Spot fire Dec isionsit e 8.0 Audio: Conf:

Transcription

1 Spot fire Dec isionsit e 8.0 Audio: Conf: Dylan Cotter Application Specialist, Business Development

2 Agenda Spotfire DecisionSite Introduction -Company Update -DecisionSite Analytic Applications and Benefits Oracle Features Used Demonstration -Leveraging Oracle Technologies within DecisionSite Summary & Q/A

3 Spot fire Overview Leader in Guided Analytic Applications and Services 800+ Global 2000 Customers; 30,000+ users 160+ World Wide Employees- Sales and Support Headquartered in Somerville, MA and Göteborg, Sweden Dominant in life science - All major Pharmas Biotechs - Discovery: Proteomics, Genomics, HTS, Lead Optimization, ADME/Tox - Development: Clinicals, Pilot, Manufacturing, Supplychain, Sales/Marketing

4 Dec isionsit e Plat form Powerful data access - access to many data sources State of the art visualizations - multiple, linked, dynamic plots Easy to use - intuitive UI, Guides Extend analysis methods - deploy new algorithms or tools Develop new Analytic Applications - support future analysis processes Share decisions - dynamic, interactive reports

5 Produc t Overview Access to any data - One-click data retrieval to ad-hoc querying - Integrated - Multiple sources - Unified data view Continuous data exploration and analysis - Linked Visualization - Dynamic filtering - One-click analytic formulae and computations - Drill down to details

6 Dec isionsit e Post ers Enable teams to collaborate around data driven decisions - Across geographies, - Across time zones - Across boundaries - Across disciplines Extends the value of Guided Analytics across the enterprise to facilitate better, faster team decision-making Manages decisions as company assets creating Decision I.P. Interactively filters data via range sliders, check boxes, or radio buttons with dynamic detail drill down

7 Spot fire is used ac ross t he ent ire Life Sc ienc e Value Chain Adaptation Results Compound Properties ADME Properties Adverse Events FDA Target Identification Lead Discovery Lead Optimization ADME/Tox Clinical Target Validation Hit Identification Lead Promotion Safety Report FDA Making highly informed risk-based decisions requires - Early establishment of a 360 view of candidate compounds - Analytic approach supporting an iterative, exploratory process

8 1. High-Throughput Sc reening Spotfire configuration - High Throughput Screening Shared users - Biologists in primary & secondary screening Solution Business Impact - Automated workflow/processing of high throughput screening data - Multiple views and slices of the processed data revealing inconsistencies - Best practices for analyzing HTS data are institutionalized - Better quality/confidence leads delivered to secondary screening and medicinal chemistry

9 2. Lead Ident ific at ion Spotfire configuration - Chemogenomic analytics Shared users - Toxicologists, pharmacologists, chemists Solution Business impact - Identify compounds with similar gene expression signatures ( fingerprints ) - Incorporate chemical structure, clinical chemistry and histopathology data into the analysis to better define relationships between compounds - Use compound relationships to anticipate toxic behavior in unknown compounds

10 3. Com pound Profiling Spotfire configuration - Lead Discovery Shared users - Medicinal Chemists Business impact - Compounds profiled across departmental and domain borders - Chemists get insight into biology, biologists insight into chemistry - Best practices for compound selection can be institutionalized - Better quality leads delivered to ADME/Tox / pre-clinical areas

11 4. Func t ional Genom ic s Spotfire configuration - microarray data analysis Shared users - Biologists in target discovery Business impact - Identify data sources - Select methods of data transformation - Incorporate appropriate tools analysis to test hypothesis - Add known information to extend the analysis - Identify subsets of genes for further study - Decision process involves identifying subsets of genes for further study, accept or reject hypothesis and share conclusions

12 5. Clinic al Trials Phase I, II, III Spotfire configuration - Adverse Event Analysis Shared users - Clinical trial/data managers, statisticians, and medical monitors Business impact - Identify types/frequency of adverse events - Outliers indicating errors in data recording - Explore frequency/severity of adverse events, demographic influences, statistically significant dependencies between event type and dosage - Issues in clinical trials can be detected earlier

13 6. Pharm ac eut ic al Sales & Mark et ing Spotfire configuration - Pharmaceutical Sales & Marketing Shared users - Business analysts, brand/product managers, sales/marketing managers Business impact - Leverage very expensive IMS into analytic environment - Drive informed sales force deployment decisions - Integrate IMS / prescription data, patient demographics, physician data, and GIS data - Market and sell in area where effect is optimal

14 Analyt ic Applic at ions Support Many Needs Extend the Analysis: - Validate microarray results with rtpcr - Compare gene expression with protein expression - Chemogenomics: integrate chemistry support - Toxicogenomics: integrate Toxicology data Protein expression Compare microarray and rtpcr data Chemogenomics Toxicogenomics

15 Orac le Feat ures Used Today Spotfire DecisionSite Server supports Oracle Enterprise/Standard Databases: - Oracle 10g - Oracle9i Release 2 (9.2.0.x) and Release 1(9.0.1) - Oracle8i Releases and DecisionSite s Information Interaction Services can use Oracle as as federated database access Query and Join Engine for multiple and disparate database access Storage of the Meta Layer of Disparate data sources as an Information model that is a business representation of data sources

16 Orac le Feat ures Used Today Use of Oracle SQL functions for data manipulations Oracle Chemistry cartridges in combination with partner companies provide: - Chemical Storage technologies - Chemical content repositories - Integration capabilities - Screening data repositories Enhanced Information Link APIs for Oracle name resolver service provides row level security to data retrieved for analysis

17 Dec isionsit e 8.0 Arc hit ec t ure DecisionSite Client Application Manager Import Agent Visualization Calculations Filtering Other Application Clients Excel Intranet... Browser APIs DecisionSite Server HTTP/COM App Manager APIs HTTP/SOAP Web Service APIs Reusable Components Application Manager Applications Guides Tools Library Posters Guides Analysis Calculations Security & Administration Java Information Interaction Services Information Links Information Interaction Model JDBC WinNT LDAP JAAS SPI MySQL SQL svr JDBC SPI DB2 Custom Oracle csv,txt other

18 Inform at ion Int erac t ion Servic es Implement a solution that allows for rapid report development and reduces reliance on IT developers to create and deploy reports. Administrators create query environments without having to program Can publish queries and/or query elements to the right user user communities without programming Allow users to Focus on analysis and decisions instead of data retrieval Utilize Oracle SQL Functions for Data Manipulations Implement Oracle row level securtity

19 Inform at ion Link s How to implement a solution that allows for rapid report development and reduces reliance on IT developers to create and deploy reports? Allow users to access the data they need to do their jobs without knowing how to program databases Load (and reshape) data with a single click ask questions to refine data returned E.g. - Ask the user to select Business Units and Markets over a data range

20 Dem o Guided Workflow for Lead Identification How to Create an Information Model and Link How to Capture and Share the Analysis Process

21 Dem o Retrieve Data - Screening, Chemical Properties, and Structure Visualize and Browse data Explore drug-ability of compounds - Which ones have drug-like properties? - Which ones are potent for our target (leukemia)? Explore selectivity and structure of findings - How do compounds with a similar structure compare? Report results of analysis Do it!

22 Sum m ary Powerful data access - access to many data sources State of the art visualizations - multiple, linked, dynamic plots Easy to use - intuitive UI, Guides Extend analysis methods - deploy new algorithms or tools Develop new Analytic Applications - support future analysis processes Share decisions - dynamic, interactive reports

23 Sum m ary Spotfire DecisionSite is the preferred analysis environment for 18,000+ scientists and ultimate database front end for highly interactive visual analytics and data trending providing the exploratory flexibility that doesn t come from BI/reporting or Statistics Guided Analytics are rapidly emerging as the best way to deploy complex, analytic applications to a mainstream (non-expert) user base Oracle s Data Mining tools and Text Mining Option provide rapid insight for large volumes of data in the database and combined with Spotfire DecisionSite s interactive visual environment serve as the optimal analytic solution Spotfire offers many tools to support the Application Developer - Connection with data warehouse and other disparate sources - Integration with other applications

24 Cont ac t Inform at ion Thank you for your attention! /freedom to wonder_power to decide dylan.cotter@spotfire.com

25 Abstract: Spotfire is an independent software vendor (ISV) that leverages the Oracle technology platform to provide interactive visual analysis software. Spotfire DecisionSite s interactive visual analytics speeds data analysis for decision-makers across the organization, helping them make decisions faster, more easily and with increased confidence. In this eseminar, we will show you how data analysis groups in research and development such as cheminformatics, bioinformatics, and computational chemistry can leverage Oracle technologies with Spotfire s DecisionSite 8.0. We will show how DecisionSite's Information Services provides unified access to your data through an intuitive information model where users can perform ad-hoc querying using easy pointand-click Information Links. Information Links give users role-based access to data without the need to know query languages or underlying database schemas and take advantage of many Oracle features including Oracle Chemical Cartridge integration, SQL functions for data manipulation, and row level security for data retrieved for analysis. We will present how DecisionSite s high-impact visualization and analytic capabilities incorporating Oracle technologies let users examine the chemical and biological dimensions of their data and perform a wide array of numerical and structural analysis. We will show how to capture the ad hoc analysis processes from an organization s domain experts for sharing in re-usable Guided Analytic Applications and how DecisionSite Posters make analytic decisions a core company asset.