Academic Qualification:

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1 Dr. Shashikala R. Inamdar, Professor and Chairperson P. G. Dept. of Studies in Biochemistry, Karnatak University, Dharwad Pavate Nagar, Dharwad , India, srinamdar2009@gmail.com Academic Qualification: PhD in Biochemistry, Karnatak University, Dharwad, India M.Sc. in Biochemistry, Karnatak University, Dharwad, India; I class with distinction, First Rank B.Sc. in Biochemistry, Karnatak University, Dharwad, India in I class with distinction Positions held/professional Experience: Professor of Biochemistry (CAS), Dept. of Biochemistry, Karnatak University, Dharwad from 11 th Nov 2005 till date. Honorary Visiting Professor, School of Translational Medicine, University of Liverpool, UK from August 2009 to December 2015 Honorary Visiting Professor, School of Clinical Sciences, University of Liverpool, U.K. from October 2006 to March Reader, Department of Biochemistry, Karnatak University, Dharwad from November 1997 to 11 th November Sr. Lecturer, Department of Chemistry, Karnatak University, Dharwad from November 1993 to November Lecturer, Department of Chemistry, Karnatak University, Dharwad from November 1988 to November Scientist B, Department of Food Chemistry, Central Food Technological Research Institute, Mysore, India from February 1987 to March Lecturer, Department of Biochemistry Gulbarga University, Gulbarga from August 1983 to June Area of Specialization: Lectins, Glycobiology and Cancer Research No. of Ph. D students guided: 6 (Completed), 7 (working).

2 Honors/Awards: Agilent Technologies Pvt. Ltd. USA Research Gift Award of 25, US$ (Twenty five thousand US dollars) as a research grant in May 2013 International Collaboration: UKIERI (UK India Education and Research initiative) Research Award 2008 and project got extension till 2014 and collaboration is ongoing with the University of Liverpool, UK A position of Honorary Visiting Professor is conferred at the Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, UK from 2006 to 2007 and from June 2009 to 31 st Dec Industry Collaboration: A project entitled An integrated approach to develop a process for preparation of recombinants of antitumor Sclerotium rolfsii lectin (SRL) in E. coli as novel targeted anticancer drugs for human colon and ovarian cancer providing affordable health care to cancer patients is supported by a grant of Rs. 263 lakhs including company s contribution by Department of Biotechnology, under Biotechnology Industry Partnership Programme BIPP, in collaboration with Unichem laboratories Pvt.Ltd. Project is initiated in 2014 and MoU has been signed. Chaired a scientific session at 33 rd IACR National Conference, Discovery, Innovation and Translation in Cancer Research held at Jaipur University, Jaipur, from 12 th to 15 th Feb Technology entitled Recombinant protein with Serological and Cancer diagnostic application has been selected and has won Silver Medal (2008) for commercialization by India Innovates growth program, organized by FICCI, Lockheed Martin and IC 2 Institute, Texas, USA. DST Travel Award for Attending and presenting work at the International conference, Interlec at University of Edinburgh, UK in Awarded British Commonwealth Academic Staff Fellowship 2006, to study the interaction of TF antigen binding fungal lectins with human colon cancer cell lines at the University of Liverpool, UK. JRF -UGC Junior Research Fellowship from to SRF -UGC Senior Research Fellowship from to JRF -CSIR JRF to (CSIR JRF NET). M. Sc. I rank to Karnatak University National Merit Scholarship

3 Membership & Fellowship of professional Bodies: Member: CFG (Consortium for Functional Glycomics), USA Member; International Society for Glycobiology, SFG, USA Member; International Lectin Society (INTERLEC) Life Member: Society of Biological Chemists (India) Member: Academic council of SDM College of Engineering and Technology Dharwad since Member of Governing body, Kittur Rani Chennama Memorial School, Kittur since Present status of research in Glycobiology: The major research interest of the Glycobiology group is focused on understanding the structure-function relationship of lectins (carbohydrate binding proteins) of fungal and plant origin. Lectins with unique carbohydrate binding specificities are becoming important molecular tools for understanding the structure of cell surface glycans, particularly altered glycosylations during patho-physiological conditions. The main emphasis is especially on those lectins which bind to tumor associated antigens such as TF, Tn, CA 125 and sialyl Lewis antigens as they can be used as diagnostic tools. Lectins are also studied for their immunomodulatory effects following their interaction with normal and cancer cells in vitro and in vivo so as to develop them as possible therapeutic agents. SRL-mediated cell signalling in human colon cancer HT29 cells by mrna and mirna microarrays has shown that SRL affects multiple signalling pathways. SRL interacting receptors identified and to develop lectins as therapeutic molecule are in progress. The work is also focused to explore lectins for insecticidal effects for developing pest resistant transgenic plants. Publications in international Journals: 31 Papers presented at international conferences: 23 Patents: 1) Indian Patent granted, # 1265/MUM/2004, dated. 9 th June 2006; Title; Lectins from Sclerotium rolfsii and Rhizoctonia bataticola with unique cell surface recognition ability for potential application in cancer diagnosis Inventors: Padma Shastry, Shashikala R. Inamdar, B. M. Swamy (Joint patent of National center for cell science, Pune (India) & Karnatak University, Dharwad). 2) Method for preparing blood group A1 specific recombinant lectin with ability to recognize cancer associated glycans and thereof

4 Indian patent: Application Number 30/MUM/2008 Patent jointly filed by Unichem Labs and KUD. 3) Cancer cell binding recombinant lectins with antitumor activity and method of preparation Indian patent: Application Number 350/MUM/2009 Patent jointly filed by Unichem Labs and KUD (Technology based on the above patents selected for commercialization and was awarded silver medal for best technologies under India Innovates growth program 2008). 4) Cancer cell binding recombinant lectins with antitumor activity and methods of preparation International Application (PCT) Number WO 2010/095143A2 Patent jointly filed by Unichem Labs and KUD. 5) Cancer cell binding recombinant lectins with antitumor activity and methods of preparation European Patent Number / Patent jointly filed by Unichem Labs and KUD (2012) RESEARCH PROJECTS: As Principal Investigator 1. An integrated approach to develop recombinant Sclerotium rolfsii (SRL) antitumor lectins in E. coli as novel targeted anticancer drug and drug delivery system for human colon and breast cancer, providing affordable health care to cancer patients, DBT sponsored BIPP, Biotechnology Industry Partnership Programme, under BIRAC, with Unichem Laboratories Pvt.Ltd, Mumbai. from Dec Rs.263 lakhs including Unichem contribution of 133 lakhs and BIRAC support of 38 lakhs to KU Dharwad and and 92 lacs to Unichem. Labs. 2. Gene and Protein profiling of human colon cancer cells following their interaction with antitumor lectin from Sclerotium rolfsii (SRL) and Identification of lectin binding receptors to explore lectins potential as diagnostic and therapeutic agent. Agilent Technologies, Pvt. Ltd. Santaclara, USA. From July 2013 to July US$=25,000.00/-. 3. Exploring The Potential of RBL, A Cytotoxic Lectin from Rhizoctonia bataticola for Ovarian Cancer Research: Molecular Signalling involved in RBL mediated Cytotoxicity in Ovarian Cancer. Funded by CSIR New Delhi. December Rs= 25 lakhs 4. Investigating the role of a mitogenic lectin from Cephalosporium curvulum, a pathogenic fungus causing mycotic keratitis. Dept. of Science and Technology, India. August Rs= lakhs.

5 5. Tumour suppressing activity of Sclerotium rolfsii lectin on colon cancer. UK India Education and Research initiative (UKIERI). April Rs=32.00 lakhs. 6. Exploring the potential of TF antigen binding property of lectin from Sclerotium rolfsii for its Anti Cancer Effect. Dept. of Biotechnology, India. April Rs=32.00 lakhs. As Co-investigator with Dr. B. M. Swamy: Four Karnatak University, India has recently been recognized by University Grant Commission, India as one of the six Universities in India, as University with Potential of Excellence (UPE) with focused area of research being, Antitumor activity an integrated approach and has received total grant of Rs.50 crores and I am working in this focused area of research as Dy. Coordinator and also associated with UGC sponsored CPEPA and DBT sponsored IPLS programme. Organizing National conference: As a convenor successfully organized a National conference on Glycobiology of Cancer; Lectins as tools and Targets GCLTT-2013, from 7 th to 9 th of Nov.2013 at Karnatak University Dharwad, India as a part of UKIERI Project dissemination activity. The conference sponsored by UKIERI, UPE, CPEPA programmes of UGC and Agilent Technologies Pvt. Ltd. USA It exposed our faculty and students to current trends in Glycobiology and research prospects. Editor; Cancer Glycobiology of Journal of Glycobiology 2013 OMICS Publishing Group Open Access Collaborations: International 1. Prof. Jonathan Rhodes and Dr. Lu Gang Yu School of Translational Medicine, University of Liverpool, Liverpool, (UK) 2. Prof. David Smith, Glycoconsortium; Core H Facility, Emory University School of Medicine, Atlanta (USA). 3. Prof. Demetres D. Leonidas, National Hellenic Research Foundation, Institute of Biological Research & Biotechnology, Athens, Greece. 4. Prof. Dr. Els JM Van Damme, Head of Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Faculty Bioscience Engineering, Ghent University, Belgium 5. Prof. Guy Smagghe, Head of Research Group on Insect Physiology and Pest Control, Laboratory of Agrozoology, Department of Crop Protection, Faculty Bioscience Engineering, Ghent University, Belgium 6. Professor Albert M. Wu, Glyco-immuno chemistry Research Laboratory, Inst. of Mol. & Cellular Biology, Chang-Gung University, Tao-Yuan, Taiwan Countries visited: UK, USA, Japan, Italy, Belgium and Greece for scientific meetings and collaborative laboratories.

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