Nanogenizer-110P Series High Pressure Homogenizer

Transcription

1 Nanogenizer-110P Series High Pressure Homogenizer Nanoemulsion Cell Disruption Nanodispersion Deagglomeration Liposome Unique Benefits Always a Discount for Public Research Energy efficient: 1/2 energy loss of the most homogenizers Small: Integrated design deliver the light weight and small dimensions Smart: Programming control systems confer diligent functions Silent: Noiseless performance with high energy efficiency Strong: More than 120 ml/min at 30,000 psi Nanogenizer-110P series electric ultrahigh pressure homogenizer is an equipment operated with the touch screen and controlled intelligently by program. It can be used for laboratory preparation of fat emulsion, liposome, nanosuspension, microemulsion, lipid microsphere, nanoemulsions, dairy products, infusion solutions, cell disruption, juice homogeneity, fine chemical engineering, dye and etc. The maximum working pressure is Psi/3100 Bar. All parts touching with medium are FDA approved sanitary materials including 316L stainless steel, 17-4ph stainless steel, titanium alloy, tungsten carbide, PTFE, UHMWPE. Specifications Catalog No. Nano15k Nano20k Nano25k Nano30k Nano45k Flow rate 120ml/min 120ml/min 120ml/min 120ml/min 100ml/min Min. Sample 1ml 1ml 1ml 1ml 1ml Max. Pressure 15,000psi 20,000psi 25,000psi 30,000psi 45,000psi Dimensions (cm) Weight 35 kg 40 kg 40 kg 45 kg 50 kg Max. Temp. Power Cleaning Features 80ºC (176ºF) 110V/220V Flush to clean Digital display of pressure or pressure gauge Phone: +1(323) Fax : +1(323) notice by Genizer. All rights reserved. English Version

2 Nanogenizer-110P Series High Pressure Homogenizer Standard Features NanoGenizer-110P Parts Control System Pressure Gauge Inlet type Outlet type Feed Reservoir Collector Reservoir Product material Material standard Warranty Y-type Diamond interaction chamber with cooling option High pressure programming control systems : Touch Screen, Speed control, Auto stop control by volume, time, pressure or temperature, settable volume control as low as 1ml, display of flow rate and time, overload protection Electric 1/4" HP coupling 1/4" HP coupling 20ml Syringe 20ml Syringe 316L stainless steel, Tungsten Carbide, Viton, Teflon, UHMWPE Pharmaceutical Grade, FDA & GMP approvable 1 year against any manufacturing defects Control Screen Available Option Parts Control System Detector Outlet type Feed Reservoir Collector Reservoir Cylinder High Pressure Extruders, Homogenizing valves - Two stages, Heat Exchanger Mechanical control; Speed, start, stop control Pressure gauge, Pressure and Temp. transducer Tri-Clover or Luer 10ml, 20ml, 50ml, 100ml, 200ml, 500ml Syringe, Cylinder or Online Titanium High pressure Cylinder (Resistant to strong acid and base) Homogenizing Chamber Phone: +1(323) Fax : +1(323) notice by Genizer. All rights reserved. English Version

3 Handgenizer Hand Driven Testing High Pressure Homogenizer Handgenizer : A better choice for small scale research Nanoemulsion Cell Disruption Nanodispersion Deagglomeration Liposome Exclusive Benefits Best option for testing homogenizing technology on the market Handgenizer HG-0.5ml (2000bar 200Mpa 30,000Psi) For the customer with a limited budget but high-quality standards Bringing scalable, self-shearing, processing technology to samples as small as 0.5 ml Inlet Lightest high-pressure homogenizer worldwide Outlet Compatibility design: High pressure connection compatible with (Microfluidizer) & Ultra-high pressure, up to 30,000 psi Adjustable 3 speed: 1 st Stage: 10,000psi; 2 nd Stage: 20,000psi; 3 rd Stage:30,000psi Autoclavable (no disassembly required) Portable and flexible The HG-0.5ml hand drive testing high pressure homogenizer was developed in response to customer demand for testing high pressure processing nanotechnology with applications in the pharmaceutical, biotechnology, chemical, nutraceutical, food, cosmetic and energy industries. The HandGenizer technology provides up to 30,000psi high pressure homogenization without the compress gas, air or electric motor. The HandGenizer provides options of the Y-type Diamond interaction chamber, cavitation nozzle, impact valve, Self- Shearing processor or membrane extruder. The unique, patent technology of the HandGenizer and Self-Shearing processor enables users to test smaller sample sizes than with other methods with more uniform distribution and guaranteed scale up. Discount available for Public Research. Genizer.com notice. HandGenizer and Self-Shearing are patent technology by Genizer. All rights reserved. English Version

4 Handgenizer HandGenizer Hand Driven Testing High Pressure Homogenizer Options for Chamber Type Y-type interaction Chamber (Microfluidizer). Collision-Type Generator (Nanomizer) Compatible with connection of Microfluidizer and Avestin Homogenization Zone Y-type Impingement Cavitation Chamber Specifications Description Hand Drive High Pressure Homogenizer Minimum Sample Size 0.6 ml per stroke Flow rate 1ml~15ml/ minute (user dependent) Temperature Limit 75ºC (167ºF) Power Requirements Hand drive Dimensions W x D x H 25 cm x 40 cm x 20cm (10 x 16 x 8 ) Weight 15 kg (32 lbs) Cleaning Flush to clean Sterilizing Whole unit Autoclavable Stages 3 stage: 10,000psi, 20,000psi, 30,000psi Compatibility Connection compatible with (Microfluidizer) Standard Feature Chamber Type Self-shearing (Material: Diamond) Feed Reservoir 10 ml syringe type Collector Reservoir 10 ml syringe type Pressure Gauge 35,000psi (250Mpa, 2500bar) SS316 Application Water, oil, emulsion, liposome, alcohol, high-viscosity liquid or solid suspension Warranty 1 year Option Feature Impact Chamber Chamber Type (Material: Diamond) Interaction chamber (Microfluidizer) Cavitation Chamber (BEE without EC) Impact Chamber (Most manufactures) Membrane extruder (Millipore) 5ml, 25ml,100 ml syringe type Feed Reservoir Collector Reservoir 5ml, 25ml,100 ml syringe type Product Cooling Immersed coil in ice bath tray Product training Available Discount available for Public Research. Genizer.com notice. HandGenizer and Self-Shearing are patent technology by Genizer. All rights reserved. English Version

5 Y-TYPE Diamond for High Pressure Homogenizer Nanoemulsion Cell Disruption Nanodispersion Deagglomeration Liposome Unique Benefits Always a Discount for Public Research Best option for Y-Type Diamond Full replacement for the chamber of Microfluidizer processors Lower cost and higher quality Longer warranty period Real-time cooling option to reduce oversized particles in USP729 Retaining protein activity High pressure connection with the homogenizers of other manufacturers, such as BEE International Y-Type Diamond High pressure homogenizers are equipped with various types of valves, nozzles, or chambers. Among them, the Y-Type is one of the most powerful. These chambers are made from abrasion-resistant materials, with diamond being the most durable and expensive option. Y-Type is firstly disclosed in PAT. NO It has been used by several manufacturers, such as Microfluidics (F20Y, F12Y Interaction Chamber), Avestin (Static Homogenizing Valve) and Nanomizer (Collision-Type Generator). In the Microfluidics system (FIG. 1), the flow stream is split in two channels that are redirected at right angles over the same plane and propelled into a single flow stream. High pressure promotes a high speed at the crossover of the two flows, which results in high shear, turbulence, and cavitation over the single outbound flow stream. We have been providing high quality Y-type Diamond s for high pressure homogenization in compliance with FDA standards. The Single-Slotted Chamber can be used as a full replacement for the chambers from M-110Y, M-110P, M-110L, M- 110S, and M-110EH Microfluidizers and the Static Homogenizing Valve from Avestin. The Multi-Slotted Chamber can be used as a full replacement for the chambers used on production units, such as M-210, M-7115, M-7125, and M Our confidence in the quality of our products allows us to provide a 1-year warranty, compared to the 90-day warranties of other manufacturers.

6 Y-TYPE Diamond for High Pressure Homogenizer Specifications FIG. 1 Single-Slotted Y-Type FIG. 2 Multi-Slotted Y-Type Description Brand Materials Compatibility and Full Replacement for Microfluidizer Processors & Avestin EmulsiFlexs Standard Warranty Dimensions W x D x H Weight Cleaning Sterilizing Pressure Range Chamber Type Available (See price list) Y-Type Diamond Single-Slotted, Multi-Slotted OEM with High Quality Diamond, 316SS stainless steel Single-Slotted: M-110Y, M-110P, M- 110PS, M-110L, M-110S and M-110EH Multi-Slotted: M-7115, M-7125, M-7250 and M year (up to 5 years available) 35mm x 35mm x 85mm (Single-Slotted) 45mm x 45mm x 165mm (Multi-Slotted) 1 lbs. (0.5kg) (Single-Slotted) 3 lbs. (1.5kg) (Multi-Slotted) Flush to clean Whole unit autoclavable 0-4,5000 psi Single-Slotted: F12Y, F20Y, and Static Homogenizing Valve Multi-Slotted: F12Y-4, F12Y-5, F12Y-6, F12Y-7, F20Y-4, F20Y-6, F20Y-7 Y-6 DIXC 6-slotted Y-Type Diamond High Pressure Inlet Impingement Zone High Shear Zone Low Pressure Outlet

7 Diamond with COOLING SYSTEMS Chamber with Real-Time Cooling Cooling Water In FIG. 3 Single-Slotted Y-Type with cooling system Cooling Water Out The outside temperature of a working chamber can exceed 80ºC and much higher from inside, which reduces the quality of the product. For example, in the pharmaceutical industry, an overheated chamber leads to the formation of oversized particles. Particles in the parenteral > 5 microns (µm) or PFAT5 > 0.05% are not favored by the FDA and United States Pharmacopeia (USP) 729. During cell disruption, protein activity will also be compromised. Further, the real-time cooling chamber is a better choice for preparation of Emulsified Fuel in the safer temperature. The traditional method cools the chamber by immersing it entirely in cooling liquid, but the chamber s thick steel cover makes this an ineffective solution. This patent fabrication has the cooling option inside the chamber (Fig. 3, Fig. 4), which allows for much more effective heat exchange. Specifications FIG. 4 Multi-Slotted Y-Type with cooling system Cooling Water In Inner surface fabricated for heat transfer Cooling Water Out Description Brand Materials Compatibility and Full Replacement for Microfluidizer Processors & Avestin EmulsiFlexs Standard Warranty Dimensions W x D x H Weight Cleaning Sterilizing Pressure Range Chamber Type Available (See price list) Y-Type Diamond Single-Slotted, Multi-Slotted OEM with High Quality Diamond, 316SS stainless steel Single-Slotted: M-110Y, M-110P, M- 110PS, M-110L, M-110S and M-110EH Multi-Slotted: M-7115, M-7125, M-7250 and M year (up to 5 years available) 35mm x 35mm x 85mm (Single-Slotted) 45mm x 45mm x 165mm (Multi-Slotted) 1 lbs. (0.5kg) (Single-Slotted) 3 lbs. (1.5kg) (Multi-Slotted) Flush to clean Whole unit autoclavable 0-4,5000 psi Single-Slotted: F12Y-RT, F20Y-RT, and Static Homogenizing Valve-RT Multi-Slotted: F12Y-4-RT, F12Y-5-RT, F12Y-6-RT, F12Y-7-RT, F20Y-4-RT, F20Y-6-RT, F20Y-7-RT

8 Y-Type Diamond F12: Size of Slot Y: Y-TYPE 1: Number of slots RT: Real-Time cooling option Symbol Description of the Catalog No. F12Y-1M-RT Abbreviation of compatible manufacturer (M: Microfluidics, A: Avestin, B: BEE International) Catalog No. Manufacture Compatibility Full Replacement for F12Y-1M Microfluidics M-110Y, M-110P, M-110PS, M-110L, M-110S and M-110EH F20Y-1M Microfluidics M-110Y, M-110P, M-110PS, M-110L, M-110S and M-110EH F12Y-4M Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-4M Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-5M Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-5M Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-6M Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-6M Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-7M Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-7M Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-1B BEE International Nano DeBEE 45, Micro DeBEE 45, Mini DeBEE 45 F20Y-1B BEE International Nano DeBEE 30, Mini DeBEE 30, Micro DeBEE 30 F12Y-nB BEE International DeBEE 1000, DeBEE 2000, DeBEE3000, DeBEE2000P F20Y-nB BEE International DeBEE 1000, DeBEE 2000, DeBEE3000, DeBEE2000P F12Y-1A Avestin (Static Homogenizing Valve) Avestin F20Y-1A Avestin (Static Homogenizing Valve) Avestin F12Y-1M-RT Microfluidics M-110Y, M-110P, M-110PS, M-110L, M-110S and M-110EH F20Y-1M-RT Microfluidics M-110Y, M-110P, M-110PS, M-110L, M-110S and M-110EH F12Y-4M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-4M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-6M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-6M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-7M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F20Y-7M-RT Microfluidics M-7115, M-7125, M-7250 and M-210 F12Y-8M Microfluidics M-7115, M-7125, M-7250 and M-210 Warranty: 1 year.

9 Upgrading to Y-type F12: Size of Slot Y: Y-TYPE 1: Number of slots RT: Real-Time cooling option Symbol Description of the Catalog No. F12Y-1M-RT Abbreviation of compatible manufacturer (M: Microfluidics, A: Avestin, B: BEE International) Original Chamber Upgrade to Brand New Warranty time F12Y or F20Y Diamond Single- Slotted Chamber (Microfluidics) F12Y or F20Y Ceramic Single- Slotted Chamber (Microfluidics) F12Y or F20Y Diamond Multi- Slotted Chamber (Microfluidics) F12Y or F20Y Ceramic Multi- Slotted Chamber (Microfluidics) F12Y-1M-RT or F20Y-1M-RT Single-Slotted Diamond Chamber F12Y-1M-RT or F20Y-1M-RT Single-Slotted Diamond Chamber F12Y-RT or F20Y-RT Multi-Slotted Diamond Chamber F12Y-RT or F20Y-RT Multi-Slotted Diamond Chamber Diamond Nozzle on Nano Mini or Micro DeBEE (BEE International) Zirconia Nozzle on Nano Mini or Micro DeBEE (BEE International) Diamond Nozzle on Production Unit (BEE International) Zirconia Nozzle on Production Unit (BEE International) F12Y-1B or F20Y-1B Y-Type Single-Slotted Diamond Chamber F12Y-1B or F20Y-1B Y-Type Single-Slotted Diamond Chamber F12Y-1B or F20Y-1B Y-Type Multi-Slotted Diamond Chamber F12Y-1B or F20Y-1B Y-Type Multi-Slotted Diamond Chamber Other Unit Y-Type Interaction Diamond Chamber The Y-Type, regarded as one of the most powerful chambers to date, has been used by several manufacturers, including Microfluidics (Y-Type ), Avestin (Static Homogenizing Valve) and Nanomizer (Collision-Type Generator). We provide upgrading service from your original interaction Chamber. We deliver the brand new Y-Type Interaction Diamond Chambers to exchange your old chambers. So far the Chamber from Microfluidics and Nozzle from BEE International is upgradable. Please send the information if you want to upgrade Chamber or Valve or Nozzle in your high pressure homogenizers from the other manufactures. Warranty:.