Application of three-dimensional printing technique in manufacturing scaffolds for bone tissue engineering. doi: /j.issn

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1 Chinese Journal of Tissue Engineering Research July 16, 2015 Vol.19, No.30 3D 1 2 ( ) 1 3D 2 3D 3 3D ( ) 3D 3D 20 3D 3D 3D 3D MEDLINE Science Direct 3D 3D D 3D 3D 3D :R318 :A : (2015) D [J] (30): doi: /j.issn Application of three-dimensional printing technique in manufacturing scaffolds for bone tissue engineering Yu Qiang 1, Tian Jing 2 ( 1 Second College of Clinical Medicine, Southern Medical University, Guangzhou , Guangdong Province, China; 2 Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou , Guangdong Province, China) Abstract BACKGROUND: Three-dimensional printing technique has been applied in medical fields since it was invented in the end of 20th century. Recently it has been widely used in manufacturing scaffolds for bone tissue engineering. OBJECTIVE: To review the basic concept of the scaffold for bone tissue engineering, the basic requirements for three-dimensional printing technique in scaffold engineering, different materials used in bone tissue engineering, the advantages and limitations of three-dimensional printing technique and the outlook of three-dimensional printing technique applied in manufacturing scaffold for bone tissue engineering. METHODS: The first author did a computer-aided retrieval of the MEDLINE database, Science Direct database, CNKI database, and CQVIP database for articles relevant to three-dimensional printing technique used in manufacturing scaffolds for bone tissue engineering published between January 1990 and February The key words were three-dimensional printing, tissue engineering, rapid prototyping technology, scaffold, materials in English and Chinese, respectively. Repetitive studies were excluded, and 33 of 52 related literatures were adopted in result analysis. RESULTS AND CONCLUSION: Three-dimensional printing technique has many advantages such as high Yu Qiang, Second College of Clinical Medicine, Southern Medical University, Guangzhou , Guangdong Province, China Corresponding author: Tian Jing, Master, Professor, Associate chief physician, Master s supervisor, Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou , Guangdong Province, China Accepted: P.O. Box 10002, Shenyang

2 . 3D resolution, high velocity and the freedom to build unlimited geometries. There are some requirements for the powder and binder used to construct bone tissue engineering scaffolds using the three-dimensional printing technique, such as the flowability, stability and wettability. A wide range of materials can be used: synthetic and natural polymers, ceramics, as well as composites of the aforementioned. Various kinds of powder take responsibility of different features of scaffolds, resulting from the advantages and disadvantages of different materials. Although this technique has some limitations such as high cost and the difficulty of commercial production, its application still has a bright future. Subject headings: Tissue Engineering; Cells; Stents Yu Q, Tian J. Application of three-dimensional printing technique in manufacturing scaffolds for bone tissue engineering. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(30): Introduction [1] [2] [3] [4] / / [5-7] 3D 3D 3D 3D 4 3D 3D 1 Data and methods MEDLINE Science Direct 3D three-dimensional printing tissue engineering rapid prototyping technology scaffold materials 3D D 3D D 2 Results [1-3][4-7] [8-12] [13-18] 3D [19-31] [32-33] 3D ( ) [8] [9] 3 ISSN CN /R CODEN: ZLKHAH 4871

3 . 3D A B C D 1 3D A B 1 2 C 3 D 4 ( 2 ) 3D [10-11] 3D 40% 60% [12] D 3D 3D 1989 Emanual Sachs 3D z 3D [13] 3D 3D [14] 3D 3D 5 1 3D 3D 3D 3D 4872 P.O. Box 10002, Shenyang

4 . 3D 2 [14] 30 pl 6 m/s 1 m/s 5 10 µm [15] [16-17] 3D [18] 3D D [19] (PLA) (PGA)(PLGA) PLA PGA FDA Vacanti [20] PGA PLA Sherwood [21] 3D PLGA/PLLA PLGA/TCP 6 Tay [22] 3D ( ) [23] ( ) (tricalciumphosphate TCP) (hydroxylapatite HA) [24] Ca P [25] [26] 3D β (β C) β 15 ISSN CN /R CODEN: ZLKHAH 4873

5 . 3D β β Zhou [27] (CaP) (CaSO 4 ) 3D Fierz [28] 3D mm mm 70% Jun [29] 2 2 3D [30] [31] 3 Discussion 3D 3D 3D [32] 3D 3D 3D 3D 3D 3D 3 [33] 3D 3D 3D 3D 3D 4 References [1] Mourino V, Boccaccini A R. Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds. J R Soc Interface. 2010;7(43): P.O. Box 10002, Shenyang

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