Top 10 GC Operation Tools That Drive Lab Productivity

Transcription

1 Top 10 GC Operation Tools That Drive Lab Productivity Lab Manager Webinar Feb. 13, 2018 Cassie Eisele, GC Sample Introduction Product Manager George Reiner, GC Software Product Manager 1

2 Ten Tools to Improve Productivity Introduction Productivity is essential in today s analytical laboratory. Each additional sample we can perform = income But there are key productivity killers lurking in every corner of your laboratory Errors in sample preparation Inefficient use of time Unplanned downtime Complicated data analysis Agilent GC systems have a wide range of productivity improvement tools that cover the entire GC analysis workflow. Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting You might already have some of these available to you! 2

3 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #1 Increase productivity and reduce need for rework with automated sample preparation 3

4 Sample Preparation Save money by avoiding costly rework! Automates basic sample preparation techniques (e.g Addition, extraction, heating and mixing) Increases productivity by replacing manual techniques with automation Decreases variability and resulting need for rework Reduces usage of sample amounts 4

5 Sample Preparation Easy SamplePrep makes it easier than ever Easy SamplePrep uses intuitive drag and drop programming to build your sample prep program The program tracks resources used and ensures sequence completion with Easy Sequence Queue 5

6 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #2 Use sample overlap to save time running sequences. Save even more time when using automated sample preparation on your GC! 6

7 Sample Overlapping Easier than you might think Sample overlap increases throughput by allowing the autosampler to begin processing the next sample before the current run finishes. 7

8 Sample Overlapping Saving you time with every sequence Choose the best option based on the autosampler sample preparation time, total GC run time, and likelihood of sample degrading or evaporating in the syringe. Without Sample Overlap: The First Run With Sample Overlap: The Second Run The Third Run The First Run The Second Run The Third Run Sample Preparation Time Time Saved with Sample Overlap 8

9 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #3 GC Calculators help save you time by avoiding costly errors that may take down your system during method development. Plus, now they re right on the driver screens! 9

10 GC Calculators Catch costly method errors before you inject! Using the calculators helps you catch mistakes that may cost you a lot of time. Understand how your injected volume will expand within your liner. Optimize the pressures and flows within your method without performing long analyses. Calculate appropriate times for solvent venting. Translate your methods to new column dimensions and improve speed. 10

11 GC Calculators Now right on the GC Driver! The traditional GC Calculators have been around since the 90s. Vapor Volume Pressure Flow Method Translator Solvent Vent Integrated right into the GC Driver Available as you are editing a method Take input directly from your method or use the typical defaults 11

12 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #4 Get control of your retention times to avoid costly retiming of methods and ease transfer from development to production. Use Retention Time Locking (RTL) with Agilent s Electronic Pressure Control (EPC)! 12

13 5 th Generation Electronic Pressure Control (EPC) 3 rd, 4 th Generation EPC psi -- Diffusion bonded plate (2D) -- one cable -- three gas connectors -- credit card size 7890B GC The first GC to regulate pressure to psi The only EPC regulating pressure to 1/1000 psi 6890N GC 1 st, 2 nd Generation EPC psi -- cables -- gas lines & connectors -- large size 5890 GC 5 th Generation EPC - Metal injection molded (3D) Digital signal pathways - Flexibility - More precise RTL the best reliability and precision at every generation 13

14 Retention Time Locking (RTL) Agilent s proprietary means to consistent retention times Precisely match Chromatographic retention times for all systems using the same nominal column and method. Provides consistency and quality control Day to day, regardless of maintenance Column to column after major maintenance System to system for simplified QC review Lab to lab to optimize QC resources Uses our 6 th Generation EPC on Intuvo 5 th Generation EPC on 7890B Controls pressure to 1/1000 psi Compensates for weather changes 14

15 Retention Time Locking (RTL) It s come a long way since the 90s Available on ALL Agilent CDSs Easily transfer methods from development system to production RTL Wizard in OpenLAB CDS 2 Guides new users through the simple process of setting up RTL Easy to ignore for experienced users 15

16 Practical Use of 1/1000 psi control and RTL Essential for triple quad GC/MS timing Response Time Column 1 at psi psi psi 0.96 psi Potential GC detector mis-identification Narrower isolation window provides greater precision, accuracy, and sensitivity Agilent worries about the 3 rd decimal, so I don t have to worry about the 1 st or 2 nd decimal point - Pharma (USA) Obvious loss of GC/TQ sensitivity 16

17 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #5 Take advantage of the innovative technology advancements available for your 7890 to save on resources and decrease your cycle times 17

18 Efficiency Gained through Innovative Technology Technology refresh from 6890 to 7890 Productivity gains Capillary Flow Technology devices implementing Backflush to save time in sample prep and keep MS source clean Save Resources Sleep-Wake SW to save as much as 15% in He costs He Conservation Module to reduce He use and cost Hydrogen Sensor integrated and autocalibrated to use hydrogen Faster Cycle time Cooling rates reduced from 6.5 min to 4.0 min (3.5 min with oven insert) 18

19 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #6 Keep on top of maintenance procedures to prevent unplanned downtime. Agilent s Early Maintenance Feedback (EMF) helps you track maintenance and warns you about pending maintenance. Agilent s Parts Finder helps you quickly identify and order parts. 19

20 Early Maintenance Feedback (EMF) Alerts you about pending maintenance Prevent unplanned downtime by staying on top of your maintenance. User selects intervals for maintenance tasks Sequences don t stop (unless you want them to). EMF system warns you as you approach and exceed your limits. Available on all Agilent CDS platforms as well as Intuvo User Interfaces. 20

21 Early Maintenance Feedback (EMF) Now on Intuvo touchscreen and browser The Maintenance section of the Intuvo user interfaces provides direct access to setting up EMFs. Enables visual at instrument notification of maintenance status. 21

22 Agilent Parts Finder Easy way to find and order Agilent parts Aware of the connected instrument Also able to lookup parts for LC and Mass Spec instruments Quickly locate the part number and add to the parts list or favorites Print the parts list or save it to a file Links to the Agilent.com store for quick ordering through the Agilent website via CSV save. Update file with up-to-date parts and part numbers available via the Agilent website for download. 22

23 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #7 Use retention gaps to protect your column and eliminate the need to trim the column 23

24 Modular Intuvo Flow Chips High purity inert silica flow path Thermally conductive proprietary alloy Intuvo ultra inert treatment Inert Modular, configurable Click-and-run connections Intuvo Flow Chip cross section Carrier gas High purity silica channel 24

25 Intuvo Inert Flow Path Optimized for active compounds 5 ppb Injection of pesticide mix TQ MRM Transitions Agilent 7000 TQ/MS Chrysene-d12 Perylene-d12 Pyroclostrobin Phosalone EPN Coumaphos 25

26 Intuvo Guard Chip and No-trim Columns Running more, maintaining less Simple disposable design No column trimming Retention time reproducibility Less maintenance time Less recalibration and requalification Less unplanned downtime 26

27 Intuvo Guard Chip and No-trim Columns No retention time shifts after maintenance Conventional Column Intuvo Column Shifts beyond retention time window Maintaining retention times 0.5 min 0.5 min Pesticide mix injected before and after 300 mm column trim Pesticide mix injected before and after guard chip change 27

28 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #8 Use online diagnostics to stay updated on the instrument status and get help with maintenance and troubleshooting procedures 28

29 Intuvo Graphical User Interface Main status screen System status 29

30 Intuvo Graphical User Interface Real time plot System status Real-time chromatograms pa min. 30

31 Intuvo Graphical User Interface Maintenance screens System status Real-time chromatograms Step-by-step user maintenance and troubleshooting 31

32 Intuvo Graphical User Interface Parts finder System status Real-time chromatograms Step-by-step user maintenance and troubleshooting Finding parts fast Find Inlet Parts Replace Inlet Liner Inlet Liner Part Number

33 Autonomous Leak Checking Avoiding unplanned downtime Microfluidic-enabled 6 th generation EPC modules allow hands-free leak checking to confirm and document leak-free operation autonomously. 33

34 Internet of Things A full suite of customer support Intuvo serves up a web homepage User help for Maintenance, troubleshooting and diagnostics Accessible through any approved PC or mobile device securely on internal network 34

35 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #9 OpenLAB CDS 2 s Peak Explorer and Peak Details features enable you to break through the data analysis bottleneck to speed up data analysis. 35

36 Peak Explorer & Peak Details Powerful data analysis features Peak Explorer is a feature of OpenLAB CDS 2 Each line represents an injection Each dot represents an integrated peak Gold dots = identified peaks Blue dots = unidentified peaks View an entire sequence at a glance Peak Details Peak Explorer Peak Details (also in OpenLAB CDS 2) is a window that zooms in on the peak of interest. Easy to confirm symmetry or noise level. Especially powerful because all windows are linked together So you can use up/down and left/right arrows to quickly review your data! 36

37 Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting PRODUCTIVITY TIP #10 Use OpenLAB CDS MatchCompare to speed up data analysis, while achieving consistent comparisons with written confirmation. 37

38 OpenLAB MatchCompare Available on ChemStation, EZChrom and OpenLAB CDS 2 Compare an unknown sample, by selecting the sample chromatogram (in data analysis within OpenLAB CDS). To start the comparison, select Compare current chromatogram under the MatchCompare menu item (or select Compare on CDS 2). 38

39 MatchCompare Results Provides written confirmation of comparison Perfect Match Small extra 37min. Single Contaminant (15 min) Throws larger peaks out of tolerance No Match Clearly different samples Written report proves comparison was made! 39

40 Summary Increase your productivity and decrease your down time with these 10 tips and tricks! Many of these are available on your instrument today! For more information about possible upgrades to your GC contact your Agilent representative Sample Prep Sample Introduction GC Analysis Data Analysis & Reporting 40

41 Thank You For Attending As a special thank you for your interest in Top 10 GC Operation Tools that Drive Lab Productivity you are eligible for 25% off* your next purchase of GC columns and supplies. Code 8066: NORTH AMERICA & SOUTH AMERICA Code 8190: EUROPE, MIDDLE EAST, AFRICA AND INDIA Code 8547: SINGAPORE, ASIA PACIFIC, KOREA AND JAPAN Order on agilent.com/chem/store** or contact your Agilent representative or authorized distributor and reference your regional code when ordering. *This great offer expires in 30 days! Some restrictions apply. **in countries where available 41