Translational Medicine What, Why and How: An International Perspective

Transcription

1 Translational Medicine What, Why and How: An International Perspective

2 Translational Research in Biomedicine Vol. 3 Series Editor Samuel H.H. Chan Kaohsiung Associate Editor Julie Y.H. Chan Kaohsiung

3 Translational Medicine What, Why and How: An International Perspective Volume Editors Barbara Alving Bethesda, Md. Kerong Dai Shanghai Samuel H.H. Chan Kaohsiung 14 figures, 7 in color, and 14 tables, 2013 Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

4 Barbara Alving, MD Uniformed Services University of the Health Sciences 7118 Glenbrook Road Bethesda, MD (USA) Kerong Dai, MD Clinical Translational Center of Stem Cell and Regenerative Medicine Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai (China) Samuel H.H. Chan, PhD Center for Translational Research in Biomedical Sciences Kaohsiung Chang Gung Memorial Hospital 123, Taipei Road Kaohsiung 83801(Taiwan) The Chang Gung Medical Foundation is the patron of this book series. Library of Congress Cataloging-in-Publication Data Translational medicine : what, why, and how : an international perspective / volume editors, Barbara Alving, Kerong Dai, Samuel H.H. Chan. p. ; cm. -- (Translational research in biomedicine, ISSN X ; v. 3) Includes bibliographical references and indexes. ISBN (hard cover : alk. paper) -- ISBN (electronic version) I. Alving, Barbara M. II. Dai, Kerong. III. Chan, Samuel H. H. IV. Series: Translational research in biomedicine ; v X [DNLM: 1. Translational Medical Research. 2. Academic Medical Centers--trends. W T7] dc Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Copyright 2013 by S. Karger AG, P.O. Box, CH 4009 Basel (Switzerland) Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN X e-issn ISBN e-isbn

5 Section Title Contents VII Foreword Chan, S.H.H. (Kaohsiung) VIII Preface Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung) 1 The What and Why of Translational Medicine Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung) 6 Partnership Model for Academic Health Science Systems to Address the Continuum from Discovery to Care, at Scale Fish, D.; Chantler, C.; Kakkar, A.K.; Trembath, R.; Tooke, J. (London); on behalf of UCLPartners 18 The US Initiative: Clinical and Translational Science Awards The UC Davis Perspective Tarantal, A.F.; Rainwater, J.; Wun, T.; Berglund, L. (Sacramento, Calif.) 29 National Agenda and Strategies for the Development and Implementation of Translational Medicine Zhao, Y. (Beijing) 36 Developing a Translational Research Workforce in the USA Pearson, T.A. (Rochester, N.Y.); Kapoor, W.N. (Pittsburgh, Pa.); Holloway, R.G. (Rochester, N.Y.) 47 Training Translational Investigators in China Shi, T.Z. (Catonsville, Md.); Dai, K. (Shanghai) 56 Translational Medicine in Taiwan: The Role of Private Foundation Funding Chan, S.H.H. (Kaohsiung) 63 Utilizing Pilot Funding and Other Incentives to Stimulate Interdisciplinary Research Denne, S.C.; Sajdyk, T. (Indianapolis, Ind.); Sorkness, C.A.; Drezner, M.K. (Madison, Wisc.); Shekhar, A. (Indianapolis, Ind.) 74 Building Expertise in Translational Processes through Partnerships with Schools of Business Cheng, S.K.; Dilts, D.M. (Portland, Oreg.) 82 Creating Ethical, High-Value Industry-Academic Partnerships Steele, S. (Rochester, N.Y.); Holroyd, K.J. (Nashville, Tenn.); Fadem, T.J. (Philadelphia, Pa.) V Alving B, Dai K, Chan SHH (eds): Translational Medicine What, Why and How: An International Perspective. Transl Res Biomed. Basel, Karger, 2013, vol 3, pp I VI (DOI: / )

6 89 Increasing the Efficiency and Quality of Clinical Research with Innovative Services and Informatics Tools Disis, M.L.; Tarczy-Hornoch, P.; Ramsey, B.W. (Seattle, Wash.) 98 Engaging the Community in Research with the HealthStreet Model: National and International Perspectives Cottler, L.B.; Striley, C.W. (Gainesville, Fla.); O Leary, C.C. (St. Louis, Mo.); Ruktanonchai, C.W. (Gainesville, Fla.); Wilhelm, K.A. (Darlinghurst, New South Wales) 110 Evaluating Translational Research Kane, C. (Ithaca, N.Y.); Rubio, D. (Pittsburg, Pa.); Trochim, W. (Ithaca, N.Y.) 120 Envisioning the Future of Translational Medicine: A Snapshot of 2016 Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung) 123 Author Index 124 Subject Index VI Contents Alving B, Dai K, Chan SHH (eds): Translational Medicine What, Why and How: An International Perspective. Transl Res Biomed. Basel, Karger, 2013, vol 3, pp I VI (DOI: / )

7 Section Title Foreword Welcome to volume 3 of Translational Research in Biomedicine, a monograph series dedicated to the dissemination of seminal information in contemporary biomedicine with a translational orientation. This volume marks a new milestone of this series. Beginning with this volume, Translational Research in Biomedicine will be published under the generous patronage of Chang Gung Medical Foundation, Taiwan. This patronage will reduce substantially the increasing financial constraints on scientific publication, and allow us to concentrate on publishing timely and crucial themes in translational medicine. This volume is designed to be a key reference for translational medicine. During the last decade, translational medicine has become a household word in the arena of medical research and beyond. Closer scrutiny, however, has revealed that the term translational medicine has been interpreted and presented widely, ranging from pure rhetoric in political orations, golden geese to entrepreneurs or shareholders, to conscientious solutions to health issues. My personal view is that this multiplicity arises from the lack of a comprehensive overview on the what, why, and how aspects of translational medicine. This volume is designed to fill this void based on an international perspective. I wish to express my deepest appreciation to Drs. Barbara Alving and Kerong Dai, whose patience and sustaining efforts have made this timely volume, Translational Medicine What, Why and How: An International Perspective, a reality. Last but not least, the publication of Translational Research in Biomedicine would not have been possible without the foresight, enthusiasm, and whole- hearted support of my dear friend, Dr. Thomas Karger. Samuel H.H. Chan, Kaohsiung Series Editor VII Alving B, Dai K, Chan SHH (eds): Translational Medicine What, Why and How: An International Perspective. Transl Res Biomed. Basel, Karger, 2013, vol 3, pp VII (DOI: / )

8 Preface Although translational medicine is now a common term throughout the scientific world, a comprehensive monograph that addresses the what, why, and how aspects of translational medicine, particularly from an international perspective, has not been forthcoming. This volume will fill this void. Fourteen chapters written by eminent experts with diversified experience will address three general themes: What is translational medicine?, Why do governments, research institutions, and other organizations invest in translational medicine?, and How is translational medicine carried out internationally?. In so doing, it is our intention to make this volume a key reference of translational medicine. Our sincere thanks go to the authors who have kindly consented to contribute their expert opinion to this volume and to Chang Gung Medical Foundation in Taiwan for sponsoring the Translational Research in Biomedicine series. Barbara Alving, Bethesda, Md. Kerong Dai, Shanghai Samuel H.H. Chan, Kaohsiung Volume Editors VIII Alving B, Dai K, Chan SHH (eds): Translational Medicine What, Why and How: An International Perspective. Transl Res Biomed. Basel, Karger, 2013, vol 3, pp VIII (DOI: / )