Schering Foundation Workshop 3 Excitatory Amino Acids and Second Messenger Systems

Transcription

1 Schering Foundation Workshop 3 Excitatory Amino Acids and Second Messenger Systems

2 Schering Foundation Workshop Editors: Gunter Stock Ursula-F. Habenicht Vol. 1 Bioscience 'C' Society Workshop Report Editors: D. J. Roy, B. E. Wynne, R. W. Old Vol. 2 Round Table Discussion on Bioscience~ Society Editor: J. J. Cherfas Vol. 3 Excitatory Amino Acids and Second Messenger Systems Editors: V. I. Teichberg, L. Turski This series will be available on request from Schering Research Foundation, P.O. Box , W Berlin 65, FRG Held and published on behalf of Schering AG, Berlin

3 Schering Foundation Workshop 3 Excitatory Amino Acids and Second Messenger Systems V.I. Teichberg, L. Turski, Editors With 62 Figures Springer-Verlag Berlin Heidelberg GmbH

4 ISBN ISBN (ebook) DOI / This work is subjcct to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or paris thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in ils current version, and permission for usc must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg 1991 Originally published byspringer-verlag Berlin Heidelberg New York in 1991 Softcover reprint ofthe hardcover lst edition 1991 The use of general descripted names, registcred names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are excmpt trom the relevant protective laws and regulations and thercfore free for general use. Produci liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such informati an by consulting the relevant literature. 25/ O - Printed on acid-free pa per

5 In memory of my parents Adela and Mieczyslaw Turski who lived in love and died in love Lechoslaw Turski

6 Foreword The renewal of interest in excitatory amino acids in the 1980s has altered the direction of neurobiology. L-Glutamate, widely regarded as a general perpetuator of nonspecific excitation, has become generally regarded as a widely distributed and important neurotransmitter in the CNS. In the past three decades evidence has accumulated that excitatory amino acids are involved in many neurological diseases and that pharmacological intervention may offer prospects of novel and more effective therapies. Numerous studies on experimental animals demonstrate that excitatory amino acid antagonists have anxiolytic, antiepileptic and muscle relaxant effects. Particular interest has developed in the possible neuroprotective efficacy of excitatory amino acid receptor antagonists in neurological diseases such as hypoxia/ischemia, hypoglycemia, epilepsy, and chronic neurodegenerative disorders (Huntington's, Alzheimer's, and Parkinson's disease, amyotrophic lateral sclerosis, and AIDS). Thus, the drugs changing neurotransmission mediated by excitatory amino acids possess potential therapeutic value. This volume is part of the Schering Research Foundation Workshop Series. It is the goal of the Schering Research Foundation to promote the association between industrial and basic research. The support and the organization of highly qualified symposia belong to the armamentarium by which this purpose is fulfilled, and we are convinced that the workshop "Excitatory Amino Acids and Second Messenger Systems" has contributed to this. Gunter Stock Ursula-F. Habenicht

7 Preface The Schering Foundation Workshop which took place in Berlin on June 27-28, 1991, succeeded in capturing some of the recent excitement in the search for links between excitatory amino acids and second messenger systems. This book contains the proceedings of this workshop: in it leaders in the field unravel the novel relationships between excitatory amino acids and arachidonic acid, nitric oxide, cyclic nucleotides, inositol phospholipids, the ubiquitous calcium ion and enzymes such as nitric oxide synthase, phospholipases and kinases. The effervescence that characterizes this research clearly signals the advent of a new era in the study of excitatory amino acids. We cannot help but anticipate the establishment, in the not too distant future, of causal relationships between the events initiated at the plasma membranes - by the activation of the ever-increasing number of excitatory amino acid receptor subtypes - and the short- and long-term perturbations of the intracellular activities of neurons and glia. We hope that this book will serve as a catalyst to stimulate further research. Vivian I. Teichberg Lechoslaw Turski

8 Table of Contents Diversity and Organization of Excitatory Amino Acid Receptors in the CNS Daniel T. Monaghan and Jean A. Beaton Molecular Biology of Glutamate-Gated Channels: Focus on AMP A and Kainate Peter H. See burg, William Wisden, Todd A. Verdoorn, Kari Keiniinen, Pia Werner, Hannah Monyer, and Bernd Sommer 17 3 From Excitatory Amino Acid Receptors to Long-Term Potentiation: An Insight into the Role of Ca 2 + Simon Alford and Graham L. Collingridge Evidence that Arachidonic Acid Plays a Role in Long-Term Potentiation Marina A. Lynch Glutamate Release by Reversed Glutamate Uptake Is Inhibited by Arachidonic Acid Marek Szatkowski, Boris Barbour, and David Attwell Intracellular and Intercellular Messengers Produced by Metabotropic (Qp), AMPA, and NMDA Excitatory Amino Acid Receptors Joel Bockaert, Olivier Manzoni, Aline Dumuis, Philippe Marin, Mireille Lafon-Cazal, Michele Sebben, Jean-Philippe Pin, Fritz Sladeczek, and Laurent Fagni... 73

9 XII Table of Contents 7 Glutamate Receptors, Nitric Oxide, and Cyclic GMP John Garthwaite, Eric Southam, and Stephen J. East Nitric Oxide: A Messenger of Cerebellar Granule Cells Jarda T. Wroblewski, Lech Kiedrowski, Robert Raulli, and Erminia Costa Protein Dephosphorylation as a Mediator of NMDA Receptor Signal Transduction Shelley Halpain and Paul Greengard Phosphoinositide-Linked Glutamate Receptors: Prominent Actions in Neurons and Glia Jay M. Baraban, Timothy H. Murphy, Kathleen R. Stratton, RachelS. Fiore, and Paul F. Worley Neuromodulation of Non-NMDA Class Glutamate Receptor Channels in Hippocampal Neurons Joanna Jen and Charles F. Stevens Regulation of Glial Kainate Receptor Function by Extracellular Ligands and Intracellular Messengers Arturo Ortega, Maria L. Cotrina, and Vivian/. Teichberg 169 Subject Index...,

10 List of Contributors Simon Alford Department of Pharmacology, The Medical School, The University of Birmingham, Edgbaston, Birmingham Bl5 2TT, United Kingdom David Attwell Department of Physiology, University College London, Gower Street, London WCIE 6BT, United Kingdom Jay M. Baraban Departments of Neuroscience, Psychiatry and Behavioral Sciences and Neurology, John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA Boris Barbour Department of Physiology, University College London, Gower Street, London WCIE 6BT, United Kingdom Jean A. Beaton Department of Pharmacology and Department of Internal Medicine, Division of Neurology, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE , USA Joel Bockaert Graham L. Collingridge Department of Pharmacology, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom

11 XIV List of Contributors Erminia Costa Fidia Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road N.W., Washington, DC 20007, USA Maria L. Cotrina Department of Neurobiology, TheW eizmann Institute of Science, Rehovot , Israel Aline Dumuis Centre CNRS-INSERM de Phannacologie-Endocrinologie, Rue de la Cardonille, Stephen J. East Department of Physiology, University of Liverpool, Brownlow Hill, P.O. Box 14 7, Liverpool L69 3BX, United Kingdom Laurent F agni RachelS. Fiore Departments of Neuroscience, Psychiatry and Behavioral Sciences and Neurology, John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA John Garthwaite Department of Physiology, University of Liverpool, Brownlow Hill, P.O. Box 14 7, Liverpool L69 3BX, United Kingdom Paul Greengard Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York A venue, New York, NY 10021, USA Shelley Halpain Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA Joanna len Molecular Neurobiology Laboratory, The Salk Institute, North Torrey Pines Road, La Jolla, California 92037, USA

12 List of Contributors XV Kari Keiniinen Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 1m Neuenheimer Feld 282, D-6900 Heidelberg, FRG Lech Kiedrowski Fidia Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road N. W., Washington, DC 20007, USA Mireille Lafon-Cazal Marina A. Lynch Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom Olivier Manzoni Philippe Marin Daniel T. Monaghan Department of Pharmacology and Department of Internal Medicine, Division of Neurology, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE , USA Hannah Monyer Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D-6900 Heidelberg, FRG Timothy H. Murphy Departments of Neuroscience, Psychiatry and Behavioral Sciences and Neurology, John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA Arturo Ortega Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel

13 XVI List of Contributors Jean-Philippe Pin Robert Raulli Fidia Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road N.W., Washington, DC 20007, USA Michele Sebben Peter H. Seeburg Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D-6900 Heidelberg, FRG Fritz Sladeczek Bernd Sommer Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 1m Neuenheirner Feld 282, D-6900 Heidelberg, FRG Eric Southam Department of Physiology, University of Liverpool, Brownlow Hill, P.O. Box 147, Liverpool L69 3BX, United Kingdom Charles F. Stevens Molecular Neurobiology Laboratory, The Salk Institute, North Torrey Pines Road, La Jolla, California 92037, USA Kathleen R. Stratton Departments of Neuroscience, Psychiatry and Behavioral Sciences and Neurology, John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA Marek Szatkowski Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom

14 List of Contributors XVII Vivian I. Teichberg Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel Lechoslaw Turski Department of Neuropsychopharmacology, Schering AG, P.O. Box , MiillerstraBe , D-1000 Berlin 65, FRG Todd A. Verdoorn Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 1m Neuenheimer Feld 282, D-6900 Heidelberg, FRG Pia Werner Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 1m Neuenheimer Feld 282, D-6900 Heidelberg, FRG William Wisden Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, 1m Neuenheimer Feld 282, D-6900 Heidelberg, FRG Paul F. Worley Departments of Neuroscience, Psychiatry and Behavioral Sciences and Neurology, John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA Jarda T. Wroblewski Fidia Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road N.W., Washington, DC 20007, USA