MF-ChemiBIS. Today s most comprehensive solution for your bio-imaging needs and applications. Documenting Nature

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1 MF-ChemiBIS Today s most comprehensive solution for your bio-imaging needs and applications Documenting Nature

2 MF-ChemiBIS Excellence in bio-imaging The DNR Advantage As pioneers in bio-imaging technologies and innovations, we ve helped to set the standards in the global life-science research community. Our indepth knowledge and experience of research processes allows us to stay one step ahead, in a field where new discoveries are made at every turn. A complete solution for all your imaging and documentation needs. Top row from left to right: GFP ; Ethidium Bromide ; SYBR Safe. Bottom row from left to right: Flamingo Pink ; Coomassie Brilliant Blue ; Luciferase.

3 MF-ChemiBIS excellence in bio-imaging Technology & Performance The MF-ChemiBIS delivers reliability and versatility in answering the needs of molecular biology laboratories and research facilities of all sizes anywhere in the world. This advanced high performance documentation and analysis system, offers many exciting built-in leading-edge features, and includes a novel capture and analysis software, with optional accessories to answer advanced applications. Available in two configurations: MF-ChemiBIS 3.2 and MF-ChemiBIS 2.0. Fully automated The MF-ChemiBIS is fully automated and computer controlled. Zoom, Focus, Iris, Illumination and all parameters are motorized and monitored. A high performance super sensitive robotic camera. Unique liquid cooling system For optimal imaging. Ease of work Using application specific interchangeable trays, the MF- ChemiBIS features a comfortable working space for manipulating and working with your sample. Versatile Illumination Epi and Trans white light Epi and Trans UV illumination Optional Dual UV illumination with 254nm, 312nm or 365nm Wide range of quality LED s and filters for versatile excitation of different fluorophores.

4 MF-ChemiBIS excellence in bio-imaging Unique Design Features Robotic Camera for super sensitive results Our enhanced detector sensitivity and unique robotic camera technology gets you closer to the sample for maximum detection. Exclusive DNR engineering moves the camera, not the sample - so you re never compromising on accuracy. A complete solution for all 1D & 2D applications Chemiluminescence and Bioluminescence applications Basic and advanced Fluorescence applications Colorimetric Colony and plate imaging Plant and small animal in vivo imaging abilities (super sensitivity bioluminescence) Variable options for wave-length excitation with interchangeable LED cassettes Fully automated system - precise repeatable focus positioning Interchangeable drawers - convenient work space, easy to clean, transportable Image resolution up to 12 MP Robotic motion allows the camera to move toward the sample, maximizing signal detection.

5 Super Sensitive The MF-ChemiBIS combines high quality optics and advanced camera technology allows the highest performance in low signal experiments. Dynamic Range The MF-ChemiBIS advanced detector enables linear measurements of more than 5 orders of magnitude. Liquid Cooling System DNR s one-of-a-kind cooling system brings the CCD detector to its optimum performance levels. Reaches - 70ºC with unrivaled cooling stability, minimum dark noise, high sensitivity and superior signal detection. Fully Automated MF-ChemiBIS is fully automated and computer controlled. Zoom, Focus, Iris, Illumination and all parameters, are monitored and controlled at all times by the user. High Sensitivity Pg Pg HRP conjugated secondary antibody specifically detects two fold dilutions of Actin - specific antibody. Accuracy Wide Dynamic Range A low light imaging standard with a continually glowing Tritium light source shows the wide detection range of the MF-ChemiBIS. The marker overlay feature enables the combination of a visible marker on the chemiluminiscent image with perfect accuracy.

6 MF-ChemiBIS excellence in bio-imaging Versatile Illumination Epi and Trans white light Epi and Trans UV illumination Optional Dual UV illumination with 254nm, 312nm or 365nm For Advanced Fluorescence wide range of quality LED s enabling versatile excitation of different fluorophores Optional wide range of high quality emission filters Common dyes and stains Fluorescence Colorimetric Chemiluminescence Ethidium bromide, SYPRO Orange, SYPRO Red, Cy 2, Cy 3, Pro-Q Diamond, Deep Purple Rhodamine Red, SYPRO Ruby, SYBR Green, GelStar, SYBR Gold, Fluorescein, Texas Red GFP, Qdots and more Silver Stain, Coomassie Brilliant Blue, Ponso staining, film, and more Chemiluminescence ECL, ECL-Plus, Lumi Light Plus, Super Signal, CDP Star, CSPD ECL, ECL-Plus, Lumi Light Plus, Super Signal, CDP Star, CSPD Other TLC plates, spot and slot blots, autoradiographs, microplate, macroarrays, membranes, and more Cy3 Cy5.5 69KD 36KD Cy2 29KD Cy5 14.3KD Cy 2,3,5 and 5.5 channel overlay excited by the LED s versatile illumination system. Cy2 detection of conjugated carbonic Anhydrase - dilutions of 540 pg to 130 pg Cy3 detection of conjugated BSA - dilutions of 540 pg to 30 pg Cy5 detection of conjugated Lysozme dilutions of 160 pg to 20 pg Cy5.5 detection of conjugated GPD - dilutions of 350 pg to 20 pg

7 Special Software Solutions We offer Image Analysis Software that gives you custom solutions with powerful and user-friendly software for just about any type of image or application. Acquisition Software For more intuitive navigation and easier, time-saving work flow Auto exposure feature for optimal image capture Up to 3 fluorophores overlay options Signal enhancement feature to extract the weakest signal of your experiment Advanced capture options for complex experiments And much more Analysis Software Gel analysis software and the most up-to-date versions of our image acquisition software are applicable for all DNR bio-imaging systems. Gel Capture TotalLab Quant ID Advanced Analysis Prodigy Same Spot 2D Analysis

8 Specifications: MF-ChemiBIS Family Cooling system Type Temperature Camera Type Effective resolution MF-ChemiBIS 3.2 Effective resolution MF-ChemiBIS 2.0 Gradation Dynamic range Exposure time Binning Super bright lens F-number- F/0.95 Illumination & darkroom Dark chamber Emission filters Illumination modes HeptaLED system (optional) Software Image capture Image analysis Liquid cooling system To a minimum temperature of C CCD 2,184x1,510; up to 12.8 Mpixel image resolution 1,640x1,214; up to 8 Mpixel image resolution 16bit (65,536 gray levels) ~ 5 orders of magnitude 0.03 seconds to 24 hours 1x1, 2x2, 3x3, 4x4, 5x5, 6x6, 7x7, 8x8 DNR s Smart Dark Chamber 5-position filter wheel with a wide range of quality filters available Trans-UV (optional 254nm, 312nm, 365nm), Trans-WL, Epi-WL Optional: Epi-UV (254nm, 312nm, 365nm); dual UV (optional combination 254nm, 312nm, 365nm) 470 nm, 500 nm, 525 nm, 568 nm, 588 nm, 621 nm, 740 nm GelCapture, lifetime free upgrade Advanced 1D analysis, colony counting and array analysis. Optional advanced 1D analysis software featuring database and dendogram options Optional Advanced 2D analysis software featuring the SameSpots novel technology Contact DNR for further details DNR Bio-Imaging Systems Ltd. P.O. Box 34, Mahale HaHamisha Jerusalem Israel Phone: U.S. Toll-Free USA: Visit us at: