Applied Biosystems. Enterprise Informatics Discovery through Manufacturing. May 17 th, 2005

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1 Applied Biosystems Enterprise Informatics Discovery through Manufacturing May 17 th, 2005

2 Increased Value for Our Customers Core Enabling Technology / End-to-End Solution Required Quality Test Perform Diagnostic Method Calculate Normalized Operating Points Normalize OP Control Rules QC Strategy Data / Risk Analysis Results Reporting Process Industries Sample Sample Collection Barcode Chemical Processing Sample Prep Process Validation Data Collection & Storage Data Analysis Results Reporting Forensics Case Management Question Scientific Sample Solution Collection Hypothesis Sample Preparation Sample Analysis Data Collection & Storage Data Analysis Results Reporting Life Science Reducing Time to Results, Increasing Productivity Applied Biosystems offers highly advanced informatics solutions capable of integrating disparate data and research applications. We: Quickly reach an understanding of the customer s process with the goal of increasing productivity, improving quality and reducing costs Organize processes across facilities and integrate to outside services Implement large scale experiment/process design templates to maximize impact Facilitate large-scale distributed process management & optimize workflow Satisfy demanding information management requirements

3 Value-Add Services Built Upon Enabling Technologies & Professional Services Next Generation Service Drug Targets & Validation Diagnostics Forensics Case Management Genomics Sequencing Analysis Gene Expression Studies Proteomics Expression Studies Pharma Manufacturing (QA/QC) Vertical Services Vertical Value-Add Services End to End Solutions Consulting Services Technology Services Horizontal Professional Services Support Services AB Toolkits AB Instrument Platforms Enabling Technologies

4 SQL*LIMS v5 Software Web / Browser client, JAVA applet / servlet based (Windows, Linux, Unix IE, Netscape, Firefox) J2EE, Web services extensible framework (Oracle/Apache exposed services for SOAP, WSDL,.NET, COM and other common application framework technologies) Server & Client are configuration based, build workflows, calculations; define specifications, attach SOP s, documents, build user logic loopback directly from configuration / setup screens Deploy and manage easily in single lab or across the globe, securely, standards based LDAP and encryption to allow hosting across firewalls

5 SQL*LIMS v5 Software and Oracle Technology Architecture Configure for a small lab or large, global operation Easily scale to global system with minimal need for re-validation Multi-tiered Simplifies Applied Biosystems instrument and application integration Client Application server Database Web browser Client Web Services Web Server Business Intelligence

6

7 SQL*LIMS v5 Sofware Rich use of graphical controls to navigate to log a sample, perform an analytical task, result entry, review and approve data or run report

8 A Configuration Setup Screen for an Instrument Calibration / Reagent Tracking routine Building a definition or activity is mostly a mouse click to add a node, fill in a blank or selection from a list of values

9 Systems Integration MRP Systems Other Enterprise Systems 3 rd Party Applications Accounting Inventory Quality Document Mgmt SQL*LIMS v5 Software

10 Instrument Integration ABI Instruments 3 rd Party Instruments Robotics SQL*LIMS v5 Software

11 SQL*LIMS v5 tightly integrates Oracle Reports And easily integrates with ANY 3 rd party reporting tool, statistical package or desktop application that is ODBC compliant Out-of-the-box: Printer, File, Browser, , Oracle10gAS Portal OTN: WebDAV, FTP, Oracle9iAS Wireless Standards-based deployment JSP and Servlet Open Java-API to add your own destinations and notifications

12 Built-in Reporting Capabilities with Flexible Formatting Excel RTF Web PDF & Printer XML

13 Northwest Analytical charting package Integrates directly with SQL*LIMS

14 Applied Biosystems & SQL*LIMS Software A history of innovation and commitment to providing laboratory informatics solutions First Commercial LIMS LIMS 2000 SQL*LIMS v1.1 Oracle v5.1 SQL*LIMS v2.0 Oracle v6 SQL*LIMS v3.0 Oracle v7 SQL*LIMS v4.0 Oracle v8i SQL*LIMS v5i Oracle 10g SQL*LIMS v2.1 SQL*LIMS v3.1 Y2K SQL*LIMS v4.1 SQL*Stability SQL*Schedule SQL*QA SL*Solution SAP SQL*GT Life Science LIMS SL v4 Archiver v5 v6 v7

15 Validation Services Streamlining the process Industry Proven and FDA Approved Validation Services Validation Manual Sets, including IQ & OQ Scripts. Save Months and Important Resources by not having to build your own scripts. Lowers total cost of validation. Complete IQ/OQ/PQ services and assistance available. Directly from ABI or approved Third Party On-site Vendor Site Audits. Dedicated Quality Assurance Staff (8 people) Source Code Escrow Accounts

16 Licensing/Trademarks Copyright 2005 Applied Biosystems. All rights reserved. This document or parts thereof may not be reproduced in any form without the written permission of the publisher. Information in this document is subject to change without notice. Applied Biosystems assumes no responsibility for any errors that may appear in this document. This document is believed to be complete and accurate at the time of publication. In no event shall Applied Biosystems be liable for incidental, special, multiple, or consequential damages in connection with or arising from the use of this document. Applied Biosystems and SQL*LIMS are registered trademarks, and AB (Design), Applera, SL Solution, SQL*QA, SQL*Protocol, SQL*Stability, and SQL*Schedule are trademarks of Applera Corporation or its subsidiaries in the U.S. and/or certain other countries. Oracle is a registered trademark of Oracle Corporation and/or its affiliates. Java is a trademark of Sun Microsystems, Inc. All other trademarks are the sole property of their respective owners.

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