KeyChem-Basic Microreactor KeyChem Series

Transcription

1 Introductory Kit KeyChem-Basic Microreactor KeyChem Series KeyChem Series #02 Basic YMC offers a full line of flow chemistry components for manual or PC-controlled operations. KeyChem-L represents the laboratory scale set up, whereas the CYTOS series of products provides the technical platform for pilot scale productions and other customized systems. Demonstration and rental equipment is available at our facilities in Germany. Feasability studies, custom synthesis and custom preparative HPLC separations are also available on request.

2 KeyChem-Basic Safe, green chemistry Various concepts are currently being established for continuous, micro-structured synthesis processes, such as microreaction technology, flow chemistry and flow reaction technology (FRT). Technology experts assume that about 30% of all syntheses worldwide can be optimised using continuous flow reaction technology to ensure more efficient, safer and greener chemistry. Micro-structured reactors and components allow reaction conditions that are difficult or completely impossible to achieve with traditional chemistry in flasks: for example, extremely exothermic reactions can be controlled easily and safely, due to the short retention times and faster heat transfer that are possible. Furthermore, microreactors can be operated at high pressure, which means that syntheses at super-critical conditions can lead to new types of reaction, ideally accompanied by improved yields, shorter reaction times and reduced energy consumption. With this in mind, YMC offers an extensive range of components and systems for initial exploratory studies, traditional research and development in the lab and scalable systems for use at pilot and/or production scale. Our experienced specialists provide support and assistance and we are willing to do so at your premises if required. The concept - for simple trials and teaching The YMC module principle enables you to combine various components that can be added to at any time. For your first steps in micro-fluid chemistry, you will require: - an affordable syringe pump - YMC microreactors and retention loops plus - suitable connecting technology. YMC microreactors and retention loops are available in various dimensions and materials. Faster reaction speeds Improved yields Less solvent and/or reagent consumption FRT (Flow Reaction Technology) Dynamic mixing Improved robustness Improved safety at work Better for the environment

3 Introductory Kit Application This example of a chemical reaction shows how Flow Reaction Technology can make your life easier. In batch synthesis one may find out that the products of the lithiation again react to undesired products. This is even to be monitored at low temperature. Flow Reaction systems are capable of improving the reaction selectivity dramatically. This is due to flow effect (1) and the micro mixing effect (2). 1) The flow effect allows to shorten residence time for the reactant by adjusting the flow rate 2) Due to usage of a micro mixer the reaction intermediate reacts more effectively As an additional benefit this lithiation can be processed at room temperature, so that no temperature control is necessary anymore and the process will need less energy. 1 2 Batch 0 C 35% 54% Flow 25 C 93% 2%

4 KeyChem-Basic Simple T-type mixer reaction unit YSP series Syringe pump YSP Syringe adapter (female type) YMC-P T type reactor (SS, 0.3 mm ID) YMC-P T type reactor (SS, 0.5 mm ID) YMC-P T type reactor (SS, 1.0 mm ID) YMC-P EASYFITT10Ø (pack of 10) YMC-P Price 2,550 Simple reaction with micro mixer YSP series Syringe pump YSP Syringe adapter (female type) YMC-P KeyChem Mixer Deneb (Helix type KC-M-H-SUS 1 SUS) KeyChem Mixer housing YMC-P Tubing Connector 1/16 PEEK M6HN YMC-P Price 2,870 Two step reaction with micro mixer YSP series Syringe pump YSP Syringe adapter (female type) YMC-P KeyChem Mixer Deneb (Helix type SUS) KC-M-H-SUS 1 KeyChem Mixer housing YMC-P Tubing Connector 1/16 PEEK M6HN YMC-P Price 4,450

5 Introductory Kit Heating / Cooling YSP series Syringe pump YSP Syringe adapter (female type) YMC-P KeyChem Mixer Deneb (Helix type SUS) KC-M-H-SUS 1 Stand-alone Type Thermo Stage TS-C-M 1 (low temperature version)* KeyChem series tubing connector YMC-P * different types are possible: Low Temperature: C High Temperature: RT 150 C Price 8,730 Pressurized flow Dual plunger pump (pressure gauge/peek) MCK P 2 Syringe adapter (female type) YMC-P KeyChem Mixer Deneb (Helix type SUS) KC-M-H-SUS 1 KeyChem Mixer housing YMC-P Tubing Connector 1/16 PEEK M6HN YMC-P Price12,660

6 KeyChem-L The next level! KeyChem-L PC controlled Characteristics Ideal positioning in the laboratory thanks to its modular construction: the PC, pump and heating elements are separate components The system can be adapted to your individual requirements User-friendly control software Excellent mixing and temperature regulation And last but not least, an affordable price Reactors You can choose from different sizes of microreactors and retention loops. Temperature control Peltier-controlled thermostats with a wide temperature range are available to suit all your needs. Dosing system The MR2 dosing system allows you to implement complex dosages for several components using automated multi-way valves. This means that you can use the YMC control software to program rinsing runs with solvents followed by automatic reactant dosing. The system uses both Hamilton glass syringes and disposable syringes for corrosive, toxic or odorous reactants. Product name Reactor Residence time unit KeyChem Mixer Hadar (Y type SUS) KeyChem Mixer Deneb (Helix type SUS) KeyChem Mixer Spica (Static type SUS) KeyChem Residence time unit Sirius (1.5 ml SUS) KeyChem Residence time unit Sirius (3.0 ml SUS) KeyChem Residence time unit Sirius (4.5 ml SUS) Thermostat Coupling type 2 Thermo Stages (Low temperature type) Pump MR2 Syringe pump (1-5 way valve 2, 1-2 way valve 2) with 4 axes Incl. Control Software and PC Part. No. KC-M-Y-SUS KC-M-H-SUS KC-M-S-SUS R S6 R S6 R S6 TS2-C MRSY04-22 KeyChem-Lumino KeyChem systems can be quickly and simply set up for photo catalysis: KeyChem-Lumino is a photo microreactor module available in stainless steel (SUS316) with a quartz glass cover or with a TiO 2 coating. It is illuminated by a protected high-intensity light source. KeyChem-Lumino photo microreactors are routinely available with different light sources: adjustable 6-way UV/LEDs (365 nm) (standard) Low pressure mercury lamp (254 nm) excimer lamp (308 nm) KeyChem-Lumino Thermostat Special thermostat for use in photochemistry. A special photoreactor can be installed. Product characteristics Peltier elements for temperature regulation Commercially available pumps can be connected Thermostat can be used with any light source No heating or cooling medium is required Specifications Dimensions 120 x 280 x 193 mm (B x D x H) (excluding lid) Power supply AC V 100W Temperature range -15 ~ 80 C (Rt at 25 C) Accuracy + 1 C Weight approx. 4 kg Order number TS-LU

7 Production CYTOS-2000: The concept Pilot and production CYTOS is a modular system to produce larger quantities from a few hundred grams up to kilograms, depending on the synthesis process and the system setup. Larger scale production can be achieved by interconnecting several CYTOS modules (numbering up). Parallel use can turn a single CYTOS reactor into a high-performance production system. This concept has the advantage of maximum flexibility in running the system. If a reactor fails, a reserve system can take over its task without affecting the functioning of the system or, at worst, causing the system to fail. A customised selection of dose and temperature control components is available for CYTOS, which can be controlled using intuitive software with data recording. Customized design YMC is capable to give advice and support to customers who aim to scale up processes from Lab to production. This has always been one of the key factors that made YMC a successful and global acting company. The example on the right shows a custom made photoreaction system for production purposes fulfilling the following requirements: Intended use: Polymer synthesis (incl. photoreactions) Customer s demands: 1. Pulse-free pumps for a wide flow rate 2. Photoreaction system 3. Product tank with agitator and thermostat Customized design 1. The system was equipped with four low-pulsation plunger pumps, where two of them are for the low flow rates and the others are for high flow rates 2. Product tank with agitator and thermostat have been installed 3. A rack for the system has been planned and built to customers demands Pumping unit KeyChem Lumino Product tank incl. Agiator + Thermostat

8 Introductory Kit Product name Product number Price T type reactor T type reactor (PEEL 0.3 mm ID) YMC-P T type reactor (PEEL 0.5 mm ID) YMC-P T type reactor (PEEL 1.0 mm ID) YMC-P SUS Mixer KeyChem Mixer Hadar (Y type SUS) KC-M-Y-SUS 530 KeyChem Mixer Spica (Static type SUS) KC-M-S-SUS 530 Glass Mixer KeyChem Mixer Hadar (Y type Glass) KC-M-Y-G 1,505 KeyChem Mixer Hadar (Helix type Glass) KC-M-H-G 1,881 KeyChem Mixer Spica (Static type Glass) KC-M-S-G 2,257 PTFE Mixer KeyChem Mixer Hadar (Y type PTFE) KC-M-Y-P 120 RTU (Residence time unit) KeyChem series Residence time units Srius (1.5 ml SUS) KeyChem series Residence time units Srius (3.0 ml SUS) KeyChem series Residence time units Srius (4.0 ml SUS) KeyChem Mixer Rigel (Y type + RTU 4.5 mm SUS) Connecting tubing (1/16 OD, 0.25 mm ID, length 10 m) (1/16 OD, 1.0 mm ID, length 10 m) Stainless steel tubing (1/16 OD, 0.5 mm ID, length 10 m) Stainless steel tubing (1/16 OD, 1.0 mm ID, length 10 m) R S6 476 R S6 502 R S6 527 KC-MR4.5-Y-SUS 1,818 YMC-P YMC-P YMC-P YMC-P KeyChem Mixer housing (for Internal observation) YMC-P KeyChem Mixer housing (Acrylic) YMC-P KeyChem Residence time unit housing YMC-P Product name Product number Price Thermostat Stand-alone Type Thermo Stage (High temperature ver. Mixer type) Stand-alone Type Thermo Stage (Low temperature ver. RTU type) Stand-alone Type Thermo Stage (High temperature ver. RTU type) Stand-alone Type Thermo Stage (Low temperature ver. Mixer type) TS-H-M TS-C-R TS-H-R TS-C-M Syringe pump YSP-series syringe pump YSP Plunger pump Single plunger pump (PEEK / 5 ml/min / Single plunger pump (SUS / 5 ml/min / Single plunger pump (PEEK / 10 ml/min / Single plunger pump (SUS / 10 ml/min / Single plunger pump (PEEK / 20 ml/min / Single plunger pump (SUS / 20 ml/min / Dual plunger pump (PEEK / 10 ml/min / Dual plunger pump (SUS / 10 ml/min / Dual plunger pump (PEEK / 50 ml/min / Dual plunger pump (SUS / 50 ml/min / YMCS P 3590 YMCS S 4020 YMCS P 3730 YMCS S 4160 YMCS P 3730 YMCS S 4160 YMCK P 5740 YMCK S 6450 YMCK P 6170 YMCK S 6880 Full PC control pump including software and PC MR2 syringe pump (1-5 way valvex2, 1-2 way valvex2) MRSY MR2 syringe pump (1-5 way valvex4) MRSY MR2 syringe pump HT (Half type) MRSY02-20 Inquiry Systems KeyChem-L microreactor system KeyChem-L KeyChem-Lumino photomicroreactor KeyChem- Lumino Europe GmbH Schöttmannshof 19 D Dinslaken Germany TEL. +49(0) , FAX +49(0) Co., Ltd. YMC Karasuma-Gojo Bld. 284 Daigo-cho, Karasuma Nisiiru Gojo-dori Shimogyo-ku, Kyoto Japan TEL. +81(0) , FAX +81(0) America, Inc. 941 Marcon Boulevard Suite 301 Allentown, PA18109 USA TEL , FAX India Ltd. CX - 07, 3rd Floor, Lobe - 1, Tower - A, The Corenthum, Plot No- A-41, Sector - 62, Noida (UP) India. TEL. +91(0) , FAX +91(0) In Austria: OmniChrom HandelsgmbH Frömmlgasse 40-42/15 A-1210 Wien TEL. +43(0) , Fax +43(0) In Switzerland: Chr.-Merian-Ring 31a CH-4153 Reinach TEL. +41(0) , Fax +41(0)