Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Version: 1.0

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1 Version: 1.0 SECTION 1: Identification 1.1. Identification Trade name : Product code : Recommended use and restrictions on use Recommended use Restrictions on use 1.3. Supplier : For rapid cooling of fresh or paraffin embedded tissue : Other uses Leica Biosystems Richmond, Inc 5205 Route 12 Richmond, IL USA T LBSNA-LBS-QA@leicabiosystems.com - leicabiosystems.com 1.4. Emergency telephone number Organization/Company Emergency number ChemTrec International Calls (call collect) Australia 24 Hr Poisons Information Centre SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mixture GHS-US classification Not classified 2.2. GHS Label elements, including precautionary statements GHS-US labeling No labeling applicable 2.3. Other hazards which do not result in classification 2.4. Unknown acute toxicity (GHS US) Not applicable SECTION 3: Composition/Information on ingredients 3.1. Substances Name : Name Product identifier % GHS-US classification 1,1,1,2-Tetrafluoroethane (CAS No) Not classified Full text of hazard classes and H-statements : see section Mixtures Not applicable 01/11/2018 EN (English US) Page 1

2 SECTION 4: First-aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse eyes with water as a precaution. : Call a poison center/doctor/physician if you feel unwell Most important symptoms and effects (acute and delayed) 4.3. Immediate medical attention and special treatment, if necessary Treat symptomatically. SECTION 5: Fire-fighting measures 5.1. Suitable (and unsuitable) extinguishing media Suitable extinguishing media 5.2. Specific hazards arising from the chemical Reactivity : Water spray. Dry powder. Foam Special protective equipment and precautions for fire-fighters Protection during firefighting SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures : The product is non-reactive under normal conditions of use, storage and transport. : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. : Ventilate spillage area For emergency responders Protective equipment : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Wear personal protective equipment. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions : Store in a well-ventilated place. Keep cool. SECTION 8: Exposure controls/personal protection 8.1. Control parameters 01/11/2018 EN (English US) 2/7

3 Not applicable 8.2. Appropriate engineering controls Appropriate engineering controls Environmental exposure controls : Ensure good ventilation of the work station. : Avoid release to the environment Individual protection measures/personal protective equipment Hand protection: Protective gloves Eye protection: Safety glasses Skin and body protection: Wear suitable protective clothing Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state Color Odor Odor threshold : Gas ph : 2-3 Melting point Freezing point Boiling point Flash point Relative evaporation rate (butyl acetate=1) Flammability (solid, gas) Vapor pressure Relative vapor density at 20 C Relative density Specific gravity / density : 1.21 Solubility Log Pow Auto-ignition temperature : Mixture contains one or more component(s) which have the following colour(s): Colourless : There may be no odour warning properties, odour is subjective and inadequate to warn of overexposure. Mixture contains one or more component(s) which have the following odour: Ether-like odour 01/11/2018 EN (English US) 3/7

4 Decomposition temperature Viscosity, kinematic Viscosity, dynamic Explosion limits Explosive properties Oxidizing properties 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions No dangerous reactions known under normal conditions of use Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity LC50 inhalation rat (mg/l) LC50 inhalation rat (ppm) Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity Reproductive toxicity Specific target organ toxicity single exposure Specific target organ toxicity repeated exposure Aspiration hazard > 2000 mg/l/4h (Rat; Literature study) > ppm/4h (Rat; Literature study) ph: 2-3 ph: /11/2018 EN (English US) 4/7

5 SECTION 12: Ecological information Toxicity Ecology - general : The product is not considered harmful to aquatic organisms or to cause long-term adverse effects in the environment. LC50 fish mg/l (LC50; 96 h) EC50 Daphnia mg/l (EC50; 48 h) Persistence and degradability Persistence and degradability Not readily biodegradable in water Bioaccumulative potential BCF other aquatic organisms (BCF) Log Pow 1.06 (OECD 107: Partition Coefficient (n-octanol/water): Shake Flask Method) Bioaccumulative potential Low potential for bioaccumulation (BCF < 500) Mobility in soil Other adverse effects Effect on the global warming GWPmix comment : No known effects from this product. : No known effects from this product. SECTION 13: Disposal considerations Disposal methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information Department of Transportation (DOT) In accordance with DOT Transport document description : UN3159 1,1,1,2-Tetrafluoroethane, 2.2 UN-No.(DOT) : UN3159 Proper Shipping Name (DOT) : 1,1,1,2-Tetrafluoroethane Class (DOT) : Class Non-flammable compressed gas 49 CFR Hazard labels (DOT) : Non-flammable gas DOT Quantity Limitations Passenger aircraft/rail (49 CFR ) DOT Quantity Limitations Cargo aircraft only (49 CFR ) : 75 kg : 150 kg 01/11/2018 EN (English US) 5/7

6 Other information : Product ships as UN3159 under DOT SP for all shipment originating within the United States of America. This US DOT special permit is valid for use in the US only. Special permit DOT SP does not apply to shipments originating outside of the US, where UN ID 1950 must be used. Transport by sea Transport document description (IMDG) : UN ,1,1,2-Tetrafluoroethane, 2.2 UN-No. (IMDG) : 3159 Proper Shipping Name (IMDG) : 1,1,1,2-Tetrafluoroethane Class (IMDG) : Non-flammable, non-toxic gases Air transport Transport document description (IATA) : UN ,1,1,2-Tetrafluoroethane, 2.2 UN-No. (IATA) : 3159 Proper Shipping Name (IATA) : 1,1,1,2-Tetrafluoroethane Class (IATA) : Gases : Non-flammable, non-toxic SECTION 15: Regulatory information US Federal regulations Listed on the United States TSCA (Toxic Substances Control Act) inventory International regulations CANADA Listed on the Canadian DSL (Domestic Substances List) EU-Regulations National regulations US State regulations U.S. - Pennsylvania - RTK (Right to Know) List SECTION 16: Other information SDS US Leica This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product 01/11/2018 EN (English US) 6/7

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