Lombardi Comprehensive Cancer Center. Cancer Informatics Summit 2/21/2013. Subha Madhavan, Ph.D.

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1 Lombardi Comprehensive Cancer Center Cancer Informatics Summit 2/21/2013 Subha Madhavan, Ph.D. Director, Innovation Center for Biomedical Informatics Georgetown University Medical Center Director, Clinical Research Informatics Lombardi Comprehensive Cancer Center

2 Vincent T. Lombardi Famous professional football coach Fell ill at Washington Redskins practice on Georgetown University field Winning isn t everything, it s the only thing. Treated for cancer at Georgetown Cancer Center named in his honor

3 Lombardi At a glance Established in 1970 In 1974, Georgetown Lombardi became the 16th NCI-designated Comprehensive Cancer Center Over $100M in research funding ever year $35M CCSG + peer-reviewed funding base 94 full members; 186 cancer-connected faculty members 4 Research programs & 9 Shared resources 220 ongoing trials

4 Key Accomplishments Development of human papillomavirus (HPV) vaccine to prevent cervical cancer R. Schlegel Discovery of GADD-4 DNA repair gene A. Fornace Nuclear hormone receptor networks in breast cancer R. Clarke Monoclonal antibody therapy L. Weiner

5 General Organizational Structure Director (Weiner) Deputy Director (Atkins) Clinical Care (Marshall) Clinical Research (Giaccone) Population Sciences (Mandelblatt) Basic Research (Wellstein) Minority Health (Campbell) Shared Resources (Byers) Administration (VanderHoek)

6 Administration Another view of the cancer center IAC Director Deputy Dir EAC Community Advisory Council AD Basic/Transl Research Education AD Minority Health AD Administration MO BC CPC ET Shared Resources AD Population Network Representative Trial Oversight AD Clinical AD Shared Resources

7 Georgetown

8 Innovation Center for Biomedical Informatics (ICBI) Faculty 5 Senior staff members 5 Research associates 5 Support staff 2 Consultants 5 Students/Trainees - 2 Expertise in bioinformatics, clinical informatics, biomathematics, biostatistics, clinical genomics, molecular biology, high-throughput molecular assays, enterprise class software development, data management, data security, & project management

9 Informatics Org Chart Cancer Center Director CTSA PI CCSG SR Director Dean of Research ICBI Director Director, Operations Financial Analyst Office Manager Communications/ Scientific writing Highthroughput omics Technology Development Health IT ChemiInformatics Data Coordination & Biocuration Clinical Research Informatics FTEs supporting Cancer Center 8 Total FTEs - 22

10 Informatics Funding $3.5M Total Annual Funding in 2012

11 Lombardi Information Architecture (current & future)

12 Integrated Data Environment: G-DOC Links to Many of Data Silos Pathway Studio Systems biology Literature Cytoscape Visualization networks JMol/Marvin Molecule Visualization JBrowse Genome Visualization G-DOC Ingenuity Analysis Pathways, GO, Variants RedCap Clinical Research Disease Classification Tools EHR s

13 Over 330 registered users from six countries ~250 unique hits/month

14 Making Patients Part of Healthcare Through Technology Innovations

15 Next Generation Sequencing Big Data Analytics on the Cloud Genomic Data De-identified Clinical data PC User Genome Data Amazon S3 Bucket Amazon EC2 Compute Instances G-DOC Web Portal Clinical Data Amazon Glacier Vault MongoDB EC2 Instances Oracle RDS Instance

16 Informatics for Discovery, Clinical Research, Clinical Care omics data analysis EHR/PHR integration Biomarker discovery Disease classification Genotype-Phenotype correlation Biospecimen management and analysis Technology/method development Clinical Research Clinical Education Informatics education Partnerships Joint grants Joint appointments Contracted services Shared resources Medical internships Shared IP Joint publications Basic/Traslational Biospecimen Website : icbi@georgetown.edu

17 Challenges & Opportunities Major Challenges: Diverse set of policies and regulations across participating institutions Lack of resources (human and IT) Multiple clinical & research information silo es Significant Opportunities/Strengths: Technology development Community engagement Test bed for innovation omics methods & integration Collaborations with CTSA