THE GERMAN MEDICAL INFORMATICS INITIATIVE

Transcription

1 THE GERMAN MEDICAL INFORMATICS INITIATIVE AND THE MIRACUM CONSORTIUM Prof. Dr. Hans-Ulrich Prokosch Chair of Medical Informatics, University of Erlangen-Nürnberg CIO University Hospital Erlangen MIRACUM Coordinator IDDEAS Workshop & International Advisory Board Meeting 1

2 The German Medical Informatics Initiative Goals Improve research opportunities and patient care through innovative IT solutions (initially at university hospitals) Intensify the exchange and sharing of data between the research community and the health care delivery system Position medical informatics as a progressive field in research, teaching and continuing education As a key element of the funding scheme data integration centers (DIC) are to be set up and interlinked by the university hospitals

3 The German Medical Informatics Initiative Timeline and Current Status 11/2015 Announcement /2016 4/2017 July Drafting Consortia 4 Funded Consortia Conceptual phase Development and networking phase Consolidation and further development phase

4 The German Medical Informatics Initiative (MII) Timeline and Current Status Funding 100 Mio 150 Mio Supplementary Modules 10 year plan Conceptual Phase Development- /Networking Phase Extension Phase

5 MII Conceptual Phase 2016/17 29 / 33 German Univ. Hosp.

6 MII Development / Networking Phase not funded University Hospitals were 18 offered / 33 to apply for admission in one of the funded German consortia University Hospitals

7 MIRACUM The largest MII Consortium eight University Hoapitals & Medical Faculties two universities for applied science one industrial partner (Averbis GmbH) 1

8 MIRACUM will be (9+/2018)... the largest MII Consortium ten (eleven) University Hospitals & Medical Faculties two universities for applied science one industrial partner (Averbis GmbH) handling clinical and research data of more than 12 million patients 1

9 Seite 9 Medizininformatik-Initiative Sebastian Claudius Semler

10 Titelmasterformat Governance Structures durch of theklicken MII bearbeiten MII Coordination Office TMF. MFT. VUD MII Coordination Office TMF German Umbrella Organization for networked medical research MFT Association of the German Medical Faculties VUD Association of the German University Hospitals

11 Governance Structures of the MII Research Ministry General Assembly National Steering Group (NSG) DIFUTURE. HiGHmed. MIRACUM. SMITH Advisory Board Dialogue Forum WG Consent WG Data Sharing WG Interoperability MII Coordination Office TMF. MFT. VUD WG Communication

12 Governance Structures of the MII National Steering Group (NSG) DIFUTURE. HiGHmed. MIRACUM. SMITH NSG-Taskforces ( ) WG Consent WG Data Sharing WG Interoperability Taskforce Data Privacy/Protection In cooperation with WG Data Sharing and Interoperability Taskforce Use & Access Taskforce DIC-Comparison Taskforce Core Dataset In cooperation with WG Consent und WG Data Sharing Taskforce Consent Implementation Taskforce Metadata... und many more

13 Longterm goal of the MII cross-consortial interoperability Federated data storage and data sharing Portal for Central Project (Data Use) Application Project Registry Consortia Univ. Hospitals Univ. Hospitals Univ. Hospitals Univ. Hospitals

14 (exemplary) NSG Working Group Results 1. Core Data Set Definition (Basic Modules, Extension Modules) Person, Case, Demographics, Diagnosis, Procedures, Laboratory Data, Medication Generic Policy for Data Use and Data Sharing 3. Generic Broad Consent Patient Information use of EHR data for research use of insurance data for research use of biomaterials Data Integration Centre Audit criteria (V0.1) 14

15 Medical Informatics for Research and Care in University Medicine

16 MIRACUM is... the largest MII Consortium ten (eleven) University Hospitals & Medical Faculties two universities for applied science one industrial partner (Averbis GmbH) handling clinical and research data of more than 12 million patients 1

17 MIRACUM DIC Architecture Clinical Module ID-/Consent-Management Research Module Routine business intelligence Consent- Management Research queries Source system 1 Data Harmonization Comm- Server Source system 2 Clinical data repository NLP Research data repository Research data longterm archive Clinical Decision Support Local ID- Management Federation 17

18 The MIRACUM toolbox Medical Informatics ReusAble eco-system of Open source Linkable and Interoperable software tools + X MIRACOLIX Tools: Talend, ARX, RELMA, OHDSI,... Platforms: i2b2/transmart, XNAT, cbioportal,... Data Models: I2b2, Standards: IHE, FHIR 18

19 MIRACUM DIC 0.9 pilot data integration during the conceptual phase Source data 21 Core Data Set Person, Case, Demographics, Integrated Data Repository Toolkit ETL IDRT Talend Diagnosis, Procedures Data Repository i2b2 Standardized German billing data set Queries SQL SQL no data harmonization required Federation L-i2b2 R Pilot Architecture

20 MIRACUM DIC Architecture Clinical Module ID-/Consent-Management Research Module Routine business intelligence Consent- Management Research queries Source system 1 Data Harmonization Comm- Server Source system 2 Clinical data repository NLP Research data repository Research data longterm archive Clinical Decision Support Local ID- Management Federation 20

21 MIRACUM Federated Analysis Bring the analysis to the data Erlangen Frankfurt Freiburg Gießen R-Script SQL- Statement Magdeburg Mainz Mannheim Marburg 5

22 MIRACUM Federated Analysis Bring the analysis to the data SQL / R SQL / R SQL / R SQL / R Erlangen Frankfurt Freiburg Gießen R-Script SQL- Statement SQL / R SQL / R SQL / R SQL / R Magdeburg Mainz Mannheim Marburg 5

23 MIRACUM Federated Analysis Bring the analysis to the data SQL / R SQL / R SQL / R SQL / R Erlangen Frankfurt Freiburg Gießen Proof-of-Concept Analysis: R-Script aggregated results SQL- Statement Stroke / Thrombectomy Analysis of Guideline Adherence SQL / R SQL / R SQL / R SQL / R Colorectales Cancer Analysis of Therapy Patterns Magdeburg Mainz Mannheim Marburg 5

24 First Analysis and Publications Combined Sunburst-Plot of Treatment-Pathways for 18,376 patients with colorecal cancer from 11 hospitals 24

25 First Analysis and Publications 25

26 MIRACUM Data Integration Centres MII Goals Improve research opportunities and patient care through innovative IT solutions (initially at university hospitals) Intensify the exchange and sharing of data between the research community and the health care delivery system Position medical informatics as a progressive field in research, teaching and continuing education As a key element of the funding scheme data integration centers (DIC) are to be set up and interlinked by the university hospitals 26

27 MIRACUM Use Cases MII Goals Improve research opportunities and patient care through innovative IT solutions (initially at university hospitals) Intensify the exchange and sharing of data between the research community and the health care delivery system Position medical informatics as a progressive field in research, teaching and continuing education As a key element of the funding scheme data integration centers (DIC) are to be set up and interlinked by the university hospitals 27

28 MIRACUM Use Cases IT supported patient recruitment for clinical trials Phenotyping Querying EHR database / DIC data repositories Prediction Models for COPD/Asthma and Brain Cancer Patients Federated machine learning Prediction Model Deployment SMART App Integration in EHR environments Supporting Precision Medicine in Moleculare Tumorboards bioinformatics pipelines (e.g. Galaxy) integration of clinical and genomic data (e.g. cbioportal) 28

29 Research and Teaching MII Goals Improve research opportunities and patient care through innovative IT solutions (initially at university hospitals) Intensify the exchange and sharing of data between the research community and the health care delivery system Position medical informatics as a progressive field in research, teaching and continuing education As a key element of the funding scheme data integration centers (DIC) are to be set up and interlinked by the university hospitals 29

30 Research and Teaching MII Goals Improve research opportunities and patient care through innovative IT solutions (initially at university hospitals) Intensify the exchange and sharing of data between the research community and the health care delivery system Position medical informatics as a progressive field in research, teaching and continuing education As a key element of the funding scheme data integration centers (DIC) are MIRACUM will establish > 10 new biomedical informatics professorships to be set up and interlinked by the university hospitals 30

31 MIRACUM Research and Teaching MIRACUM Summer School 29. July 03. August 2018 Alsace (France) Medical (Research) Informatics Essentials Prof. Dr. James Cimino Director of Informatics Institute The University of Alabama at Birmingham, USA

32 Supplementary Activities buildung on MIRACUM New grant proposal RECUR ( ) Nationwide Registry for Recurrent Urolithiasis in the Upper Urinary Tract MIRACUM DIC Infrastructure

33 Supplementary Activities buildung on MIRACUM New grant proposal RECUR ( ) Nationwide Registry for Recurrent Urolithiasis in the Upper Urinary Tract MIRACUM DIC Infrastructure enhanced with patient acquired data across 11 hospitals Patient App EHR system Data integration centre RECUR Distributed Patient Registry

34 My thanks to our MIRACUM Team... and for your interest Förderkennzeichen: 01ZZ1801A