Wearable Technology for CB Exposure Monitoring

Transcription

1 Wearable Technology for CB Exposure Monitoring Christian Whitchurch DTRA J9-CBA, Chief Scientist Distribution Statement A: Approved for public release; distribution is unlimited.

2 About Us The Defense Threat Reduction Agency (DTRA) is a combat support agency of the U.S. Department of Defense, founded in 1998, headquartered at Fort Belvoir, Virginia. DTRA includes 2,000 military and civilian personnel located around the world.

3 DTRA mission To safeguard the US and its Allies from Weapons of Mass Destruction (Chemical, Biological, Radiological, and Nuclear) and High-Yield Explosives by providing capabilities to reduce, eliminate and counter the threat, and mitigate its consequences Chemical Biological Radiological Nuclear High-Yield Explosives

4 Chemical and biological threats Chemical Traditional chemical warfare agents (e.g., nerve agents, vesicants) Toxic industrial materials and toxic industrial chemicals Emerging and non-traditional agents Biological Traditional biological threat agents (e.g., anthrax and ebola) Emerging diseases (e.g., pandemic flu, SARS) Enhanced threats (genetically engineered or especially virulent)

5 Current Issue Context Current front line for biosurveillance is at the diagnostician Insufficient cue for deploying Dx tools prior to overt symptoms S&T Challenge Gain warning of threat exposure prior to onset of mission disruptive symptoms. Stop relying/waiting on sickness to present itself Result to the Warfighter Deploy MCMs sooner, save lives, complete mission Potentially change tactics/operations Move the frontline of BSV to the left, giving the clinician more time and information.

6 Evolution of Wearable GPS 1980->2015 ECG 1911->2015 Glucose 1945->2015

7 Program Goal Way Ahead Goal: A suite of wear-and-forget sensors to provide warning of threat exposure prior to acute symptoms Result: Preserved force strength through force protection Not a specific diagnostic, but rather a cue for reflexive testing, trigger not confirmation You have drifted off your baseline immuno profile, recommend seek care before symptoms arise. Your vitals/chemistry are shifting consistent with toxic chem exposure, recommend immediate masking and evaluate surroundings. Fills gaps in existing and planned near/mid term environmental CB detection systems to broaden the range of threats addressed and prevent surprise

8 Proposed Strategy Leverage advances in wearable sensor technology to increase survivability to CB events by maximizing early warning and thereby enabling informed, time sensitive decisions. Host based Mission (risk) adaptive Truly threat agnostic Intentionally non-specific (Sick vs. Healthy)

9 FOUO Why would we expect to see something? FOUO

10 USAMRIID: Leading DoD Infectious Disease Research US Army Medical Research Institute for Infectious Disease Ft. Detrick, MD Vaccine R&D at USAMRIID Marburg & Ebola Virus USAMRIID Core Competencies Biological agent research: e.g. vaccines Safety, security and surety standards Medical countermeasures Training and education Rhesus & Cynomolgus Macaque models* Implantable Telemetry USAMRIID-MITLL Collaboration World class respective subject matter expertise RIID has provided MITLL a uniquely detailed and rich dataset *Species noted for physiological similarity to humans Presymptomatic Diagnosis- 9 MITLL Marburg Virus: Centers for Disease Control and Prevention's Public Health Image Library #275

11 Temperature (C) Early Warning Suggested by Obvious Anomalies Heart Rate (beats per minute) Temperature Current Diagnosis Point: Fever (~4 Days) Heart Rate Time (Days from Infection) Change in Heart Rate Diurnal Pattern Time (Days from Infection) Presymptomatic Diagnosis- 10 MITLL

12 P(infected) Combined ECG metrics Initial Results Subject mglp004 Mean Score Moving Average Mean Score Mean Score Fever Time (Days from Challenge) Time (days) Presymptomatic Diagnosis- 11 MITLL

13 Potential Key (low n) USAMRIID & MIT-LL study shows physiological markers for bio infection hours prior to onset of fever (Ebola & Marburg). Known physiological markers for chemical exposure may be exploitable through non-invasive individual monitoring in concert with existing environmental monitors. Wearable sensors for wide range of CB relevant host based targets; vision offered by COTS wearable biosensors as developed primarily for diabetes market Current Dx tools are point measurements in time. Persistent monitoring provides new data rich stream, including change and rates of change.

14 FOUO More markers? Gait, cough, GI sounds,.? Cognitive, eye tracking,? What else? FOUO

15 Informing Decisions PPE Risk awareness Early drug delivery Quarantine Force readiness Long term health/performance monitoring Triage 14

16 Interest and Opportunity Operational interest Expressed: USMC, SOCOM, PM Soldier, MSCoE Tech Transition interest JHRM JPM CA JPM MCS IEW ATD, JCACS ATD OGA interest Expressed: NIH, NSF, HHS, DHA, NASA, IARPA Industry alignment Expressed: (stack of proposals source selection sensitive) DoD Flexible Hybrid Electronics Initiative demo platform goal #1: Human Monitoring Systems International teaming: UK, and AUS strong advocates.

17 The really hard questions Warfigher relevance COEs, PORs Technical possibility Development timeline Cost Calendar Legal acceptance Social acceptance Cross agency & international partnership Industry alignment

18 POC Christian Whitchurch