Thermo Scientific TSQ Quantum XLS Ultra Triple Quadrupole GC-MS

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1 c h r o m a t o g r a p h y Thermo Scientific TSQ Quantum XLS Ultra Triple Quadrupole GC-MS Introducing Ultra Selective GC-MS/MS Persistent Organic Pollutants Food Safety Drug Screening Forensic Evidence Sports Doping Part of Thermo Fisher Scientific

2 TSQ Quantum XLS Ultra Triple Quadrupole GC-MS The Gold Standard in GC-MS/MS Higher Mass Resolution with breakthrough Ultra Selective Reaction Monitoring (U-SRM). Best in class selectivity and precision for an extensive range of GC/MS applications. Fast GC runs for multi-component analysis of more samples simultaneously. The Thermo Scientific TSQ Quantum XLS Ultra triple quadrupole mass spectrometer is the highest performing GC-MS/MS instrument available. It features best in class target compound selectivity, analytical performance, and lab productivity its the new Gold Standard from the technology leader in GC-MS/MS. HyperQuad technology is included which delivers highly increased mass resolving quadrupoles for ultra selective SRM, with best in class sensitivity, and allows unsurpassed analytical performance for the most difficult of matrix challenges. This is the most selective GC tandem quadrupole instrument available, yielding ultimate analytical performance particularly with regards to discrimination against chemical matrix background and detection of targets. Consequently, the TSQ Quantum XLS Ultra GC-MS/MS is expressly applicable for labs seeking high performance and productivity advantages, especially in environmental, food safety, forensics, drugs and doping applications. Low fg Sensitivity Greatly Increased Mass Resolution Unsurpassed Analyte Selectivity Highest Productivity for Real Life Samples 2

3 The Highest Performing GC-MS/MS Instrument Available 3

4 TSQ Quantum XLS Ultra Triple Quadrupole GC-MS Unique Value for Your Most Challenging Analyses The increased resolution offered by the new TSQ Quantum XLS Ultra GC-MS/MS enables more precise and reliable analyses to meet rigorous international standards. Unique Target Compound Selectivity for POPs, Dioxin/dl-PCBs and Bioactive Compounds HyperQuad technology for very highly resolved Q1 precursor selection (< 0.2 Da U-SRM) Unsurpassed analyte selectivity in very complex matrix extracts Superior results from less cleaned real life sample extracts Reliable, first time peak integration, quantitation Ion ratio confirmation compliant to official regulations Superior Sensitivity, Superior Precision High precision at lowest concentration levels Lowest LOQs e.g. at low fg levels for TCDD LOD < 1 ppb in typical difficult biological matrices as urine, blood, plan tissue High Productivity Save precious sample prep time Screen more compounds in one run Especially suited for multi component trace analysis Designed for fast-gc applications (10 15 m column lengths) t-srm acquisition for more than 1000 compounds in one fast run Exceptional Robustness Maximum uptime for unattended operation with proven IRIS source Unique matrix pre-filter Robustness for a large number of matrix samples Ion volumes for quick exchange by vacuum interlock Ease-of-Use Workflow Software Simplified method installation and maintenance from Master Methods Workflow software with custom reporting tools 4

5 High-throughput, workflow oriented software boosts lab efficiency. DuraBrite IRIS Technology Inside DuraBrite IRIS technology delivers greater sensitivity and extended maintenance cycles for more samples and more productivity. Experience the benefit of Exchangeable Ion Volumes: replace the ion volume without venting the MS system. Designed for quick source maintenance, or for changing from EI to NCI or PCI operation and back for increased system uptime. The new DuraBrite IRIS source technology delivers double benefits: highly inert materials prevent sensitive compounds such as drugs and pesticides from degradation and matrix components cut by the pre-filter do not enter the quadrupole analyzer. DuraBrite IRIS technology offers greater sensitivity, extended maintenance cycles and strong routine matrix robustness allowing more samples to be analyzed and increasing laboratory productivity. 5

6 TSQ Quantum XLS Ultra Triple Quadrupole GC-MS Ultra Selective GC-MS/MS......when Standard SRM Isn t Enough Optimize Clean-up Procedures Leave your Background Interferences behind at the First Stage of MS Single reaction monitoring (SRM) has become an established technique for analyzing target compounds in the most challenging of matrices. With the Thermo Scientific TSQ Quantum XLS GC-MS/MS, we introduced highly selective SRM (H-SRM). This capability allowed laboratories to target compounds with cleaner backgrounds than ever before. The desire to produce fast results, however, often means sample purification steps are reduced and as a result, even higher performance is required from their GC-MS/MS systems. Building on the success of the Quantum XLS system, another step up in SRM selectivity with Ultra Selective SRM (U-SRM) is introduced with the TSQ Quantum XLS Ultra GC-MS/MS. HyperQuad technology allows increased resolution of up to 0.1 amu. This translates into the most selective SRM available. Reduce Chemical Noise Extend Limits of Detection in the Most Difficult Matrices Improve Peak Integration Efficiency with Cleaner Mass Chromatograms 6

7 During U-SRM, Q1 (first quadrupole) is set to only transmit the precursor mass of the target compound within a < 0.2 m/z window. This means there is less opportunity for interfering masses to be transmitted to enter the collision cell, ultimately reducing chemical noise. This reduction in noise allows increased detection capability in some of the most difficult matrices. It also extends the possibility for less vigorous sample clean-up to be carried out. Another advantage is cleaner mass chromatograms than ever obtained before, allowing easy peak identification and integration. This means data can be evaluated quickly and easily, providing faster answers for high through-put laboratories

8 TSQ Quantum XLS Ultra Triple Quadrupole GC-MS Compelling Solutions... Your lab s next competitive advantage. The TSQ Quantum XLS Ultra triple quadrupole mass spectrometer addresses the requirements of the most demanding analytical tasks across applications. Food safety, environmental, clinical, forensic, toxicology, pharmaceutical and metabolomic sanalyses can all benefit from the highest performing instrument available. Unsurpassed Target Compound Selectivity Clinical, forensic/doping, toxicological, metabolomic, and pharmacokinetic quantification /screening all require exceedingly selective MS analyzers. Reliable results that withstand any legal interrogation are key in drug related applications. The TSQ Quantum XLS Ultra GC-MS/MS comes with selectivity that is unmatched by any other GC triple quadrupole analyser. Chromatographic Integrity in Difficult Matrices Bioanalysis takes advantage of GC/MS/MS analysis for small molecule quantitation. Metabolomics applications especially require target compound GC/MS quantitation for small compounds in difficult matrices which benefit from the extraordinary selectivity and robustness of a TSQ Quantum XLS Ultra GC-MS/MS. Designed for Tomorrow's Challenges Frequent contamination crises in both food and environmental sectors result in extensive monitoring programs with lower detection limits and high sample matrix diversity. This is a big challenge for laboratories which leads to the need for powerful analytical methodologies to be able to succeed. From POPs to pesticides, with femtogram level sensitivity and U-SRM capability, the TSQ Quantum XLS Ultra GC-MS/MS delivers a complete system that is capable of meeting the regulatory challenges of both today and tomorrow. TSQ Quantum XLS Ultra GC-MS/MS: 2378-TCDD in a non-compliant milk sample (top: 2 transitions for native TCDD and 2 for 13 C labeled IS TCDD below). A fast decision on compliance or non-compliance regarding maximum TEQ levels can be made. 8

9 TSQ Quantum XLS Ultra GC-MS/MS analysis of lindane isomers in green tea. Signal/noise increases significantly due to heightened resolution and reduced chemical background in the chromatogram. Animal fat sample with reduced sample clean-up PCDD/F-TEQ value is 0.95 pg/g fat. 125 fg of 2,3,7,8-TCDD injected. Endrin 1 pg in contaminated land sample ran both in SRM (Q1 0.7 amu) and U-SR< (Q1 0.1 amu). 9

10 TSQ Quantum XLS Ultra Triple Quadrupole GC-MS Maximize Productivity with Workflow-Oriented Software Options Lab Forms Software Packages The TSQ Quantum XLS Ultra system offers reliable, robust performance, ideally suited for GC/MS applications from research to routine. Thermo Scientific Lab Forms applications QuanLab Forms, EnviroLab Forms and ToxLab Forms complement routine GC/MS applications and streamline your workflows. Simplified workflows for efficient navigation Dynamically linked data review and reporting Powerful software packages follow laboratory workflows for maximum productivity. Lab Forms Core Capabilities The Lab Forms packages offer common user tools that simplify workflows and make getting from sample to result easier and more efficient. Easy Navigation A dashboard guides users to their activities to move quickly to the desired mode. Configure and customize the application, develop and create methods, or focus on daily production to program batches, review data, and generate reports. User Role Capabilities Optional user roles allow you to control access to program settings and functions based on the user s job types. This allows simplified routine workflows and protects methods and data from inadvertent changes. Optimized Data Review The Lab Forms Data Review environment is designed to simplify reviewing complex data sets by incorporating easy-to-interpret flags. These flags can highlight data that falls outside of your lab s criteria, allowing you to easily spot and correct any issues, simply and easily. Active Reporting Where the Lab Forms software packages truly redefine workflows is with a revolutionary approach to data review and reporting. Through powerful Smart Reporting, data review and data reporting are dynamically linked in Active View, allowing for real-time changes to the reports based on changes to the data. Any changes to data are immediately reflected in the report no reprocessing, no reanalyzing the data. Manual integrations are flagged for auditing purposes, so a record is kept of the changes made to the batch. Custom Reports Lab Forms software offers the ability to use custom reporting by creating special Microsoft Excel reports. These custom reports can be automated at a batch or sample level, using the same processes as the integrated standard reports. QuanLab Forms QuanLab Forms comes with your TSQ Quantum XLS Ultra system, providing you with a simple tool for routine GC/MS data acquisition, analysis and reporting. A wide selection of standard, pre-configured reports allows you to easily report data in a style that suits your lab s needs, plus customizable reports allow you to tailor reports for your specific applications. Generate reports in real time during sample acquisition, or review and report data through the intuitive Data Review screen. 10

11 Thermo Scientific TargetQuan The dedicated quantitation package is specifically designed for the isotope dilution technique, covering protocols like EPA 1613, JIS K 0311/0312, or EN Dedicated Quantitation Package TargetQuan software, is available as part of the Thermo Scientific Xcalibur data system. It has been tailored to the EPA, EN, and JIS protocols for analysis of persistent organic pollutants, such as halogenated dioxins and furans, polychlorinated biphenyls, brominated flame retardants, and many more. The software package consists of three individual programs, TargetQuan, Response, and Reporter. TargetQuan software is the main quantitation application, which includes the user interface for method setup, peak integration, and result viewing. Response deals with calibration curves, while Reporter helps to created printed or electronic chromatogram documents. Features Quantitation based on relative response factors (RRF) User definable dependency of standards One quantitation mass and up to two ratio masses for confirmation based on isotopic abundance Freely configurable spreadsheet for data viewing and method setup Automated or manual peak integration Retention time correction Toxicity equivalents (TEQ) according to WHO definition including lower, medium, and upper boundary calculation User definable summation of calculated amounts or TEQs for reporting of sum TEQ values Allows quantitation based on average response of selected compounds (for EPA 1613) Ready To Go The software comes with templates for quantitation of polychlorinated dioxins, furans (like EPA 1613 and more), and other POPs. Automation Built-in scripting allows for full automation from creating a calibration curve to measuring samples unattended. The simple scripting functionality enables you to tailor the software to follow the workflow of your laboratory. Reporting Spreadsheets can be printed, saved, exported, or ed directly from the TargetQuan application. Columns, headings, and display settings can be arranged as desired and saved as layout files for easy access. The Reporter application comes with an intuitive editor for creating reporting templates using drag-and drop objects. Using the templates, chromatogram reports can be printed or stored as document files automatically from a sequence. LIMS Export Any selected set of parameters and compound can be exported to a LIMS system using CSV, ASCII, or XLS file export. File export can be initiated automatically through a sequence, or manually. Xcalibur Data System The Xcalibur data system provides confident control from method development to reporting using the TSQ Quantum XLS system. Xcalibur software is also used to provide tools for generating and maintaining your own spectral libraries. It is compatible with commercial libraries such as NIST, Wiley, Maurer-Pfleger- Weber and others. Xcalibur software provides complete control of the TRACE GC Ultra and FOCUS GC, the mass spectrometer and optional liquid or headspace autosamplers. Easy Interpretation of Mass Spectral Data Thermo Scientific Mass Frontier software provides a suite of options that allows the MS operator to interpret mass spectral data. This optional software package assists the operator in structural identification, isotope pattern determination, and spectral classifications. 11

12 Laboratory Solutions Backed by Worldwide Service and Support Tap our expertise throughout the life of your instrument. Thermo Scientific Services extends its support throughout our worldwide network of highly trained and certified engineers who are experts in laboratory technologies and applications. Put our team of experts to work for you in a range of disciplines from system installation, training and technical support, to complete asset management and regulatory compliance consulting. Improve your productivity and lower the cost of instrument ownership through our product support services. Maximize uptime while eliminating the uncontrollable cost of unplanned maintenance and repairs. When it s time to enhance your system, we also offer certified parts and a range of accessories and consumables suited to your application. To learn more about our products and comprehensive service offerings, visit us at In addition to these offices, Thermo Fisher Scientific maintains a network of representative organizations throughout the world. Africa-Other analyze.sa@thermo.com Australia analyze.au@thermo.com Austria analyze.at@thermo.com Belgium analyze.be@thermo.com Canada analyze.ca@thermo.com China analyze.cn@thermo.com Denmark analyze.dk@thermo.com Europe-Other analyze.emea@thermo.com Finland / Norway / Sweden analyze.se@thermo.com France analyze.fr@thermo.com Germany analyze.de@thermo.com India analyze.in@thermo.com Italy analyze.it@thermo.com Japan analyze.jp@thermo.com Latin America analyze.la@thermo.com Middle East analyze.emea@thermo.com Netherlands analyze.nl@thermo.com New Zealand analyze.au@thermo.com Russia/CIS analyze.emea@thermo.com South Africa analyze.sa@thermo.com Spain analyze.es@thermo.com Switzerland analyze.ch@thermo.com UK analyze.uk@thermo.com USA analyze.us@thermo.com Thermo Fisher Scientific, Austin, TX USA is ISO Certified Thermo Fisher Scientific Inc. All rights reserved. Mass Frontier is a trademark of HighChem Ltd. Microsoft and Excel are registered trademarks of Microsoft Corporation. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details. BR52183_E 06/11M