12. D.D. Breimer. (1999), Future challenges for drug delivery. Journal of Controlled Release, 62, Dashevsky A, Mohamad A. (2006), Development

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1 REFERENCES: 1. Ahmad Mohamad, Andrei Dashevsky (2006),pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD.European Journal of Pharmaceutics and Biopharmaceutics, 64: Aiman A. O, Kinam P (1997), Characterization of protein release through glucose sensitive hydro gel membrane, Biomaterials, 18, Akihiko Kand, Teruo O (2002), pulsatile drug release control hydrogels, Advance Drug Delivery Rev, 54, Alessandra Maroni, Lucia Zema, Maria Dorly Del Curto, Giulia Loreti, Andrea Gazzaniga. (2010), Oral pulsatile delivery: Rationale and chronopharmaceutical formulations. International Journal of Pharmaceutics, Anil K. Anal, (2007), Time-Controlled Pulsatile Delivery Systems for Bioactive Compounds, Recent Patents on Drug Delivery & Formulation, 1: Anuradha K. Salunkhe, Remeth J. Dias, Kailas K. Mali, Niranjan S. Mahajan and Vishwajeet S. Ghorpade, (2011), Formulation and evaluation of floating pulsatile drug delivery system of Metoprolol tartrate. Scholars Research Library,Der Pharmacia Lettre, 3(3): Asim Sattwa Mandal, Nikhil Biswas, Kazi Masud Karim, Arijit Guha, Sugata Chatterjee,Mamata Behera, Ketousetuo Kuotsu. (2010), Drug delivery system based on chronobiology A review. Journal of Controlled Release, 147: B Botti, C Youan (2004), Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery? Journal Control Release, 98, Bin L, Zhu J, Zheng C, Gong W. (2008), A novel system for three-pulse drug release based on tablets in capsule device. International Journal of Pharmaceutics, 352: Bodmeie R, Dashevsk A, Paeratakul O, Puttipipatkhachorn S, Sungthongjeen S. (2004), Development of Pulsatile Release Tablets with Swelling and Rupturable Layer. Journal of Controlled Release; 95: Conte U, Maggi L, Torre M.L, Giunchedi P, Manna A L. (1993), Press coated Tablets for Time Programmed Release of Drug. Biomaterials, 14:13:

2 12. D.D. Breimer. (1999), Future challenges for drug delivery. Journal of Controlled Release, 62, Dashevsky A, Mohamad A. (2006), Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat ECD. International Journal of Pharmaceutics, 318: Efentakis M, Politis, S. (2006), Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. European Polymer Journal, 42: Erhard Haus. (2007),Chronobiology in the endocrine system. Advanced Drug Delivery,Reviews Fukui E, Miyamura N, Kobayashi M. (2001),An in vitro investigation of the suitability of press- coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting. Journal of Controlled Release, 70: Fukui E, Uemura K, Kobayashi M. (2000), Studies on Applicability of Press-Coated Tablets using Hydroxypropylcellulose (HPC) in the Outer Shell for Timed-Release Preparations Journal of Controlled Release, 68: Ganiyu J A, Donald LW, Joseph D, Gresser Debra, J Trantolo (1995), Pulsed FSH release from an implantable capsule system, Journal Control. Release, 34, Gazzaniga A, Paluga L, Foppoli A (2007), Oral pulsatile delivery system. Application and design stareges, European Journal Pharm and Biopharm, 67(5), Gazzaniga A, Palugan L, Foppoli A, Edvige M. (2008),Oral pulsatile delivery systems based on swellable hydrophilic polymers. European Journal of Pharmaceutics and Biopharmaceutics 68: Hao Zou, Xuetao Jiang, Lingshan Kong,Shen gao.( 2008,) Design and Evaluation of a Dry Coated Drug Delivery System With Floating Pulsatile Release. Journal of pharmaceutical sciences Vol 97, NO. 1: Hitesh Dalvadia, Jayvadan K Patelb (2010), Chronpharmaceutics, pulsatile drug delivery system as current trend, Chronpharmaceutics Asian Journal of Pharmaceutical Sciences, 5 (5),

3 23. Inna K, Roland B (1999), Floating or pulsatile drug delivery system on coated effervescent cores, International Pharma, 187, J.Kausalya, J.Lakshmi Eswari, S.Padma Priya, Kumaravel Rajan, V.Vaijayanthi, Anusha Rupenagunta, B.Senthilnathan,(2011)Design, development and evaluation of Pulsatile Drug Delivery of flurbiprofen microspheres. Journal of Pharmacy Research, 4(6), Jonathan C.D. Sutch, Alistair C. Ross, Walter Ko ckenberger, Richard W. Bowtell, Ross (2003), Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy. Journal of Controlled Release, 92: Joseph K,langer R(2001), Responsive polymric delivery systems. Advance Drug Delivery Rev, 46, Kazunori K,Atsushi H, Yukio N (2001), Block copolymer micelles for drug delivery :design characterization and biological significance, Advance Drug Delivery Rev, 01(47), Krogel, I.; Bodmeier, R. (1999), Floating pulsatile drug delivery system based on coated effervescent cores. International Journal of Pharmaceutics; 187: Lin S Y, Li M J, and Lin K H. (2004), Hydrophilic Excipients Modulate the Time Lag of Time- Controlled Disintegrating Press-coated Tablets. AAPS Pharm Sci Tech, 5 : 4 Article Lin S Y, Li M J, and Lin K H. (2004) Formulation Design of Double-layer in the Outer Shell of Dry-coated Tablet to Modulate Lag Time and Time controlled Dissolution Function: Studies on micronized ethyl cellulose for dosage form Design. AAPS Journal. 6:3 Article Lin S Y, Lin K H, Li M J. (2001),Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet. Journal of Controlled Release; 70: M.E. Sangalli, A. Maroni, A. Foppoli, L. Zemaa, F. Giordano, A. Gazzaniga. (2004), Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: a study on process parameters and in vitro performances. European Journal of Pharmaceutical Sciences, 22:

4 33. Manivannan Rangasamy. (2010), colon targeted drug delivery systems: a review. International Journal of Drug Formulation & Research Vol. 1 (II) Michael H. Smolensky, Nicholas A. Peppas b. (2007), Chronobiology, drug delivery, and chronotherapeutics. Advanced Drug Delivery, Reviews 59: Mukesh C. Gohel, Manhapra Sumitra G. (2002),Modulation of active pharmaceutical material release from a novel tablet in capsule system containing an effervescent blend. Journal of Controlled Release, 79: Ozeki Y, Ando M, Watanabe Y, Danjo K. (2004), Evaluation of novel one-step drycoated tablets as a platform for delayed-release tablets. Journal of Controlled Release, 95: P Roy, A Shahiwala (2009), Multiparticulate formulation approach to pulsatile drug delivery: current perspectives, Journal Control Release, 134, Patel Gayatri C, Patel Madhabhai M. (2009), A comparative in vitro evaluation of enteropolymers for pulsatile drug delivery system. Acta Pharmaceutica Sciencia 51: Raimar Lo benberga, Jae Seung Kimb, Gordon L. Amidon. (2005), Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs. European Journal of Pharmaceutics and Biopharmaceutics, 60: Rajan K. Verma and Sanjay Garg, (2001) Current Status of Drug Delivery Technologies and Future Directions, Pharmaceutical Technology On-Line, 25 (2), Sachin Survase, Neeraj Kumar. Pulsatile drug delivery: current scenario. CRIPS 2007 Vol. 8 No. 2, Saslawski O, Weigarten C, Benoit JP (1988), Magnetically responsive microspheres for the pulsed delivery of insulin, Life Sci, 42, Shajahan Abdul, S.S. Poddar. (2004), A flexible technology for modified release of drugs:multi layered tablets. Journal of Controlled Release 97: Shaji Jessy, Patole Vishal. (2007), Novel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin. Journal of Pharmaceutical sciences 6(1):

5 45. Shan-Yang Lin, Kung-Hsu Lin, Mei-Jane Li. (2001), Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet,journal of Controlled Release,70 : Sharma, S. Pawar, A. (2006), Low density multiparticulate system for pulsatile release of meloxicam. International Journal of Pharmaceutics; 313: Shiwani Sharma, Anshul Dutt Sharma, Roopa Saharawat (2011), Pulsatile drug delivery system: a review an advanced approach: Review Article, International Journal Of Pharmacy & Technology, 3(2), Siegel RA, Pitt CG (1995), A stargy for oscillatory drug release-general scheme and simplified theory, Journal Control, Release, 33, Sirkiä T, Mäkimartti M, Liukko-Sipi S and Marvola M. (1994),Development and biopharmaceutical evaluations of a new press-coated prolonged-release salbutamol sulphate tablet in man. European Journal of Pharm, 1: Srisagul Sungthongjeen, Pornsak Sriamornsak, Satit Puttipipatkhachorn, (2008),Design and evaluation of floating multi-layer coated tablets based on gas formation. European Journal of Pharmaceutics and Biopharmaceutics, 69: Sungthongjeen S, Puttipipatkhachorn S, Paeratakul O, Dashevsky A, Bodmeier R (2004), Development of pulsatile release tablets with swelling and rupturable layers, Journal Control Release, 95, Sungthongjeena S,Puttipipatkhachorna S, Paeratakulc O, Dashevskyb A, Bodmeierb R. (2004), Development of pulsatile release tablets with swelling and rupturable layers.(2004), Development of pulsatile release tablets with swelling and rupturable layers. 53. T. Bussemer, R. Bodmeie. Formulation parameters affecting the performance of coated gelatin capsules with pulsatile release profiles. International Journal of Pharmaceutics 267 (2003) T.Y. Fan, S.L. Wei, W.W. Yan, D.B. Chen, J. Li.( (2001),An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and crosslinked polyvinylpyrrolidone in the core tablets. Journal of Controlled Release, 77:

6 55. Usha Yogendra Nayak, Gopal Venktesh Shavi, Yogendra Nayak, Ranjith Kumar Averinen (2009),Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system. Journal of Controlled Release, 136 : Zhang Y, Zhang Z, Fang W. (2003), A novel pulsed-release system based on swelling and osmotic pumping mechanism. Journal of Controlled Release, 89: Zou, H.; Jiang, X.; Kong, L.; Gao, S. (2008) Design and evaluation of a dry coated drug delivery system with floating-pulsatile release. Journal of Pharmaceutical sciences, 97: