Agilent s Kalabie Electronic Lab Notebook (ELN) Product Overview

Transcription

1 Agilent s Kalabie Electronic Lab Notebook (ELN) Product Overview Agilent Software and Informatics Division

2 LSCA Portfolio Chemical Analysis Life Sciences Materials Sciences Petrochemical/Chemical Environmental Testing Food Testing Forensics Pharma/Biotech Research and Disease Discovery Discovery/Development QA/QC Academia/Government Diagnostics Surface Science Materials Characterization Particle Sizing Software and Informatics Workstations Networked Data Systems Enterprise Solutions

3 Agilent Software and Informatics LIMS Preferred Providers LabVantage StarLIMS Labtronics Kalabie ELN Bioinformatics GeneSpring Pathway Architect Chromatography / Instrumentation / Spectrometry ChemStation EZChrom Elite OpenLAB ICM MassHunter Professional Services Enterprise Content Management OpenLAB ECM EMC 2 Help Help laboratory laboratory managers managers / / directors directors reduce reduce the the time, time, effort effort & cost cost to to go go from from raw raw data data to to final final insight insight

4 Vision: The ELN is a focal point Research Processes Collaborate ELN Inform Research Management Support - Share Chemistry Biology Analytics Research Activities Agilent s Kalabie Electronic Lab Notebook (ELN)

5 The 3 main problems Kalabie ELN is adressing How to improve R&D productivity? Cost of R&D are surging but throughput remains flat How to improve individual productivity? How to enhance internal knowledge sharing and collaboration? How to streamline overall research processes? How to secure Intellectual Property and cut some associated costs? How to protect valuable IP information? How to ease information gathering for patent creation? How to enhance overall quality of experiment documentation? How to reach IT efficiency:high reliability with low cost of operation? R&D systems are mission critical : how to maximize uptime? How to rationalize systems management by avoiding desktop variability? What global partner can stand by me to support my business?

6 What is Kalabie ELN? Kalabie provides a robust platform that can be used to Document and manage experiments and insights Protect Intellectual Property Facilitate collaboration by implementing transversal processes between users Support and bridge multiple R&D disciplines through adapted Activity Profiles Connect to the R&D IS system Accommodate for special requirements by extensibility at various levels

7 An ELN with the User in Mind Kalabie has been designed to be the R&D scientist everyday workspace Day start / Day close permanent environment for experiments Give access to all IS needed resources through integration Kalabie provides a scientist dedicated working environment by specialty (role/area-specific) Activity Profiles allows the definition of specific workflows for each specialty Increase scientist individual productivity without overloading the workspace with unnecessary functions

8 Application domains: Breadth and Depth By managing Activity Profiles, Kalabie is usable across domains while preserving value by providing specific workflows Kalabie Configurations Multidiscipline Standard Chemistry Specific/Custom Standard Multidiscipline or domain-specific as well as custom Activity Profiles Business Components Communication Components Core Components A single tool across all domains of the R&D organization

9 Product Features User-centric feature set Simple and straightforward UI (focus on R&D not software training!) Multidiscipline, Chemistry or custom environment: adapted to you discipline Knowledge Sharing & Mining Share, Find, Reuse and Report Integration to the Lab Informatics System The all day every day window to your Lab informatics A true, highly scalable, enterprise solution with rapid deployment IP Protection and compliance Includes mechanisms for IP protection 21 CFR part 11 compliant

10 Kalabie multidiscipline environment Meta data entry to facilitate information classification and searching System provided information (Author, Notebook reference, Date ) User selected information from Admin references (Project, sub-project ) Rich Flexible entry/attachment of text, images, objects Insert and attach using Rich text Palette, Drag and drop and right click Sophisticated version management of attachments File size and types permitted are managed in Kalabie Admin Attached files are opened using the software choice of the user (application on client station) Protocol Library Content managed through the Kalabie Administration module is available to all authorized users Cascading lists to fill protocol section with the appropriate library protocol content Possibility to append several entries from the library within the same protocol section in an experiment.

11 Example: Biodiesel analysis Results Section

12 Kalabie Snapshots: biology and others

13 Kalabie for Chemical Synthesis Follows chemist s workflow (from design to results handling) Contains contextual information (Project, Study, Lit. references ) Advanced reaction design Multi-role molecule entry (reactant, intermediate, product, impurity, solvent, reagent and catalyst) Accepts copy/paste of a reaction from Drawing Tool Connects on local or global repositories for molecule searches Allows structure validation (when connected to Checker) Computes atom-atom mapping (uses cartridge functions) Complete set of calculation functions Composition, expected results and results tables allow chemists to manipulate and convert quantities needed within their experiments Structured but flexible interface User interface is a mix of predefined, structured fields and rich text fields (like the protocol where lot of illustrations and attachments can be inserted) Accurate batch management Mixture definition (multi compounds and multi additives) and reuse in subsequent experiments Ability to fill analytical properties form and to record analysis performed

14 Unitary, Multi-step Synthesis

15 Kalabie Snapshots: chemistry

16 Knowledge Repository Mining Various search modes Keywords Full text Structure-driven Fields Advanced modes Personal files Permanent requests Exports Excel, RDF, SDF

17 Reporting The experiment PDF (IP document) is available for each Activity Profile Simple data export from Kalabie Explorer to Excel is always available Export to Word Standard 3rd party report tool against DB

18 Integration with the Lab Informatics System Kalabie has been designed to integrate specialized modules in a seamless way Kalabie is a 3-tier architecture which allows integration to be done a each level At the client level allowing the integration with desktop software e.g. Molecular Drawing tools At the middle tier (the Application Server) e.g. access to information sources, ADMS At the database level for data management e.g archiving systems. Examples of integration realized Accelrys (Accord tools, Pipeline Pilot), MDL (Isis Draw, Isis Direct), Chemaxon (JChem), NuGenesis, Inventories (CAP, ACD), Registration, Naming Tools (ACD) OpenLab ECM

19 IP Protection IP Protection is based on key internal mechanisms Electronic Signature Long term data format preservation by relying only on XML and PDF core formats Administration options allowing the user to manage the type of data that may be incorporated into the ELN Search capabilities to find out anteriority information 21 CFR part 11 conformity and particularly the audit trail mechanism

20 IP Protection: Document Generation WYSIWYS: what you see is what you sign Includes all experiment elements Use PDF as the standard format

21 IP Protection: Signature Workflow Signature workflow offers: Graphical status Notification of next signers Configuration: Witness rules # level of validation

22 Kalabie Benefits

23 Users Benefits User Centric Work environment Kalabie provides users with an interface that follows naturally the way they work (process oriented) Other vendors are document oriented Multi disciplined Kalabie is truly designed to handle multiple disciplines (chemistry, biology, analytics ) and will store all experiment types on the same knowledge base Others were originally designed for one discipline Successful projects 100% Kalabie projects successfully deployed in production as of today All Kalabie implementation are connected to the existing IS Complexity has always been mastered to simplify users daily processes

24 Architecture & Company Excellence Open and Scalable Integrated Enterprise Solution Our customers have been using Kalabie in full production for over 4 years, over multiple sites and hundreds of end users. The solution has been tested in real conditions for speed and efficiency (ex Sanofi Aventis) Kalabie is designed to integrate the customer R&D IS (ex. MerckSerono, Sanofi- Aventis, Solvay ) Kalabie will interface with the tools and applications that the customer uses already. Others oblige customers to take their whole suite The OpenLAB portfolio & The Agilent Brand premium The portfolio approach means that, not only will Kalabie integrate perfectly with ECM, but also that Agilent recognizes the need for integrating solutions from other vendors Long term guarantee is key for a system that is expected to handle the customer s Intellectual Property over many decades Agilent offers guarantees that are difficult to match by smaller players

25 Kalabie in action (Reference Subset)

26 Kalabie Reference Examples Merck Serono: the new division for innovative small molecules and biopharmaceuticals of Merck. In production since Users in three countries (Geneva, Boston, Rome) on two continents. A single system to cover all discovery chemistry activities (standard synthesis, parallel synthesis, analytical experiments). Integration with MDL, Accelrys technologies. Migration of legacy notebook system (MDL technology) into Kalabie ELN. Significant gains from tight integration with instrument data content management system, Registration, Inventory and Patent filing systems. Over 36,000 experiments recorded

27 Deployment Example LAN Local Inventory WAN Compound Registration RS3 Oracle Reactions Molecules Accord Oracle LAN Local Inventory Isis Host Oracle Analytical Data Management Isis Host Oracle ELN Database Naming Tool Kalabie Server Data Access Layer Accord SDK Combichem Content Management Kalabie USA Europe Courtesy of Merck Serono

28 Kalabie Reference Examples Solvay Pharmaceuticals Acquisition of Fournier by Solvay Pharmaceuticals to further expand its business 8000 FTE. R&D 15% of Sales. Kalabie supports for 200 synthesis chemists (Trad Medchem, Parallel Synthesis, Combichem) Common application and knowledge base for 3 research centers Germany, Holland and France Harmonization of practise across sites Support for existing IP process and its mid term evolutions First common application between Solvay and Fournier Research organizations

29 Kalabie Reference Examples Pierre Fabre Dermo Cosmetics : Guepard Project Pierre Fabre selected Kalabie as the backbone of its information system for 120 staff working in Dermo Cosmetics R&D. Completely deployed since Q Pierre Fabre aim was to gain productivity, centralize knowledge and coordinate complex activities within projects across their different R&D activities. Using the standard Kalabie core functions, the working environment is adapted to different groups: formulation, non clinical security, toxicology, pilot, clinical security (in vitro, sensorial analysis, hypo-allergenicity, photo biology, bio metrology ) According to customer: «Guepard is a major step in setting up informatics tools to improve R&D overall efficiency»

30 Kalabie Reference Examples Sanofi Aventis: one of the largest Pharma WW Key selection factors were Usability as an all day/every day tool for chemists flexibility, adaptability and scalabilty Capacity for integration with existing IS Multi-site, multi-discipline, multi-lingual project deploying out to several hundred users on two continents (target 700+ users in )

31 Kalabie Reference Examples Industrial Affairs - Process Development: Kalabie for Synthesis chemists deployed since End 2002 Application used in native language: English, French, German and Hungarian Over experiments recorded 4 sites operational with deployment to all sites going on Kalabie for Analysts V1 delivered => V2 to follow Provide dedicated environment for the various Analytic practices (NMR, HPLC, Powder Analysis, GC) Research (SMA) - Chemical Development: Deployed on 3 sites, 3 languages. Other sites to follow Configuration based on Gap Analysis workshop on existing Industrial Affairs project.

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