements; functional food selective breeding of aquaculture species sustainable production of feed zero-waste recirculation systems microalgae resources for biofuel production improve the photosynthetic efficiency enhance lipid productivity improve harvest, separation, purification processes Finding novel bioactives improve technical aspects overcome the supply problem anti cancer, biofilm inhibitors, antibiotics develop enabling technologies for high throughput enzyme screening marine biopolymers as novel competitive commercial products in food, cosmetics and health Develop automated high-resolution biosensing technologies Antifouling strategies restauration of (marine) ecosystems biosensors for routine analysis Adapted from: European Science Foundation, Position Paper 15, Marine Biotechnology: A New Vision and Strategy for Europe

4 Masterplan Marine Biotechnology Schleswig-Holstein Marine Biotechnology uses benefits from produces develops products for is applied in Marine bioresources Technologies/ methods Raw materials/ intermediate products Product areas (examples) Application areas Macro-organisms: Plants Animals Microorganisms: bacteria Genetics / genomics Biochemistry / proteomics Cell biology techniques Metabolomics Cultivation methods Systems biology Ecological methods Proteins: Collagen Carbohydrates: Lipids: Agar Omega-3 fatty acids Secondary metabolites: Polyketides Pharmaceuticals Feed Dietary supplements Antifouling Cosmetics Chemicals Industrial biotechnology Biofuels Health Aquaculture Food Cosmetics Industry Energy Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

5 Marine Biotechnology R&D in Schleswig-Holstein Source: Masterplan Marine Biotechnologie Schleswig-Holstein

6 Marine Biotechnology companies in Schleswig-Holstein Source: Masterplan Marine Biotechnologie Schleswig-Holstein

7 Examples of policy guidelines and initiatives on national and international level Policy guidelines Initiatives European level An Integrated Maritime Policy for the European Union -The Blue Book Blue growth strategy National level High-tech strategy 2020 for Germany National research strategy bio economy 2030 National masterplan of maritime technologies Programs Horizon 2020 Diverse federal programs, e.g. KMUinnovativ, Basic technologies for the next generation of biotechnological processes Projects and initiatives Micro B3 SUBMARINER Susfood ANIHWA INTERREG Baltic Blue Growth JPI Oceans, Marine KIC, EuroMarine, Marine Fungi, Networks, associations ERA-Net MB ERASysBio ERA-NanoSci ERA-Net Bioenergy ETPs (European technology platforms) Food security through aquaculture in Malawi Origin and function of metaorganisms Sun protection from macroalgae Offshore cultivation of microalgae Bundesverband Aquakultur e.v. Kieler Algenstammtisch Kompetenznetzwerk Aquakultur Maritimes Cluster Norddeutschland Nordverbund Marine Biotechnologie Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

8 Companies involved in national or international funding programs (n=17) No Yes Yes, european Yes, european and german Source: Masterplan Marine Biotechnologie Schleswig-Holstein

9 Main challenges for MB companies during cooperation with scientific institutions Lacking financial means Slow structures at cooperation partners Uncertain legal structures (IPR, liability) Missing interest of cooperation partner Commercial risk is too high Spatial distance Communication during project Finding cooperation partners and making contact Decreasing interest of partner during cooperation Want of confidence to cooperation partner Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

10 Main challenges for MB R&D Institutes during cooperation with companies Economic potential unclear Communication and making contacts is too difficult Differing interests Difficulties accessing information Uncertain legal structures (IPR, liability) Spatial distance Lacking financial means Decreasing interest of partner during cooperation Missing interest of cooperation partner Competitive situation Incapable of action Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

11 Financing volume Contract Research The Fraunhofer-Gesellschaft at a Glance The Fraunhofer-Gesellschaft undertakes applied research of direct utility to private and public enterprise and of wide benefit to society. Nearly 24,000 staff 2 billion 1.7 billion Major infrastructure capital expenditure and defense research Almost 30% is contributed by the German federal and Länder Governments. 66 institutes and research units 2014 More than 70% is derived from contracts with industry and from publicly financed research projects.

12 The Fraunhofer-Gesellschaft in Germany Itzehoe Lübeck Rostock Bremerhaven Oldenburg Bremen Hannover Potsdam Berlin Teltow Braunschweig Magdeburg Cottbus Oberhausen Paderborn Halle Dortmund Schkopau Leipzig Duisburg Kassel Schmallenberg Dresden St. Augustin Erfurt Jena Aachen Freiberg Euskirchen Gießen Chemnitz Wachtberg Ilmenau Fraunhofer Institution for Marine Biotechnology and Cell Technology (EMB) Darmstadt Würzburg Bayreuth Erlangen Bronnbach St. Ingbert Kaiserslautern Fürth Nürnberg Saarbrücken Karlsruhe Pfinztal Ettlingen Stuttgart Straubing Freising Freiburg Augsburg Garching München Oberpfaffenhofen Kandern Prien Efringen- Holzkirchen Kirchen

13 Working group Aquatic cell technology and Aquaculture Cell Technologies Cell culture of aquatic organisms In-vitro manipulation Cryopreservation Cellular test systems Technical Center for Applied Food Research TFAL Food and feed from aquatic resources Food-Prototypes Dietary supplements Land-based integrated multitrophic aquaculture Integrated cultivation of plants/ algae and animals in marine aquaculture systems controlled environment saving water broader product range Breeding of novel aquaculture candidates Implementation of omnivor species Reduction of fish meal and oil

14 Koi-Herpes-Virus- Diagnostics and containment of CyHV-3 in carp aquaculture Our expertise in fish cell culure development allows us to develop novel cell lines (from skin, gill, brain, head kidney, ) that can produce high amounts of virus particles Viruses are used as source material for the development of vaccines Quelle: Control, 4 d Control, 6 d Control, 8 d Virus I, 4 d Virus II, 6 d Virus II, 8 d

15 Tecnical Center for Applied Food Research TFAL Utilization of marine ressources (from aquaculture facilities and wild catches) for: Development of novel food prototypes from marine ressources Development and analyses of dietary supplements for human and animal nutrition Development of innovative processing technologies Example: Lemonade made with macroalgae (kiwi/quince flavour)

16 Facilities at the Fraunhofer EMB - One-of-a-kind, completely flexibe aquaculture facilities, containing the biggest landbased marine IMTA in Germany - 90 m³ outdoor pond for the cultivation of macroalgae - 6 m³ ponds for mussels - 3 circular ponds for fish rearing, 3,5 m³ each - Classical recirculating aquaculture system with modern biofilters as reference cycle (3 x 3,5 m³)

17 Aquaculture in Malawi: Joint project of EMB, GMA and University of Malawi Aquaponics for improving food security and sources of income for native people Improving reproduction of native fish species (Oreochromis karongae) through breeding and optimal larval rearing Low Tech solutions for larval rearing using solar power for regions with insecure energy supply

18 Marine Bioeconomy in Schleswig-Holstein Activities of EMB Industry, households Agrosystems Cellular and molecular biology technologies for aquaculture Biorefinery Aquaculture Production, processing, extraction of marine raw materials Mariculture Marine resources Development of novel food and feed prototypes and ingredients from marine resources Land Multitrophic aquaculture and novel aquaculture candidates Sea Coast

19 THANK YOU Fraunhofer Institution for Marine Biotechnology (EMB) Dr. Marina Gebert Moenkhofer Weg 239 a D Luebeck Tel.: +49 (0) 451/ Fax: +49 (0) 451/ Marina.gebert@emb.fraunhofer.de Internet: Sponsored by the European Union, European Fond for regional development (EFRE)

20 Links: EU: National: S-H: Associations: Submariner ( ERA-Net Marine Biotechnology ( Nationaler Masterplan Maritime Technologien ( Nationaler Strategieplan Aquakultur ( Masterplan Marine Biotechnologie (bei: DAFA ( KNAQ ( Bundesverband Aquakultur (