A bold vision for 2025

Transcription

1 Leading the Biomedical Revolution in Precision Health: How Stanford Medicine is Developing the Next Generation of Health Annual Stanford Medicine Population Health Sciences Colloquium October 26, 2015 Lloyd B. Minor, M.D. Carl and Elizabeth Naumann Dean, Stanford University School of Medicine A bold vision for 2025 Health care today Precision Health tomorrow after the fact predictive and preventive one size fits all personalized fragmented patient centered uninvolved participatory low value preeminent 2 1

2 The P s of Precision Health predictive and preventive targets interventions and stops disease before it starts personalized tailors care to individual variations (i.e., Precision Medicine) patient centered coordinates care and empowers patients and families participatory involves individuals in their own health care preeminent delivers the best health outcomes at the lowest cost 3 Predictive and Preventive Targets interventions and stops disease before it starts today tomorrow Lipid profile Immune profile 4 2

3 Personalized Tailors care to individual variations (i.e., Precision Medicine) today Some targeted treatments for cancer tomorrow Targeted treatments for other diseases Thyroid Colorectal Endometrial Lung Pancreatic Breast Other Gyn 32% 31% 43% 41% 41% 51% 56% Percentage of patients whose tumors were driven by certain genetic mutations 5 Patient centered Coordinates care and empowers patients and families today tomorrow 6 3

4 Participatory Involves individuals in their own health care today tomorrow By 2020, eighty percent of the adult population will own a smartphone Economist, February 28, Preeminent Delivers the best health outcomes at the lowest cost today trial and error dosing adverse drug reactions late diagnoses reactive treatment unnecessary hospitalizations tomorrow Outcomes Cost Value 8 4

5 Why now? Now is a time of unprecedented possibilities for human health, a time when new knowledge and technologies are accelerating the pace of biomedical discovery. A biomedical revolution is underway. Physical Sciences Engineering Life Sciences 9 Why Stanford Medicine? A place driving change. San Francisco Bay Area 10 5

6 The Precision Health difference Precision Health Precise Personalized Proactive Includes prediction and prevention Focuses on keeping you healthy Health care Precision Medicine Precise Personalized Reactive Relies on diagnosis and treatment Focuses on treating you when you re sick Sick care 11 How will Stanford Medicine lead? Preeminent Clinical Transformative Biomedical Platforms Innovative investments and creative collaborations Fundamental Research & Biomedical Data Science 12 6

7 Predictive, Preventive, and Longitudinal Stanford Health Brain & Behavior Cardiac Cancer Transplantation Population Health Sciences Human Immunology Diagnostics/ Imaging Health Value Science Brain & Behavior Neurosciences Cardiac Cancer Lucile Packard Children s Hospital Stanford Musculoskeletal/ Orthopaedics Cancer Biology Genomics/ Omics ChEM H Maternal, Fetal, Newborn Health Stem Cell/ Regenerative Medicine Fundamental Research & Biomedical Data Science 13 The driver: Big data Genomics Epigenomics Metabolomics EMR history Lab tests Imaging Social factors Environment Lifestyle choices New Stanford Department of Biomedical Data Science Biostatistics (quantitative models) Biomedical Informatics (qualitative models) 14 7

8 Building a learning health system Data influences practice and practice influences data 15 My discovery Superior Canal Dehiscence 16 8

9 Vital role for population health sciences Environment Lifestyle Choices Infectious Agents Social Factors Medical Genetics 17 Partnering with Google 18 9

10 Health technology 19 Sharing health data We need to incentivize individuals to share their data and create a new culture of engagement. Survey on participation in Large Scale Research Cohort Science, 10 July 2015: Vol. 349 no pp

11 There s a role for all of us Together we at Stanford Medicine have an opportunity to develop the next generation of health care. 21 Leading the Biomedical Revolution in Precision Health: How Stanford Medicine is Developing the Next Generation of Health 11