Curriculum Vitae PERSONAL DETAILS

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1 Curriculum Vitae PERSONAL DETAILS Name: Sabine Kling Date of birth: August 25, 1986 Work address: Center for Applied Biotechnology and Molecular Medicine Room Y13-L-86, University of Zurich Winterthurerstrasse 190, 8057 Zurich, Switzerland Mobile phone: +41(0) RESEARCH Postdoctoral Fellow: 01/2016-present University of Zurich, Zurich (Switzerland) Project 1: Molecular mechanisms related to biomechanical properties. Project 2: Numerical simulation of refractive laser ablation in specific patients with highly irregular corneas. Supervisor: Prof. Farhad Hafezi Postdoctoral Fellow: 10/ /2015 University of Geneva, Geneva (Switzerland) Project 1: Establishing Corneal Cross-linking (CXL) in a mouse model: biomechanical and morphological analysis. Project 2: Theoretical model of CXL efficacy. Project 3: CXL in thin corneas and the effect of oxygen availability. Supervisor: Prof. Farhad Hafezi EDUCATION Ph.D in Vision Sciences: 10/2009-9/2013 Optics Institute Daza de Valdés, CSIC, Madrid (Spain) Doctoral thesis: Corneal Biomechanics: Measurement, Modification and Simulation, Supervisor: Prof. Susana Marcos Viva voce: January 30th, 2014, Obtained qualification: sobresaliente cum laude [where cum laude is the highest qualification requiring unanimity of the five tribunal members] MSc. in Investigation in Vision Sciences: 09/ /2011 University of Valladolid, Valladolid (Spain) Master thesis: Alterations of Corneal Biomechanical Properties due to Hydration, Storage Media and UV Collagen Cross-linking: in Vitro Experiments as Input for Finite Element Modeling, Supervisor: Prof. Susana Marcos Average qualification: 9.59, Master thesis: 10 (with honors) Dipl.Ing.(FH) in Physical Engineering: 09/ /2009 University of Applied Sciences of Isny, Isny (Germany) Diploma thesis: Biomechanical Response of Normal and Cross-linked Corneas, Supervisor: Prof. Michael Mrochen Average qualification: 1.08, Diploma thesis: 1.0 (with honors)

2 GRANTS Predoctoral fellowship: 10/ /2013 Ministerio de Economía y Competitividad (Spain) Travel grant: 09/ /2011 University of Valladolid (Spain) ERASMUS: 09/ /2009 European Union student exchange program Scholarship of the NTA: 2 semester University of Isny (Germany) HONORS / AWARDS Extraordinary Award: 03/2015 Sponsor: University of Valladolid (Spain) Theo Seiler Young Researcher Award: 12/2013 Sponsor: Theo Seiler (Switzerland) Student International: 10/2009 Sponsor: IHK Bodensee-Oberschwaben (Germany) Extraordinary Award: 10/2009 Sponsor: University of Isny (Germany) RESEARCH STAYS Wellman Center for Photorefractive Medicine: May/2012-Aug/2012 and Jul/2013-Aug/2013 Massachusetts General Hospital, University of Harvard (MA, USA), Projects: (i) Brillouin microscopy in ex vivo corneas after CXL, with and without epithelium. (ii) Measurement of acoustic resonance frequencies in bovine eyes. Institute of Vision: 18/Jul/ /Oct/2011 University of Crete (Greece) Project: Corneal rigidity of thin corneal flaps, before and after CXL. Department of Construction Engineering: 04/Nov/ /Nov/2010 and 13/Jul/ /Jul/2011 University of Oviedo (Spain) Project: Finite element modeling of the cornea in ANSYS software. Optics Institute Daza de Valdés : 01/Sep/ /Feb/2009 Consejo Superior de Investigaciones Científicas (CSIC), Madrid (Spain) Project: Geometrical expansion behavior and biomechanical stiffness following CXL in ex vivo corneal tissue. Institute for Refractive and Ophthalmic Surgery: 01/Feb/ /Jul/2009 Zurich (Switzerland) Project: Strip extensiometry measurements to analyze corneal stiffening after CXL; the effect of different riboflavin concentration and UV fluence.

3 SUPERVISION Co-director MD-PhD thesis: Arthur Hammer Corneal cross-linking: Molecules implicated and impact on corneal edema, OTHER QUALIFICATIONS Languages German (native proficiency) English (full professional proficiency) Spanish (full professional proficiency) French (limited working proficiency) Programming Languages Matlab (advanced) ANSYS (advanced) HTML (intermediate) LaTeX (intermediate) C++ (basics) LabView (basics) Further FELASA Category B course 038/12: Introductory Course in Laboratory Animal Science FELASA Category C course: Training for Persons Responsible for Directing Animal Experiments Training as a LASER Safety Officer Course about Programmable Logic Controllers (PLC): 70 hours Course about welding: 30 hours Course about Neural Networks for Machine Learning: 64 hours

4 Publication List PEER-REVIEWED ARTICLES (ORIGINAL WORK) As a Postdoc: Hammer, A., Rudaz, S., Guinchard, S., Kling, S., Tabibian, D., Richoz, O., Hafezi, F. (2016) Analysis of stromal riboflavin compounds in the rabbit cornea in vivo, Experimental Eye Research, in press Kling, S., Richoz, O., Hammer, A., Tabibian, D., Jacob, S., Agarwal, A., & Hafezi, F. (2015). Increased biomechanical efficacy of corneal cross-linking in thin corneas due to higher oxygen availability. Journal of Refractive Surgery, 31(12), [IF 3.468] Hammer, A.*, Kling, S.*, Boldi, M. O., Richoz, O., Tabibian, D., Randleman, J. B., & Hafezi, F. (2015). Establishing Corneal Cross-Linking With Riboflavin and UV-A in the Mouse Cornea In Vivo: Biomechanical Analysis. Investigative ophthalmology & visual science, 56(11), [IF 3.404] Richoz, O., Kling, S., Hoogewoud, F., Hammer, A., Tabibian, D., Francois, P.,... & Hafezi, F. (2014). Antibacterial efficacy of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL). J Refract Surg, 30(12), [IF 3.468] Richoz, O., Kling, S., Zandi, S., Hammer, A., Spoerl, E., & Hafezi, F. (2014). A constant-force technique to measure corneal biomechanical changes after collagen cross-linking. PloS one, 9(8), e [IF 3.534] Richoz, O., Mosquera, S. A., Kling, S., Hammer, A., Magnago, T., Bosch, M. M., & Hafezi, F. (2014). Determination of the excimer laser ablation rate in previously cross-linked corneas. J Refract Surg, 30(9), [IF 3.468] Submitted / in preparation: Kling, S.*, Hammer, A.*, Conti, A., Hafezi, F. Establishing Corneal Cross-Linking with Riboflavin and UV-A in the Mouse Cornea in Vivo: Morphological, Biochemical, and Physiological Analysis Tabibian, D.*, Kling, S.*, PhD 1,*, Hafezi, F. No additional effect of UV corneal collagen cross-linking after repeated in vivo treatment in mice Kling, S., Hafezi, F. UV Irradiation parameters and Corneal Cross-linking Efficacy: Experimental and Theoretical Analysis * shared first authorship As a PhD student: Akca, B. I., Chang, E. W., Kling, S., Ramier, A., Scarcelli, G., Marcos, S., & Yun, S. H. (2015). Observation of soundinduced corneal vibrational modes by optical coherence tomography. Biomedical optics express, 6(9), [IF 3.648] Kling, S., Akca, I. B., Chang, E. W., Scarcelli, G., Bekesi, N., Yun, S. H., & Marcos, S. (2014). Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties. Journal of The Royal Society Interface, 11(101), [IF 3.856] Kling, S., Bekesi, N., Dorronsoro, C., Pascual, D., & Marcos, S. (2014). Corneal viscoelastic properties from finiteelement analysis of in vivo air-puff deformation. PloS one, 9(8), e [IF 3.534]

5 Kling, S., & Marcos, S. (2013). Contributing factors to corneal deformation in air puff measurements. Invest Ophthalmol Vis Sci, 54(7), [IF 3.404] Kling, S., & Marcos, S. (2013). Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests. J Refract Surg, 29(7), [IF 3.468] Scarcelli, G., Kling, S., Quijano, E., Pineda, R., Marcos, S., & Yun, S. H. (2013). Brillouin Microscopy of Collagen Crosslinking: Noncontact Depth-Dependent Analysis of Corneal Elastic Modulus. Investigative ophthalmology & visual science, 54(2), [IF 3.404] Kling, S., & Marcos, S. (2013). Finite-element modeling of intrastromal ring segment implantation into a hyperelastic cornea. Investigative Ophthalmology and Visual Science, 54, [IF 3.404] Kling, S., Ginis, H., & Marcos, S. (2012). Corneal biomechanical properties from two-dimensional corneal flap extensiometry: application to UV-riboflavin cross-linking. Investigative ophthalmology & visual science, 53, [IF 3.404] Dorronsoro, C., Pascual, D., Pérez-Merino, P., Kling, S., & Marcos, S. (2012). Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas. Biomedical optics express, 3(3), [IF 3.497] Kling, S., Remon, L., Pérez-Escudero, A., Merayo-Lloves, J., & Marcos, S. (2010). Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments. Investigative ophthalmology & visual science, 51(8), [IF 3.404] CONTRIBUTIONS TO BOOKS Kling, S., Hafezi, F. (in press). Pediatric Corneal Cross-linking. In J. Alió (Ed.), Keratoconus: Recent Advances in Diagnosis and Treatment. Springer. Hafezi, F., Kling, S. (in press). Controversies and Perspectives Protecting the Limbus during CX - Side: Against. In B. Randleman, F. Hafezi & S. Khandelwal (Eds.), Corneal Collagen Cross-linking 2 nd edition (chapter 39). Thorofare, New Jersey: Slack Inc. CONFERENCE PROCEEDINGS As a Postdoc: S. Kling, F. Hafezi, Untersuchung der molekularen Vorgänge in PACK-CXL im Bezug auf Hornhautinfektionen, Kongress der Deutschen Ophthalmologischen Gesellschaft, Berlin (Germany), 2015, Oral presentation S. Kling, A. Hammer, O. Richoz, F. Hafezi, The Effect of Pulsed Cross-linking on Corneal Biomechanics, XXXIII Congress of the ESCRS, Barcelona (Spain), 2015, Oral presentation S. Kling, A. Hammer, O. Richoz, F. Hafezi, Biomechanical Efficacy of UV Cross-Linking Protocols in Thin versus Thick Corneas, 6th EuCornea Congress, Barcelona (Spain), 2015, Oral presentation S. Kling, A. Hammer, O. Richoz, F. Hafezi, The Effect of pulsed UV Corneal Cross-linking (CXL) on Corneal Biomechanics, 108. Jahreskongress der Schweizerischen Ophthalmologischen Gesellschaft - SOG, Fribourg (Switzerland), 2015, Poster presentation

6 S. Kling, A. Hammer, D. Tabibian, O. Richoz, A. Agarwal, S. Jacob, F. Hafezi, Optimizing UV Cross-Linking Protocols for Thin Corneas, 108. Jahreskongress der Schweizerischen Ophthalmologischen Gesellschaft - SOG, Fribourg (Switzerland), 2015, Poster presentation S. Kling, D. Tabibian, O. Richoz, A. Hammer, A. Agarwal, S. Jacob, F. Hafezi, Biomechanical Efficacy of UV Cross- Linking Protocols in Thin versus Thick Corneas: The Effect of Oxygen, UV Absorption and Osmotic Pressure, ARVO Annual Meeting, Denver (CO, USA), 2015, Poster presentation S. Kling, A. Hammer, O. Richoz, F. Hafezi, Establishing UV Collagen Cross-Linking in a Mouse Model: Biomechanical and Morphological Evaluation, 10th International Congress of Corneal Crosslinking, Zurich (Switzerland), 2014, Oral presentation As a PhD student: S. Kling, S. Marcos, Corneal Biomechanics: Measurement, Modification, Simulation, 10th International Congress of Corneal Crosslinking, Zurich (Switzerland), 2014, Invited oral presentation S. Kling, N. Bekesi, C. Dorronsoro, S. Marcos, Finite element modeling for the dynamic biomechanical characterization of the in-vivo cornea, ARVO Annual Meeting, Orlando (FL, USA), 2014, Poster presentation S. Kling, S. Marcos, Corneal Biomechanics, 9th International Congress of Corneal Crosslinking, Dublin (Ireland), 2013, Oral presentation S. Kling, E.W. Chang, B.I. Akca, G. Scarcelli, S.H. Yun, S. Marcos, Novel Non-Contact Method to Assess Corneal Biomechanical Properties by OCT Vibrography, Illuminating the Body: New Frontiers in Medical Imaging Using Optical Coherence Tomography, Boston (MA, USA), 2013, Poster presentation S. Kling, E.W. Chang, G. Scarcelli, S. Marcos, S.H. Yun, OCT-Vibrography: A Novel Non-Contact Method to Estimate Corneal Biomechanical Properties, ARVO, Seattle (WA, USA), 2013, Poster presentation S. Kling, H. Ginis, D. Pascual, C. Dorronsoro, G. Scarcelli, E. Chang, S.H. Yun, S. Marcos, Spatially depth-resolved corneal elasticity: applications to cross-linking, 8th International Congress of Corneal Crosslinking, Geneva (Switzerland), 2012, Oral presentation S. Kling, H. Ginis, D. Pascual, C. Dorronsoro, G. Scarcelli, E. Chang, S.H. Yun, S. Marcos, Corneal biomechanics: Deformation imaging with Air-puff, 8th International Congress of Corneal Crosslinking, Geneva (Switzerland), 2012, Invited oral presentation S. Kling, J.J. del Coz Diaz, J.L. Suarez, S. Marcos, An orthotropic, viscoelastic model for the cornea and the effect of implanting an intra-stromal ring segment, 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS), Vienna (Austria), 2012, Oral presentation S. Kling, H. Ginis, S. Marcos, Propiedades biomecnicas de la cornea determinadas por extensiometra bidi- mensional a partir de trazado de rayos, X Reunión Nacional de la Óptica, Zaragoza (Spain), 2012, Oral presentation S. Kling, H. Ginis, S. Marcos, Corneal Biomechanical Properties and their Change with Corneal UV-Riboflavin Crosslinking from 2D Flap-Extensiometry, ARVO, Fort Lauderdale (FL, USA), 2012, Poster presentation S. Kling, P. Pérez-Merino, S. Ortiz, J.J. del Coz Diaz, S. Marcos, Corneal Biomechanical Characterization from In-Vitro Eye Inflation, Optical Coherence Tomography and Finite Element Modeling, EVER, Crete (Greece), 2011, Oral presentation

7 S. Kling, P. Pérez-Merino, S. Ortiz, D. Pascual, S. Marcos, Biomechanical Properties From Corneal Surface and Limbus Expansion upon Intraocular Pressure Variation from Optical Coherent Tomography and Fi- nite Element Modeling, Engineering the Eye III, Benasque (Spain), 2011, Poster presentation S. Kling, P. Pérez-Merino, S. Ortiz, D. Pascual, S. Marcos, Corneal Biomechanical Properties From An Inflation Porcine Eye Model In Treated And Virgin Eyes, Euromech 518 Workshop Biomechanics of the Eye, London (UK), 2010, Oral presentation S. Kling, P. Pérez-Merino, S. Ortiz, D. Pascual, S. Marcos, Corneal Biomechanical Response to Intraocular Pressure Changes From Scheimpflug and Anterior Segment OCT, ARVO, Fort Lauderdale (FL), 2010, Poster presentation S. Kling, L. Remón, A. Pérez-Escudero, J. Merayo-Lloves, S. Marcos, Biomechanical effects in cross-linking, Jornadas de Jóvenes Investigadores en Óptica Visual, Madrid (Spain), 2010, Oral presentation S. Kling, L. Remón, A. Pérez-Escudero, J. Merayo-Lloves, S. Marcos, Corneal biomechanical properties after crosslinking from quantitative imaging in an inflation porcine corneal model, ASETCIRC (Asociación Española de Tecnología y Cirugía de Implantes, Refractiva y Córnea), Madrid (Spain), 2010, Invited oral presentation S. Kling, L. Remón, A. Pérez-Escudero, J. Merayo-Lloves, S. Marcos, Biomechanical response of normal and crosslinked porcine corneas, ARVO, Fort Lauderdale (FL), 2009, Poster presentation PATENT Swiss Patent Application 00764/15 Filing date: 28/May/2015