CONTRIBUTION OF BACTERIAL INJECTION SYSTEMS TO HUMAN DISEASE

Transcription

1 WORKSHOPS CURRENT TRENDS IN BIOMEDICINE 2018 SEDE ANTONIO MACHADO BAEZA, SPAIN CONTRIBUTION OF BACTERIAL INJECTION SYSTEMS TO HUMAN DISEASE Baeza, Spain 5 th -7 th November 2018

2 Organized by: Sophie Bleves Jorge E. Galán Matxalen Llosa Marseille, France. New Haven, CT, USA. Santander, Spain. SCOPE Bacterial secretion systems are trans-envelope multiprotein assemblies devoted to the transport of specific macromolecules. In particular, the Type III, Type IV and Type VI secretion systems share the ability to inject their substrates into human cells, playing an important role in virulence. The transported substrates, so-called effectors, modulate cellular processes for the benefit of the bacterial pathogens. Their role in pathogenesis has been well established in an increasing number of human pathogens causing diseases such as salmonellosis, legionellosis, brucellosis, lung pneumonia, gastric ulcer, or gastric carcinomas. In spite of the differences among these secretion systems, they all converge into a number of common strategies of human cell subversion. This workshop aims to gather experts in each secretion system in order to compare them and to highlight common targets in the human cell. The workshop will address our knowledge of the architecture of the secretion machineries, the secretion mechanism, and the role of effectors in the target cell. The scientific outcome will provide us with a holistic comprehension of the mechanisms of bacterial pathogenicity, and will open the way to the design of possible common strategies for anti-pathogen therapies by targeting the secretion machine, the effectors, or their targets.

3 FORMAT OF THE WORKSHOP The workshop will bring together a maximum of 15 speakers and 35 participants, to form a group of around 50 people. The scientific programme will start in the morning of Monday, November 5 th, and will end around noon on Wednesday, November 7 th. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. VENUE OF THE WORKSHOP The workshop will be held in Baeza, at the Sede Antonio Machado, a XVII century building turned into a Conference Centre of the Universidad Internacional de Andalucía (UNIA). This Seat includes a residence, where participants will be accommodated. Baeza is a World Historic Heritage town, renowned for its Renaissance and Gothic buildings. SPEAKERS Steffen Backert Department of Biology, Division of Microbiology, Friedrich Alexander University Erlangen/Nuremberg. Erlangen, Germany. Sophie Bleves Laboratoire d Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée, CNRS, Aix- Marseille University. Marseille, France. Ulla Bonas Department of Genetics, Institute for Biology, Martin Luther University Halle Wittenberg. Halle, Germany.

4 Carmen Buchrieser Institut Pasteur, Biologie des Bactéries Intracellulaires; CNRS UMR Paris, France. Eric Cascales Laboratoire d'ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), Aix- Marseille Université, CNRS, UMR Marseille, France. Peter J. Christie Christoph Dehio Jorge E. Galán Department of Microbiology and Molecular Genetics, McGovern Medical School. Houston, TX, USA. Biozentrum, University of Basel. Basel, Switzerland. Department of Microbial Pathogenesis, Yale University School of Medicine. New Haven, CT, USA. Elisabeth L. Hartland Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research / Department of Molecular and Translational Science, Monash University. Clayton, Australia. Matxalen Llosa Departamento de Biología Molecular, Universidad de Cantabria (UC), Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC, UC-CSIC-SODERCAN). Santander, Spain.

5 Amy E. Palmer Craig R. Roy Feng Shao Miguel A. Valvano Samuel Wagner Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado Boulder. Boulder, CO, USA. Boyer Center for Molecular Medicine, Department of Microbial Pathogenesis, Yale University. New Haven, CT, USA. National Institute of Biological Sciences (NIBS). Beijing, China. Wellcome-Wolfson Institute for Experimental Medicine, Queen s University Belfast. Belfast, UK. Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Section of Cellular and Molecular Microbiology, University of Tübingen / German Center for Infection Research (DZIF), Partner-site Tübingen. Tübingen, Germany. DEADLINE: 7 th SEPTEMBER 2018 MORE APPLICATIONS WILL BE ACCEPTED IN CHRONOLOGICAL ORDER UNTIL COMPLETING THE WORKSHOP MORE INFORMATION AND APPLICATION: workshops.biomed@unia.es

6 Universidad Internacional de Andalucía Sede Antonio Machado Palacio de Jabalquinto Plaza de Santa Cruz, s/n Baeza (Jaén), Spain Tel: Fax: