Transforming Change Management with Modern Systems
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1 Transforming Change Management with Modern Systems Mike Jovanis, VP Vault Quality
2 Abstract Transforming Change Management with Modern Systems Assessing impact, and creating and executing a change plan are difficult with global stakeholders and multitude of systems. Extensive coordination is often needed between different functional areas such as quality, manufacturing, and regulatory. Join us and hear how modern systems break down organizational silos transforming change management. In this session, we will discuss: Providing a framework to systematically assess global operational and regulatory impact How to gain greater visibility between quality and regulatory departments, and how to work together Structuring change releases and putting into effect in a global environment Gaining better intelligence and efficient changes for greater agility and better decision-making
3 Importance of Change Management COST Complex / global supply chains Managing Cost Speed & Agility 3
4 The Challenge 200+ Changes a year for a single product Evaluated changes in a year for a top 20 Implemented 15,000 of the requests 40,000 Months to Years From initial assessment to final regulatory approval and implementation
5 Transforming Change Management People Change Management Process Technology 5
6 People
7 Cross-functional Responsibility Quality Regulatory Change Control Manufacturing Supply Chain Other
8 People Culture Change Breaking down silos between groups Changing people s mindset to embrace new ways of doing things Empowerment Empower people to make decisions with accessible information Behavior Shift Drive behavior change to collaborate across functional areas Executive Support With significant changes across the organization, support from executives is essential for success 8
9 Process
10 Increasing Process Complexity Crossfunctional Globalization Outsourcing 10
11 Key Questions to Ask Is the current process working? Can we make changes at the right speed? Do we involve critical external parties? Product recall can cost an organization between 1 Quality incidents are due to >40% supplier/vendor quality issues 2 60 % FDA CDER warning letters given to manufacturing sites in India 3 $15M* *One Manufacturer $14B 11
12 Changing the Process Better Intelligence Cross-functional processes that enable information access to all relevant parties for faster and more informed decision-making Impact-based Triaging Over-engineering processes hinders agility and scalability Amount of effort and control should reflect impact Enables consistent, scalable processes End-to-End Seamlessly incorporate all parties into a single process Process should easily work across functional areas Transparency See who is responsible for each part of the process Providing status and process visibility allows everyone to be part of the process and help drive change 12
13 Technology
14 Fragmented Solutions External Quality Internal Quality Deviations / Investigation System CAPA System Global Health Authorities Supply Chain Manufacturing Document Repositories Affiliates CTLs CMOs Partners / Vendors Collaboration Portals Regulatory Systems Co-development CDMOs Audit System Change Management Systems Excel Spreadsheets Excel ECM System QMS 14
15 Globalization Adds Further Complexity 15
16 Key Change Management Challenges Assessing Impact Executing Change Inventory and Ship Decisions Most changes require prior regulatory approval Lack of visibility into global and regulatory impact Manual effort to collect and aggregate all site / supplier info to support decision-making Action tracking across multiple systems Inefficient, long cycle times, and increased potential of errors Lack of global status visibility Lack of timely approvals and limited visibility into approval status Incomplete / fragmented information impedes quick, accurate decisions
17 Can You Have Better Intelligence? How are global sites impacted? When should the change be implemented? How should changes be bundled? Which countries have regulatory approval for change? Which changes require regulatory filings, in which markets? Which documents require updating? How do we optimize inventory? 17
18 Unified System Single place to ensure all change control and quality issues are resolved and regulatory approvals are in place before shipping Unified System Across Functional Areas Unified Quality System Change Management Deviations CAPA Audits Document Management Complaints Regulatory Information Management System Document Training Supplier Quality Investigations 18
19 Unifying Systems Across Functional Areas Global Visibility Uniform Platform Content Management System QMS System Regulatory System Quality Event CAPA Change Control Document Change Control Implementation Actions Regulatory Actions
20 Incorporating Internal and External Parties Bidirectional communication with all critical stakeholders CTL / CLO R&D Regulatory CTL / CLO Manufacturing Quality Supplier CMO Manufacturing CMO Supplier Supplier 20
21 Ease of Adoption Across All Employees Modern solution support a changing workforce and environment Intuitive, single user interface Native mobile Consumer web experience Built-in compliant capabilities Reduces training need & increases user adoption Global, remote, or mobile workforce Aligned with how people work / find information Increased compliance
22 Summary
23 Transforming Change Management People Process Technology Culture & Executive Support Unified Across People & Functional Areas Enables People and Process Change 23
24 Transforming Change Management with Modern Technology A Unified Global Solution Raw Material (Excipient) Labeling Drug Substance Drug Product Packaged Item Improved visibility to in-flight changes Reduced time spent searching for information Effective specification and material management RISK Full visibility to registration impacts Improved product supply planning and compliance Reduced regulatory risk 24
25 Enabling with Cloud Technology Easily Incorporate External Parties Real-time visibility into quality processes and data More collaborative vendor relationships Directly engage partners anywhere in the world Bring Together Quality, Regulatory, & Manufacturing Data Complete quality view for greater insights Resource allocation based on performance Seamless Quality & Document Management Processes Accelerate event identification to correction Streamline change management process Supports a Changing Workforce Find information quickly Native mobile capabilities, work from anywhere Easy to use, train, and administer 25
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