G3Lab Universal SmartGlass Bioreactor System

Transcription

1 Data File #807-DST-001-Rev1 G3Lab Universal SmartGlass Bioreactor System Next generation development platform with intelligent control Scale Available in 1L, 2L, 5L, and 10L for research or process development Measure Obtain real-time ph, DO, and temperature measurements Adjust Select the best configuration for optimal results Reproduce Easily set up and store parameters with TruBio software Trust Rely on USP Class VI / traceable and certified wetted materials

2 The SmartGlass Bioreactor System At Finesse, our goal is to enable customers to quickly and efficiently manufacture innovative drugs and vaccines. The SmartGlass, SmartSensors, and SmartParts combination brings next generation control and measurement to glass bioreactor applications. A SmartGlass vessel is controlled by either a G3Lab or G3Pro Universal SmartController and Finesse TruBio software. This turn-key package provides a complete solution for research, process development, or seed train production applications. Benefits Compatible with most cell culture or fermentation applications Controlled environment for optimal growth Short set-up time Plug-and-play with Finesse Universal SmartControllers Powered by TruBio software Standard service packages cgmp capable Capabilities Measurement and control of critical process parameters: ph Dissolved Oxygen Temperature Agitation Accurate gas control with mass flow controllers Sophisticated feeding strategies using up to four SmartPumps Finesse SmartGlass Bioreactor Vessel Optional scales for weight control Novel impeller design for superior mixing

3 TrupH Electrodes TruDO Optical and TruDO G3Lab Universal Bioreactor Controller with a TruFlow Gas Manifold TruBio Software Screens SmartGlass Vessels Designed for R&D and process scale-up, the Finesse SmartGlass family allows end users to design a system that optimizes the cell growth environment. The cold loop provides more rapid and even cooling than the traditional cold finger. The novel impeller design provides superior mixing without damage to cells. And the sensor holders allow sensors to be placed and sealed with a simple twist. Sterilizable TruSensors Finesse SmartGlass uses the TrupH and TruDO sterilizable sensors, which provide superior reliability and stability. The TrupH sensor is also available with an integral temperature sensor, for more accurate temperature compensation. The TruDO sensor is available in either the standard or the optical design. Both offer solid performance and superior reliability, and are fully compatible with the TruSens transmitter blade. Universal SmartControllers G3Lab systems control bench top single-use or sterilizable bioreactors (up to 20L), and rockers (up to 50L). The system consists of a utility tower and a TruFlow gas manifold. G3Lab controllers minimize footprint while maximizing process flexibility. By leveraging the same industrial automation components as the G3Pro, G3Lab systems enable fully traceable cgmp process scale-up and scale-down in the laboratory environment. TruBio Software Choose the preferred control platform (DeltaV or μc) based on your application. In both cases, TruBio software enables the user to create a process flow without the need for complicated programming. Finesse provides full support for system configuration, documentation, and / or validation.

4 G3Lab Universal SPECIFICATIONS Utility Tower Dimensions (H W D) Enclosure Rating Operating Temperature Storage Temperature Relative Humidity Certifications Weight / Shipping Weight Agitation ph Dissolved Oxygen (DO) Temperature Foam Level Liquid Control Cold Finger Solenoid Gas Control Scales / Balances Auxiliary Digital Input Digital Output Thermal Control External Pumps ph Cables DO Cables Agitator Heater Glass Vessels x 240 x mm (17.3 x 9.5 x 19 inches) NEMA2 5 40ºC ( F) C ( F) 5% 95% non-condensing CE: EN-60101, and EN Kg / 21.4 Kg (31 lb. / 47 lb.) Finesse SmartMotor Controller Glass Vessel Agitator TruSens Transmitter (Electrochemical Sensors) TruSens Transmitter (Electrochemical Sensors) TruSens Transmitter (RTD) Conductivity Input Four (4) variable-speed peristaltic SmartPumps, Watson-Marlow 114 series Digital Solenoid Valve Standard (DV/PC) Four (4) MFCs Standard (DV/PC) Eight (8) solenoid valves Optional (DV) Six (6) MFCs and Eighteen (18) Solenoid Valves Analog Input via Scale Port Seven (7) Analog Inputs and Four (4) Analog Control Loops Two (2) 24V DC Two (2) Dry-Relay Contacts Heater Blanket, Chilled Water Source Two (2) Watson-Marlow Pumps on a Finesse Pump Tower K8, VP D4, VP6, VP8 Finesse IEC-5 15 Receptacle 1 20 L Standard Cover Color Options* Blueberry Tangerine Raspberry Lime Sterling Silver Stainless Steel *Additional and custom colors are available at an additional charge and longer lead times. The color swatches represented here are from photos of G3Lab Universal Covers. These printed colors may vary from actual product color.

5 SmartGlass SPECIFICATIONS Vessel Size 1L 2L 5L 10L Length mm / inches 205 / / / 15.2 Width mm / inches 110 / / / 6.7 Inner diameter mm / inches 100 / / / 6.3 Volume (L) Total Working Minimum Working Wetted material Borosilicate Glass, SS316L, Silicone SmartGlass Accessory Kits Cell Culture Accessory Kit Qty Fermentation Accessory Kit Qty Air Overlay Assembly 1 Impeller, Marine, 3-Blade 1 Impeller, Rushton, 6-blade 1 Microsparger Assembly, Frit 1 Accessories Kit, Mammalian Cell Culture, 3L Vessel 1 Baffle Assembly 3 Condenser 1 Impeller, Rushton, 6-blade 2 Macrosparger Assembly, L-Pipe 1 Accessories Kit, Microbial Fermentation, 3L Vessel 1 Common Accessory Kit Qty 12mm Port Assembly 3 Septum Port Assembly 1 Triple-Inlet Port Assembly 1 Fixing Screw Assembly, M8 4 Open-Pipe Sparger 1 Macro/Microsparger Pipe Assembly 1 Foam/Level Sensor Port Assembly 1 Sample Port Pipe Assembly 1

6 Toll free Finesse Solutions, Inc. Europe Asia-Pacific Tel Global Headquarters Via Sogn Gieri 27a 3A Intl Business Park, #07-08 Fax Leonard Court CH-7402 Bonaduz, Tower A Santa Clara, CA Switzerland Singapore sales@finesse.com USA Every effort has been made to ensure the accuracy of the information in this document. However, Finesse reserves the right to change its products without notice. The following are Finesse Solutions, Inc. trademarks: TruView, TruBio, TruService, TruTorr, TruFluor, TruLogic, TruConnect, TruMigrations, TruCables, TruHousings, SmartGlass, SmartRocker, TruDO, TrupH, SmartFactory, SmartChip, SmartSystems, SmartBag, SmartPuck, SmartReader, SmartBag Reader, SmartTray, SmartController, SmartSensor , Finesse Solutions, Inc.