Bellingham + Stanley Refractometers Latest Applications

Transcription

1 2017 Bellingham + Stanley Refractometers Latest Applications

2 Bellingham + Stanley A World Leader in the Manufacture and Sales of High Quality Refractometers and Polarimeters ISO Bellingham + Stanley Ltd. operates a Quality Management System complying with ISO 9001:2008 (Certificate Number LRQ ) 2

3 Past and Present.. 3

4 Company Locations and Representation Bellingham + Stanley Head Office and Factory, Tunbridge Wells, UK Bellingham + Stanley USA Sales & Service for USA, Atlanta, USA Bellingham + Stanley Authorised Dealers and Distributors in over 90 Countries 4 Xylem Sales & Support Centres in every continent

5 Markets & Applications

6 Industry Sectors Research, Education & Government Industrial Food Beverages & Sugars 6

7 Market Split Industrial 7% Education 11% Food 31% Pharma 22% Beverage 29% 7

8 Research, Education & Government Research Laboratories commercial & government Education Schools, Colleges & Universities 8

9 Industrial Pharmaceutical (USP781/831) Chemical Petrochemical Aviation (fuel, ice inhibitors) Hydraulic fluids Fire fighting foam Surfactants, detergents Shampoo Starches (paper/textiles) Flavours, fragrances Essences, oil Cosmetics Resins & adhesives Petrochemicals, waxes Lubricants, quenchants Biofuels, ethanol, oils DEF/AdBlue, antifreeze Seawater 9

10 Food Fruit Ripeness Canned Fruits Jams, Jellies, Gelatine Stabilisers (gum acacia etc.) Liquid egg Yeast cultures Honey Edible oils Dairy (Yoghurt/milk/butter) Ketchup & salsas Mustards Cooking sauces & soups Edible starches Confectionary (fondants,) Toffee, Taffy Cocoa & chocolate Brine 10

11 Beverages & Sugars Carbonated Drinks Diet Drinks Soft Drinks Syrups Orange Juice Juices General Fruit Concentrates Lactic Acid Beverages Energy Drinks Milkshakes Flavoured Waters Beer Malts Ciders Wine Alcohol Alcopops Sugar Fructose Glucose Molasses Cane Juice Beet Juice Corn Syrup Coffee Sweet Tea 11

12 Global Customers 12 all trademarks recognized

13 Latest Application 13

14 Precise Control 14

15 RFM300-T & RFM300-M Measurement Specification Model RFM330-T RFM340-T Scale Brix, RI & user Brix, RI & user Range Brix RI Brix RI Resolution 0.1 / / (Selectable to 6 d.p.) Accuracy 0.1 / Brix: 0.01 / ( RI) Brix: 0.03 / ( RI) Precision (Reproducibility*) Reading time 0.05 / Brix / RI) 4 seconds minimum (dependant on precision required) Working Temp Range 0 C or 10 C below ambient whichever is greater to 80 C Automatic Temp Comp Brix, User (to any C) User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3), PHR-MEAN, Urea and more; plus customer programmable user scales via PC. Interface 3 x USB (A) 1 x USB (B) 1 x Ethernet 1 x Serial (RS232) Using a traceable homogenous sample under laboratory conditions at 20 C 15

16 Production Line Effeciency 16

17 RFM300-Flow for Tare House Also great for fruit juice and carbonated beverage producers as a funnel flowcell reduces the need to clean the prism between each sample! 17

18 Making Measurement Easy 18

19 It s not that simple! Natural light is made up of light of different colour or wavelength (energy) RI depends on the wavelength of light RI also depends on temperature When defining RI, the wavelength and temperature are specified: 20 N N is the symbol for RI D 20 C D = sodium D line (589 nm) For air, For water, 20 N D = N = D 19

20 Control = Profitability (Case Study) 20

21 2017 Refractometers The Models

22 Eclipse Professional Handheld Refractometers NEW - Easy Read Scales NEW - Higher resolution Bright Field of View Sealed construction Unique Dribble Feed Zero adjust (lock) Ergonomic Design Anti-roll supports Push on prism flap Serial Numbered Certificate 22

23 OPTi Refractometer - Features 23 Single & Dual (Duo) Scale Models Full & High Range Robust sealed design Silicon rubber keypad (not plastic!) 2-second read time Zero calibration (all models!) AG Test Mode (unique!) -HAL- High Ambient Light Detection Temperature Display Temperature in C or F Simple operation No operator errors = PRECISION Portable or laboratory (back-up!) Certificate by B+S (UKAS/NIST traceable)

24 OPTi Refractometer ONE to FOUR OPTi ONE Scale: 0-54 Brix Code: Covers 80% of applications OPTi TWO Scale: Brix Code: Covers syrups and jams at a low price OPTi THREE Scale: 0-95 Brix Code: 38-A1 Covers Full Brix scale incl. syrups for confectionary OPTi FOUR Scale: 0-83 Brix Code: Best price covering commonly used Brix scale 24

25 Digital Refractometers 25

26 RFM700-M Series Refractometers Food, beverage, sugar & other applications with ATC. Launch: January

27 RFM700-M Series - Technical Specification Model RFM712 RFM732 RFM742 Scale % Sugar ( Brix) Range Resolution Accuracy Reading time seconds (delay option) Working Temp Range Automatic Temp Comp Interface 5 80 C to 20 C USB A,B Ethernet & RS232 27

28 RFM300 Series Refractometers RFM300-M Series keypad for industrial applications RFM300-T Series touchscreen for lab & factory 28

29 Instrument Key Feature Flat Prism Dish with sapphire prism Easy application and cleaning 29

30 RFM300-M Important Features Measurement Range up to 1.58 RI Wide measurement beam non-homogenous samples Keypad membrane for safe factory use Super flat prism dish for easy cleaning Choice of RI accuracy RFM330-M and RFM340-M Peltier temperature control to 70 C Intelligent thermal control 6 sensors Rapid temperature response/stability SMART temperature stability checks sample & calibration 30

31 RFM300-Flow Refractometers Macro flowcell Funnel flowcell Same spec as RFM300+s 31

32 RFM-T Series Refractometers RFM300-T Series for industrial applications RFM900-T Series for high precision applications covering RI 32

33 RFM-T Series New & common features 33 7 Touchscreen full colour HD display USB (A), USA (B), Ethernet & RS232 connectivity Single low noise, low maintenance, inter-changeable fan 6 decimal place precision Refractive Index 3 decimal place precision Brix Remote diagnostics via Ethernet Simple USB Back-up & Clone for multi-instr. configuration Print to Secure PDF RFM300-T Series for industrial applications with easy-clean prism and wide beam optics for measuring non-homogenous samples RFM900-T Series for high precision applications covering a wide RI range and fully confirming to Pharmacopeia and FDA reg. 21 Part 11

34 RFM-T Series Common Features 34 Peltier + Air Flow Temperature Control Controlled Sample Containment Flat prism dish especially RFM300-T Series Intelligent and accurate thermal sensing Network connection via ethernet for remote lab monitoring RFID User Identification & Clearance Strict Password Control 8000 stored results for tabular display or o/p Chemical-Resistant ABS Construction

35 Materials of Construction ABS Housing Sapphire Prism Kalrez* Seals (RFM900-T) 316 Stainless Steel Sample Dish PEEK* Insulation and Spill Barrier * Chemically-Resistant Plastics 35

36 Controlling Sample Temperature to Target Value System of Powerful Peltier Devices Single low-noise, easy maintenance fan Pumped Air Flow (with single dust filter) Rapid Heating/Cooling of Sample Configurable on-screen filter change prompt Wide Operating Temperature Range: 10 below ambient to 80 C 36

37 Software Features At least 4 menu languages Installation Wizards Methods system for one-touch configuration 4 levels of security NONE-LOW-MEDIUM-HIGH SMART & other temp. stability checks settings Readings Limits Check 37

38 Software - Methods Measuring mode and measuring specifications can be stored against a product code/name Scale and Temperature Compensation Target temperature for readings Reading limits/tolerances Result verification feature Analytical Methods coffee / D 2140 / pharma MEAN Wizard to facilitate set-up of methods Insert an image to help users navigate! 38

39 Software - Quality Management Meeting the requirements of FDA 21 CFR Part 11, GLP, HACCP Date and Time Recording Product and Operator Identifiers: (Audit Trail*) Reading Log: (not available to highest level of security) Calibration Log: (Audit Trail*) Calibration Check and Report PIN Password Control: (in accordance with CFR21 Part 11) 39

40 Interfaces -Ethernet connection for LAN -USB (A) x 3 -USB B connection x 1 Back Plate Image -RS232 serial x 1 cables not supplied generally available The RS232 is used for GLP printers (dot-matrix type) 40

41 RFM300-T Refractometer Series RI Flattest prism Wide beam optics 41

42 RFM300-T & RFM300-M Measurement Specification Model RFM330-T RFM340-T Scale Brix, RI & user Brix, RI & user Range Brix RI Brix RI Resolution 0.1 / / (Selectable to 6 d.p.) Accuracy 0.1 / Brix: 0.01 / ( RI) Brix: 0.03 / ( RI) Precision (Reproducibility*) Reading time 0.05 / Brix / RI) 4 seconds minimum (dependant on precision required) Working Temp Range 0 C or 10 C below ambient whichever is greater to 80 C Automatic Temp Comp Brix, User (to any C) User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3), PHR-MEAN, Urea and more; plus customer programmable user scales via PC. Interface 3 x USB (A) 1 x USB (B) 1 x Ethernet 1 x Serial (RS232) Using a traceable homogenous sample under laboratory conditions at 20 C 42

43 RFM300-T Features RFM300-T Series New Opportunities! -High resolution capacitive touchscreen -Wide beam optics range 1.32 to 1.58 RI -Peltier Temperature Control -Enhanced Brix performance 0-30 ±0.01 Brix - Flattest Easy Clean prism -SMART temperature control -Dual Display function for Brix & equivalent SG for beverages 43

44 RFM300-T & RFM300-M - Application Scope RFM300-M/T wide beam optics and flat prism Suitable for harsh industrial applications Beverage Sauces & soups Confectionery Sugar syrups & concentrates Edible Oils Industrial surfactants & emulsions 44

45 RFM900-T Refractometer Series RI Kalrez gasket Pharma & Petro 45

46 RFM900-T Features RFM900-T Series New Opportunities! -High resolution capacitive touchscreen -Wide range 1.30 to 1.70 RI -Peltier Temperature Control -Up to 6 decimal places RI -Easy clean prism -SMART temperature control 46

47 RFM900-T Measurement Specification Model RFM960-T RFM970-T Scale Brix, RI & user Brix, RI & user Range Brix RI Brix RI Resolution 0.1 / / (Selectable to 6 d.p.) Accuracy 0.1 / / Precision (Reproducibility*) 0.05 Brix RI Brix RI (6 d.p. RI) Reading time 4 seconds minimum (dependant on precision required) Working Temp Range 0 C or 10 C below ambient whichever is greater to 80 C Automatic Temp Comp User Scale Library Brix, User (to any C) 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3), PHR-MEAN, Urea and more; plus customer programmable user scales via PC. Interface 3 x USB (A) 1 x USB (B) 1 x Ethernet 1 x Serial (RS232) Using a traceable homogenous sample under laboratory conditions at 20 C 47

48 RFM900-T - Application Scope RFM900-T - very wide measuring range - RI and Temperature Suitable for high end laboratory applications Research Institutes & academia Pharmaceuticals incl. veterinarian Healthcare & Cosmetics Petroleum & derivatives Chemicals & Industrial Flavours, Fragrance & Essences 48

49 Why buy an RFM-T/ M Series Refractometer? Capable of six decimal place precision RI (3 d.p. Brix) Peltier temperature control Ergonomically designed so that any spills are dealt with by its sloping shape or by the PEEK spill barrier. High definition full colour capacitive touchscreen RFID user clearance on all models USB & Ethernet connectivity Almost noise free, maintainable fan RFM300-T Series with wide beam optics and flattest easy-clean prism for difficult samples within food, beverage and other harsh industrial applications. Keypad version available (2017) RFM900-T Series wide measuring range RI with Kalrez gasket for use in the chemical, petrochemical, pharmaceutical, flavours & fragrance industries 49

50 What makes a good reading? Sample Type Experimental Protocol Sample Preparation QUALITY MEASUREMENT Human Interaction (Care) Instrument Capability Instrument Setup Interpretation 50

51 Jan 2017 Certified Reference Materials Product Training

52 CRM Verification & Calibration Bellingham + Stanley A UKAS accredited calibration laboratory No A UKAS accredited testing laboratory No

53 CRM - ILAC-MRA Statement The United Kingdom Accreditation Service (UKAS) is one of the signatories to the International Laboratory Accreditation Co-operation (ILAC) Arrangement for the mutual recognition of calibration certificates. This means your local accreditation body accepts UKAS certification as if it were it s own! This is very powerful in terms of persuasion! 53

54 CRM Commercially Available Samples Water & 0.00 Brix Sugars Range 5-60 Brix Oils Range Brix (1.46 to 1.56RI) AG Fluids Brix (1.334 to 1.40RI) Solid Materials* glass, silica *Not recommended for digital instruments 54

55 CRM Example Certificate of Calibration (AG40) 55

56 Thank you for your attention Any questions?.

57 Coffee Break

58 2017 Polarimeters

59 Polarimeters - Past and Present.. 59

60 Polarimeter Principle D = dextrorotatory (right hand or clockwise) Light source Polariser L = Laevorotatory (left hand or counter clockwise). Tube (sample) = angle of rotation Analyser Eye 60

61 Polarimeter Scales Chemical and Pharmaceutical Industries - Angular Scale ( A) % Concentration Sugar and Food Industries - International Sugar Scale ( Z) Purity % Inversion % Invert Sugar % Concentration 61

62 Temperature Optical Rotation is affected by temperature Typically 20 C is used when measuring optical rotation in Europe (25 C USP) Normally samples are stabilised at the required temperature of measurement before analysis Or special temperature controlled tubes are used 62

63 ADP High Resolution / Security Polarimeter 63

64 ADP450- Patented XPC Technology XPC Technology - Xylem s patented on-board Peltier temperature control system 64

65 ADP430 / 450 Accuracy Accuracy Resolution Reproducibility Angular ( A) ± ±0.002 Sugar ( Z) ±0.03 ±0.001 ±0.006 Validation Documentation (IQ/OQ/PQ) 65

66 Software Quality Management Meeting the requirements of FDA (21 CFR Part 11)*, GLP, ISO... Date and Time Recording Product and Operator Identifiers (Audit Trail*) Reading Log (not available to highest level of security) Calibration Log (Audit Trail*) Calibration Check and Report PIN Password Control (in accordance with 21 CFR Part 11*) 66

67 ADP 430 / 450 Methods Similar to RFM900 Series Rapid configuration Specific Rotation & Concentration Methods % Invert Sugar & % Inversion (start finish) Methods Pharmaceutical MEAN Method RFID User Clearance & Tabular navigation thru audit logs 67

68 Standard Display A METHOD system is available in place of the standard MODE function by internal software switch! 68

69 Specific Rotation 69

70 Reading mode options 70

71 ADP 430 / 450 Advantages HIGHEST SPEC POLARIMETER competes with. LOWEST price 3-decimal polarimeter in market ADP450- Patented XPC Technology CONFORMS to minimum requirements of EP/USP/BP/JP CONFORMS to technical requirements 21 CFR Part 11 CONFORMS to technical requirements of ICUMSA HIGH SALES POTENTIAL 71

72 Why buy the ADP430 / 450 ADP450- Patented XPC Technology. Peltier temperature control with easy to fit tubes. New Single or Continuous Read Mode Quick identification of drift, bubbles or erroneous results Specific / Concentration Calculation reduces risk of user error faster than manual calculation Connection capabilities ensure instrument is ready for future lab Storing results / batch / User ID improving results + traceability Above 5 A it matches performance of many high end competitors! 72

73 ADP 600 Series Polarimeter 73

74 Our Models.. ADP600 Series New Opportunities! 74 -High Resolution 4 decimals -High Accuracy 3 decimals -Multiple Wavelength 6 options (UV/Vis) -Peltier Temperature Control -HD Touch-screen display -Latest Technology Communications

75 ADP600 USP Nomograms NOT at 589nm Nomogram Wavelength Acceptance (Specific Rotation) Metyrosine 546nm Iopamidol 436nm Saquinavir Mesylate 436nm Finasteride 405nm Lisinopril 405nm Metaraminol Bitartrate 405nm Methydopate Hydrochloride 405nm Timolol Maletate 405nm Indinavir Sulfate 365nm Physostigmine 365nm Ropivacaine Hydrochloride 365nm Vidarabine 365nm Dextromethorphan Hydrobromide 325nm 1%* 1%* 75

76 Polarimeter Selection Guide TEMP Accuracy 589nm Wavelength Model Peltier ±0.02 ±0.01 ± nm 365nm 405nm 436nm 546nm 589nm ADP430 ADP450 ADP610 ADP620 ADP622 ADP640 ADP650 ADP660 76

77 ADP600 Peltier Performance Sample Temp Set Temp Stabilisation Time 35 C 20 C 4 minutes 5 C 20 C 5 minutes 22 C (ambient) 20 C 2 minutes 77 The speed and efficiency of the Peltier system enables the set point temperature to be reached in the quickest time possible, typically within two minutes for a 10ml sample in a glass tube at or around ambient temperature. Above are the extremes! Read More! FAQ-ADP-029 Don t forget pharmacopeia only requires an accuracy/stability to ±0.5 C

78 Touchscreen Display.. - Display (Graphic User Interface) - High definition 7.4 touch-screen x 800 pixel LED - Backlit LCD - Clearly defined - Colour coded menu structure - Easy to use - Sharp contrast - Finger and Glove friendly 78

79 Communication & Connections -Ethernet connection for LAN -USB (A) x 4 -USB B connection x 1 -RS232 serial x 1 - (cables not supplied generally available) 79

80 Our Models.. ADP600 Series Polarimeters: - ADP600 Models, Wavelengths & Order Codes - ADP610 = 589nm (order code 37-61) - ADP620 = 546 & 589nm (order code 37-62) - ADP622 = 365 & 589nm (order code 37-63) - ADP640 = 405, 436, 546 & 589nm (order code 37-64) - ADP650 = 365, 405, 436, 546 & 589nm (order code 37-65) - ADP660 = 325, 365, 405, 436, 546 & 589nm (order code 37-66) 80 - Additional wavelengths can be added at point of order (not retrospectively)

81 Common Features.. Measurement Specifications - Scales = Angular degrees + user definable (see below) - Ranges = ±89 (-355 to +355 Angular - via Method selection) - Resolution = 0.001/ Angular (Specific Rotation , concentration via Method selection) - Reproducibility = Angular - Accuracy = ±0.003 Angular - Other scales/methods - User definable scales via Methods for Specific Rotation, Concentration, Inversion (A-B) etc. Batch MEAN Method for Pharmacopoeia and GLP - Automatic Temperature Compensation (ATC) = None, sugar (ICUMSA), quartz, user defined - Reading Time (seconds) = (range specific) - Working Temperature Range = 15 to 35 C - Interface = 4 x USB (A), 1 x USB (B), 1 x RS232 1 x Ethernet - Ambient Humidity Range = <90% RH 81

82 Why buy an ADP600 Series Polarimeter? 82 Meets ALL requirements of Pharmacopeia (BP/EP/USP/JP) UV/Vis capability 325nm offered only by 2 others! (RESEARCH) Air Peltier System Allows the customer to use ANY tube Connections on the side Easy Access PDF / external print capabilities Option to upgrade wavelengths at a later date Designed for easy maintenance customer able to change lamp with no training Facilitates operation in FDA controlled environment (21 CFR Part 11) Un-paralleled technical support from B+S Over all it s EASY to use

83 Jan 2017 Certified Reference Materials Product Training

84 CRM - ILAC-MRA Statement The United Kingdom Accreditation Service (UKAS) is one of the signatories to the International Laboratory Accreditation Co-operation (ILAC) Arrangement for the mutual recognition of calibration certificates. This means your local accreditation body accepts UKAS certification as if it were it s own! This is very powerful in terms of persuasion! 84

85 CRM Commercially Available Samples Water & 0.00 Brix Sugars Range 5-60 Brix Oils Range Brix (1.46 to 1.56RI) AG Fluids Brix (1.334 to 1.40RI) Solid Materials* glass, silica *Not recommended for digital instruments 85

86 CRM Polarimeters & Saccharimeters Sugar 100 Z point (34 A) Quartz Plates: 15 Z (5 A), 100 Z (34 A), -30 Z ( A) Thermal Block for temp. sensor Quartz Compensation Infinite Shelf Life (typically 3-year check) Traceable to PTB UKAS Certificate Code (589.44nm) UKAS Certificate Code (other wavelengths)

87 CRM Polarimeters & Saccharimeters NEW multi pack of QCP plates, can hold up to 3 quartz control plates. Certification can be carried out from 546nm to 900nm.

88 Thank you for your attention Any questions?.