BioMed Central Media Kit. The Open Access Publisher SPRINGER NATURE...2 OUR SOLUTIONS...3 JOURNALS & DISCIPLINES...5

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1 The Open Access Publisher 2017 Media Kit BioMed Central Open-access research that covers a broad range of disciplines, and reaches influencers and decision makers. CHEMISTRY - BIOCHEMISTRY - GENERAL CHEMISTRY HEALTH - HEALTH SERVICES RESEARCH - PUBLIC HEALTH SPRINGER NATURE...2 OUR SOLUTIONS...3 JOURNALS & DISCIPLINES...5 BIOLOGY - BIOINFORMATICS - CELL & MOLECULAR BIOLOGY - GENERICS AND GENOMICS - NEUROSCIENCE MEDICINE - CANCER - CARDIOVASCULAR DISORDERS - CRITICAL, INTENSIVE CARE AND EMERGENCY MEDICINE - IMMUNOLOGY - INFECTIOUS DISEASES

2 SPRINGER NATURE SPRINGER NATURE QUALITY CONTENT Springer Nature is a leading publisher of scientific, scholarly, professional and educational content. For over a century, our brands have been setting the scientific agenda. We ve published ground-breaking work on many fundamental achievements, including the splitting of the atom, the structure of DNA, and the discovery of the hole in the ozone layer, as well as the latest advances in stemcell research and the results of the ENCODE project. Our dominance in the scientific publishing market comes from a companywide philosophy to uphold the highest level of quality for our readers, authors and commercial partners. EARLY-CAREER SCIENTISTS, STUDENTS BOARD-LEVEL SENIOR MANAGERS RESEARCHERS, CLINICIANS, DOCTORS 20 JOURNALS RANK #1 IN 1 OR MORE SUBJECT 9 OF THE TOP 20 SCIENCE JOURNALS BY MORE NOBEL LAUREATES PUBLISHED WITH US THAN ANY OTHER SCIENTIFIC PUBLISHER VENTURE- CAPITALISTS, INVESTORS PROFESSORS, LIBRARIANS, EDUCATORS POLICY-MAKERS, OPINION LEADERS WORLD-RENOWNED EDITORIAL CONTENT Most highly-cited journals Broad range of disciplines covered Editors are among the foremost minds in science BEST-IN-CLASS COMMERCIAL SERVICES Diverse and impactful advertising solutions Highly-trained and experienced teams focused on your success Unrivaled targeted access to readers across our global network Springer Nature is proud to offer a wide range of Open Access, peer-reviewed research titles across our various portfolios. These portfolios include BioMed Central, Nature Research and SpringerOpen. By combining editorial excellence and technological innovation, our Open Access journals make the highest-quality research more visible and shareable for any audience. Since Open Access titles publish content that scientists reference regularly in order to stay up-to-date on incremental scientific research results coming out in their fields, these titles are visited by researchers of all experience levels who work around the world. Nature Research publishes a variety of research and reviews subscription journals, alongside leading Open Access journals, ranging from the multidisciplinary journals Nature Communications and Scientific Reports to the highly specialized titles in the Nature Partner Journals (npj) series. BioMed Central is notably the pioneering Open Access publisher, and our innovative spirit is what makes us one of the leading STM publishers. NATURE.COM/NCOMMS #3 IN MULTIDISCIPLINARY SCIENCES FACTOR: FACTOR: INDEX: SCORE: SCORE: 5.549W NATURE.COM/SREP #7 IN MULTIDISCIPLINARY SCIENCES FACTOR: FACTOR: INDEX: SCORE: SCORE: 5.549W NATURE COMMUNICATIONS IS FULLY OPEN ACCESS AND PUBLISHES HIGH-QUALITY RESEARCH IN ALL AREAS OF THE BIOLOGICAL, CHEMICAL, PHYSICAL AND EARTH SCIENCES. ITS S REPRESENT IMPORTANT ADVANCES OF SIGNIFICANCE TO SPECIALISTS WITHIN EACH OF THESE DISCIPLINES. SCIENTIFIC REPORTS IS HOME TO RAPIDLY PUBLISHED, HIGHLY VISIBLE, SCIENTIFICALLY VALID RESEARCH. MULTIDISCIPLINARY IN SCOPE, IT PUBLISHES SOUND ORIGINAL RESEARCH PAPERS ACROSS THE SCIENCES. 2 BioMed Central Media Kit 2017 *2015 Journal Citation Reports (Thomson Reuters, 2016)

3 ADVERTISING SOLUTIONS The Open Access Publisher BioMed Central is a rapidly growing STM (Science, Technology and Medicine) publisher within the Springer Nature family and the pioneer of open access publishing. We publish over 300 journals spanning all areas of biology, clinical medicine, health and applied sciences, chemistry and open science. Over 185 BioMed Central journals have Impact Factors, many of which are ranked at the top of their subject categories. By using its combined expertise, scale and the reach of our brands, BioMed Central continues to grow and innovate in order to better serve academic researchers, students, teachers, institutions, professionals and the wider public, by helping them discover more. BANNER ADVERTISING ADVANCED TARGETING LEAD GENERATION BRAND AWARENESS BRAND ASSOCIATION BioMed Central utilizes IAB standard banner sizes and positions as well as expandable and rich media banners. BioMed Central provides unparalleled dynamic contextual targeting, native advertising, and audience segmentation alongside peer-reviewed full-text articles across BioMed Central s network of journal websites. Dynamic contextual targets keywords, phrases or scientific concepts and combines them using Boolean logic to deliver your ads next to relevant publications only. TIME-BASED METRICS Exposure to banner ads produces more than a click. Springer Nature offers comprehensive performance reports that include time-based metrics: exposure time per visitor (seconds), total exposure time (hours), multi-view heat maps. The inclusion of time-based metrics on our performance reports provides a more holistic view of a banner s overall performance. Start seeing the whole picture and understand the full impact of your campaign! THIRD PARTY LEAD GENERATION IMMEDIATE ACCESS BRAND ASSOCIATION BRAND AWARENSSESS Directly target your audience by sending a bespoke to a focused segment. Full list of 64,000 recipients* WEBCAST SPONSORED CONTENT LEAD GENERATION DIRECT ACCESS BRAND AWARENESS CONTENT STEWARDSHIP BioMed Central s customizable webcast program offers an interactive forum to communicate your message directly to a live audience in your topic area of interest. BioMed Central sources thoughtleaders and moderators to deliver an educational webinar, and offers a platform to launch an impactful multichannel marketing campaign. LEAD GENERATION CONTENT STEWARDSHIP CONTENT ASSOCIATION BRAND AWARENESS Series: Special Issues and Thematic Series are regularly developed by BioMed Central s journals and feature high quality themed articles series by leading experts focusing on topics of current interest to the scientific community. Sponsorship includes banner advertising on the dedicated series page and alongside the series articles. Supplements: BioMed Central s journal supplements undergo full peer review to ensure that they meet our high editorial standards. A team of dedicated project managers provide support throughout the publication process, ensuring rapid publication following acceptance. Reprints: With over 280 scientific and medical journals to select from, BioMed Central s reprint service can supply articles that support a company s activities by providing materials that can be used as symposium handouts, when meeting specialists or exhibiting at conferences. Media Kit 2017 BioMed Central 3 *Publisher Data 2016

4 ADVERTISING SOLUTIONS BIOMEDCENTRAL.COM/ADVERTISERS VALUABLE RESOURCES Springer Nature has information portals dedicated to advertising solutions and topics accessible whenever you have a question or need inspiration. publish thought leadership pieces on our blog to keep you up-to-date and informed about the latest news and trends in marketing. To be one of the first to know about exclusive advertising offers from Springer Nature, visit nature.com/advertising and subscribe to our advertising alerts. All of our advertising products, information, specs, guidelines and audience breakdowns can be found there. We also biomedcentral.com/advertisers ACCESS OUR AUDIENCE OVER 3 MILLION REGISTERED USERS* BioMed Central has over 3 million registered users across over a broad range of scientific disciplines. Advertising across the BioMed Central network of websites provides a comprehensive and targeted reach into the life sciences and healthcare markets. OVER 3 MILLION REGISTERED USERS* 64,000 DIRECT ADDRESSES* OVER 12 MILLION AD IMPRESSIONS PER MONTH** 33% NORTH AMERICA 3% SOUTH AMERICA 28% EUROPE 4% AFRICA 27% ASIA 5% OCEANIA JOB TITLE ** Graduate Student Lecturer/Associate Professor Medical Profession/Physician/Clinician Postdoctoral Researcher Postdoctoral Fellow Professor/Instructor Staff Scientist Principal Investigator Undergraduate Student Technician/Research Assistant Consultant Department Head Lab Director/Chief Scientist Research Director/VP Research/CSO NEXT GENERATION Positioning your brand in-front of the decision makers of the future by reaching early-career scientists. TECHNOLOGIES USED** PCR/RT-PCR DNA Isolation & Purification Real-time/Quantitative PCR Bioinformatics Software Cell/Tissue Culture Antibody-Based Protein Detection (Western, ELISA) RNA Isolation & Purification Gene Expression Analysis/Epigenetics Animal Models Cloning PLACE OF WORK** Academic Hospital Government RS Researchers enjoy free unrestricted access to any articles at any time published in our journals. 2-D Gel Electrophoresis Next-Gen Sequencing Microscopy/Fluorescent Probes and Dyes Nucleic Acid Electrophoresis Immunoassays Nucleic Acid Sequence Analysis/DNA and RNA Sequencing Flow Cytometry/Single Cell Analysis Blood Analysis BioMarker Research/Analysis Chromatography Private Institution Commercial/Industrial DECISION MAKERS We reach senior scientists and authors at leading institutions and companies. 4 BioMed Central Media Kit 2017 *Publisher Data 2016, **Publisher Data 2015

5 JOURNALS CHEMISTRY JOURNALS Biochemistry Total Journals in Cluster: 16** Recipients: 9,641** BMC Biotechnology biomedcentral.com/bmcbiotechnol /161 Biotechnology & Applied Microbiology Cell Communication & Signaling biosignaling.com Cell Division celldiv.com Nutrition & Metabolism nutritionandmetabolism.com /187 Cell Biology /187 Cell Biology /78 Nutrition & Dietetics General Chemistry Total Journals in Cluster: 6** Recipients: 3,520** Chemistry Central Journal ccj.springeropen.com Geochemical Transactions geochemicaltransactions.com / /81 Chemistry, Multidisciplinary Geochemistry & Geophysics Heritage Science heritagesciencejournal.com n/a n/a n/a n/a n/a n/a n/a Journal of Cheminformatics jcheminf.com n/a n/a 5/143 Computer science, Information Systems HEALTH JOURNALS Health Services Research Total Journals in Cluster: 13** Recipients: 6,721** BMC Health Services Research biomedcentral.com/bmchealthservres /87 Health Care Sciences & Services Human Resources for Health human-resources-health.com /74 Health Policy & Services Implementation Science implementationscience.com /87 Health Care Sciences & Services BMC Family Practice biomedcentral.com/bmcfampract /20 Primary Health Care Public Health Total Journals in Cluster: 11** Recipients: 7,321** BMC Public Health biomedcentral.com/bmcpublichealth /172 Public, Environmental & Occupational Health Environmental Health ehjournal.net Orphanet Journal of Rare Diseases ojrd.com Particle and Fibre Toxicology particleandfibretoxicology.com /225 Environmental Sciences /165 Genetics & Heredity /89 Toxicology Media Kit 2017 BioMed Central 5 *2015 Journal Citation Reports (Thomson Reuters, 2016), **Publisher Data 2016

6 BIOLOGY JOURNALS Bioinformatics Total Journals in Cluster: 23** Recipients: 7,379** BMC Bioinformatics biomedcentral.com/bmcbioinformatics /77 Biochemical Research Methods BMC Biology biomedcentral.com/bmcbiol BMC Structural Biology biomedcentral.com/bmcstructbiol /86 Biology /72 Biophysics BMC Systems Biology biomedcentral.com/bmcsystbiol /56 Mathematical & Computational Biology Cell & Molecular Biology Total Journals in Cluster: 40** Recipients: 13,563** BMC Cell Biology biomedcentral.com/bmccellbiol /187 Cell Biology BMC Molecular Biology bmcmolbiol.biomedcentral.com Microbial Cell Factories microbialcellfactories.com / /161 Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Stem Cell Research & Therapy stemcellres.com /187 Cell Biology Genetics & Genomics Total Journals in Cluster: 56** Recipients: 11,442** BMC Genetics biomedcentral.com/bmcgenet /165 Genetics & Heredity BMC Genomics biomedcentral.com/bmcgenomics /161 Biotechnology & Applied Microbiology Epigenetics & Chromatin epigeneticsandchromatin.com /165 Genetics & Heredity Genome Biology genomebiology.com /161 Biotechnology & Applied Microbiology Genome Medicine genomemedicine.biomedcentral.com /165 Genetics & Heredity Neuroscience Total Journals in Cluster: 29** Recipients: 7,281** Alzheimer s Research & Therapy alzres.com BMC Neuroscience biomedcentral.com/bmcneurosci Journal of Neuroinflammation jneuroinflammation.com Molecular Brain molecularbrain.com /192 Clinical Neurology /256 Neurosciences /256 Neurosciences /256 Neurosciences 6 BioMed Central Media Kit 2017 *2015 Journal Citation Reports (Thomson Reuters, 2016), **Publisher Data 2016

7 MEDICINE JOURNALS Cancer Total Journals in Cluster: 22** Recipients: 9,315** Breast Cancer Research breast-cancer-research.com /213 Oncology Molecular Cancer molecular-cancer.com /289 Biochemistry & Molecular Biology Radiation Oncology ro-journal.com World Journal of Surgical Oncology wjso.com /213 Oncology /213 Oncology Cardiovascular Disorders Total Journals in Cluster: 6** Recipients: 7,855** BMC Cardiovascular Disorders bmccardiovascdisord.biomedcentral.com Cardiovascular Diabetology cardiab.com Cardiovascular Ultrasound cardiovascularultrasound.com Journal of Cardiovascular Magnetic Resonance jcmr-online.com / / / /124 Cardiac & Cardiovascular Systems Cardiac & Cardiovascular Systems Cardiac & Cardiovascular Systems Cardiac & Cardiovascular Systems Critical, Intensive Care and Emergency Medicine Total Journals in Cluster: 15** Recipients: 7,175** Critical Care ccforum.biomedcentral.com /33 Critical Care Medicine Immunology Total Journals in Cluster: 8** Recipients: 9,310** Arthritis Research & Therapy arthritis-research.com BMC Immunology biomedcentral.com/bmcimmunol /32 Rheumatology /150 Immunology BMC Medicine biomedcentral.com/bmcmed /151 Medicine, General & Internal Journal of Inflammation journal-inflammation.com /150 Immunology Infectious diseases Total Journals in Cluster: 4** Recipients: 8,528** Malaria Journal malariajournal.com Parasites & Vectors parasitesandvectors.com Retrovirology retrovirology.com Veterinary Research veterinaryresearch.org /83 Infectious Diseases /36 Parasitology /33 Virology /138 Veterinary Sciences Media Kit 2017 BioMed Central 7 *2015 Journal Citation Reports (Thomson Reuters, 2016), **Publisher Data 2016

8 Contact us biomedcentral.com/advertisers EUROPE Alex Palmer Head of Sales Sam Alagbe Account Executive USA Jeremy Rechtshaid Sales Manager Jack Laschever Director of Global Advertising & Sponsorship Gerard Preston Director, Global Integrated Advertising Mike Rossi Sales Director Arcadio Maldonado Account Executive Contact your Account Manager to receive our Life & Physical Sciences, Clinical Sciences and BioPharma Dealmakers media kits. The Open Access Publisher