Byos. A Clear Sky Solution for Analytical Scientists

Transcription

1 A Clear Sky Solution for Analytical Scientists

2 One-touch Platform to Launch Seamless Workflows Raw File Report in Minutes

3 Integrated application with templated workflows Workflows

4 Step 1: Click to launch templated workflow

5 Step 2: Drag-and-drop RAW files of interest

6 Step 3: Drag-and-drop FASTA of interest Sample1.fasta Sample2.fasta Sample3.fasta Sample4.fasta Sample5.fasta Step 4: Create project.

7 Byos does the work. Processes all MS/MS searches Assembles the project and extracts XICs Creates report

8 Step 5: Review Project and Report CSV

9 Heritage Products Single application with 1.) modular capabilities and 2.) templated workflows Workflows -S-S- A B C A B C PTM HCP Disulfide SVA in silico Annotate Compare in silico in silico Intact Reduced ADC de novo Capabilities 1: XIC Feature Comparison with MS/MS IDs 2: XIC Feature Comparison (MS1 only) 3: Chromatogram Analysis with MS/MS IDs 4: Chromatogram Analysis (MS1 only) 5: Intact Mass Charge Deconvolution 6: De novo sequencing Automation Module Framework Automation Module Byonic Byologic Byomap Intact Mass Supernovo

10 Workflow Automation Intact Intact Mass Drag and Drop Data OR Auto-Batch Deconvolute Report Automatically

11 Workflow Automation Bispecifics Intact Mass

12 Workflow Automation Post-Translational Modification and Quality Attributes of Biotherapeutics PTM, Hotspot, HCP, and SVA workflows FIND the protein variations Present them for review/ make XICs Report Automatically

13 Workflow Automation Cell Line Development PTM with Automation

14 Embodying Protein Metrics Product Promise Quality of Results Intuitive User Experience Vendor Neutral Solutions Workflow Automation Cost & Time Savings

15 Testimonials "With Byologic I replaced six different analytical LC/MS peptide map methods (six analysts doing six methods) with one MS method. We transferred it to the High Throughput Screening group. They can run that one method faster than it used to take one analyst to run an individual method, and we can generate and ask questions much more quickly. Using Protein Metrics software, we can also run cell-culture samples directly in days. Prior to implementing their software, it took us six months to send samples to purification and then analyze them." Matt Traylor, Ph.D., Associate Director of Analytical Development, Shire "Protein Metrics software is a powerful tool for analyzing glycosylation and other PTMS. Their software greatly alleviates the mass spec analysis bottleneck." Wilson Phung, Scientific Researcher, Applied Proteomics, Genentech/Roche I really like the Protein Metrics software. It helped us to make advances that we may not have been able to with other software. It identified protein impurities that we couldn't make with other software. I was impressed with the auto reporting features and search engine. We realized cost savings and were able to reallocate resources. We can now get deeper into our to data to find what we're looking for. The people are really great to deal with - Eric and the team - fantastic, we get a very good response from them." Mimi Roy, Ph.D., Director of Analytical Development, BioMarin

16 Protein Metrics Product Promise Byonic Protein and Peptide ID BYOS Intact Mass Sample ID and Comparison Byomap Chromatogram Analysis Quality of Results Intuitive User Experience Vendor Neutral Solutions Supernovo mab de novo sequencing Byologic Inspection, Quant, Reporting Workflow Automation Cost & Time Savings

17 Thank You