DNA SEQUENCING 1995 MSPPSA SERIES

Transcription

1 1995 MSPPSA SERIES DNA SEQUENCING AN ANALYSIS OF MARKET SIZE & GROWTH MARKET SHARE PURCHASE PLANS & SUPPLIER ASSESSMENT FOR THE U.S. LIFE SCIENCE RESEARCH MARKET A Multi-Client Report by PhorTech International San Carlos, California December 21, 1995 Copyright 1995 by PhorTech International, 228 Crestview Drive, San Carlos CA All rights reserved. No material contained in this report may be reproduced in whole or in part without the written permission of the publisher. This report is not intended to be, and should not be construed as a recommendation for the purchase or sale of any securities mentioned herein. The information has been derived from statistical and other sources which we deem reliable but their completeness cannot be guaranteed. Opinions expressed herein are based upon our interpretation of available information and are subject to change.

2 TABLE OF CONTENTS I. BACKGROUND... 7 A. Survey Objectives... 8 B. Survey Methodology II. DEMOGRAPHIC SEGMENTATION #37. Segmentation by Organizational Type #38. Respondents Working in Core Facilities III. MARKET SIZE & GROWTH #1. Current Use of DNA Sequencing, Market Size #2+. Sharing of Instrumentation Estimates #2. Manual Sequencing Unit Installed Base Audit #10. Advanced Sequencing Instruments Installed Base Audit.. 28 IV. MARKET SHARE #2+. Manual Seqencing Unit & Dollar Market Shares #10+ Advanced Instrumentation Unit & Dollar Market Shares 41 V. PURCHASE PLANS #26. Future Purchase Plans for Advanced Instruments #27. Instruments & Suppliers Considered for Purchase #7. Forecast Change in Manual Sequencing #20. Forecast Change in Automated Sequencing VI. CURRENT SEQUENCING METHODOLOGY #28. Sequencing Strategies in Current Use #29. Individual Reagent vs. Kit Usage & Preferred Brands #30. Primary Sequencing Template Type #31. Current Methods to Purify Plasmid Templates #32. Current Methods to Purify PCR-Generated Templates #33. Current Methods to Sequence Templates #34. Sequencing Enzymes in Current Use #35. Average Consumption by Individual Researchers #36. Current Size of Sequencing Project #9. Access to Advanced Sequencing Instrumentation #8. Manual Workload - Templates/Week & Bases Called #17. Automated Workload - Templates/Week & Bases Called 94 #16. Primary Labeling Methods for Automated Work #18. Primary Application for Automated Sequencing #19. Percent Throughput for Non-Sequencing Apps VII. SUPPLIER ASSESSMENT #3. Reasons for Choosing Last Manual Seq. Purchased #4. Customer Satisfaction: Manual Sequencers #4+. Rejected Manual Sequencer Brands & Reasons

3 #6. Ranked Supplier Performance - Manual Sequencers #11. Reasons for Choosing Last Advanced Instrument #12. Customer Satisfaction: Advanced Instrumentation #14. Ranked Supplier Performance: Auto Sequencers #15. Most Important Features: Auto Sequencers #21. Reasons for Choosing Last Robotic Workstation #22. Customer Satisfaction: Robotic Workstations #24. Ranked Supplier Performance: Robotic Workstations #25. Most Important Features: Robotic Workstations VIII. FUTURE EXPECTATIONS #5. Desired Improvements in Manual Sequencers #13. Desired Improvements in Automated Sequencers #23. Desired Improvements in Robotic Workstations IX. QUESTIONNAIRE

4 LIST OF TABLES & FIGURES I. BACKGROUND... 7 Survey Objectives... 8 Survey Methodology Survey Response Rates II. DEMOGRAPHIC SEGMENTATION Distribution by Type of Organization, All Respondents Distribution by Type of Organization, DNA Sequencing Users Distribution by Type of Organization, Advanced DNA Sequencing Users Respondents Working in Core Facilities, All Respondents Respondents Working in Core Facilities, All DNA Sequencing Users Respondents Working in Core Facilities, Advanced DNA Sequencing Users III. MARKET SIZE & GROWTH DNA Sequencing Usage, by Source DNA Sequencing Usage for Life Scientists, 1994 Global Lab Product Survey US DNA Sequencing Users Population Estimate Comparison Using Other Studies Number of Doctoral-Level Researchers, Eur Auto & Manual DNA Sequencers. 24 Extrapolation of US Laboratory/Workgroups Using Manual Sequencing DNA Sequencing Installed Base, Dollars Spent on Manual Sequencers Average Number of Manual Sequencers per Respondent Unit Placements by Year, All Manual DNA Sequencing Units Market Size Estimate, Manual DNA Sequencing Units Annual US Manual DNA Sequencer Sales Estimate, by Year Annual US Manual DNA Sequencer Sales & Market Value Estimates for Dollar Placements by Year, All Manual DNA Sequencing Units Advanced Sequencing Instrumentation Installed Base Market Value Advanced Sequencing Instrumentation, Rel Frequency Installed Instruments Advanced Sequencing Instrumentation, Dollars Spent on Installed Instruments. 29 Automated Sequencing Instruments, Market Value of Installed Base Units Placements by Year, All Automated Sequencing Units Units Placements by Year, All Robotic Workstations Units Placements by Year, All Automated Film Readers Units Placements by Year, All Sequence Analysis Software Average Number of Automated Sequencers per Respondent Market Size Estimate, Automated DNA Sequencing Units Annual US Automated DNA Sequencer Sales Estimate, by Year Annual US Automated DNA Sequencer Sales & Market Value Estimates, Average Number of Robotic Workstations per Respondent Market Size Estimate, Robotic Workstations Annual US Robotic Workstations Sales Estimate, by Year Annual US Robotic Workstation Sales & Market Value Estimates for Average Number of Automated Film Readers per Respondent Market Size Estimate, Automated Film Readers Annual US Automated Film Reader Sales Estimate, by Year Annual US Automated Film Reader Sales & Market Value Estimates for Average Number of Analysis Software Packages per Respondent Market Size Estimate, Analysis Software Packages Annual US Analysis Software Sales Estimate, by Year

5 Annual US Analysis Software Sales & Market Value Estimates for Total US Sales for All Sequencing Instrumentation, by Year Compound Annual Growth Rate of Sequencing Instrumentation over 5 Years IV. MARKET SHARE Manufacturers Unit Market Shares for Manual DNA Sequencers Average Manual Sequencer Prices for Major Suppliers Manufacturers Dollar Market Share, Sum of Spend on Manual Sequencers Manual DNA Sequencer Unit Market Share, Sequencers Sold Since 1/1/ Manual DNA Sequencer Dollar Market Share, Sequencers Sold Since 1/1/ Average Manual Sequencer Prices for Major Suppliers Sold Since 1/1/ Overall Dollar Market Shares for All Advanced Sequencing Instruments Manufacturers Unit Market Shares, All Automated Sequencers Average Automated Sequencer Prices for Major Suppliers Manufacturers Dollar Market Shares, All Mentions of Automated Sequencers Automated Sequencer Dollar Market Share, Sequencers Sold Since 1/1/ Manufacturers Unit Market Shares, Robotic Workstations Average Robotic Workstation Prices for Major Suppliers Manufacturers Dollar Market Shares, All Mentions Robotic Workstations Average Automated Film Reader Prices for Major Suppliers Manufacturers Unit Market Shares, All Mentions of Auto Film Readers Manufacturers Dollar Market Share, All Mentions of Auto Film Readers Manufacturers Unit Market Shares, All Mentions Sequence Analysis Software.. 47 Manufacturers Dollar Market Share, All Mentions Sequence Analysis Software. 47 Average Sequence Analysis Software Prices for Major Suppliers Manufacturers Dollar Market Shares, Analysis Software Sold Since 1/1/ V. PURCHASE PLANS Purchase Plans for Auto Sequencers, Response Profile of Users & Non-Users /96 US Sales Projections for New Automated Sequencers Purchase Plans for Robotic Workstations, Response Profile Users & Non-Users /96 US Sales Projections for Robotic Workstations Purchase Plans for Auto Film Readers, Response Profile of Users & Non-Users /96 US Sales Projections for Automated Film Readers Purchase Plans for Analysis Software, Response Profile of Users & Non-Users /96 US Sales Projections for Analysis Software Share of Mentions, Planned Purchases of Automated DNA Sequencers Share of Mentions, Planned Purchases of Robotic Workstations Share of Mentions, Planned Purchases of Automated Film Readers Share of Mentions, Planned Purchases of Analysis Software Forecast Change in Manual Sequencing, All Manual Sequencing Respondents.. 63 Aver. Change in Manual Sequencing Over Next 12 Months by Current Users Forecast Change in Automated Sequencing, All Auto Sequencing Respondents. 65 Average Change in Auto Sequencing Over Next 12 Months by Current Users VI. CURRENT SEQUENCING METHODOLOGY Current Sequencing Strategies in Use Individual Reagent vs. Kit Use Share of Mentions, Preferred Brands of Sequencing Kits Primary Methods for Sequencing Templates Current Methods for Purifying Templates Purifying PCR-Generated Templates Current Methods for Sequencing Templates Share of Mentions, Sequencing Enzymes, by Type

6 Templates Sequenced per Week, T7 DNA Polymerase Templates Sequenced per Week, Taq Polymerase Templates Sequenced per Week, Klenow Templates Sequenced per Week, Reverse Transcriptase Templates Sequenced per Week, Vent Templates Sequenced per Week, Sequitherm Mean & Median: T7 DNA Polymerase Template Use Mean & Median: Taq Polymerase Template Use Mean & Median: Klenow Template Use Mean & Median: Reverse Transcriptase Template Use Mean & Median: Vent Template Use Mean & Median: Sequitherm Template Use Total Templates per Week (Manual & Auto), Grouped According to Basis Estimate of Total Templates Sequenced per Week in US Estimate of Total Templates Sequenced per Year in US Size of Current Sequencing Projects Access to Sequencing Instrumentation, All Respondents Currently Sequencing.. 89 Average Templates Sequenced per Week, Cross Section of Manual Seq. Users.. 91 Mean & Median: Templates Sequenced per Week by Manual Sequencing Average Bases per Template, Cross Section of Manual Sequencing Users Mean & Median: Bases Called per Template by Manual Sequencing Average Bases per Week Called, Cross Section of Manual Sequencing Users Mean & Median: Bases per Week Called by Manual Sequencing Average Templates Sequenced per Week, Cross Section of Auto Seq. Users Mean & Median: Templates Sequenced per Week by Auto Sequencing Average Bases per Template, Cross Section of Automated Seq. Users Mean & Median: Bases Called per Template by Automated Sequencing Average Bases per Week Called, Cross Section of Automated Seq. Users Mean & Median: Reported Reagent Cost for Manual & Automated Sequencing 96 Primary Labels for Automated Sequencing Verbatim Description of Applications for Automated Sequencing Non-Sequencing Applications, % of Throughput on Automated Sequencers VII. SUPPLIER ASSESSMENT Last Manual Sequencer Purchased Verbatim Comments for Last Purchased Manual Sequencer Sorted by Brand Customer Satisfaction Rates for Last Purchased Manual Sequencer Satisfaction Rates & Confidence Levels for Manual Sequencer Manufacturers Reasons for Dissatisfaction with Last Manual Seq. Purchase Sorted by Brand Reasons for Satisfaction with Last Manual Sequencer Purchase Sorted by Brand 112 Ranked Manufacturers Performance for Manual Seq.: Best Value for Money Ranked Manufacturers Performance for Manual Seq.: Easiest to Use Ranked Manufacturers Performance for Manual Seq.: Most Reliable Quality Last Advanced Instrument Purchased, All Advanced Sequencing Instruments Verbatim Comments for Last Purchased Advanced Seq. Insert Sorted by Brand. 119 Reasons for Dissatisfaction with Last Auto System Purchase Sorted by Brand Reasons for Satisfaction with Last Auto System Purchase Sorted by Brand Ranked Manufacturers Performance for Automated: Best Field Service Ranked Manufacturers Performance for Automated: Easiest to Use Ranked Manufacturers Performance for Automated: Greatest Innovator Ranked Manufacturers Performance for Automated: Instrument Throughput Ranked Manufacturers Performance for Automated: Lowest Running Costs Ranked Manufacturers Performance for Automated: Most Reliable Quality Ranked Manufacturers Performance for Automated: Most Committed

7 Most Important Features of Automated Sequencers Reason for Selecting Brand of Robotic Workstation Sorted by Brand Verbatim Comments Regarding Robotic Workstation Decision, by Brand Ranked Manufacturers Performance for Robotics: Application Flexibility Ranked Manufacturers Performance for Robotics: Best Field Service Ranked Manufacturers Performance for Robotics: Easiest to Use Ranked Manufacturers Performance for Robotics: Greatest Innovator Ranked Manufacturers Performance for Robotics: Level of Automation Ranked Manufacturers Performance for Robotics: Most Reliable Quality Most Important Features of Robotic Workstations VIII. FUTURE EXPECTATIONS Suggested Improvements in Manual DNA Sequencers Suggested Improvements in Automated DNA Sequencers Suggested Improvements in Robotic Workstations IX. QUESTIONNAIRE