Radiopharmacies, Radioisotopes and Accelerators Team BEST developments

Transcription

1 Radiopharmacies, Radioisotopes and Accelerators Team BEST developments Small accelerator workshop RR JOHNSON, TEAM BEST 23 march TeamBest product line 2. There are new configurations 3. Central pharmacy direction 4. Can there be something new to further healthcare?

2 TEAMBEST DELIVERS THE WHOLE PACKAGE Team Best supplies radioisotope production systems. Production targets Radiochemical separation Target material and target reprocessing Site design licensing

3 Key Features of New Cyclotrons Ease of operation Optimize energy of cyclotron and design for application Integrate targetry and radiochemistry Cost of Acquisition and Operation. Support and service Ease.

4 Sigma (mb) Positron emitter cross sections Cu 64 I Energy (MeV) Pick accelerator energy to cover cross section curve

5 Sigma (mb) Sigma (mb) Ge 68 Generator isotope cross sections Energy (MeV) Sr Pick accelerator energy to cover cross section curve Energy (MeV)

6 CYCLOTRON SYSTEM s SELECT 14/15 MeV Mev 70 MeV As accelerator energies Integrate Isochronous magnetic field, efficient RF, reliable H - ions, vacuum, materials science, radiochemistry, radioprotection, system process control

7 Revenue Economy PROFORMA Constraints Proforma Profit & Loss Statement for MINI Site CYCLOTRON INPUT VALUES FOR DIFFERENT RESULTS COLOR CODE Values track to year 2014 column COLOR CODE External Sales $312,500 $328,125 $344, Avg. price/reimbusement per dose FDG $ 125 $ 125 $ 125 FIXED PRICE Labor Costs Pharmacy Manager Wage Inflation Revenue Total Annual doses FDG /day,5 days Staff Pharmacist $ 50,000 4% Pharmacy Technician $ 40,000 Cost of Goods Sold Pharmacy Technician $ 40,000 MAKE SURE THAT THE COST ANALYSIS DELIVERS FAVOURABLE RESULTS Materials FDG $7,500 $7,725 $7,957 $50/run X 150 External Sales $312,500 $328,125 $344,531 Cyclotron Engineer/ Chemist Infrastructure $83,400 $86,736 $90,205 Cyclotron Engineer/ Chemist Avg. price/reimbusement per dose FDG $ 125 $ 125 $ 125 FIXED PRICE Labor & Benefits $149,500 $155,480 $161,699 Benefits Cost 15% of Wages Cyc Maint/Ser/Parts $24,000 $125,000 $125,000 TOTAL $ 149,500 Total Annual doses FDG /day,5 days Other Expenses $96,000 $98,880 $101,846 Materials FDG $7,500 $7,725 $7,957 $50/run X 150 Total COGS ex. Depr. $360,400 $473,821 $486,708 Infrastructure $83,400 $86,736 $90,205 Depreciation $150,000 $150,000 $150,000 Fixed Costs Total Operating Costs $510,400 $623,821 $636,708 Service & Maint $ 800 per month Labor & Benefits $149,500 $155,480 $161,699 Rent $ 2,500 per month Office Supplies $ 150 per month Cyc Maint/Ser/Parts $24,000 $125,000 $125,000 Total Operating Income -$197,900 -$295,696 -$292,177 Utilities $ 3,500 per month Other Expenses $96,000 $98,880 $101,846 Sg&A (10% of sales) Total Infrastructure $ 83,400 Annual Cyclotron Maint/Parts/Service $ 24,000 first year Cyclotron Basis $ 750,000 Cap-X Total COGS ex. Depr. $360,400 $473,821 $486,708 $31,250 $32,813 $34,453 Cost Basis Years Annual Depr. $ 750,000 5 $ 150,000 Depreciation $150,000 $150,000 $150,000 5 years EBT -$229,150 -$328,509 -$326,630 Other Expenses Total Operating Costs $510,400 $623,821 $636,708 Cap loan 5 yrs plus annual $169,836 $169,836 $169,836 $0 after loan payment Travel & Ent $ 700 per month Total Operating Income -$197,900 -$295,696 -$292,177 Sg&A (10% of sales) $31,250 $32,813 $34,453 Ratiation Monitoring $ 1,000 per month Rental Equipment $ 500 per month EBT -$229,150 -$328,509 -$326,630 Net Income before Dividends -$398,986 -$498,345 -$496,466 $0 Professional Services $ 500 per month Decommission $ 3,000 per month Cap loan 5 yrs plus annual $169,836 $169,836 $169,836 Dues/Books/Subscriptions $ 100 per month Printing & Promotional $ 200 per month Net Income before Dividends -$398,986 -$498,345 -$496,466 Fees & Other $ 2,000 per month Total Other Expenses $96,000 Annually

8 B70 for INFN legnaro On the boat, operation this year 70 MeV x 700 ua = 50 kw one Big, Fat, Ugly, PIG! LOL Loverly Actually cusp source JJ Seabrook ~2011

9 Ion gauge readback, Torr Fractional composition, % Partial pressure, uncalibrated Vacuum 1.00E-06 H 2 H 2 O N E E-08 IG top IG exit port 1.00E m/z 1.00E Nitrogen/CO Oxygen Water 30 Hydrogen Time from cryos cold, hours 1.00E-08 Time from cryos cold, minutes

10 Integrated beam loss Stripping vs. Pressure 6.00% Vacuum Stripping vs Pressure N2ESP (Torr) 5.00% 4.00% 3.00E E E E % 2.00% 1.00% 0.00% Energey (MeV)

11 Integrated Losses (%) Accumulated Loss vs. Energy 1.6 Comparison of 70p Lorentz to Vaccum (8e-8Torr) Stripping Losses Lorentz Vacuum Energy (MeV)

12 Main screen Current Operator Navigation Bar Ion Source Output Target Current And Total Activity Beam Diagnostics Visible Beam On RF Dee Voltage Main Magnet Current Machine Status Vacuum Reading Alarms, Warning

13 Cyclotron ion source Emittance control Gas loading beam stripping Cost? External Source 14

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15 General description Tuner Tuner Motor M Motor Coupler M Tuner fix Dee #1 Dee #2 RF Pick-up RF Pick-up Coupler Tuner fix M Motor Motor M Phase Phase Power monitor RFL RFL Power monitor RF Amp RF Amp LLRF Digital Control START logic CW/Pulse operation RF Conditioning Master/Slave LLRF Digital Control START logic CW/Pulse operation RF Conditioning Cyclotron Supervisory PLC Operation control Interlock & Safety 20th ICCA, Vancouver, September 16, 2013

16 Beam stability test Beam jitter is within +/-4uA of the average of 416µA over a two hour period (or 1%). Stability over two hours is better than 4µA (or 1%). Ion source warming up 2 hours 412 ua 420 ua

17 RF Endurance test Dee Voltage stability: 4 x min snapshot 40 hour test

18 B15p 15 MeV 200 ua Upgrades to 1000 ua POSITRON EMITTERS 15 MeV x 1mA= 15 kw

19 OUTLINE OF PET CYCLOTRON BUNKER IN RECENT TENDER DOCUMENT MARCH 2015 Neutron Radiation levels n (usv/uahr) MCNP CALCULATION OF NEUTRON RADIATION LEVELS BEST MARCH 2015

20 Include local shielding and simplify doors

21 Simple block door MCNP estimate Production target Block door Neutron Dose Rate per microa of beam during F18 production (on the XY plane passing on the source point)

22 B14/15 Two targets can be irradiated simultaneously one on each opposite port. Targets on opposite ports can be irradiated in any configuration.

23 Target Windows The isolation windows of TeamBest target cells are preformed passivated havar. Their dome shape allows a thin central region (~ 20 um) and holds a very high pressure (tested to bursting at 2500 lb/in 2 ). This design eliminates the need for a helium cooling system for the beam windows.

24 Target body: cast silver passivated with Platinum Length: 150 mm Shape: 10 mm entrance tapering to 15 mm Operating pressure: 600 PSI Gas target

25 Water target Closed for operation Open for window change

26 Materials Choices for production targets Havar foil after 2042 ua hrs Niobium Sputtered Havar foil after 5585 ua hrs

27 J. Phys. D: Appl. Phys. 47 (2014) Niobium-based sputtered thin films for corrosion protection of proton-irradiated liquid water targets for [18F] production H Skliarova1, O Azzolini, O Cherenkova-Dousset1R R Johnson and V Palmieri

28 Cyclotron produced Tc 99m The supply of Tc99m for Nuclear Medicine procedures has been interrupted several times recently and this has prompted the development of accelerator techniques for the production of Tc99m. The figure below indicates the production yields for the process p+mo100 ->Tc99m+2n. J. Esposito

29 Pneumatic actuated Low current station. 7 kw Target loaded and unloaded automatically.

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31 TARGET TRANSPORT The target is transported to the landing terminal and reaction cell robot, all of which is located in a hot cell. The reaction cell is positioned adjacent to the target and the grabber positions the target in the reaction cell. The chemical dissolution occurs and separation steps are executed. The cleared target body is removed for storage.

32 The separation of the Mo 100 target material and the Tc 99m is first accomplished by a dry distillation process as shown below. The irradiated target material oxidised and is transported to the processing unit The process steps correspond to drying the target material elute and subliming and differentially distilling the oxides. The resulting Tc 99m oxide is then further purified in small columns for the final Tc 99m radiochemical.

33 Direct Production of Tc99m mci for 2,000,000 population Central Pharmacy can service need

34 RADIO-NUCLIDIC PURITY Saturated thick target yields for Tc radioisotopes calculated for proton beam energy loss MeV with the best commercially available enrichment of 100Mo. Relative activities of isotopes were calculated for 6h irradiation and 6h cooling time Lebeda O, Nucl. Med. Biol. Nov;39(8): (2012) Lebeda O, Nucl. Med. Biol. Nov;39(8): (2012) Pharmacopoeia (USP) limits for generator produced 99m Tc at the time of administration 0.1 % 99 Mo 0.01% Other radionuclidic impurities Experimental results, Ruth et.al. 18 MeV

35 RADIOISOTOPIC COMPOSITION AT 15 MeV BEST 15p CYCLOTRON 1 hour irradiation time Target Relative composition (EOB) (%) Tc-96 Tc-95 Tc-94 Tc-93 Purity of 99mTc Half-life 4.8 d 20.1h 293min 2.75h % Mo % hour irradiation time Target Relative composition (EOB) (%) Tc-96 Tc-95 Tc-94 Tc-93 Purity of 99mTc Half-life 4.8 d 20.1h 293min 2.75h % Mo %

36 15 MeV

37 J. Esposito private communication

38 CONCLUSIONS Ease operation Optimize energy of cyclotron and design for application Integrate targetry and radiochemistry Cost of Acquisition and Operation. Unify nuclear medicine and therapy delivery Facilitate Health Care Delivery Can we manage to do something new for Health Care?

39 Team Best supplies radioisotope production systems. Production targets Radiochemical separation Target material and target reprocessing Site design licensing

40 Team Best supplies radioisotope production systems. Production targets Radiochemical separation Target material and target reprocessing Site design licensing RRJ, General MGR