Safe Harbor Statement

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2 Safe Harbor Statement This presentation may contain forward-looking statements as defined in the Private Securities Litigation Reform Act of These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the Company s expectations and projections. Risks and uncertainties include general industry conditions and competition; economic conditions, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental laws and regulations; and trends toward health care cost containment. A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 to the Company s Annual Report on Form 10-K for the fiscal year ended January 3, Copies of this Form 10-K, as well as subsequent filings, are available online at or on request from the Company. The Company does not undertake to update any forward-looking statements as a result of new information or future events or developments.

3 Michael Mahoney Company Group Chairman Worldwide Franchise Chairman DePuy

4 DePuy Franchise Orthopaedics Spine Sports Medicine Neurosurgery

5 We compete in very large markets with consistent growth rates and tremendous untapped potential to keep people moving DePuy is a market leader with solid market momentum and strong financial performance DePuy will grow by leading in core markets, innovating into new growth segments and expanding globally with a focus on emerging markets

6 Worldwide Market Size 2009 Market: $38.6B 6.4% Growth 2014 Market: $53.6B 6.8% CAGR Other ** $3.1B Neuro* $4.8B Hips $6.4B Other ** $4.1B Neuro* $7.4B Hips $8.1B Sports $3.9B Knees $7.2B Sports $5.8B Knees $9.6B Spine $8.7B Trauma $4.5B Spine $12.2B Trauma $6.4B * Includes neuromodulation ** Includes extremities, bone cement, biologics, etc. Source: Internal Estimates Note: All figures operational

7 2009 DePuy Growth Exceeds Market Growth Faster Than Market in Most Segments OPERATIONAL DEPUY GROWTH OPERATIONAL MARKET GROWTH (INTERNAL ESTIMATE) Hips 7.9% 3.5% Knees 4.9% 4.3% Trauma & Extremities 10.1% 7.9% Spine 10.9% 8.8% Sports 12.0% 8.5% Neuro 4.2% 6.6%* Total 7.5% 6.4% * Includes neuromodulation Source: Internal Estimates Note: All figures operational Above Market Below Market

8 DePuy Franchise SALES YE 2009 GROWTH 2009 CAGR WW MARKET POSITION 2009* $5.4B 7.5% 8.3% #1 Growth Strategies Win in core markets Lead and innovate in new growth segments Drive operational effectiveness to fuel growth Accelerate global expansion Strengthen franchise capabilities * Internal Estimate Note: All growth figures operational

9 Hip Replacement SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 7.9% #2 5.0% $8.1B Growth Strategies Extend leadership in high performance portfolio Improve surgical efficiency Strengthen position in revisions * Internal Estimate Note: All figures operational

10 Hip Solutions: Leadership in High Performance Pinnacle Widest range of solutions Unparalleled clinical heritage High stability with low wear Pinnacle CoMplete Expected first ceramic-on-metal in U.S. (pending FDA approval) Durability, stability for active patient Enhanced wear characteristics Metal on Poly Available WW Ceramic on Poly Available WW Metal on Metal Available WW Ceramic on Metal Available O.U.S., Pending FDA Approval Ceramic on Ceramic Available O.U.S., Pending FDA Approval

11 High Performance Solutions: Finsbury High performance, large diameter hip bearings DeltaMotion Proprietary ceramic-on-ceramic O.U.S. Stability, range of motion Reduced risk of dislocation, low wear Adept Hip System for resurfacing Excellent clinical heritage

12 Surgical Efficiency Solutions: Anterior Approach Unique bone-preserving stem Enhances operating room efficiency Less pain, quick recovery Driven by excellence in professional education

13 Hip Revision Solutions Strengthening position in fast growing segment New platform launches Corail Revision Gription TF ReClaim Unparalleled range of hip options

14 Knee Replacement SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 4.9% #2 6.0% $9.6B Growth Strategies Drive high performance portfolio Improve surgical efficiency Reinforce leadership in knee revisions * Internal Estimate Note: All figures operational

15 High Performance Knee Solutions Sigma High Performance Platform High performance instrumentation Fixed & mobile bearing Sigma High Performance Partial Knee Replace only affected part of knee Natural motion, quick recovery AOX poly: Pending FDA approval

16 Surgical Efficiency Solutions TruMatch : Patient-specific instruments Improves operating room productivity 15% reduction in OR time 52% reduction in prep time Offers unique advantages CT scan Metal saw and pin captures

17 Knee Revision Solutions Strengthen leadership in high growth segment Function with wear resistance Only rotating platform design Stability Wide range of options Excellence in professional education

18 Spine SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 10.9% #2 7.0% $12.2B Growth Strategies Win in degenerative spinal care Strengthen leadership in deformity Accelerate growth in vertebral body augmentation (VBA) * Internal Estimate Note: All figures operational

19 Win in Degenerative VIPER 2 minimally invasive solutions Single solution for thoracic to lumbar spine Used for both simple and complex cases New implant options Introducing VIPER 3D System in Q3 Brings MIS solutions to complex surgery Open surgery results, percutaneous approach

20 Win in Degenerative COUGAR LS New Lateral Approach Platform Excellent visualization and access Simplified cage insertion Complement to VIPER 2 Neuro-monitoring enabled Uses standard hospital equipment Hospital cost savings

21 Strengthen Leadership in Deformity EXPEDIUM Spine System Most sophisticated deformity system New favored angle screw facilitates all deformity correction maneuvers in one implant New universal connector set enables seamless revision constructs

22 DePuy Pipeline Highlights Pending CoMplete * Acetabular Hip System GRIPTION TF (TIFOAM)* Hip and Knee AOX Poly for Sigma and LCS Affixus Hip Fracture Nail* MEDSTREAM * Programmable Pump Approved/Cleared/Launched Planned Submissions Planned Submissions Planned Submissions ASPHERE * RECLAIM Hip Revision Next Generation Knee System DeltaMotion Hip System* Contoured Metal Heads Next Generation DVR Bone Preserving Hip Stem Hip Bearings TruMatch * Wrist Plate* Personalized Solutions New Poly Hip Bearings Hip Resurfacing System Shoulder Fracture Platform Sigma CR150* DVR Express Next Generation Hip System Mobile Bearing CONFIDENCE Spinal Cement System LX TLIF Cage WW Screw Next Generation Shoulder A.L.P.S. System Modules* (Anatomic Fibula, Anatomic Elbow, EXPEDIUM LX Platelet Rich Plasma System CAIS Cartilage Regeneration Proximal Tibia) VIPER LX COUGAR LS Lateral Cage TLIF Cage ScoliScore AIS Prognostic Test* VaprVue & Coolpulse 90 GRYPHON BR ANCHOR NEXTRA System ORBIT GALAXY Detachable Embolic Coil* * U.S. submission only. This information is accurate as of the date hereof to the best of the Company s knowledge. Johnson & Johnson assumes no obligation to update this information. Selected Highlights as of 6/3/10

23 Accelerate Global Expansion Japan Strengthen portfolio Emerging market growth Increase professional education Develop segmented portfolio Expand manufacturing, R&D

24 We compete in very large markets with consistent growth rates and tremendous untapped potential to keep people moving DePuy is a market leader with solid market momentum and strong financial performance DePuy will grow by leading in core markets, innovating into new growth segments and expanding globally with a focus on emerging markets

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26 DePuy Appendix

27 Sports Medicine SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 12.0% #3 8.0% $5.8B Growth Strategies Drive innovative arthroscopy platforms Expand minimally invasive office-based technologies Advance biologic solutions for cartilage repair * Internal Estimate Note: All figures operational

28 Trauma SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 8.9% #4 7.0% $6.4B Growth Strategies Launch Affixus Hip Fracture Platform Continue expansion of A.L.P.S. Locked Plating portfolio Register key brands in targeted Asian markets * Internal Estimate Note: All figures operational

29 Extremities SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 11.8% #1 11.0% $1.3B Growth Strategies Enhance market-leading shoulder portfolio Shoulder fracture platform Unique glenoid solutions Bone conservation technologies * Internal Estimate Note: All figures operational

30 Neuro SALES GROWTH 2009 WW MARKET POSITION 2009* WW MARKET CAGR* TOTAL WW MARKET REVENUE 2014* 4.2% #3 9.0% ** $7.4B ** Growth Strategies Establish leadership in neurovascular Expand into neuromodulation drug delivery systems Leverage foundation in neurosurgery to expand into emerging markets * Internal Estimate ** Includes neuromodulation Note: All figures operational