The new main building of the Leopoldina in Halle. July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 1

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1 The new main building of the Leopoldina in Halle July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 1

2 Japan-German Cooperation in Science Microbiology as an Example Jörg Hacker Supporting Tomorrow s Leading Researchers: Innovations and Challenges Approaches by Japan and Germany Symposium to Commemorate 150 Years of German Japanese Friendship, Tokyo, July 15, 2011 July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 2

3 Science for Diplomacy July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 3

4 Dejima, Bay of Nagasaki 1828 View to Dejima and to the Bay and the Harbor of Nagasaki in 1828 (Fig. 1 in Siebold: Nippon, ²1897) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 4

5 Philipp Franz von Siebold ( ) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 5

6 Science for Diplomacy until 1860 Dejima Philipp Franz von Siebold in Japan Philipp Franz von Siebold in Japan 1861 Treaty of amity and commerce: There shall be eternal peace The friendship treaty of 1861 AA and constant friendship between Their Majesties the King of Prussia and the Tycoon of Japan, as well as between their heirs and successors, July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 6

7 Cooperation in Microbiology July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 7

8 Robert Koch ( ) in his laboratory July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 8

9 Kitasato Shibasaburõ and Emil von Behring Kitasato Shibasaburõ ( ) Emil Adolf von Behring ( ) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 9

10 The new concept serotherapy July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 10

11 The antitoxin effect Kitasato Shibasaburo at the Robert Koch Institute July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 11

12 Kiyoshi Shiga and Walther Kruse Kiyoshi Shiga ( ) Walther Kruse ( ) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 12

13 Discovery of the dysentery bacillus The Shiga Kruse bacillus Shigella dysenteriae Source: Wikipedia July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 13

14 Paul Ehrlich and Shachiro Hata Paul Ehrlich ( ) Sahachiro Hata ( ) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 14

15 A first drug against spirillosis Paul Ehrlich and Sahachiro Hata July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 15

16 New collaborations New developments July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 16

17 Groups of Pathogens Bacteria Fungi Protozoa Viruses Prion proteins Worms July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 17

18 The most important infectious diseases world-wide Diarrhoeal disease 2.1 Mio. AIDS/HIV 2. 9 Mio. Tuberculosis 1.6 Mio. Malaria 1.0 Mio. Measles Pulmonary infections 3.9 Mio. Sleeping sickness Tetanus Whooping cough Syphilis Hepatitis C Meningitis The most important infectiosus diseases and estimated cases of mortality world wide per year. Source: WHO July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 18

19 The German epidemic EHEC/HUS strain E. coli O104:H4 Unusual Characteristics: Shiga Toxin 2 producing Intimin (eae) negative Enteroaggregative (EaggEC plasmid) Multiple antibiotic resistances dpa/christian Charisius Genome sequence analysis (Brzuszkiewicz et al., Juni 2011): High similiarity to entero aggregative E. coli (EAEC) Shiga Toxin charakteristic for enterohemorrhagic E. coli (EHEC) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 19

20 Proposed scheme of the origin on the new E. coli strain O104:H4 E. coli O104:H4 From: Brzuszkiewicz et al. (2011) Arch. Microbiol. DOI: /s (Göttingen Genomics Laboratory July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 20

21 Genome of Sakai outbreak EHEC strain O157:H7 Hayashi et al. (2001) DNA Res. 8: July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 21

22 Modern Diagnostics Quelle: meda muenster.de July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 22

23 Development of Pathoblockers X Toxins Fe3+ Fe 3+ Fe 3+ X Iron uptake systems X Adhesines X Flagella Plasmid X Capsule Chromosomal DNA X Invasine July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 23

24 Efficient Vaccines are needed against: Malaria (Plasmodium) AIDS (HIV) Tuberculosis (Mycobacterium tuberculosis) Sleeping sickness (Trypanosoma) Many pathogens causing stomach and intestine diseases (E. coli, Salmonella, Helicobacter pylori) Pathogens causing nosocomial infections (S. aureus, E. coli) July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 24

25 In support of Tomorrows Leading Researchers July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 25

26 Role models for cooperation Bilateral cooperation International Research Training Groups International Consortia Confererences Awards July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 26

27 The Koch and Kitasato Institutes Long lasting cooperation The Robert Koch Institute in Berlin, built in 1897 Kitasato Institute in Tokyo, built in 1915 July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 27

28 2010: International research training group July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 28

29 The Human Genome Sequencing Consortium France, China, the UK, USA, Germany, and Japan Germany Max Planck Institute for Molecular Genetics, Berlin German Research Center for Biotechnology, Braunschweig Japan Genomic Science Center Yokohama Image: ISTOCKPHOTO/DAVID MARCHAL School of Medicine, Tokyo July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 29

30 2011: German-Japanese Collaboration in Computational Neuroscience July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 30

31 Humboldt-Colloquium "Sustainable relations between Japan and Germany in a globalising world - Medical Science since Philipp Franz von Siebold and Koan Ogata" Date: 2011/9/16-18 Waseda University Tokyo July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 31

32 G8 Academies Meeting 2007 in Halle July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 32

33 Joint G8+ Science Academies Statement on Water & Health 2011 July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 33

34 Gottfried Wagener Prize 2011 Winner 2011 Motonari Uesugi Institute for Integrated Cell Material Sciences, Kyoto University Winner s Team : Noriko Koizumi, Makiya Nishikawa, Motonari Uesugi Development of Small Molecules Tools for Cell Therapy July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 34

35 Robert-Koch Prize 2006 Peter Palese and Yoshihiro Kawaoka for their outstanding research on influenza viruses July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 35

36 The year 2011 July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 36

37 The new main building of the Leopoldina in Halle July 15, 2011 Japan-German Cooperation in Science Microbiology as an Example 37