COURSE GUIDE UNIVERSIDAD CATÓLICA DE VALENCIA PLANT AND ANIMAL BIOTECHNOLOGY 3º Course - BIOTECHNOLOGY DEGREE

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1 1 COURSE GUIDE UNIVERSIDAD CATÓLICA DE VALENCIA PLANT AND ANIMAL BIOTECHNOLOGY 3º Course - BIOTECHNOLOGY DEGREE Year

2 2 COURSE GUIDE ECTS SUBJECT: Plant and Animal Biotechnology 6 Field: Plant and Animal Biotechnology 6 Module: Bioengineering and Biotechnological Processes 36 Type of learning: Obligatory Professor: Carmen Fagoaga García Juan Carlos Gardón Poggi COURSE: 3 Semester: 2º Department: Applied and Technological Sciences carmen.fagoaga@ucv.es jc.gardon@ucv.es MODULE ORGANIZATION BIOENGINEERING AND BIOTECHNOLOGICAL PROCESSES 36 ECTS Duration and temporal location within the curriculum: The Module is structured in 6 fields and 6 subjects, taught within the 1º semester of the 3º year and the 1º semester of the 4º year. During this Module the student acquires the basic knowledge of biological and biotechnology processes that will be needed for a future professional development. Subjects and Courses Subject ECTS Courses ECTS Course/ semester PLANT AND ANIMAL BIOTECHNOLOGY 6 PLANT AND ANIMAL BIOTECHNOLOGY 6 3/2 BIOREACTORS 6 BIOREACTORS 6 3/2

3 3 BIOCHEMISTRY ENGINEERING 6 BIOCHEMISTRY ENGINEERING 6 3/1 GENETIC ENGINEERING 6 GENETIC ENGINEERING 6 3/2 CELL CULTURE 6 CELL CULTURE 6 3/2 BIOTECHNOLOGICAL PROCESSES AND PRODUCTS 6 BIOTECHNOLOGICAL PROCESSES AND PRODUCTS 6 4/1 COURSE GUIDE TO THE SUBJECT: PLANT AND ANIMAL BIOTECHNOLOGY Prerequisites: Courses of Animal and Plant Biology, Molecular Genetics, Animal Physiology and Plant Physiology GENERAL GOALS As a result of this course the students will: 1. Know in detail the methods and techniques used in plant biotechnology. 2. Know the global status of commercialized Biotech/GM crops. 3. Reason about the environmental and social impact of transgenic crops. 4. Use the main laboratory techniques in in vitro plant tissue culture and know the current methodology used in plant genetic transformation. 5. Know how to program and develop an experiment for transgenic crop detection. 6. Know in detail the methods used in biotechnology and animal breeding in order to obtain knowledge, products, goods and services, primarily in the area of human and animal health. 7. Know the basis for the application of biotechnology to animal breeding. 8. Reason about ethics, morality and the impact of biotechnologies applied to animal production. 9. Know the particular importance of animals as models for biomedical research 10. Learn skills needed to enter the world of research such as the capacity for teamwork and self-criticism.

4 4 BASIC, GENERAL, CROSS-SECTIONAL AND SPECIFIC COMPETENCES Competence measuring scale GC01. Capacity to analyze and synthesize CB1-Students acquire and understand knowledge in their field of study based on general secondary education but usually reaching a level that, although supported on advanced text books, also includes aspects involving state-of-the-art knowledge specific to their area. CB2-Students are able to apply knowledge to their work in a professional way and have the competences enabling them to state and defend views and opinions as well as perform problem-solving tasks in their field of study. CB3-Students are able to collect and interpret relevant data (generally in their field of study) and give opinions that involve reflection on relevant social, scientific or ethical issues. CB4-Students can communicate information, ideas, problems and solutions to a specialized or non-specialized audience. CB5-Students develop the necessary learning skills to undertake further studies with a high level of autonomy. CT02. Capacity to organize and plan CT03. Mastering Spanish oral and written communication

5 5 CT05. Knowing and applying Basic ITC skills related to Biotechnology. CT06. Capacity to manage information (capacity to look for and analyze information coming from different types of sources) CT07. Problem solving CT09. Capacity to work in interdisciplinary and multidisciplinary team CT10. Interpersonal skills CT12. Critical and self-critical capacity CT13. Ethics CT14. Capacity to learn CT16. Capacity to produce new ideas (creativity) CT17. Leadership abilities CT18. Taking initiatives and enterprising spirit CT19. Capacity to apply theoretical knowledge CT20. Research skills CT21. Sensitivity to environmental issues

6 6 CE22. Knowing and understanding contents, principles and theories related to biotechnology CE23. Knowing how to use laboratory equipment and to carry out basic operations for each discipline including: safety measures, handling, waste disposal and activity register CE24. Knowing basic and instrument laboratory techniques in the different areas of biotechnology. CE25. Knowing how to analyze and understand scientific data related to biotechnology CE27. Knowing and applying action plans and assessment criteria of biotechnology processes CE28. Integrating life science and Engineering into processes of development of biotechnological products and applications CE29. Contrasting and checking results of biotechnological experimentation CE30 Solving and analyzing problems posed by biotechnology CE31. Describing and calculating important variables of processes and experiments CE32. Knowing how to use different specific operating systems and software packages designed for Biotechnology CE33. Knowing and complying with legislation and ethics of biotechnological processes and applications CE34. Knowing main characteristics of molecular biosciences and biotechnology communication

7 7 LEARNING OUTCOMES COMPETENCES R-1 Students have understood and acquired the subject s contents. R-2 Students are able to solve problems or cases related to those contents by using various resources (literature, computer-based, etc.) R-3 Students are able to work and correctly perform basic activities in a lab in compliance with the relevant safety requirements. They can plan, develop and understand the purpose for the experience as well as contrast and validate the results obtained R-4 Students are able to write a clear and well-organized text on diverse aspects of the subject. CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT06, CT12, CT14, CT19, CT20, CE22, CE25, CE28 CG01, CB2, CB3 CB4, CT02, CT03, CT05, CT06, CT07, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE28, CE30, CE31, CE32, CE33 CG01, CB5, CT02, CT05, CT07, CT09, CT10, CT12, CT13, CT14, CT16, CT19, CT20, CT21, CE23, CE24, CE25, CE27, CE28, CE29, CE30, CE32, CE33, CE31 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT16, CT18, CT20, CT20, CE25, CE34 R-5 Students are able to adequately present and defend their work. R-6 Students seek bibliographic information from several sources and can analyze it with a critical, constructive attitude. CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT16, CT18, CT20, CT20, CE25, CE34 CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT12, CT14, CT16, CT18, CT20, CE25, CE31, CE32, CE34 R-7 Students cooperate with the teacher and peers throughout the learning process. They can work as members of a team. They are respectful, proactive and comply with the subject s organizational rules. CT09, CT10, CT12, CT13, CT16, CT17, CT18

8 8 ON-CAMPUS EDUCATIONAL ACTIVITIES ACTIVITY ON-CAMPUS CLASS PRACTICAL CLASSES LABORATORY SEMINAR GROUP PRESENTATION OF PAPERS OFFICE ASSISTANCE ASSESSMENT Teaching-Learning Methodology Teacher presentation of contents, analysis of competences, explanation and in-class display of skills, abilities and knowledge. Relationship with learning outcomes for the subject R-1, R ECTS 5 Group work sessions supervised by the professor. Case studies, diagnostic tests, problems, field work, computer room, visits, data search, libraries, on-line, Internet, etc. Meaningful construction of knowledge through interaction and student activity. R-3, R-4, R Activities carried out in spaces with specialized equipment. R-1, R-2, R-3, R Supervised monographic sessions with shared R-1, R-4, R-5 participation 0.16 Application of multidisciplinary knowledge Personalized and small group attention. Period of instruction and/or orientation carried out by a tutor to review and discuss materials and topics presented in classes, seminars, readings, papers, etc. Set of oral and/or written tests used in initial, formative or additive assessment of the student R-5, R R-1, R-2, R R-1, R-2, R-3, R-4, R-5, R-6, R Total The subject and/or course is organized ON-CAMPUS EDUCATIONAL ACTIVITIES and INDEPENDENT WORK ACTIVITIES OF STUDENT, with an estimated in ECTS. Proper distribution is as follows: 35-40% for ON-CAMPUS EDUCATIONAL ACTIVITIES and 65-60% INDEPENDENT WORK ACTIVITIES OF STUDENT. (For a course of 6 ECTS: 2.4 and 3.6 respectively). The teaching-learning methodology described in this guide in a generic way, shape in the lesson plans in which the subject and / or course is organized.

9 9 INDEPENDENT WORK ACTIVITIES ACTIVITY GROUP WORK INDEPENDENT WORK Teaching-Learning Methodology Group preparation of readings, essays, problem solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. Work done on the university e- learning platform ( ) Student study: Group Individual preparation of readings, essays, problem solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. Work done on the university e- learning platform ( ) Relationship of Course with Learning Outcomes ECTS R-1, R-2, R-3, R-4, R-5, R-6, R R-1, R-2, R-3, R-4, R-5, R-6, R Total 3.6 SYSTEM FOR ASSESSING THE ACQUISITION OF THE COMPETENCES AND ASSESSMENT SYSTEM Assessment Tool LEARNING OUTCOMES ASSESSED Allocated Percentage Written test* R-1, R-2, R-3, R-4 70 Laboratory practical test ** R-6, R-8, R-9, R-10, R-11 15

10 10 Group work presentation and additional activities (laboratory report**.) R-1, R-2, R-3, R-4, R-5, R-6, R-7 15 * There will be a written test for each of the didactic units. Both should be passed with a minimum of 5/10 to be able to pass the whole course. It is also necessary that students take at least 2.5 in each of the didactic units of the subject to pass the theory test. ** A minimum of 5/10 is required for each of the laboratory papers and additional tasks to be able to pass the whole course. The attendance to the laboratory practice sessions is mandatory and essential to be able to evaluate the practical part of the subject. In all the written evaluations carried out in the subject, the spelling will be taken into account, so that for each misspelling (including tildes), 0,1 points will be subtracted from the final mark of the test until a maximum of 2 points. This rule will apply except in mobility students Additional assignments can be proposed to upgrade the final mark to a maximum of 1/10 points. MENTION OF DISTINCTION: The mention of Distinction will be awarded to students who have achieved a score equal to or greater than 9.0. The number of Distinctions granted will not exceed 5% of students enrolled in a subject in the corresponding academic year unless enrollment is under 20, in which case only one Distinction may be granted (Royal Decree 1125/2003). DESCRIPTION OF CONTENTS COMPETENCES DIDACTIC UNIT 1 - ANIMAL BIOTECHNOLOGY Chapter 1. Introduction to Animal Biotechnology Chapter 2. Drosophila: A Model for Biotechnologists Chapter 3. Animal Models for Human Diseases Chapter 4. Transgenic Animals Chapter 5. Applications of Transgenic Animals Chapter 6. Cloning and Stem Cells Chapter 7. Biotechnology of animal reproduction Chapter 8. Aquatic animals model in biotechnology research and its applications Laboratory Sessions: 1. In vitro fertilization. (5 sessions). CG01,CT02,CT03, CT05,CT06, CT07, CT10,CT12,CT13,CT14, CT16, CT17, CT18,CT19, CT20, CT21, CE22,CE23,CE24, CE25, CE27,CE28, CE29,CE30, CE31,CE32, CE33,CE34

11 11 DIDACTIC UNIT 2 - PLANT BIOTECHNOLOGY Chapter 1. Introduction to Plant Biotechnology Chapter 2. Plant genomes Chapter 3. Methods I: In vitro plant tissue culture Chapter 4. Methods II: Plant genetic transformation techniques Chapter 5. Methods III: Vectors, markers and promoters in plant genetic transformation Chapter 6. Methods IV: Analysis and detection of transgenic plants Chapter 7. Transgenic Crops Chapter 8. Legal and environmental considerations: class assignment to be prepared by groups. CG01, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT16, CT17, CT18, CT19, CT20, CT21, CE22, CE23, CE24, CE25, CE27, CE28, CE29, CE30, CE31, CE32, CE33, CE34 Laboratory sessions: 1. In vitro tissue culture (2 sessions) 2. Detection of transgens in plant food sources (3 sessions) REFERENCES ANIMAL BIOTECHNOLOGY Verma A. & Singh A. ANIMAL BIOTEHCNOLOGY, MODELS IN DISCOVERY AND TRANSLATION, 1st Edition, Elsevier Science and Technology, 2014 Clark, D. & Pazdernik N., BIOTECHNOLOGY, 2nd edition, Elsevier Science and Technology, 2016 Pariera-Raja, F. ANIMAL BIOTECHNOLOGY, Wisdom Press, 2013 Houdebine, L.-M. ANIMAL TRANSGENESIS AND CLONING. Wiley, Bishop, J. TRANSGENIC MAMMALS. Longman, Strigfellow DA and SM Seidel (Eds), MANUAL OF INTERNATIONAL EMBRYO TRANSFER SOCIETY. Edition Savol, IL IETS. Gustavo A. Palma. BIOTECNOLOGÍA DE LA REPRODUCCIÓN. Agro-Veterinaria. A.A. Mackenzie. PLICACIONES DE LA BIOTECNOLOGÍA EN LA SANIDAD Y LA PRODUCCIÓN ANIMAL. OIE. Mutto A., Mucci, N. Kaiser, G. BIOTECNOLOGÍA APLICADA A LA REPRODUCCIÓN Y MEJORAMIENTO ANIMAL. Editorial Académica Española, 2011 Thieman, WJ, Palladino, MA. INTRODUCCION A LA BIOTECNOLOGIA 2º Edición, Ed. Pearson, 2010

12 12 PLANT BIOTECHNOLOGY Benítez Burraco, A. AVANCES RECIENTES EN BIOTECNOLOGIA VEGETAL E INGENIERIA GENETICA DE PLANTAS (2005) Ed. Reverté García Olmedo, F. LA TERCERA REVOLUCIÓN VERDE (1998). Ed. Temas de Debate Renneberg, R. BIOTECNOLOGIA PARA PRINCIPIANTES (2008). Ed. Reverté Seidman, LA, Moore, CJ. BASIC LABORATORY METHODS FOR BIOTECHNOLOGY, 2ºED (2009), Ed. Pearson Slater, A., Scott, N., Fowler, M. PLANT BIOTECHNOLOGY: THE GENETIC MANIPULATION OF PLANTS (2008). Oxford University Press Stewart, N. PLANT BIOTECHNOLOGY AND GENETICS: PRINCIPLES, TECHNIQUES AND APPLICATIONS (2008). Wiley Thieman, WJ, Palladino, MA. INTRODUCCION A LA BIOTECNOLOGIA 2º ED (2010). Ed. Pearson. Seguí Simarro, J.M. BIOTECNOLOGÍA EN EL MENÚ. Manual de supervivencia en el debate transgénico (2013) Publicaciones de la Universidad de Valencia.

13 13 TEMPORAL ORGANIZATION OF LEARNING: THEORETICAL: CONTENT/TEACHING UNIT Nº OF MEETINGS 1 ANIMAL BIOTECHNOLOGY 15 2 PLANT BIOTECHNOLOGY 15 PRACTICES: CONTENT/TEACHING UNIT Nº OF MEETINGS 1 In vitro fertilization 5 2 In vitro plant tissue culture 2 3 Detection of transgenes in plant food sources 3 4 Test 1