Celestial. cell factories for future bioeconomy

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1 Celestial cell factories for future bioeconomy

2 Sustainable bioprocessing in Estonia: a historical opportunity Local substrate Value added chemicals

3 Biorefinery Triple Helix model Public sector Local substrate Pilot plant Industrial process optimization Competence and training centre Bioenergy New products Biofuels Industry

4 Pilot-plant for bioprocess scale-up and optimization Syngas Lignotselluloosne biomass Vetikad Vadak Tahked munitsipaaljäätmed Kohaliku tooraine töötlemine Fermentation & chemical processing Järeltöötlus To encompass a wide spectrum of products based on combinations of chemical processes and industrial biotechnology Targeting Energy, High Value Products and Waste Valorisation

5 Innovative practice in science funding - Processum example 40% Industry association Ownership of 60% Public association Etc. Etc.

6 Innovative practice in science funding - Celestial model 40% Industry association Ownership of 60% Public association

7 Building Research and Innovation excellence over 20 million in funding from highly competitive programs Competitive interdisciplinary research institute established Synthetic Biology Platform Structural funds ASTRA upgrade to core facility for synthetic biology M.Loog ERC Consolidator Grant PHOSPHOPROCESSORS synbio toolbox ERA Chair Synthetic Biology Full Ecosystem ERA chair Industrial Fermentation ECB Pilot plant design and ECB- Industrial Association A.Mertis Wellcome Trust T.Tenson Wellcome Trust Structural funds for core facilities M.Loog Wellcome Trust M.Loog HHMI Centre of Excellence CECB Research direction chemical biology Centre of Excellence ENVIRON Research direction plant biotechnology ECB + core facility + synbio curricula Centre of Excellence (CEMCE) Research directions for developing tools for syntehtic biology Teaming Project Stage 1 CelESTial Collaboration with Novo Nordisk Centre for Biosustainability

8 Cell Factory group Bioprocessing group 1 Bioprocessing group 2 Bioprocessing group 3 ERA Chair SynbioTEC Fermentation engineers Chemical engineers System biologists ERA Chair Research Team GasFerm research excellence Core Facility for Synthetic Biology and Biotechnology Research Coordination R&D strategy Business Plan Center for Biosustainability Pilot Plant Facilities & Training centre Biosustainability awareness centre and public debate platform Expert services for industry & academia European Academia and Industry ECB - Industry Association Industry expertise Wood Food Pharma Fuel Novel opportunities across sectors R & D and Innovation excellence Managerial optimization Curricula modernization Smart specialization Improved capability Implementation of the European Research Area priorities

9 Mida investeering võimaldab? Piloot-tehas kui regionaalne kompetentsikeskus 1) Kaotab vajaduse ettevõtetel oma piloot-tehas ehitada 2) Tehnoloogiate tööstus-skaalale optimeerimine 3) Otsekontakt teadusgruppidega 4) Võimalus kaasa rääkida keskuse infrastruktuuri kujundamisel 5) Seotus rahvusvahelise tehnoloogia-arenduse võrgustikuga (Teaming: CFB, Lanzatech) 6) Järelkasv ettevõttele läbi doktorantuuriteemade Plaan 60/40 PPP 7 m EUR

10 Mida investeering võimaldab puidusektorile? Piloot-tehas kui regionaalne kompetentsikeskus 1) Puidukeemia ja biotöötluse tuumiklabor 2) Lignotselluloosi fermentatsiooni platvorm tootmistüvede disain, sünteetiline bioloogia, bioprotsesside optimeerimine Dr. Lauri Vares, Dr. Siim Salmar, Dr. Petri-Jaan Lahtvee. 3) Lignotselluloosi keemilise töötlemise platvorm - Dr. Lauri Vares, prof Patric Jannasch (Mobiltas top researcher). Ligniini valoriseerimise konsortsium.

11 Greater Nordic Area Tartu ECSB Copenhagen CFB

12 In collaboration with a leading centre for synthetic biology Novo Nordisk Foundation Center for Biosustainability (CFB)

13 Traditional chemical industry source input process output Cell factories

14 CO Customized catalysts Native Synthetic Industrial waste gases Waste biomass Municipal solid waste CO 2 Gas Feed Stream Lignocellulosic biomass Gas reception Compression Fermentation Recovery Product tank H 2 Ethanol 2,3-BDA, Isoprene

15 Celestial - Life Science Campus Estonia Tartu Estonia

16 Celestial - Life Science Campus Tartu Tartu, Estonia

17 Celestial - Life Science Campus 58 22'04.8"N "E Tartu, Estonia

18 Institute of Technology (2006)

19 Teaming partnership DESIGN BUILD Genome Engineering iloop LEARN Analytics TEST Screening & Fermentation

20 Funding: 15.3 million iloop Cell design unit at ECSB + Broad Foundry Cell design unit at CFB + Broad Foundry Funding: million

21 Cell design unit at CFB + Broad Foundry Cell design unit at ECSB + Broad Foundry Faas 2 Faas 1 iloop Faas 1 Faas 2 400L ECSB 30L CFB Tartu Copenhagen Microbial scale-up plant in collaboration with industrial parners 50L IFC/ECSB Tartu 500L IFC/ECSB Tartu Mammalian scale-up and production plant

22 Biorefinery Triple Helix model Public sector Local substrate Pilot plant Industrial process optimization Competence and training centre Bioenergy New products Biofuels Industry