CURRICULUM VITAE. VINCENT ODUOL OCHIENG, B.Sc., M.Sc., Ph.D.

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1 CURRICULUM VITAE NAMES: VINCENT ODUOL OCHIENG, B.Sc., M.Sc., Ph.D. NATIONALITY: Kenyan CURRENT ADDRESS: Department of Biochemistry University of Nairobi P. O. Box TELEPHONE: ; CAPABILITIES Expertise in using the following techniques: Parasite tissue culture; Parasite in vitro drug assays; Manipulation of DNA and RNA; Molecular Population genetic analysis (RAPDs, RFLP and mtdna); Construction and analysis of cdna libraries; Transfection/transformation of DNA into eukaryotic and prokaryotic cells; Analysis of protein expression and Western blotting; In situ hybridisation; Immunohistochemistry; Immunofluorescence; Prokaryotic and Eukaryotic protein expression; Analysis of proteinprotein interactions; Mammalian tissue culture; Bioinformatics. EDUCATION: 2002: Ph.D. University of Nairobi, Faculty of Medicine (Department of Biochemistry) in conjunction with International Centre of Insect Physiology and Ecology (ICIPE) Molecular Biology, Biotechnology Unit. Thesis topic: Genetic biodiversity in Banana weevil (Cosmopolites sordidus). 1993: M.Sc. University of Nairobi, Faculty of Medicine (Biochemistry Department). Thesis title: Temporal synthesis of Cuticle Proteins During Larval Development of Tsetse Fly (Glossina morsitans morsitans). 1989: B.Sc. University of Nairobi, Faculty of Science (Majoring in Biochemistry and Chemistry) Award: Upper Second Class Honours Degree. 1984: Upper Hill School, Kenya Advanced Certificate of Education. 1982: Sawagongo High School, Kenya Certificate of Education. WORK EXPERIENCE: todate: Lecturer, Faculty of Medicine, Department of Biochemistry, University of Nairobi.

2 : Tutorial Fellow, Department of Biochemistry, University of Nairobi : Graduate assistant, Department of Biochemistry, University of Nairobi : Resident Bio-chemical analyst at TEITA Estate Limited. Personnel management: Managed two laboratory technologists in a world-class laboratory at Institute for Animal Health (U.K). University Teaching and Student supervision: Undergraduates: Involved in giving lectures and practicals to the following: Faculty of Science; BSc. 3 rd year. Bachelor of Medicine. Bachelor of Nursing. Postgraduate: Involved in teaching MSc in the following: a. MSc. Biochemistry. b. MSc. and PhD Molecular Biology and Genetic Engineering. Successfully co-supervised the following MSc. students: a. Fredrick N. Baliraine (University of Nairobi). Genetic variation in two populations of the brown ear Tick, Rhipicephalus appendiculatus in Kenya (1999). b. Eva Oduor (University of Nairobi). Characterization of amino peptidase in midgut of body louse Pediculus humanus humanus (1998). c. Kizito J. Okuru (University of Nairobi). Characterization of body louse, Pediculus humanus humanus midgut proteins recognized by resistant hosts (1996). d. Fatiya Mbarak Khamisi (at JKUAT and ICIPE). Biochemical changes in developing embryo of S. gregaria induced by pheromone produced by oviposing gregaria females. Successfully supervised the following MSc. students: a. Maghanga Samuel Mwandawiro. Isolation and characterization of Actinomyces/yeast glycosidases from Kenyan Soda lakes/hot springs. b. Matina Kyalo Functional genomics of the tsetse/trypanosome interaction c. Jane Akinyi Otadoh. Virulence Efficacy of local Trichoderma isolates as biocontrol argent (BCA) on soil pathogenic fungi. d. Nicholas Kibegwa Makwoworo. Comparative Efficacy Study on Commercially Available Insecticides Against Anopheles Gambiae Currently supervising the following MSc. students:

3 a. Irene Akinyi Omedo. Characterization of Erythrocyte Receptor Polymorphisms in a Malaria Endemic Population in Kilifi, Kenya Committee Serving: A member of University of Nairobi Safety and Health Committee Member, Department of Biochemistry Syllabus review committee. Member, Department of Biochemistry Laboratory manual preparation committee. Examinations coordinating officer for the department of Biochemistry. Coordinator, BSc III Class Coordinator, BSc Nursing 1 Class Member, Faculty of Science Brochure and Publications committee. SCHOLARSHIPS HELD: a) Sponsored by the University of Nairobi to attend two week training on Enviromental Audit (2008) b) Sponsored by the University of Nairobi to attend two week training on Safety and health (2007) c) Awarded DAAD/ Rockefeller Foundation Scholarship to study for Ph.D. ( ) d) Sponsored by the British Council for a 6-month course on the effect of naphthoquinones in Leishmania major, at the London School of Hygiene and Tropical Medicine (1997). e) Sponsored by the Commonwealth Science Council to attend Protein Technology workshop held in the University of Zimbabwe (1996). f) Awarded German Academic Exchange (DAAD) Scholarship to study for M.Sc. ( ). g) Awarded the Kenya Government Scholarship to study for B.Sc. degree at the University of Nairobi ( ). h) Sponsored by the University of Nairobi to attend two week training on Safety and health (2007) CURRENT RESEARCH PROJECTS: 1. A study of the mechanisms of action of naphthoquinones against Leishmania species. This work is part of WHO/Tropical Disease Research Programme supported project to identify and evaluate novel antileishmanial and antitrypanosomal drugs. Secondly, we are trying to understand the mechanism by which these naphthoquinones act against Leishmania, in order to define structure-activity relationships, improve drug design and identify suitable drug combinations. 2. Genetic Biodiversity in Banana weevil, Cosmopolites sordidus populations. 3. Identification of active components in local anti-malarial herbs and their efficacy on P. falciparum infections 4. Functional Genomics of the Tsetse/Trypanasome Interaction

4 LANGUAGES: English, Kiswahili & German MEMBERSHIP: Biochemical Society of Kenya American Society for Microbiology PUBLICATIONS/CONFERENCES: Nicholas K. Makworo, Dorington O.Ogoyi, Richard W. Mukabana, Vincent O. Ochieng. A comparative efficacy study of commercially available insecticides against Anopheles gambiae. (In press) Ochieng V. O, Osir E. O, Gold C and Mulaa F. J. Genetic variation among Banana Weevil populations (Cosmopolites sordidus) form different Banana-growing regions inferred from amplified polymorphism DNA (RAPD) and polymerase chain-restriction fragment length polymorphism. (In press) Ochieng V. O, Osir E. O, Gold C and Mulaa F. J. Genetic variation in Ugandan population of Banana Weevil revealed by random amplified polymorphic DNA. (In press) Ochieng, V. O. (2002). Genetic biodiversity in the Banana weevil. Ph.D. Thesis, University of Nairobi. Ochieng, V. O. (2002). Genetic diversity in banana weevil, Cosmopolites sordidus from different banana growing regions. Presented to: International workshop on Banana weevil held in Tenerife, Canary Islands; February 28 th -3 rd March. Oduol, V.O., Paget, T.A., and Croft, S.L. (1997). Mechanisms of action of naphthoquinones on Leishmania major. Presented to 6th COST/ACRIVAL/IOCD Congress on Antiparasitic Chemotherapy held in Leuven, Belgium, May 14 th - 16 th. Ochanda, J.O., Momcuoglu, K.Y., Ben-Yakir, D., Okuru, J.K., Oduol, V.O., and Galun, R., (1996). Characterization of body louse Pediculus humanus humanus mid gut proteins recognized by resistant hosts. Medical and Veterinary Entomology 10, Olembo, N.K., Nguu, E.K., Ochanda, J.O. and Ochieng, V.O. (1993). Inhibition of blood meal digestion in tsetse fly Glossina morsitans centralis fed on rabbits immunized with tsetse mid gut proteins. East African Medical Journal; Ochieng, V.O., Osir, E.O., Ochanda, J.O., and Olembo, N. K. (1993).

5 Temporal synthesis of cuticle proteins during development in Glossina morsitans. Comparative Biochemistry and Physiology 105B(2), Ochieng, V.O. (1992). Temporal synthesis of cuticle proteins during development in Glossina morsitans. MSc. Thesis, University of Nairobi REFEREES: 1. Dr. E. O. Osir, Chairman, Research Committee and Head, Molecular Biology and Biochemistry Unit, International Centre of Insect Physiology and Ecology, P. O. Box 30772, 2. Prof. F. Mulaa, Department of Biochemistry, University of Nairobi, P. O. Box 30197,