Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Version: 1.0

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1 Version: 1.0 SECTION 1: Identification 1.1. Identification Trade name Product code : Recommended use and restrictions on use Recommended use Restrictions on use 1.3. Supplier : Hematoxylin 560MX : Nuclear stain : Other uses Leica Biosystems Richmond, Inc 5205 Route 12 Richmond, IL USA T LBSNA-LBS-QA@leicabiosystems.com - leicabiosystems.com 1.4. Emergency telephone number Organization/Company Emergency number ChemTrec International Calls (call collect) Australia 24 Hr Poisons Information Centre SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mixture GHS-US classification Not classified 2.2. GHS Label elements, including precautionary statements GHS-US labeling No labeling applicable 2.3. Other hazards which do not result in classification 2.4. Unknown acute toxicity (GHS US) SECTION 3: Composition/Information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % GHS-US classification Ethylene Glycol (CAS No) < 40 Acute Tox. 4 (Oral), H302 Aluminum Sulfate (CAS No) < 5 Skin Corr. 1A, H314 Eye Dam. 1, H318 11/27/2017 EN (English US) Page 1

2 Full text of hazard classes and H-statements : see section 16 SECTION 4: First-aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Call a poison center/doctor/physician if you feel unwell. : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. Take off contaminated clothing. If skin irritation occurs: Get medical advice/attention. : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a physician immediately. : Rinse mouth. Call a poison center/doctor/physician if you feel unwell Most important symptoms and effects (acute and delayed) Symptoms/effects after skin contact Symptoms/effects after eye contact : Irritation. : Serious damage to eyes Immediate medical attention and special treatment, if necessary Treat symptomatically. SECTION 5: Fire-fighting measures 5.1. Suitable (and unsuitable) extinguishing media Suitable extinguishing media 5.2. Specific hazards arising from the chemical Reactivity 5.3. Special protective equipment and precautions for fire-fighters Protection during firefighting SECTION 6: Accidental release measures : Water spray. Dry powder. Foam. Carbon dioxide Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures : The product is non-reactive under normal conditions of use, storage and transport. : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. : Ventilate spillage area. Avoid contact with skin and eyes For emergency responders Protective equipment : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up : Take up liquid spill into absorbent material. Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling : Ensure good ventilation of the work station. Avoid contact with skin and eyes. Wear personal protective equipment. 11/27/2017 EN (English US) 2/7

3 Hygiene measures : Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Store in a well-ventilated place. Keep cool. ACGIH ACGIH TWA (ppm) 25 ppm ACGIH ACGIH STEL (mg/m³) 10 mg/m³ ACGIH ACGIH STEL (ppm) 50 ppm ACGIH ACGIH Ceiling (mg/m³) 100 mg/m³ (Ethylene glycol; USA; Momentary value; TLV - Adopted Value) ACGIH Remark (ACGIH) Kidney dam; URT & eye irr 8.2. Appropriate engineering controls Appropriate engineering controls Environmental exposure controls : Ensure good ventilation of the work station. : Avoid release to the environment Individual protection measures/personal protective equipment Hand protection: Protective gloves Eye protection: Safety glasses Skin and body protection: Wear suitable protective clothing Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Color : dark red Odor : odorless Odor threshold ph : 2-3 Melting point : Freezing point Boiling point 11/27/2017 EN (English US) 3/7

4 Flash point : 212 Relative evaporation rate (butyl acetate=1) Flammability (solid, gas) Vapor pressure Relative vapor density at 20 C Relative density Specific gravity / density : 1.06 Solubility Log Pow Auto-ignition temperature Decomposition temperature Viscosity, kinematic Viscosity, dynamic Explosion limits Explosive properties Oxidizing properties 9.2. Other information SECTION 10: Stability and reactivity Reactivity :. The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions No dangerous reactions known under normal conditions of use Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity LD50 oral rat ATE US (oral) Skin corrosion/irritation > 5000 mg/kg (Rat; Literature study) 500 mg/kg body weight ph: /27/2017 EN (English US) 4/7

5 Serious eye damage/irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity ph: 2-3 Reproductive toxicity Specific target organ toxicity single exposure Specific target organ toxicity repeated exposure Aspiration hazard Symptoms/effects after skin contact Symptoms/effects after eye contact SECTION 12: Ecological information Toxicity Ecology - general : Irritation. : Serious damage to eyes. : The product is not considered harmful to aquatic organisms or to cause long-term adverse effects in the environment. EC50 Daphnia 1 > mg/l (EC50; 24 h) LC50 fish mg/l (LC50; 96 h; Salmo gairdneri) LC50 fish 1 EC50 Daphnia 1 Threshold limit algae 1 Threshold limit algae mg/l (LC50; OECD 203: Fish, Acute Toxicity Test; 96 h; Pimephales promelas; Flow-through system; Fresh water; Experimental value) 242 mg/l (LC50; OECD 202: Daphnia sp. Acute Immobilisation Test; 48 h; Daphnia magna; Static system; Fresh water; Experimental value) 3011 mg/l (EC50; OECD 201: Alga, Growth Inhibition Test; 5 days; Algae; Static system; Fresh water; Experimental value) mg/l (NOEC; OECD 201: Alga, Growth Inhibition Test; 5 days; Algae; Static system; Fresh water; Experimental value) Persistence and degradability Persistence and degradability Readily biodegradable in water. Biodegradable in the soil. Biochemical oxygen demand (BOD) 0.47 g O₂/g substance Chemical oxygen demand (COD) 1.24 g O₂/g substance ThOD 1.29 g O₂/g substance BOD (% of ThOD) 0.36 Persistence and degradability Biodegradability: not applicable. Hydrolysis in water Bioaccumulative potential BCF fish 1 10 (BCF; 72 h) BCF other aquatic organisms (BCF) 11/27/2017 EN (English US) 5/7

6 BCF other aquatic organisms (BCF; 24 h) Log Pow (Experimental value) Bioaccumulative potential Low potential for bioaccumulation (BCF < 500). BCF fish (BCF; OECD 305: Bioconcentration: Flow-Through Fish Test; 60 days; Salmo salar; Flow-through system; Fresh water; Experimental value) Bioaccumulative potential Low potential for bioaccumulation (BCF < 500) Mobility in soil Surface tension N/m (20 C) Other adverse effects SECTION 13: Disposal considerations Disposal methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information Department of Transportation (DOT) In accordance with DOT Transport by sea Air transport SECTION 15: Regulatory information US Federal regulations Listed on the United States TSCA (Toxic Substances Control Act) inventory Subject to reporting requirements of United States SARA Section 313 CERCLA RQ 5000 lb Listed on the United States TSCA (Toxic Substances Control Act) inventory Not subject to reporing requirements of the United States SARA Section 313 CERCLA RQ 5000 lb 11/27/2017 EN (English US) 6/7

7 15.2. International regulations CANADA Listed on the Canadian DSL (Domestic Substances List) Listed on the Canadian DSL (Domestic Substances List) EU-Regulations National regulations US State regulations Carcinogens List Developmental Toxicity Reproductive Toxicity - Female No Yes No No Reproductive Toxicity - Male No significant risk level (NSRL) U.S. - New Jersey - Right to Know Hazardous Substance List U.S. - Pennsylvania - RTK (Right to Know) List U.S. - New Jersey - Right to Know Hazardous Substance List U.S. - Pennsylvania - RTK (Right to Know) List SECTION 16: Other information Full text of H-phrases: --- H H H Harmful if swallowed Causes severe skin burns and eye damage Causes serious eye damage SDS US Leica This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product 11/27/2017 EN (English US) 7/7