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1 Introducing the most dynamic and comprehensive online software and turn-key program that allows you to Assess, Analyze and Design Support TM based upon a person s genetics, lab work and presenting symptoms.

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3 Welcome to the Future of Care As we enter the era of functional medicine, health care is entering a new paradigm one where practitioners are looking for underlying causes of illness rather than band-aiding and merely treating symptoms. This movement adds a person s unique genetics to lab findings and presenting symptoms. Quite simply, an individual s genes contain information on how to make enzymes, and those enzymes take substance A and make substance B to support functions inside the body. We all inherit genetic variants called SNPs, where some of these enzymatic functions may not be working at 100 percent. Now, with the power of genetic information, we can see where those SNPs are and when they may be expressing when compared to labs and symptoms and proactively give the body the nutrients it needs to achieve optimal health and wellness. Today, the general public has access to inexpensive genetic testing, such as through 23andMe, and more and more people are looking for practitioners who can help them make informed decisions based on their results. And in response, more and more practices in the medical community and complementary health world are shifting to learn about genetics and understand the best way to support their patients and clients. If you re interested in helping your patients or clients in a brand new way, the MethylGenetic Nutrition Analysis TM web-based software and this turn-key program may be the solution to finding answers about their health not available until now. *23andMe is the registered trademark of 23andMe, Inc. is not affilated with 23andMe. The statements made in this booklet have not been evaluated by the Food and Drug Administration. The information generated by the software program is for informational purposes only and is not intended to diagnose, cure, mitigate, treat or prevent any disease. 3

4 Introducing MethylGenetic Nutrition Analysis TM For the first time ever, practitioners now have access to web-based software that incorporates lab work, patient symptoms and concerns along with genetic information side-by-side in one program. The MethylGenetic Nutrition Analysis TM proprietary software enables you to Assess, Analyze and Design Support TM for each patient or client based on their unique genetics. ASSESS ANALYZE DESIGN SUPPORT Assessing a patient using MethylGenetic Nutrition Analysis TM integrates blood labs and lab history, a symptom survey and symptom history and their raw genetic data from a personal genome analysis kit. All these data forms can be entered or uploaded into the software. Once the raw genetic data has been uploaded, MethylGenetic Nutrition Analysis TM runs its complex sequence of mathematical algorithms and automatically generates detailed reports with dynamic information including: a gene analysis, enzyme analysis, patient SNP report, a practitioner SNP report, a supplement report, and a methylgenetic analysis report. Using both the practitioner and supplement report, you can choose from the suggested supplements to design a custom supportive nutritional protocol for your patient or client based on their unique genetic nutritional needs. This integrated process allows you to see how genetic variants/snps affect someone, if lab work is verifying the issue and if the patient is expressing any symptoms. 4

5 A Comprehensive Solution: Web-Based Software + a Turn-key Tool Box The MethylGenetic Nutrition Analysis TM software is just one part of a comprehensive turn-key program to help your practice efficiently and effectively integrate genetic testing and genetic-specific nutritional support into your practice. The other components of this program include: 1. Training classes, with online pre-class videos and post-class webinars that include case studies and ongoing updates ( 2. A webinar library at 3. Marketing materials for your practice to promote genetic testing 4. A consumer-based website ( to help drive new patients to your practice 5. The MethylGenetic TM line of supplements from Professional Health Products, specially designed for this program with more than 50 custom supplements to support expressed genetic variants and related issues (visit for more information) Now let s take a look at how MethylGenetic Nutrition Analysis TM enables you to Assess, Analyze and Design Support TM for each patient or client based on their unique genetics. 5

6 It s Beyond Just the SNP: the difference between having a SNP and the SNP expressing itself As cutting edge researchers and health care practitioners investigate how genetic information can be useful in supporting patients or clients nutritionally, the overriding question is if SNPs (single nucleotide polymorphism), as they are called, are actually being expressed. Just because someone has a SNP, it doesn t always mean it s causing an issue at the cellular level. Treating the SNPs only can easily backfire and have negative consequences. Up until now, it was challenging to determine what the right approach might be. Now, through technology, you can compare SNPs to your patient s/client s lab results (urine organic acids, blood methylation pathway, neurotransmitters, hormones, and coming soon blood tests) and the patient s/client s presenting symptoms or diagnosis to contrast and compare if the SNPs are being expressed. Basic Premise of MethylGenetic Nutrition Analysis TM MethylGenetic Nutrition Analysis TM follows the basic principles of traditional naturopathy, which is the environment or terrain of the body will determine how fast it will age, and its susceptibility to pathogens and disease processes. 6 Its major focus is to help you, as the practitioner, identify and bring balance to what we call the good guys and the bad guys. The goal is to have adequate amounts of the antioxidants needed to protect the body from inflammation, adequate agents that support detoxification and the nutrients needed to rebuild tissue, as well as to adequately control, reduce and detoxify from those molecules that cause damage to the body.

7 This is a current list of the good guys and the bad guys; we are certain this list will grow quickly over time as more research yields new issues on which to focus. Good Guys (Boost) Nutrient-filled food based nutrition Superoxide dismutase Catalase Glutathione SAMe NADH Nitric Oxide BH4 Folate B12 Choline Nrf2 Balanced neurotransmitters Balanced hormones The Bad Guys (Reduce) Excess glutamate Superoxide free radical High sulfites High sulfates NOS uncoupling Peroxynitrite Zonulin High histamine High ammonia Oxidized iron The MethylGenetic Nutrition Analysis TM web-based software can help you identify where SNPs may be contributing to these imbalances, and offer you effective ways to help bring homeostasis to the body. 7

8 Assess, Analyze and Design Support TM Enter Lab Data & Lab Data History Using the MethylGenetic Nutrition Analysis TM program is as easy as logging into the software and starting a new patient record through the software dashboard. Within a minute, you ll be ready to work on the patient assessment. One of the most unique aspects of MethylGenetic Nutrition Analysis TM is that it allows you to enter a patient s lab results under the Enter Lab Work tab. Currently, labs that can be captured include urine, blood, urine organic acids, urine neurotransmitters, and Doctor s Data Methylation Profile Plasma. This section will be expanded over time. All entered labs are stored in the Lab Data History section, and currently some of the labs are integrated into the final supplement report to optimize your decision-making power when designing a nutritional protocol for your client. This is the first time ever that you can take lab information, symptoms and genetics and compare them side-by-side. 8

9 Assess, Analyze and Design Support TM Enter Survey & Survey History Tracking symptoms is vital to all patient care. MethylGenetic Nutrition Analysis TM includes a comprehensive symptom survey that addresses questions related to: Adrenals/Glutamate Ammonia Anti-aging B-12 Blood sugar Cardiovascular Digestion Environmental Toxin Exposure Female & Male Hormones Heavy Metal Toxicity Histamine Inflammation/Oxidative Stress Liver Function Low Dopamine Mitochondrial Dysfunction Muscle Mass/Strength Neurotransmitters Over Methylation & Under Methylation Thyroid All completed symptom surveys are saved in the Survey History section for future reference, and like the lab tests are integrated into the supplement report to assist with the selection of a custom protocol for your client. For the patient symptom survey, a link is ed to the patient for them to click, answer the survey questions, and then it s automatically uploaded to their file. No staff time is needed to enter the data, and it s there for your viewing and analysis. 9

10 Assess, Analyze and Design Support TM Gene Analysis The gene analysis function of MethylGenetic Nutrition Analysis TM utilizes the uploaded genetic data from 23andMe. When first opened, this screen shows all the gene analysis in alphabetical order (the name of the gene, the position it s in, the genotype, the risk and the number of variants). However, a flexible sort function enables you to re-sort by any of the categories, such as showing all the homozygous variants first. Another useful function is the? icon next to the gene name. Clicking on this icon reveals a commentary bar that provides information about that gene as well as issues or symptoms that may be the result of a genetic variation. For those highly experienced, this may be all you need, and available at a price less than other online services. 10

11 Assess, Analyze and Design Support TM Enzyme Analysis Each of the genes tracked by the MethylGenetic Nutrition Analysis TM make an enzyme; many of them work together. The software program contains mathematical formulas that look at all the genes and the number of variants each gene has and calculates a production efficiency percentage and rating of needed support (ranging from 0% efficiency/10 support rating/red box meaning needing maximum support all the way down to 100%/0 support/green box meaning no support necessary). With this report, there is again the flexibility to re-sort the results by the enzyme, production efficiency and support rating. As well, by clicking on the? icon, you can open a commentary bar that provides details about the specific enzyme, its function and the issues that may arise if too much or too little of this enzyme is produced as a result of genetic variation. From this section, you can generate and print a report for your client to take home with them. 11

12 Assess, Analyze and Design Support TM Patient SNPs The Patient SNPs section of the MethylGenetic Nutrition Analysis TM program provides a Genetic Variant Nutritional Assessment report that gives a brief description to educate you on these genetic SNPs and where the person s body may be lacking in the production of antioxidants and nutrients. This report can be printed for your patient or client for them to take home with them (just a portion of the complete report is displayed on the right). As new findings are added to the MethylGenetic Nutrition Analysis TM software, all reporting and calculating functions are dynamic and you can refresh the patient s record when you open their file again for a follow-up visit. Coming soon, the patient report will summarize the labs, symptoms and SNPs so they can see at a glance if the SNPs are being expressed. Also coming soon, dietary suggestions based upon labs, SNPs and symptoms. 12

13 Assess, Analyze and Design Support TM Practitioner SNPs The Practitioner SNPs report includes more in-depth data including the name of the gene, the number of variants, and how genes are related to the enzyme, with a calculated percentage rating of how many genes do not have a variant. Clicking on the? icon shows the specifics of that gene s function. The commentary on the right side of the screen lists ideas about supplements that may be appropriate. While some of the report s information is static, other text is dynamic and changes based on the patient s unique genetic makeup. This provides you with powerful knowledge about the patient s underlying issues and suggestions for how to address and support them. This report can also be downloaded as a PDF for your electronic files. Coming soon, the practitioner report will combine SNPs, labs and symptoms to help the practitioner determine if the SNPs are being expressed. 13

14 Assess, Analyze and Design Support TM MGNA Report The MGNA report summarizes all the SNPs, labs and symptoms that are associated with nutrients, detox pathways or toxin build up. This report is a work in progress, with upgrades coming soon. 14

15 Assess, Analyze and Design Support TM Supplement Report This final tab holds the real power of the MethylGenetic Nutrition Analysis TM software. This report actually lists for you the supplements that may be appropriate for the patient to take based upon their SNPs, labs and symptom surveys. This functionality is unprecedented. The supplement report (shown on the top of this page) gives you step-by-step guidance, showing a multi-step process for starting a new protocol with your client. Based on the client s SNPs, a list of possible supplements are provided, along with what the supplement is, what it does, recommendations as to how many supplements to take and when, as well as whether this supplement would be a permanent, temporary or optional part of the protocol. The software also includes contraindication warnings to make sure certain steps are followed when issues might be caused by taking a certain supplement based on the individual s SNPs. And since you can view the total number of SNPs, lab results and symptoms results side-by-side, you have the power to make informed decisions about their unique nutritional protocol. The functionality allows for sorting by the SNP total, lab total, or symptom total as well as by the supplements you have selected for the patient. When you are done choosing the supplements, you can generate a report for your patient with instructions for them to take home. Coming soon, a fourth calculation will be available that mathematically combines SNPs, labs and symptoms, with the ability to sort by this total. 15

16 Assess, Analyze and Design Support TM The ABCDE s of Support* For those who are experienced, the genetic reports may be all you need to determine the support needed. However, for those needing guidance, the MethylGenetic Nutrition Analysis TM software s Support supplement suggestion is based upon the following concepts. A Antioxidants and Activate the Methylation Pathways: Before pushing any methylation pathways, the body may need antioxidants or cofactors that are used in the pathways. Consequently, it may be good to start with a custom made B vitamin (no Folic Acid or B12) and multi-minerals with assimilation support. B Build Cell Health: Build cells and tissues with food based nutrition. C Cleanse & Neutralize Toxins: If pathways are filled with toxins or free radicals, one of the four Scavenger products (Histamine, Peroxynitrite, Ammonia and Glutamate Scavenger), or antioxidant support products may be needed, as well as sauna or other detox support. D Digestive Function Support: Since the software may help find food issues with gluten, histamine or excitotoxins, improving diet may be critical. The software will make dietary suggestions based upon labs, symptoms and SNPs and overall healthy eating habits. E Emotions & Balancing Neurotransmitters: Supports the utilization of amino acids and healthy production of stabilizing neurotransmitters. *S Supporting Expressed SNPs, but only after determining if labs, diagnosis or symptoms confirm the need. 16

17 Cloud Based for Instant Updates The MethylGenetic Nutrition Analysis TM software was carefully designed for flexibility so that new information and research can be added almost instantly. As we learn about new SNPs, or add new labs to the software, the changes will instantly be uploaded into your reports. You will be notified of updates, and with the click of your mouse, the patient report will be upgraded to include the new information. Research Tools In this brand new world of genetic nutrition, there are still many unknowns as to which SNPs might be the most active and cause undesirable changes with enzyme function. In the near future, research tools will be added to the software that will compare labs to SNPs to determine which SNPs consistently result in chances in enzyme function. As a user of this software, you will be the first to know this important information. Webinars for Reviewing Updates & Case Studies Every other Thursday evening at 8 p.m. EST, we hold a webinar to provide updates to the software and review one or two case studies. These webinars are recorded and available for replay at your convenience. There is no change to be part of the webinars, as it s provided as part of your subscription to the software. For the webinars, please visit An Affordable Tool for Your Practice The MethylGenetic Nutrition Analysis TM software is available for: A monthly licensing fee that includes: unlimited access to pre-run patient reports with cloud-based instant updates, research and training tools, a marketing website and webinars; and A nominal per patient report fee charged for each new patient you upload, which easily can be recouped when applied to patient charges. For multi-doctor practices, please call to ask about our special licensing pricing. 17

18 All the Tools You Need to be an Expert in Targeted Genetic Nutritional Support We re excited about this brand new, ground-breaking software and turn-key program and we know you will be too. This momentum-gaining approach to functional medicine breaks free from the take this for that method of treating symptoms. This is about finding the root cause where genetic variants are causing nutrient deficiencies or imbalance, and then compensating for those deficiencies using targeted epigenetic nutrition. MethylGenetic Nutrition Analysis TM takes away the guesswork by providing incredible data at your fingertips so you know exactly where your patient needs specific nutritional support based on their genetics, labs and symptoms or diagnosis. And with our comprehensive program, you have all the support tools necessary to efficiently integrate genetic testing and nutritional support into your practice. Now you can help your patients or clients be the very best they can be. By compensating for genetic variants with targeted nutrition, we can decrease oxidative stress, increase antioxidants, and support the healthy rebuilding of the cells all maximizing patient wellness. 18

19 A Pioneering Vision of Genetic Variant Support ROBERT MILLER, CTN, is the primary researcher and developer of the MethylGenetic Nutrition Analysis TM software. He earned his naturopathic degree from Trinity School of Natural Health and is board certified. Bob has served as a traditional naturopath for 20 years, and has spent the last several years engaged almost exclusively with genetic variants and related research. Working with many clients, he is astounded at how many peoples health concerns are related to the genetic issues. Recognizing that there was not a nutritional supplement line on the market comprehensive enough to address all of the possible genetic variants, he began working with a national company, Professional Health Products, to formulate an Epigenetics line of products for use by health care providers. Bob lectures at nationwide seminars to educate physicians and health care practitioners about genetic variants and nutritional supplementation for achieving optimal health. In 2015, Bob founded the NutriGenetic Research Institute to research and publish reports on the relationship between genetic variants and labs and presenting symptoms. His growing research team currently includes himself, a functional medicine chiropractor, a holistic nutrition consultant and health coach, and a chemist. 19

20 With unprecedented functionality, MethylGenetic Nutrition Analysis TM offers a web-based platform that enables practitioners to integrate findings from lab work, symptoms surveys and raw genetic data and then compare all the patient data in a side-by-side format a powerful decision-making tool when designing a custom nutritional protocol for your client based on their unique genetics. Only MethylGenetic Nutrition Analysis TM helps you Assess, Analyze and Design Support TM. For more information on this ground-breaking software or to try a free trial, call and ask for Yvonne or yvonnel@dnasupplementation.com. MethylGenetic Nutrition Analysis TM is proprietary software of Tree of Life Health Ministries