Program 2nd SiLA Conference

Transcription

1 Program 2nd SiLA Conference Monday, September 19th 2011, 11:00 17:30 Venue: Congress Center Basel, Room Rio, 2nd floor Chair SiLA Conference: Dr. Niggi Graber, Novartis Session 1 11:00 12:30 1) Welcome and Introduction from the SiLA President 5 min Peter Schleiffer, Zuoz, Switzerland 2) Keynote 40 min Dr. Markus Dobler, Novartis, Switzerland Lab Automation from Vision to Reality Healthcare is a dynamically changing industry driven by knowledge and innovation. Advances in science and technology enable innovative and more rapid drug discovery and development. These advances need to be supported through parallel development and integration of novel lab automation solutions. This presentation will ask questions and present insights, past learnings and future requirements on lab automation and standardization needs based thereof. 3) SiLA News and Status Update 15 min Dieter Speidel, Xeronics AG, Zürich, Switzerland & Uli Syré, infoteam Software AG, Stäfa, Switzerland

2 4) The urging need for standardization in scientific laboratory automation 30 min Sebastian Schoening, Fraunhofer IPA, Stuttgart, Germany The Fraunhofer IPA is conducting research and development in various fields related to laboratory automation and, especially, in the fields of tissue engineering, cell biology, and molecular biology. As part of our projects, we design, implement, and integrate complex setups accommodating devices from various vendors, from different Fraunhofer institutes, or even our own proprietary developments. Two recurring challenges for our automation approaches are, firstly, the consistent integration of devices and, secondly, the governance of data across several layers of hardware and software. In order to cope with these challenges, we implemented our own standardized software protocol for device communication, which was deployed and tested in the last years in several projects and in collaboration with other institutes. However, our work is not focused on the field of standardization (or on the reinvention of the wheel in general) but rather on the application of sound standards in hardware and software in order to foster our research and to achieve our project goals. Thus, the efforts and contributions made by the SiLA consortium are greatly welcome since our own approaches can now be complemented and, in many cases, be superseded by the SiLA specifications. As a direct consequence, we are working on the implementation of the SiLA standards in all current and upcoming projects. The talk discusses our viewpoints regarding the standardization in scientific laboratory automation and the benefits we expect from joining and working with the SiLA initiative. Furthermore, the discussion is exemplified by the presentation of one specific large-scale project, its objective and challenges, the progress status, and future goals. 5) Lunch Break 45 min

3 Session 2 13:15 14:45 6) Automation & Integration today and in the future 15 min Dr. Carsten Etzold, Hamilton Bonaduz AG, Bonaduz, Switzerland Solving automation and integration problems in the laboratory area since decades, Hamilton has brought in his vast experience in designing the SiLA standard. Major current problems in the integration area will be discussed as well as future solving strategies using the SiLA standard. This starts at the level of a standardized communication in between the robot and the integrated devices, goes to a standardized data storage of the same data types in the Process Management System or the Laboratory Information Management System, and leads to the possibility to design standardized top level procedures to process result data, generated by all different kinds of devices. 7) Generating valuable information through integration of Logistics Systems 15 min Yannik Hoffman, XAVO AG, Reinach, Switzerland While the seamless integration of automation is - thanks to the SiLA Standard - progressing and continuously reducing integration and implementation efforts a valuable benefit is often overseen - The benefit of generating logistics data by using the SiLA Event Receiver. Xavo Systems integrated the SiLA Event-Receiver into its Compound Management Software "Xavo Lab Logistics" offering huge benefits for the user by generating valuable logistical information "on the fly". Yannick Hofmann, CEO of Xavo Systems will demonstrate the benefits of Xavo Lab Logistics' SiLA Event-receiver.

4 8) SiLA Test Center 15 min Dr. Henning Bär, infoteam Software AG, Stäfa, Switzerland To have products for a standard, such as SiLA, a certification process is of major importance, because it increases the quality of its realizations. To achieve a SiLA certified device, developers have to design a SiLA compliant product. Then it needs to be tested. This talk will present the infoteam SiLA Test Center. It can perform various tests, such as analyzing a device s description or performing workflows on the device with expected responses. The talk will present further details of the SiLA Test Center and the plans for integration into a certification process. 9) LabwareMatch, a new SiLA compliant product information management system for the Life Science Lab Automation industry. 15 min Dieter Speidel, Xeronics AG, Zürich, Switzerland Thousands of different labware products such as microplates, tubes, vessels, tips etc. from multiple labware vendors are used today on hundreds of different lab automation device models in laboratories all over the world. Product specifications for labware products consist of various technical parameters defining labware geometry, dimensions and physical characteristics. As of today, parameter naming and units used by the different vendors in their product specifications are not conforming to any standards. SiLA addressed this issue and developed the Labware Specification Standard, which makes labware product specifications easily understandable, comparable and even machine readable. Taking advantage of this new SiLA Standard, Xeronics AG (Zurich) developed a web based multi-vendor e-catalog platform for labware specifications named LabwareMatch which supports the new SiLA Standard. Dieter Speidel, CEO of Xeronics, presents the basic concept and function principles of LabwareMatch, and provides an outlook to future community collaboration functions which shall enable users to share their data and experience for individual labware products and their implementation on specific devices.

5 10) Data Standardization as Key Enabler for Innovation in the Life Sciences Industry 15 min Uwe Geissler, Sowmyanarayan Srinivasan Cognizant Technology Solutions, Zürich, Switzerland Recent paradigm shift in the life sciences industry have changed how R&D organizations develop new medicines as well as manage scientific information and assets. Collaboration and externalization are now playing a key role in drug discovery and development. A whole new concept of a networked Pharma is emerging which leverages the strengths of the partners in the network. A key driver of collaboration is standardization. It is evident that a strong data standardization brings benefits and delivers improved innovation in the face of cost pressures. This presentation will give insights into how data standardization can enable decision-making, collaboration and innovation in order to develop new medicine. 11) PerkinElmer s Assay Technologies supporting standardized Formats and Handling in Automation-focused facilities 15 min Dr. Michael Lässle, PerkinElmer (Schweiz) AG, Schwerzenbach, Switzerland PerkinElmer Biodiscovery offers a broad range of tools for academic and pharmaceutical research and here especially drug discovery. Besides imaging solutions both the automation/detection instrumentation solutions and the reagents offering are key to success. In the area of Assay/HTS reagents PerkinElmer offers a variety of different technologies which are both useful in academic research and fulfill requirements of standardized and automated HTS-environments. Especially for drug discovery customers, the interplay of reagents and automation/detection instrumentation is often a crucial factor that determines success or failure. Apart from AlphaScreen and AlphaLisa technologies bead based platforms Europium based assay platforms like LANCE (TR-FRET) and DELFIA (TRF) will be introduced. They differ in their benefits for different applications and for different levels of throughput in semi- and fully automated facilities, as will be highlighted in this presentation.

6 12) Coffee Break Session 3 15:00 16:30 13) System integration using the SiLA interface standard 30 min Bernd Papenfuss, EQUIcon, Jena, Germany EQUIcon has developed a SiLA compliant PMS, named nicelab, based upon a workflow management system owned by EQUIcon. It contains a full dynamically, event driven scheduler which ensures minimal effort to setup and run a procedure. Any device compliant to the SiLA interface specification can be easily integrated into the system controlled by nicelab. The functionality of the device, including functions, parameter, parameter ranges and default values can be automatically read from the device and used at the nicelab. No development activities are necessary to integrate a SiLA-compliant device. A first pilot application of nicelab is a system at Roche. The presentation gives a short introduction to nicelab and illustrates it usage by the Roche pilot project. 14) Standardisation simplifies enhancing and maintaining automation systems 30 min Jason Meredith, Tecan AG, Männedorf, Switzerland Automation systems must have long operational lifetimes. Devices may require upgrade or replacement to take advantage of new innovations or handle obsolescence. Systems must remain operational and costs must be minimised. In this talk you will learn how the SiLa standard simplifies the exchange of Tecan Genesis RSP running Gemini with a Freedom EVO running Freedom EVOware within an RTS automation system.

7 15) Intelligent Store 30 min Erwin Althof, Novartis, Basel, Schweiz / Carsten Mang, Thermo Fisher Scientific, Langenselbold, Deutschland Since several years we see a steady increase of data points created in HTS screening, There has been a strong focus on the development of tools to support data management and data evaluation of this increasing amount of data. However tracking of parent child relationship in the various screening processes upstream and downstream the track from compound to data point ( logistics )is still a stepchild. With SiLA and the Thermo intelligent store concept we envisage to tackle the hardware side of a consistent logistic. The Intelligent Store is a combination out of multiple Cytomat 24 Storage units and one conveyor. Each unit is controlled by an embedded PC running the corresponding SilA Plugin and the Logical Store Service which combines all PCs in a logical ring network. Send requests to the logical ring will be passed from one PC to the other until the receiver is found. This communication structure guarantees a high degree of operational reliability even if one Cytomat is in maintenance. 16) Coffee Break 15 min Session 4 16:45 17:30 17) SiLA Outlook min Uli Syré, infoteam Software AG, Stäfa, Switzerland

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